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Sun Dong,Li Xiang,Guo Dajing,Wu Lan,Chen Ting,Fang Zheng,Chen Linli,Zeng Wenbing,Yang Ran 대한영상의학회 2020 Korean Journal of Radiology Vol.21 No.7
Objective: To investigate the value of initial CT quantitative analysis of ground-glass opacity (GGO), consolidation, and total lesion volume and its relationship with clinical features for assessing the severity of coronavirus disease 2019 (COVID-19). Materials and Methods: A total of 84 patients with COVID-19 were retrospectively reviewed from January 23, 2020 to February 19, 2020. Patients were divided into two groups: severe group (n = 23) and non-severe group (n = 61). Clinical symptoms, laboratory data, and CT findings on admission were analyzed. CT quantitative parameters, including GGO, consolidation, total lesion score, percentage GGO, and percentage consolidation (both relative to total lesion volume) were calculated. Relationships between the CT findings and laboratory data were estimated. Finally, a discrimination model was established to assess the severity of COVID-19. Results: Patients in the severe group had higher baseline neutrophil percentage, increased high-sensitivity C-reactive protein (hs-CRP) and procalcitonin levels, and lower baseline lymphocyte count and lymphocyte percentage (p < 0.001). The severe group also had higher GGO score (p < 0.001), consolidation score (p < 0.001), total lesion score (p < 0.001), and percentage consolidation (p = 0.002), but had a lower percentage GGO (p = 0.008). These CT quantitative parameters were significantly correlated with laboratory inflammatory marker levels, including neutrophil percentage, lymphocyte count, lymphocyte percentage, hs-CRP level, and procalcitonin level (p < 0.05). The total lesion score demonstrated the best performance when the data cut-off was 8.2%. Furthermore, the area under the curve, sensitivity, and specificity were 93.8% (confidence interval [CI]: 86.8–100%), 91.3% (CI: 69.6–100%), and 91.8% (CI: 23.0–98.4%), respectively. Conclusion: CT quantitative parameters showed strong correlations with laboratory inflammatory markers, suggesting that CT quantitative analysis might be an effective and important method for assessing the severity of COVID-19, and may provide additional guidance for planning clinical treatment strategies.
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Highly-sensitive Detection of Salvianolic Acid B using Alumina Microfibers-modified Electrode
Sun, Dong,Zheng, Xiaoyong,Xie, Xiafeng,Yang, Xiaofeng,Zhang, Huajie Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.11
Alumina microfibers with porous structures were prepared through hydrothermal reaction, and then used to modify the surface of carbon paste electrode (CPE). After modification with alumina microfibers, the electrochemical activity of CPE was found to be greatly improved. On the surface of alumina microfibers-modified CPE, the oxidation peak current of salvianolic acid B, a main bioactive compound in Danshen with anti-oxidative and anti-inflammatory effects, was remarkably increased compared with that on the bare CPE surface. The influences of pH value, amount of alumina microfibers and accumulation time were studied. Based on the strong signal amplification effects of alumina microfibers, a novel electrochemical method was developed for the detection of salvianolic acid B. The linear range was from 5 ${\mu}gL^{-1}$ to 0.3 mg $L^{-1}$, and the detection limit was 2 ${\mu}gL^{-1}$ (2.78 nM) after 1-min accumulation. The new method was successfully used to detect salvianolic acid B in ShuangDan oral liquid samples, and the recovery was over the range from 97.4% to 102.9%.
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상대재료의 표면거칠기에 다른 PTFE와 UHMWPE의 마찰 및 마멸 특성
Sun Dong,정구현(Koo-Hyun Chung),이경식(Kyung-Sick Lee) 한국트라이볼로지학회 2011 한국윤활학회지(윤활학회지) Vol.27 No.6
Understanding of the tribological characteristics of polytetrafluoroethylen (PTFE) and ultra-high-molecular-weight polyethylene (UHMWPE) is crucial for their applications such as bearing and total joint replacement. In this work, the effect of the surface roughness of carbon steel on the tribological behaviors of PTFE and UHMWPE was experimentally investigated by using block-on-ring tribotester with friction force monitoring capability. It was found that that the amount of material transfer layers of PTFE formed on the carbon steel was signiticantly larger than those of UHMWPE, which was responsible the lower friction coefficient of PTFE. It was also concluded that the effect of surface roughness uf carbon steel on the friction coefficient of UHMWPE was more significant than that of PTFE. For UHMWPE, it was found that the effect of surface roughness of counterface was varied with respect to applied normal force and sliding as well. Based on Archard’s wear law, the wear coefficiellt of PTFE and UHMWPE was calculated to be 3 x 10<SUP>-5</SUP> ~ 8 x 10<SUP>-5</SUP> and 7 x 10<SUP>-6</SUP> ~- 2 x 10<SUP>-5</SUP> respectively.
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Consideration of the Necessity of Coaching the Korean MILITARY in the Pendemic Era
Sundong Youn J-INSTITUTE 2021 International Journal of Military Affairs Vol.6 No.1
Purpose: It is the era of talking about post-corona beyond the corona era. Corona is having a rapid impact on society as a whole. Many scholars predict that the pandemic will not stop as a single event, but will become daily life with a different name. With the rapid development of various media such as working from home and social media, it has become an era that requires more individual initiative. Coaching can be the most needed skill in this pandemic era. Social interest in coaching is also increasing. The pandemic is further increasing the need for coaching. In this paper, we look at the research trend of coaching in the times, and especially suggest implications for coaching research methods in the military. Method: In order to understand the research trends in the field of coaching, this study searched for doctoral dissertations on the RISS site of the Korea Education and Research Information Service. As a result, papers from 1992 to January 2021 were searched. The reason for the study of the doctoral dissertation is that it was judged that targeting the research results of researchers who entered the academic field as official experts provides data on stable re-search trends. First, 489 doctoral dissertations were searched, and through content analysis, doctoral dissertations with “coaching” were selected and compressed into a total of 210. The 210 papers were categorized through content analysis. Trend analysis through content analysis has the advantage of being able to implicitly show the research trend of a specific discipline. Afterwards, the selected papers were classified by period, research field, and major re-search field, and the trend of research was analyzed. Results: As a result of the analysis, the number of dissertations related to coaching has increased since '10, and exceeded 23 publications in '16. By research area, 53 in the field of education, 53 in the field of education, 40 in the field of sports, 37 in the field of business, 21 in general coaching, 23 in medicine, 18 in religion, 9 in public institutions, and 6 in career management. Was. The main research fields were 63 papers related to the ching program, 41 coaching leadership papers, 9 scale development papers, and 1 leadership coaching paper. In the case of public organizations, the number of papers decreases when compared to other fields, and in particular, military-related research was confirmed in three cases: coaching program development, effectiveness analysis, and coaching competency model development. Conclusion: Coaching requires active research and application in the military as well as the private sector. To this end, future research is necessary to expand the quantitative expansion of military-related coaching, group coaching and group coaching, etc., research in connection with group coaching and organizational culture improvement, and development of a coaching program for all executives. Finally, through the development of a leadership coaching diagnostic tool that reflects the characteristics of each group, we measure the current level of leaders and propose research and development of educational programs.
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A Comparative Study on National Culture of SNS User : Comparison of Korea, China, and U.S.
Sundong Kwon,Taeha Kim 한국데이타베이스학회 2011 Journal of information technology applications & m Vol.18 No.4
Our work empirically investigates the cultural differences of Social Networking Service (SNS) users in China, Korea and U.S. We construct a survey questionnaire from existing literature and test it for reliability, validity, and model fit. Then we collect data and validate the cultural differences of SNS users in three nations. Our results show different rankings from existing literature in cultural dimensions about three nations. In terms of masculinity, we find China > U.S. > Korea, similar to Hofstede. In individualism, we find U.S. > Korea > China, different from Hofstede (U.S. > China > Korea). In power distance, it is shown that Korea > China > U.S., different from Hofstede (China > Korea > U.S.). Uncertainty avoidance is found that U.S. > Korea > China, lowered ranking of Korea from the top among three nations in Hofstede. We find that these outcomes would be useful in updating national culture of the three nations and for future research about cultural impacts on SNS adoption.
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Sundong Lin,Lechu Yu,Yongqing Ni,Lulu He,Xiaolu Weng,Xuemian Lu,Chi Zhang 대한당뇨병학회 2020 Diabetes and Metabolism Journal Vol.44 No.1
Background: Epithelial-to-mesenchymal transition (EMT) is required for renal fibrosis, which is a characteristic of diabetic nephropathy (DN). Our previous study demonstrated that fibroblast growth factor 21 (FGF21) prevented DN associated with the suppressing renal connective tissue growth factor expression, a key marker of renal fibrosis. Therefore, the effects of FGF21 on renal fibrosis in a DN mouse model and the underlying mechanisms were investigated in this study. Methods: Type 1 diabetes mellitus was induced in C57BL/6J mice by intraperitoneal injections of multiple low doses of streptozotocin. Then, diabetic and non-diabetic mice were treated with or without FGF21 in the presence of pifithrin-α (p53 inhibitor) or 10-[4´-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride (10-DEBC) hydrochloride (Akt inhibitor) for 4 months. Results: DN was diagnosed by renal dysfunction, hypertrophy, tubulointerstitial lesions, and glomerulosclerosis associated with severe fibrosis, all of which were prevented by FGF21. FGF21 also suppressed the diabetes-induced renal EMT in DN mice by negatively regulating transforming growth factor beta (TGF-β)-induced nuclear translocation of Smad2/3, which is required for the transcription of multiple fibrotic genes. The mechanistic studies showed that FGF21 attenuated nuclear translocation of Smad2/3 by inhibiting renal activity of its conjugated protein p53, which carries Smad2/3 into the nucleus. Moreover pifithrin-α inhibited the FGF21-induced preventive effects on the renal EMT and subsequent renal fibrosis in DN mice. In addition, 10-DEBC also blocked FGF21-induced inhibition of renal p53 activity by phosphorylation of mouse double minute-2 homolog (MDM2). Conclusion: FGF21 prevents renal fibrosis via negative regulation of the TGF-β/Smad2/3-mediated EMT process by activation of the Akt/MDM2/p53 signaling pathway.
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