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Tumor Location Causes Different Recurrence Patterns in Remnant Gastric Cancer
Sun Bo,Zhang Haixian,Wang Jiangli,Cai Hong,Xuan Yi,Xu Dazhi 대한위암학회 2022 Journal of gastric cancer Vol.22 No.4
Purpose Tumor recurrence is the principal cause of poor outcomes in remnant gastric cancer (RGC) after resection. We sought to elucidate the recurrent patterns according to tumor locations in RGC. Materials and Methods Data were collected from the Shanghai Cancer Center between January 2006 and December 2020. A total of 129 patients with RGC were included in this study, of whom 62 had carcinomas at the anastomotic site (group A) and 67 at the non-anastomotic site (group N). The clinicopathological characteristics, surgical results, recurrent diseases, and survival were investigated according to tumor location. Results The time interval from the previous gastrectomy to the current diagnosis was 32.0±13.0 and 21.0±13.4 years in groups A and N, respectively. The previous disease was benign in 51/62 cases (82.3%) in group A and 37/67 cases (55.2%) in group N (P=0.002). Thirty-three patients had documented sites of tumor recurrence through imaging or pathological examinations. The median time to recurrence was 11.0 months (range, 1.0–35.1 months). Peritoneal recurrence occurred in 11.3% (7/62) of the patients in group A versus 1.5% (1/67) of the patients in group N (P=0.006). Hepatic recurrence occurred in 3.2% (2/62) of the patients in group A versus 13.4% (9/67) of the patients in group N (P=0.038). Patients in group A had significantly better overall survival than those in group N (P=0.046). Conclusions The tumor location of RGC is an essential factor for predicting recurrence patterns and overall survival. When selecting an optimal postoperative follow-up program for RGC, physicians should consider recurrent features according to the tumor location. Purpose Tumor recurrence is the principal cause of poor outcomes in remnant gastric cancer (RGC) after resection. We sought to elucidate the recurrent patterns according to tumor locations in RGC. Materials and Methods Data were collected from the Shanghai Cancer Center between January 2006 and December 2020. A total of 129 patients with RGC were included in this study, of whom 62 had carcinomas at the anastomotic site (group A) and 67 at the non-anastomotic site (group N). The clinicopathological characteristics, surgical results, recurrent diseases, and survival were investigated according to tumor location. Results The time interval from the previous gastrectomy to the current diagnosis was 32.0±13.0 and 21.0±13.4 years in groups A and N, respectively. The previous disease was benign in 51/62 cases (82.3%) in group A and 37/67 cases (55.2%) in group N (P=0.002). Thirty-three patients had documented sites of tumor recurrence through imaging or pathological examinations. The median time to recurrence was 11.0 months (range, 1.0–35.1 months). Peritoneal recurrence occurred in 11.3% (7/62) of the patients in group A versus 1.5% (1/67) of the patients in group N (P=0.006). Hepatic recurrence occurred in 3.2% (2/62) of the patients in group A versus 13.4% (9/67) of the patients in group N (P=0.038). Patients in group A had significantly better overall survival than those in group N (P=0.046). Conclusions The tumor location of RGC is an essential factor for predicting recurrence patterns and overall survival. When selecting an optimal postoperative follow-up program for RGC, physicians should consider recurrent features according to the tumor location.
Tumor Location Causes Different Recurrence Patterns in Remnant Gastric Cancer
Sun, Bo,Zhang, Haixian,Wang, Jiangli,Cai, Hong,Xuan, Yi,Xu, Dazhi The Korean Gastric Cancer Association 2022 Journal of gastric cancer Vol.22 No.-
Purpose: Tumor recurrence is the principal cause of poor outcomes in remnant gastric cancer (RGC) after resection. We sought to elucidate the recurrent patterns according to tumor locations in RGC. Materials and Methods: Data were collected from the Shanghai Cancer Center between January 2006 and December 2020. A total of 129 patients with RGC were included in this study, of whom 62 had carcinomas at the anastomotic site (group A) and 67 at the non-anastomotic site (group N). The clinicopathological characteristics, surgical results, recurrent diseases, and survival were investigated according to tumor location. Results: The time interval from the previous gastrectomy to the current diagnosis was 32.0±13.0 and 21.0±13.4 years in groups A and N, respectively. The previous disease was benign in 51/62 cases (82.3%) in group A and 37/67 cases (55.2%) in group N (P=0.002). Thirty-three patients had documented sites of tumor recurrence through imaging or pathological examinations. The median time to recurrence was 11.0 months (range, 1.0-35.1 months). Peritoneal recurrence occurred in 11.3% (7/62) of the patients in group A versus 1.5% (1/67) of the patients in group N (P=0.006). Hepatic recurrence occurred in 3.2% (2/62) of the patients in group A versus 13.4% (9/67) of the patients in group N (P=0.038). Patients in group A had significantly better overall survival than those in group N (P=0.046). Conclusions: The tumor location of RGC is an essential factor for predicting recurrence patterns and overall survival. When selecting an optimal postoperative follow-up program for RGC, physicians should consider recurrent features according to the tumor location.
Homochiral porous nanosheets for enantiomer sieving
Sun, Bo,Kim, Yongju,Wang, Yanqiu,Wang, Huaxin,Kim, Jehan,Liu, Xin,Lee, Myongsoo Nature Publishing Group UK 2018 NATURE MATERIALS Vol.17 No.7
<P>Protein pores are highly specific in binding to chiral substrates and in catalysing stereospecific reactions, because their active pockets are asymmetric and stereoselective(1,2). Chiral binding materials from molecular-level pores with high specificity have not been achieved because of problems with pore deformation and blocking(3). A promising solution is the self-assembly of single sheets where all pores are exposed to the environment, for example as metal-organic frameworks(4), polymers(5,6) or non-covalent aromatic networks(7-10), but, typically, the pores are distant from the internal cavities with chirality. Here, we report the synthesis of homochiral porous nanosheets achieved by the 2D self-assembly of non-chiral macrocycles, with open/closed pore switching. Pore chirality is spontaneously induced by a twisted stack of dimeric macrocycles. The porous 2D structures can serve as enantiomer sieving membranes that exclusively capture a single enantiomer in a racemic mixture solution, with uptake capacity greater than 96%. Moreover, the entrapped guests inside the pores can be pumped out by pore closing triggered by external stimuli. This strategy could provide new opportunities for controlled molecule release, as well as for artificial cells.</P>
Therapeutic potential of mesenchymal stromal cells in a mouse breast cancer metastasis model
Sun, Bo,Roh, Kyoung-Hwan,Park, Jeong-Ran,Lee, Sae-Rom,Park, Sang-Bum,Jung, Ji-Won,Kang, Soo-Kyung,Lee, Yong-Soon,Kang, Kyung-Sun Elsevier 2009 cytotherapy Vol.11 No.3
<P>Mesenchymal stromal cells (MSC) have been studied intensively in regenerative medicine. However, their therapeutic potential against tumor formation and cancer metastasis is still unclear. The effects of transplantation of MSCs in early-stage of carcinogenesis, should be evaluated.</P>
Sunbo Shim,Songcheol Hong IEEE 2011 IEEE transactions on microwave theory and techniqu Vol.59 No.11
<P>A CMOS power amplifier (PA) with a compact spiral-shaped directional coupler for a mobile UHF RF identification (RFID) reader is proposed here, and its output power combiner and the directional coupler are implemented using an integrated passive device process. The two-chip solution not only enables a CMOS PA to be highly efficient, but also allows the directional coupler and the power combiner to be mounted in a compact standard package. A polar transmitter is implemented using the CMOS PA with the directional coupler to verify the operation of the proposed configuration for a UHF RFID reader. Measurements indicate that the CMOS PA with the directional coupler transmits 27.3 dBm of output with 44.6% of power-added efficiency and that the implemented polar transmitter satisfies the required UHF RFID reader specifications.</P>
Investigation of Electrical and Optical Properties of Highly Transparent TCO/Ag/TCO Multilayer.
Kim, Sunbo,Lee, Jaehyeong,Dao, Vinh Ai,Ahn, Shihyun,Hussain, Shahzada Qamar,Park, Jinjoo,Jung, Junhee,Lee, Chan,Song, Bong-Shik,Choi, Byoungdeog,Lee, Youn-Jung,Iftiquar, S M,Yi, Junsin American Scientific Publishers 2015 Journal of nanoscience and nanotechnology Vol.15 No.3
<P>Transparent conductive oxides (TCOs) have been widely used as transparent electrodes for optoelectronic devices, such as solar cells, flat-panel displays, and light-emitting diodes, because of their unique characteristics of high optical transmittance and low electrical resistivity. Among various TCO materials, zinc oxide based films have recently received much attention because they have advantages over commonly used indium and tin-based oxide films. Most TCO films, however, exhibit valleys of transmittance in the wavelength range of 550-700 nm, lowering the average transmittance in the visible region and decreasing short-circuit current (I-sc) of solar cells. A TCO/Ag/TCO multilayer structure has emerged as an attractive alternative because it provides optical characteristics without the valley of transmittance compared with a 100-nm-thick single-layer TCO. In this article, we report the electrical, optical and surface properties of TCO/Ag/TCO. These multi-layers were deposited at room temperature with various Ag film thicknesses from 5 to 15 nm while the thickness of TCO thin film was fixed at 40 nm. The TCO/Ag/TCO multi-layer with a 10-nm-thick Ag film showed optimum transmittance in the visible (400-800 nm) wavelength region. These multi-layer structures have advantages over TCO layers of the same thickness.</P>
Kim, Sunbo,Jung, Junhee,Kim, YoungKuk,Le, Anh Huy Tuan,Ahn, Shihyun,Park, Jinjoo,Kim, Yongjun,Dao, Vinh Ai,Lee, Jaehyeong,Lee, Youn-Jung American Scientific Publishers 2017 Journal of Nanoscience and Nanotechnology Vol.17 No.5
<P>This study investigates the effect of hydrogen gas ratio [H-2/H-2+Ar] had on the structural, optical and electrical properties of ITO films for use in amorphous/crystalline silicon hetero-junction solar cells. The pulsed DC magnetron sputtered ITO films showed a higher optical transmittance for a hydrogen gas ratio of 3.2%. The lowest sheet resistance (43.12 Omega/square) and resistivity (3.25x10(-4) Omega.cm) were observed for ITO films where the hydrogen gas ratio was in the range from 1.31 to 3.22%. The Hall mobility of the ITO films decreased from 55.3 to 42.5 cm(2)/V.s with an increase in the hydrogen gas ratio from 1.31 to 3.2%. The surface morphology and crystallinity of films improved for the low hydrogen gas ratio while the characteristics of the ITO films deteriorated when the hydrogen ratio was higher than 3.2%. Then, we fabricated amorphous/crystalline silicon hetero-junction solar cells using ITO films for the front anti-reflection layer, and a hydrogen gas ratio of 3.22% resulted in a short circuit current density (J(sc)) of 38.17 mA/cm(2) and an efficiency of 19.02%.</P>