Comparison of Melanoma Subtypes among Korean Patients by Morphologic Features and Ultraviolet Exposure

( Hong Sun Jang ),( Jee Hung Kim ),( Kyu Hyun Park ),( Jae Seok Lee ),( Jung Min Bae ),( Byung Ho Oh ),( Sun Young Rha ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.4

Background: Genetic alterations have been identified in melanomas according to different levels of sun exposure. Whereas the conventional morphology-based classification provides a clue for tumor growth and prognosis, the new classification by genetic alterations offers a basis for targeted therapy. Objective: The purpose of this study is to demonstrate the biological behavior of melanoma subtypes and compare the two classifications in the Korean population. Methods: A retrospective chart review was performed on patients found to have malignant melanoma in Severance Hospital from 2005 to 2012. Age, sex, location of the tumor, histologic subtype, tumor depth, ulceration, lymph node invasion, visceral organ metastasis, and overall survival were evaluated. Results: Of the 206 cases, the most common type was acral melanoma (n=94, 45.6%), followed by nonchronic sun damage-induced melanoma (n=43, 20.9%), and mucosal melanoma (n=40, 19.4%). Twenty-one patients (10.2%) had the chronic sun-damaged type, whereas eight patients (3.9%) had tumors of unknown primary origin. Lentigo maligna melanoma was newly classified as the chronic sun-damaged type, and acral lentiginous melanoma as the acral type. More than half of the superficial spreading melanomas were newly grouped as nonchronic sun-damaged melanomas, whereas nodular melanoma was rather evenly distributed. Conclusion: The distribution of melanomas was largely similar in both the morphology-based and sun exposure-based classifications, and in both classifications, mucosal melanoma had the worst 5-year survival owing to its tumor thickness and advanced stage at the time of diagnosis. (Ann Dermatol 26(4) 485~490, 2014)

Combustion characteristics of gaseous inverse O₂/H₂ coaxial jet flames in a single-element model combustor

Kim, Tae Young,Choi, Sun,Kim, Young Hoo,Ahn, Yeong Jong,Kim, Hee Kyung,Kwon, Oh Chae Elsevier 2018 ENERGY Vol.155 No.-

<P><B>Abstract</B></P> <P>To effectively design hydrogen (H<SUB>2</SUB>)/oxygen (O<SUB>2</SUB>) liquid rocket engines through understanding the combustion characteristics of H<SUB>2</SUB>/O<SUB>2</SUB> bipropellants, fundamental studies for the bipropellants in different phases are needed. This study is focused on the combustion characteristics of inverse gaseous O<SUB>2</SUB>/H<SUB>2</SUB> coaxial jet flames in a single-element model combustor as a preliminary step for succeeding studies of injection at different phases in the combustor, visualizing flame structure by direct imaging, OH<SUP>∗</SUP> chemiluminescence and OH planar laser-induced fluorescence. With increasing Reynolds number (Re), the frequency of occurrence of the local flame extinction increases and the length of the disconnected OH reaction zone is extended. The OH layer thickness increases downstream, while it is almost constant where the local flame extinction occurs and decreases with increasing Re due to the enhanced strain and scalar-dissipation rates. The excessive flame wrinkledness increases the local flame strain rate and results in the local flame extinction, exhibiting the tendency of increasing and then decreasing flame surface density with increasing Re. The probability density function of OH intensity quantifies the fluctuation intensity of OH radicals and the possibility of the local flame extinction. A useful database is provided for modeling the combustion of H<SUB>2</SUB>/O<SUB>2</SUB> bipropellants under different phases.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A useful database for modeling the H<SUB>2</SUB>/O<SUB>2</SUB> bipropellant combustion is provided. </LI> <LI> Local flame extinction frequently occurs at high Reynolds number (<I>Re</I>). </LI> <LI> OH probability density function indicates the possibility of local extinction. </LI> <LI> Flame surface density increases and then decreases with increasing <I>Re</I>. </LI> <LI> Strong burning of O<SUB>2</SUB>/H<SUB>2</SUB> causes laminar-like combustion near the injector lip. </LI> </UL> </P>

한국인에서 일광 노출의 유해성에 대한 인지도와 일광 차단제의 이용 행태에 대한 연구

김상태,김기호,오선진,이승철,강세훈,윤재일,김진준,박석범,김홍용 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.6

Background: Although deleterious effects of sunlight have been increased recently, the surveillance of the attitudes toward sun-exposure and the behavioral aspect of using sunscreens in Koreans has hot been carried out. Objective: Our purpose was to evaluate the attitude toward the harmfulness of sun-exposure and behaviors of using sunscreens in Korea. Method: Five hundred and fifty-two subjects were surveyed to assess the attitude toward sun-exposure, as well as the subjects knowledge about, and the use of sunscreens. Underlying data including demographic data, skin colors, skin types, occupation, and sun-exposure, were obtained. Results: Fifty-four percent of subjects believed that sun-exposure is bad for their skins, but, on the contrary, 12.5% believed it to be beneficial. Fifty-two percent of subjects used sunscreens. Almost all subjects(93.8%) knew why to use sunscreens but 62.7% of subjects did not know the meaning of sun protective factors(SPF). Women, indoor workers, subjects less than 40 years old, with less sun-exposed, fair colored skin, or with skin type I, II, III tended to know the deleterious effects of sunlight and the meaning of SPF and used more sunscreen. Conclusion: High risk population-men, outdoor workers, subjects oider than 40 years old, with more sun-exposed, dark colored skin, or skin type VI, V could be targeted with campaigns that promote attitudinal and behavioral changes.

Flexural Responses of Prestressed Hybrid Wide Flange Composite Girders

Sun?Jin Han,Deuck Hang Lee,Jae?Yuel Oh,Seung?Ho Choi,Kang Su Kim 한국콘크리트학회 2018 International Journal of Concrete Structures and M Vol.12 No.5

In this study, prestressed hybrid wide flange (PHWF) composite girders were proposed, and full-scale flexural tests were conducted to evaluate their structural performances. This new proposed girder system was developed and designed to effectively resist external loads considering the actual construction sequences. Two specimens with and without shear connectors were fabricated and tested to examine the effect of the shear connectors for achieving the fully-composite behaviors between a cast-in-place (CIP) concrete and the prefabricated prestressed steel–concrete composite girder. The test results showed that sufficient flexural strengths and deformation capacities can be obtained in both types of PHWF composite girders with and without shear connectors. To reflect the actual construction stages of the proposed PHWF composite girder, nonlinear flexural analyses were proposed considering the prestress effect and segmental effect before and after composite with the CIP concrete, respectively. The observed and analysis results of strain behaviors of the PHWF girder specimens were also compared and discussed in detail.

Estimation and Comparison of Cortical Thickness Index and Canal‑to‑Calcar Ratio Using Manual Method and Deep Learning Method

Sun‑Jung Yoon,Minwoo Kim,Il‑Seok Oh,Kyungho Kim,한갑수 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.3

Manual calculation of the cortical thickness index (CI) and canal-to-calcar ratio (CC) using radiographs has been widely used. The purpose of this study was to investigate the diference between manual gold standard and automatic calculation based on deep convolutional neural networks (CNNs) of the proximal femur. We obtained institutional review board approval to utilize previous radiographs for the study and the radiograph images were used to train CNN architecture. The calculation experiment of a dataset of 136 images of the proximal femur to estimate CI and CC was performed using a trained CNN architecture (Automatic). Also, manual segmentation method (Manual) to calculate CI and CC was conducted using the standard protocol by two experts as a reference for the results comparison. The mean values of the Manual and Automatic calculation of CI for the proximal femur were 0.56 and 0.54, respectively, showing a statistically signifcant diference (p=0.035). Signifcant diference (p<0.001) was also seen in the calculation of CC by Manual and Automatic method resulting in 0.42 and 0.47, respectively. In addition, the automatic method showed far better results in terms of calculation speed (less than 30 s per single image). Therefore, we suggest that the manual method be carefully considered while planning a surgery.

Properties of inverse nonpremixed pure O₂/CH₄ coflow flames in a model combustor

Choi, Sun,Kim, Tae Young,Kim, Hee Kyung,Koo, Jaye,Kim, Jeong Soo,Kwon, Oh Chae Elsevier 2015 ENERGY Vol.93 No.1

<P><B>Abstract</B></P> <P>In order to evaluate the potential of oxy-combustion of inverse nonpremixed coflow flames using a clean fuel to improve the combustion and emission characteristics compared with the normal coflow flames using air, the fundamental properties of inverse nonpremixed pure oxygen (O<SUB>2</SUB>)/methane (CH<SUB>4</SUB>) coflow flames in a model combustor are experimentally investigated. The combustion stability (extinction) limits, structure and nitrogen oxide (NO<SUB>x</SUB>) emissions of the inverse coflow flames in the quartz-windowed combustion chamber with a single shear coaxial injector and a fully opened exhaust nozzle are measured using OH<SUP>∗</SUP> chemiluminescence, a schlieren imaging system and a gas analyzer. Results show four distinct stability regimes and limits: the attached flame regime, the near-blowout flame regime, blowout limits and blowoff limits. The direct flame and OH<SUP>∗</SUP> chemiluminescence images confirm the cooling effects of chamber walls that cause no steady liftoff flame and only the near-blowout flame. The extinction limits of the inverse CH<SUB>4</SUB>/O<SUB>2</SUB> coflow flames are extended compared with the normal CH<SUB>4</SUB>/air coflow flames and reasonable levels of NO<SUB>x</SUB> emissions are observed, which supports that oxy-combustion of the inverse nonpremixed coflow flames using the clean fuel is acceptable for practical application, providing a useful database for modeling the flames in the confined chamber.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Extended stability limits of inverse nonpremixed O<SUB>2</SUB>/CH<SUB>4</SUB> coflow flames are found. </LI> <LI> Stable, attached flames and oscillating, near-blowout flames are observed. </LI> <LI> Direct flame and OH<SUP>∗</SUP> chemiluminescence images indicate no steady liftoff flame. </LI> <LI> Reasonable levels of NO<SUB>x</SUB> emissions are observed. </LI> <LI> Inverse nonpremixed O<SUB>2</SUB>/CH<SUB>4</SUB> coflow flames are acceptable for practical applications. </LI> </UL> </P>

孤山 尹善道의 삶과 文學 小考

오선주(Oh Sun-Ju) 한국시조학회 2005 시조학논총 Vol.23 No.-

이 글은 강호자연과 정치현실을 반복적으로 넘나든 孤山 尹善道의 삶과 그의 문학에 대해서 고찰한 것이다. 특히 강호와 조정의 두 현실에 대해서 어떤 인식 양상을 보이며, 작품에 어떻게 투영되어 나타나는가에 초점을 두어 살폈다. 그리고 이를 바탕으로 그의 문학관을 검토하였다. 먼저 정치적 시련의 시초가 된 상소문을 통해서 정치현실과 타협하지 않는 직선적 성격과 이에 내재된 강한 정치적 성향을 지적하고, 이를 출처관과 관련지어 논의하여 재설명하였다. 이에 두 면모는 각각 대결의식과 두 현실을 상황에 따라 넘나드는 모습으로 투영됨을 확인하였다. 그리고 윤선도가 주로 기거한 金鎖洞의 산수 경관을 술회한 〈金鎖洞記〉의 내용을 분석하여 자연관의 총체가 ‘會心’으로 집약됨을 밝혔다. 이 회심에는 강호 생활에 대한 만족과 그에 따른 윤리의식이 내포되어 있는데, 이것이 그대로 작품에 투영되고 있다. 끝으로 단편적으로 문학에 대해 언급한 글을 살펴보고, 자연의 법칙과 윤리의식을 작품에 담아내야 한다는 것이 윤선도의 문학관이라고 규정하였다. This study is about literature of Gosan Yun Sun-do(孤山 尹善道) and his life that haunted Gang-ho(江湖) natures and political realities repeatedly. Especially, it considers what aspect of cognition he had about two realities. Gang-ho(江湖) and the Imperial Court(朝廷) and how it throws image on his works. And through these. it is examined what his viewpoint of literature is. First of all, through a memorial to the Throne that put him in first political trial, we can know that he was so strict that he didn't compromise with political realities and at the same time, he has a strong political inclination hidden behind his character. These two aspects are reflected on his works as his confrontation will and his agony between the two realities two realities. And through analysing the contents of 〈金鎖洞記〉 that recollect landscapes of 金鎖洞 where Yun Sun-do mostly stayed, it can be found that his total viewpoints of nature is complacency. This complacency including the satisfaction of Gang-he life and his ethics is intactly reflected on his works. Finally, it is dearly revealed that he tried to embody the principle of nature and ethics in his literary works and his reference to the literary as well.

중환자 가족의 사회적 지지, 부담감 및 삶의 질과의 관계 연구

이강오,김유선 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Background and Objectives: The study is aimed at identify social support, burden and quality of life in Intensive Care Unit (ICU) Patient's family, to investigate the correlation among social support, burden and quality of life in ICU patient's family. Materials and Method: The data for this study were collected through a research which was conducted to ninety seven in ICU patient's family in C university hospital in Gwangju City, from August 16 to October 23, 2004. The instruments used for this study are the social support measurement tool developed by Brandt & Weinert (1981) and adapted and revised by Ga-SiI Oh & Mi-Hyee Seo, the burden measurement tool developed by Montgomery's and adapted and revised by Sun-Hak, Oh, the quality of life measurement tool developed by Seong-GiI Min in accordance with the guidelines of WHOQOL. The data collected were analysed using SPSS Win to descriptive statistics, t-test, ANOVA, Scheffe & Tukey post-validation test, and Pearson's correlation. Results: Regarding correlations, while there was a significantly positive correlation between social support and quality of life. There was significantly negative correlation between burden and quality of life. Also, there was significantly negative correlation between social support and quality of life. ConclusIon: There were close correlation among social support, burden, and quality of life in ICU patient's family. Thus, the establishment of nursing interventional program is necessary to promote quality of life in ICU patient's family.

모델연소실 내 산소-메탄 비예혼합 역확산화염의 연소특성 연구

최선(Sun Choi),김태영(Tae Young Kim),김희경(Hee Kyung Kim),권오채(Oh Chae Kwon) 한국추진공학회 2015 한국추진공학회 학술대회논문집 Vol.2015 No.5

지구온난화로 인한 기후변화에 대응하기 위해 다양한 노력이 요구되는 가운데 연소효율을 증가시키고 공해물질의 배출을 저감할 수 있으며 연소 후 이산화탄소 포집이 용이한 산소-메탄 비예혼합 역확산화염의 연소특성에 대한 연구를 수행하였다. 모델연소실 내에서 산소-메탄 비예혼합 역확산화염의 연소안정한계를 측정하고, 화염구조 파악을 위해 OH* 자발광 기법을 통해 반응영역을 확인하였다. In response to the concern over global warming, there has been substantial interest in either developing high-efficiency or low-emission combustion devices. The use of inverse nonpremixed oxygen (O₂)-methane (CH₄) flames as one possible technology for achieving the high-efficiency and low-emission is considered and thus the combustion characteristics of the oxy-fuel inverse flames in a model combustor are experimentally investigated. The combustion stability limits and structure of O₂-CH₄ inverse flames are measured using OH* chemiluminescence.

모델연소실 내 GCH₄/GO₂ 및 GH₂ /GO₂ 동축류 제트화염의 연소특성 기초 연구

최선(Sun Choi),김태영(Tae Young Kim),김희경(Hee Kyung Kim),권오채(Oh Chae Kwon) 한국추진공학회 2016 한국추진공학회 학술대회논문집 Vol.2016 No.12

로켓 엔진의 차세대 액체이원추진제로서 각광을 받고 있는 메탄(CH₄)/산소(O₂) 이원추진제의 기초연소특성 및 연소 안정화의 고유특성 확인을 위해 수소(H2)/산소 이원추진제 연소특성과 비교 연구를 수행하였다. 기초 연소특성 연구를 위한 모델연소실 내에서 기체 메탄(GCH₄)/기체 산소(GO₂) 및 기체수소(GH₂)/GO₂의 동축류 제트화염의 연소안정한계와 직접 사진, OH<SUP>*</SUP> 자발광 이미지를 측정한 결과, GCH₄/GO₂와 GH₂/GO₂ 모두 산소-연료 모멘텀비((O/F)mom)가 감소함에 따라 연소안정한계는 확장되는 경향을 보였으나 GH₂/GO₂ 화염에 비해 GCH₄/GO₂ 화염은 좁은 연소안정한계가 측정되었고, 또한 GCH₄/GO₂ 화염은 이론당량비 조건에서, GH2/GO₂ 화염은 연료과농 조건에서 최대 OH* 강도가 측정됨을 OH<SUP>*</SUP> 자발광 가시화를 통해 확인하였다. Liquid methane (CH₄)/oxygen (O₂) bipropellants have been recently considered as a next-generation propellant due to eco-friendly and non-toxic properties, low cost and high performance. To investigate the unique features of CH₄/O₂ bipropellants, the fundamental combustion characteristics of gaseous CH₄/O₂ and H₂/O₂ coaxial jet flames in a model combustor are investigated through measuring the combustion stability limits and visualizing flames. Results show that the combustion stability limits of GCH₄/GO₂ flames are reduced compared with the GH₂/GO₂ flames. The maximum OH<SUP>*</SUP> intensity of GCH₄/GO₂ flames is observed at near-stoichiometric condition, while the GH₂/GO₂ flames at fuel-rich condition.