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Fingertip Force and Muscle Activation Patterns at Varying grasp Objects
Suji Park(Suji Park),Juhyun Park(Juhyun Park),Seyeon Oh(Seyeon Oh),Chaeyeon Heo(Chaeyeon Heo),Sieun Ho(Sieun Ho),Seonhong Hwang(Seonhong Hwang) 호서대학교 기초과학연구소 2022 기초과학연구 논문집 Vol.30 No.1
In this study, we tried to collect and analyze the kinetic and neurological information such as finger-tip forces and EMG for several representative (the most commonly used) grasp movements to explore their force and muscle activation patterns based on the newly defined grasp taxonomy. Ten able-bodied (five males, five females) volunteered to participate and they performed five different grasp tasks: holding a bottle (Bottle), turning a doorknob (Knob), cutting with a knife (Knife), brushing with a toothbrush (Toothbrush), holding a thick book (Book) after we attached five force sensitive resistor (FSR) sensors on the tip of fingers and four surface electromyogram (sEMG) electrodes on the lower arm of the subject’s dominant hand. Root Mean Square (RMS) and Mean Absolute Value (MAV) from the mean maximum values of sEMG(%) and fingertip force(kgf) of all ten subjects were extracted as features. The classification from the feature dataset using convolutional neural network (CNN) was applied and analyzed the results of accuracy and repeatability. The mean maximum values of EMG and fingertip forces during five different grasp tasks, and the MAV and RMS which were extracted features from the above were compared with task pairs. They showed significant differences in comparison of four pairs of tasks which were Bottle and Knife (p = 0.005 in both MAV and RMS), Bottle and Toothbrush (p = 0.005in both MAV and RMS), Bottle and Book (p = 0.013 in both MAV and RMS), Knob and Toothbrush (p = 0.047 in MAV and p = 0.028 in RMS). The classification accuracy of the Bottle grasp task was the largest at 60% (true positive predictive rate is 60% and false postive rate is 40%), while the other tasks showed an 30-40% of accuracy. Repeatability was 60% in the Bottle task and 50% in the Knob task, and those of the other tasks were ranged 30-40%. Overall, it is believed that the small number of samples in the study is the main reason of the low accuracy and repeatability of the classification. A total of nine variables (four sEMG and five forces) showed different significances in paired mean comparisons for five grasp tasks (graspping a bottle, turning a doorknob, cutting with a knife, brushing teeth with a toothbrush, holding a thick book). A comparison of the reduced variable from feature extraction also showed different classification accuracy for five grasp tasks.
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Expression of Prostaglandin E2 Receptors in Acquired Middle Ear Cholesteatoma
Sujie Wang,Li Xie,Yanfei Zhang,Pengfei Xu,Aiguo Liu 대한이비인후과학회 2018 Clinical and Experimental Otorhinolaryngology Vol.11 No.1
Objectives. To investigate the expression of prostaglandin E2 receptor subtypes, E-prostanoid (EP) 1–4 receptors, in acquired cholesteatoma and its possible role in the pathologic process of this disorder. Methods. Specimens of human acquired cholesteatoma were obtained from 29 patients and 19 skin biopsies of normal external auditory canal were as controls. The mRNA and protein expression of EP receptors was assessed by quantitative real-time polymerase chain reaction, immunohistochemistry and Western blot. Results. In acquired cholesteatoma, EP1–EP4 receptors were mainly expressed on squamous epithelium and subepithelial infiltrated inflammatory cells. In external auditory canal skin, EP1–EP4 receptors were mainly expressed on squamous epithelium and glandular epithelium. The expression of EP4 receptor on mRNA and protein levels were significant lower in acquired cholesteatoma compared with controls. EP1–EP3 receptors had no significant difference between the experimental and control group. Conclusion. Low expression of EP4 may play a crucial role in the pathologic process of inflammation reaction and bone destruction in acquired cholesteatoma, but not EP1, EP2, or EP3 receptors.
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( Suji Kim ),( Woo Bin Park ),( Hyun-eui Park ),( Hong-tae Park ),( Han Sang Yoo ) 대한인수공통전염병학회 2019 창립총회 및 학술대회 초록집 Vol.2019 No.1
Background: An opportunistic intracellular pathogen Mycobacterium avium subsp. hominissuis, a member of the nontuberculous mycobacteria (NTM) cluster, causes respiratory disease in immunosuppressed hosts. In particular, infected companion dogs are a potential role to transmit the agent to children or immunosuppressed peoples. However, an underlying mechanism on the pathogeneses of M. avium hominissuis in dogs is not well known. Therefore, the purpose of this study is to investigate a host-M. avium hominissuis interactome in canine PBMCs and DH82 during the infection. Method: Peripheral blood mononuclear cells were isolated from six healthy beagles buffy coats by density gradient centrifugation. DH82 and PBMCs were stimulated in vitro with M. avium hominissuis strain 104. Total RNAs were extracted from the cells at 2h, 6h, 12h, and 24h after infection and gene expressions were quantified using real-time PCR. Results: M. avium hominissuis induces different gene expression in canine PBMCs and DH82. While PBMCs produced both M1 and M2-associated genes (TNF-α, IL-6, IL-1β, IFN-γ, IL-23, CXCL11, IDO1, IL-10, IL-4, IL-13, and CCL22), DH82 produced an M1-pattern of genes (IL-6 and TNF-α). In particular, M1-related genes expressed in canine PBMCs were increased until 6h after infection, on the other hand, M2-related genes were significantly up-regulated after 12 h infection. Conclusion: This result might reveal a specific interaction between M. avium hominissuis and the immune system in canine. As increasing interaction between human and companion animals, this study would contribute to prevent or treat M. avium subsp. hominissuis infection in dog and human. Acknowledgment: This work was carried out with the support of “Cooperative Research Program of Center for Companion Animal Research (Project NO. PJ013985012018)” RDA, the BK21 PLUS and RIVS, SNU, Korea.
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Suji Lee,김영진,Jo Won Jung,최재영,박한기,Yu Rim Shin,최병욱 대한영상의학회 2019 Korean Journal of Radiology Vol.20 No.9
ObjectiveTo evaluate flow pattern characteristics in the ascending aorta (AA) with four-dimensional (4D)-flow MRI and to determine predictors of aortic dilatation late after tetralogy of Fallot (TOF) repair. Materials and MethodsThis study included 44 patients with repaired TOF (25 males and 19 females; mean age, 28.9 ± 8.4 years) and 11 volunteers (10 males and 1 female, mean age, 33.7 ± 8.8 years) who had undergone 4D-flow MRI. The aortic diameters, velocity, wall shear stress (WSS), flow jet angle (FJA), and flow displacement (FD) at the level of the sinotubular junction (STJ) and mid-AA were compared between the repaired TOF and volunteer groups. The hemodynamic and clinical parameters were also compared between the aortic dilatation and non-dilatation subgroups in the repaired TOF group. ResultsThe diameters of the sinus of Valsalva, STJ, and AA were significantly higher in the repaired TOF group than in the volunteer group (p = 0.002, p < 0.001, and p = 0.013, respectively). The FJAs at the STJ and AA were significantly greater in the repaired TOF group (p < 0.001 and p = 0.003, respectively), while velocities and WSS parameters were significantly lower. FD showed no statistically significant difference (p = 0.817). In subgroup analysis, age at TOF repair was significantly higher (p = 0.039) and FJA at the level of the AA significantly greater (p = 0.003) and mean WSS were significantly lower (p = 0.039) in the aortic dilatation group. FD were higher in the aortic dilatation group without statistical significance (p = 0.217). ConclusionPatients with repaired TOF have an increased FJA, dilated AA, and secondarily decreased WSS. In addition to known risk factors, flow eccentricity may affect aortic dilatation in patients with repaired TOF.
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Suji Kim,Mee-Young Shin,Kun-Ho Son,Ho-Yong Sohn,Jae-Hwan Lim,Jong-Hwa Lee,In-Sook Kwun 한국식품영양과학회 2014 Preventive Nutrition and Food Science Vol.19 No.3
Yam (Dioscorea batatas) is widely consumed as functional food for health promotion mainly in East Asia countries. We assessed whether yam root (tuber) or bark (peel) extracts stimulated the activity of osteoblasts for osteogenesis. MC3T3-E1 cells (mouse osteoblasts) were treated with yam root extracts (water or methanol) (study I) or bark extracts (water or hexane) (study II) within 0∼10 μg/mL during the periods of osteoblast proliferation (5∼10 day), matrix maturation (11∼15 day) and mineralization (16∼20 day) as appropriate. In study I, both yam root water and methanol extracts increased cell proliferation as concentration-dependent manner. Cellular collagen synthesis and alkaline phosphatase (ALP) activity, both the indicators of bone matrix protein and inorganic phosphate production for calcification respectively, were also increased by yam root water and methanol extract. Osteoblast calcification as cell matrix Ca and P accumulation was also increased by the addition of yam root extracts. In study II, yam bark extracts (water and hexane) increased osteoblast proliferation and differentiation, as collagen synthesis and ALP activity and osteoblast matrix Ca and P deposition. The study results suggested that both yam root and bark extracts stimulate osteogenic function in osteoblasts by stimulating bone matrix maturation by increasing collagen synthesis, ALP activity, and matrix mineralization.
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Study on Context-Aware Service for Domestic Tourists
SuJi Han,Younghwan Pan 한국HCI학회 2014 한국HCI학회 학술대회 Vol.2014 No.12
Demands for domestic travel are gradually increasing, but tourism infrastructure and detailed local guides are insufficient corresponding to them. Thus, this study will look into the behavior of applications users" tourism through surveys with the users and suggest that recommendations of appropriate information should be provided together according to the users" situations in guide application services to promote convenience in using the services.
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