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BRCA1 and MicroRNAs: Emerging Networks and Potential Therapeutic Targets
Suhwan Chang,Shyam K. Sharan 한국분자세포생물학회 2012 Molecules and cells Vol.34 No.5
BRCA1 is a well-known tumor suppressor implicated in familial breast and ovarian cancer. Since its cloning in 1994, numerous studies have established BRCA1’s role in diverse cellular and biochemical processes, such as DNA damage repair, cell cycle control, and transcriptional regulation as well as ubiquitination. In addition, a number of recent studies have functionally linked this tumor suppressor to another important cellular regulator, microRNAs, which are short (19-22 nt) RNAs that were discovered in the nematode in 1993. Soon their presence and function were validated in mammals, and since then, the role of microRNAs has been actively investigated in almost all biological processes, including cancer. In this review, we will describe recent progress in the understanding of the BRCA1 function through microRNAs and the role of microRNAs in regulating BRCA1, with emphasis on the implication of these processes on the development and progression of cancer. We will also discuss the therapeutic potential of microRNA mimics or inhibitors of microRNAs to affect BRCA1 function.
Suhwan Yu,Kihan Kim 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07
This study aimed to investigate the viewing experience of Taekwondo competitions, compare and analyze the viewing experience according to the type of Taekwondo competition, derive the viewing experience structure of Taekwondo contents, and confirm the potential of Power Taekwondo as a sustainable sports content developed for the purpose of popularizing Taekwondo.
Suhwan Kim 한국산업경영시스템학회 2015 한국산업경영시스템학회지 Vol.38 No.2
This paper deals with rescheduling on unrelated parallel-machines with compressible processing times, assuming that the arrival of a set of new jobs triggers rescheduling. It formulates this rescheduling problem as an assignment problem with a side constraint and proposes a heuristic to solve it. Computational tests evaluate the efficacy of the heuristic.
Technical Efficiency and It’s Determinants on Korean Rice Farmers
Suhwan Lee,이종하 조선대학교 지식경영연구원 2024 기업과 혁신연구 Vol.47 No.1
This study examines the technical efficiency of Korean rice farms from 2013 to 2017 using the Korean Farm Household Economic Survey. We employ the true fixed/random effect model to estimate the technical efficiency. In addition, we examine the determinants of their technical efficiency by considering the households of rice farmers and the regional characteristics of rice production. The empirical analysis reveals that rice production in South Korea exhibited an increasing return to scale from 2013 to 2017. Secondly, among the four input variables, labor input exhibits the largest elasticity, and the size of the elasticity remains similar, despite some variables such as land and intermediate costs having a very small negative effect on rice production. Thirdly, the results of the technical efficiency factor indicate that full-time work, education level, being male, and higher age positively influence rice farm technical efficiency. Conversely, factors such as the debt ratio, share of agricultural subsidies, share of non-farm revenue, and family size have a negative impact on rice farm technical efficiency. Lastly, an analysis of technical efficiency in three regions with similar rice yields shows that the average technical efficiency of rice farms is 0.964. This implies that rice farmers could increase production by 3.6% using the same inputs. Furthermore, the North and South regions exhibit higher technical efficiency compared to rice farmers in the Central region. These results suggest that it is necessary for policymakers to focus on improving access to labor, education, and credit for rice farmers. In addition, encouraging full-time farming and targeting support for younger or male farmers might be beneficial to improving the technical efficiency of rice farms. Regional disparities in efficiency also imply that tailored support programs could be effective. rice farms.