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Suguru Kuniyoshi,Shiho Oshiro,Gennan Hayashi,Tomohisa Wada International Journal of Computer ScienceNetwork S 2023 International journal of computer science and netw Vol.23 No.5
A 500 km/h linear motor high speed terrestrial transportation service is planned to launch 2027 in Japan. In order to support 5G service in the train, the Sub-carrier spacing frequency of 30 kHz is planned to be used instead of common 15 kHz sub-carrier spacing to mitigate Doppler effect in such high-speed transportation. In addition, to increase the cell size of 5G mobile system, plural Base Station antenna will transmit the identical Down Link (DL) signal to form the expanded cell size along the train rail. In this situation, forward and backward antenna signals will be Doppler shifted by reverse direction respectively and the receiver in the train might suffer to estimate accurate Channel Transfer Function (CTF) for its demodulation. In this paper, Delay and Doppler Profiler (DDP) based Channel Estimator is proposed and it is successfully implemented in signal processing simulation system. Then the simulated performances are compared with the conventional Time domain linear interpolated estimator. According to the simulation results, QPSK modulation can be used even under severe channel condition such as 500 km/h, 2 path reverse Doppler Shift condition, although QPSK modulation can be used less than 200 km/h with conventional Channel estimator.
Review : Precursor Lesions of Pancreatic Cancer
( Suguru Yonezawa ),( Michiyo Higashi ),( Norishige Yamada ),( Masamichi Goto ) The Editorial Office of Gut and Liver 2008 Gut and Liver Vol.2 No.3
This review article describes morphological aspects, gene abnormalities, and mucin expression profiles in precursor lesions such as pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), and mucinous cystic neoplasm (MCN) of the pancreas, as well as their relation to pancreatic ductal adenocarcinoma (PDAC). The gene abnormalities in precursors of PDAC are summarized as follows: (1) KRAS mutation and p16/CDKN2A inactivation are early events whose frequencies increase with the dysplasia grade in both PanIN and IPMN; (2) TP53 mutation and SMAD4/DPC4 inactivation are late events observed in PanIN3 or carcinomatous change of IPMN in both PanIN and IPMN, although the frequency of the TP53 mutation is lower in IPMN than in PDAC; and (3) also in MCN, KRAS mutation is an early event whose frequency increases with the dysplasia grade, whereas TP53 mutation and SMAD4/ DPC4 inactivation are evident only in the carcinoma. The mucin expression profiles in precursors of PDAC are summarized as follows: (1) MUC1 expression increases with the PanIN grade, and is high in PDAC; (2) the expression pattern of MUC2 differs markedly between the major subtypes of IPMN with different malignancy potentials (i.e., IPMN-intestinal type with MUC2+ expression and IPMN-gastric type with MUC2-expression); (3) MUC2 is not expressed in any grade of PanINs, which is useful for differentiating PanIN from intestinal-type IPMN; (4) de novo expression of MUC4, which appears to increase with the dysplasia grade; and (5) high de novo expression of MUC5AC in all grades of PanINs, all types of IPMN, MCN, and PDAC. (Gut and Liver 2008;2:137-154)
Suguru Odajima,Toshiyuki Seki,Sayako Kato,Keisuke Tomita,Yuichi Shoburu,Eitaro Suzuki,Masataka Takenaka,Motoaki Saito,Hirokuni Takano,Kyosuke Yamada,Aikou Okamoto 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.5
Objective: Direct oral anticoagulants (DOACs) are increasingly being used for the treatment of cancer-associated venous thromboembolism (CAT). However, there is limited evidence of the efficacy of DOACs for the treatment of gynecological CAT. Thus, this study aimed to investigate the efficacy and safety of edoxaban for the treatment of gynecological CAT using Japanese real-world data. Methods: We reviewed the medical records of patients with 371 gynecological cancer who received edoxaban or vitamin K antagonist (VKA) between January 2011 and December 2018. Results: Altogether, 211 and 160 patients were treated with edoxaban and VKA, respectively. Fourteen patients (6.8%) in the edoxaban group and 22 (13.8%) in the VKA group showed recurrence of venous thromboembolism (VTE). Cumulative VTE recurrence was not significantly different between the 2 groups (p=0.340). Adverse events occurred in 15 (7.1%) and 11 (6.9%) patients in the edoxaban and VKA groups, respectively (p=0.697). Subgroup analysis of the edoxaban and VKA groups according to different tumor types, including ovarian, endometrial, and cervical cancer, showed equivalent outcomes in terms of VTE recurrence and adverse events. Patients without pulmonary embolism (PE) were mostly omitted from initial unfractionated heparin (UFH) therapy prior to administration of edoxaban. However, this did not increase the recurrence of VTE. Conclusion: This study confirmed that edoxaban is effective and safe for the treatment of gynecological CAT. This finding was consistent for different types of gynecological cancer. Additionally, initial UFH therapy prior to the administration of edoxaban may be unnecessary for patients without PE.
Sparse Convex Clustering Based on ℓ₂-Norm Regularization on Probability Simplex
Suguru Yasutomi,Toshihisa Tanaka 대한전자공학회 2015 ITC-CSCC :International Technical Conference on Ci Vol.2015 No.6
Convex clustering is a clustering method that does not require the number of clusters in advance. This method is based on the mixture models which have all the samples as the means of clusters and clustering is achieved by finding sparse mixing weights. However, a large number of iterations are needed until convergence because its objective function does not evaluate the sparsity of the mixing weights. This article derives an efficient algorithm for convex clustering with regularization that represents sparsity. Focusing on the fact that sparse solutions on the probability simplex which is the solution space of the convex clustering have a large ℓ₂-norm, we use the ℓ₂-norm to regularize the solution. Experimental results show that the proposed method converges faster ones and the proposed regularization is adequate to represent sparsity.
Suguru Kuniyoshi,Rie Saotome,Shiho Oshiro,Tomohisa Wada International Journal of Computer ScienceNetwork S 2023 International journal of computer science and netw Vol.23 No.9
In Japan, high-speed ground transportation service using linear motors at speeds of 500 km/h is scheduled to begin in 2027. To accommodate 5G services in trains, a subcarrier spacing frequency of 30 kHz will be used instead of the typical 15 kHz subcarrier spacing to mitigate Doppler effects in such high-speed transport. Furthermore, to increase the cell size of the 5G mobile system, multiple base station antennas will transmit identical downlink (DL) signals to form an expanded cell size along the train rails. In this situation, the forward and backward antenna signals are Doppler-shifted in opposite directions, respectively, so the receiver in the train may suffer from estimating the exact Channel Transfer Function (CTF) for demodulation. In a previously published paper, we proposed a channel estimator based on Delay and Doppler Profiler (DDP) in a 5G SISO (Single Input Single Output) environment and successfully implemented it in a signal processing simulation system. In this paper, we extend it to 2×2 MIMO (Multiple Input Multiple Output) with spatial multiplexing environment and confirm that the delay and DDP based channel estimator is also effective in 2×2 MIMO environment. Its simulation performance is compared with that of a conventional time-domain linear interpolation estimator. The simulation results show that in a 2×2 MIMO environment, the conventional channel estimator can barely achieve QPSK modulation at speeds below 100 km/h and has poor CNR performance versus SISO. The performance degradation of CNR against DDP SISO is only 6dB to 7dB. And even under severe channel conditions such as 500km/h and 8-path inverse Doppler shift environment, the error rate can be reduced by combining the error with LDPC to reduce the error rate and improve the performance in 2×2 MIMO. QPSK modulation scheme in 2×2 MIMO can be used under severe channel conditions such as 500 km/h and 8-path inverse Doppler shift environment.
Opinion Extraction based on Syntactic Pieces
( Suguru Aoki ),( Kazuhide Yamamoto ) 한국언어정보학회 2007 학술대회 논문집 Vol.2007 No.-
This paper addresses a task of opinion extraction from given documents and its positive/negative classification. We propose a sentence classification method using a notion of syntactic piece. Syntactic piece is a minimum unit of structure, and is used as an alternative processing unit of n-gram and whole tree structure. We compute its semantic orientation, and classify opinion sentences into positive or negative. We have conducted an experiment on more than 5000 opinion sentences of multiple domains, and have proven that our approach attains high performance at 91% precision.