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오픈소스하드웨어를 이용한 침상머리각도 측정 시스템의 래피드 프로토타이핑
조봉언(Bong-Un Jo),박영상(Yeong-Sang Park),서숙길(Sugkil Seo),김진걸(Jin-Geol Kim),이영삼(Young-Sam Lee) 제어로봇시스템학회 2015 제어·로봇·시스템학회 논문지 Vol.21 No.11
When the study on the relationship between the Head-of-Bed (HOB) angle and ventilator-associated pneumonia is performed, the fact that the HOB angle can only be measured intermittently imposes a significant limitation on the study. Therefore, there has been demand for the development of a device that can measure the HOB angle continuously. In this paper, we propose the rapid prototyping of an HOB measurement system using open-source hardware and software. The proposed system helps to maintain the HOB angle at a particular angle by displaying the angle and helps the medical study of pneumonia patients by enabling continuous data acquisition. Firstly, we eliminate the process of making an MCU board by utilizing an open-source hardware mbed LPC1768. Secondly, we reduce the software evelopment time by using libraries and hence enabling the easy use of peripherals. Thirdly, for rapid prototyping, we build the enclosure of the proposed system using a 3D printer. The proposed system can be attached and detached to and from a bed. Therefore, we can attach it to the bed of a patient for whom measurement of the HOB angle is necessary. Finally, we check the measurement performance and the validity of the proposed system through an experiment utilizing an incremental encoder.
Ban, Jung Ok,Lee, Hee Soon,Jeong, Heon-Sang,Song, Sugkil,Hwang, Bang Yeon,Moon, Dong Cheul,Yoon, Do Young,Han, Sang Bae,Hong, Jin Tae American Association for Cancer Research 2009 Molecular Cancer Research Vol.7 No.6
<P>Chemotherapeutic strategies commonly use multiple agents to overcome drug resistance and to lower drug toxicity. Activation of nuclear factor-kappaB (NF-kappaB) is implicated in drug resistance in cancer cells. Previously, we reported that thiacremonone, a novel sulfur compound isolated from garlic, inhibited NF-kappaB and cancer cell growth with IC(50) values about 100 microg/mL in colon cancer cells. In the present study, we tested whether thiacremonone could increase susceptibility of cancer cells to chemotherapeutics through inactivation of NF-kappaB. Colon cancer cells were cotreated with thiacremonone (50 microg/mL, half dose of IC(50)) and lower doses of each chemotherapeutic agent (half dose of IC(50)) for 24 hours. NF-kappaB activity was completely abrogated in cells treated with a combination of thiacremonone and docetaxel, whereas thiacremonone on its own did not alter NF-kappaB activity. This combined drug effect was also found with other anticancer drugs in colon cancer and in other cancer cells. In good correlation with inhibition of cell growth and NF-kappaB activity, the combination treatment also regulated NF-kappaB target genes. Oral treatment of mice with thiacremonone (1 mg/kg) by administering it in drinking water for 4 weeks significantly augmented docetaxel (1 mg/kg, i.p., four times)-induced decrease of tumor growth accompanied with regulation of NF-kappaB activity and NF-kappaB target genes. These results warrant carefully designed clinical studies investigating the combination of thiacremonone and commonly used chemotherapeutic agents for the treatment of human cancers.</P>