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- 저자 : Suenghee (검색결과 2 건)
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A Study on Influence of Color Stimulus on Stress
Suenghee Lee,Jinsook Lee,Heewon Lee 한국색채학회 2017 AIC 2017 Jeju Vol.2017 No.10
This research aimed to figure out the influence of color stimulus to stress by comparing stress levels before and after color stimulus. The Psychosocial Well-being Index(PWI) was used to measure the stress level of subjects in an experiment space of red and green object color and light-source color, and 10 lx and 100 lx lighting. The data was compared and analyzed. The study results showed that color stimulus had an influence on stress. Also, it was found that lighting brightness had an influence on stress. Stress was found to be much lower in time of object color stimulus than in time of light source color stimulus. It is interpreted that Red light source gets subjects to suffer high stress while Green object color is helpful to the subject in their stress relaxation.
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Molecular mechanism of cofilin dephosphorylation by ouabain
Jung, Jaehoon,Kim, Moonhee,Choi, Suenghee,Kim, Min-Jeong,Suh, Jae-kyung,Choi, Eung Chil,Lee, Kyunglim 이화여자대학교 약학연구소 2008 藥學硏究論文集 Vol.- No.17
We previously reported that phosphorylated cofilin-triosephosphate isomerase(TPI) complex interacts with Na,K-ATPase and enhances the pump activity through the phosphorylation of cofilin via Rho-mediated signaling pathway, In this study, we tested the hypothesis that the dephosphorylation of cofilin may be induced through Na,K-ATPase inhibition by ouabain. The phosphorylation level of cofilin by ouabain which decreases in a time- and dose-dependent manner in various human cell lines, remains unchanged by pretreatment with Src inhibitor, PP2; epidermal growth factor receptor (EGFR) inhibitor, AG1478; Raf-1 kinase (Raf) inhibitor, GW5074; and ERK. kinase (MEK) inhibitor, PD98059, and by transfection of Ras dominant negative mutant (RasN17). This suggests that ouabain dephosphorylates cofilin through the Src/EGFR/Ras/Raf/MEK pathway. Ouabain activates Ras/Raf/MEK pathway, but down-regulates Rho kinase (ROCK)/LIM kinase (LIMK)/cofilin pathway, implying that there may be a cross-talk by ouabain between the Ras/Raf/MEK. and the ROCK/LIMK/cofilin pathways. Immunofluorescence and flow cytometry suggest that ouabain-induced active form of cofilin may be involved in cytoskeletal reorganization and cell volume regulation. Thus, these findings demonstrate a new molecular mechanism for the dephosphorylation of cofilin through the inhibition of Na,K-ATPase by ouabain. ⓒ 2006 Elsevier Inc. All rights reserved.
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