지구과학 학습용 Computer program 연구 : 고등학교 지구과학Ⅰ 제1단원을 중심으로 Centering around the First Unit of Highschool Earth Science Textbook Ⅰ

尹世重,金在炫,崔錫源 공주대학교 사범대학 과학교육연구소 1984 과학교육연구 Vol.16 No.1

A Computer program which could be used for teaching material in new curriculum of highschool earth science course was programed with Goldstar Co. model FC-100 personal computer in BASIC language. The main contents of this program are calculation of radius, mass, average density, the acceleration of gravity of earth and evidences for rotation of earth etc. All these substances are explained with Korean or English and by means of derivation of formula, calculation or dynamic graphs.

부산 금정산 주변 지하수의 수질 특성

김정숙,함세영,한석종 부산대학교 환경문제연구소 1998 環境硏究報 Vol.16 No.-

The purpose of this study is to examine chemical characteristics of groundwater for granitic and andesitic rocks in the vicinity of Mt. Geumjung, Pusan city, to establish the possible hydrogeochemical model of groundwater, and to evaluate the potential of groundwater pollution. According to the Piper diagram, groundwater in the study area mostly belongs to Ca^2^+-HCO_3 and Na^+-HCO_3 types. High concentration of Ca^2^- and Na^+ in groundwater are ascribed to the dissolution of plagioclase. Statistical methods (correlation analysis and factor analysis) were introduced to make the interpretation of analyzed data. Factor 1, consisting of pH, EC, Na^+, K^+, NH_4^+, Cl^- SO_4^2 and NO_3^-, explains the: effects of water-rock interaction such as dissolution of plagioclase and mica, and the influence of anthropogenic sources (domestic and industrial wastes). Factor 2, consisting of SiO_2, Ca^2^+ and HCO_3^- explains the dissolution of Ca-plagioclase. A hydrogeochemical modeling code, PHREEQC identifies and quantifies water-mineral reaction in fissures of the bedrock. The result of the modeling indicates the dissolution of major elements and formation of the kaolinite mineral.

부산 금정산일대 용천수, 지하수 및 지열수의 지화학적 특성

조명희,함세영,한석종,성익환,이병대,조병욱 부산대학교 환경문제연구소 1999 環境硏究報 Vol.17 No.1

Spring, groundwater and thermal water from the area and the vicinity of Mt. Geumjeong and Mt. Baekyang, Pusan city, has been sampled and analyzed for major and minor elements. According to the Piper diagram, spring water belongs to Ca^2^+-HCO_3^- and Na^+-HCO_3^- types, groundwater to Ca^2^+-HCO_3^- type, and thermal water to Na^+-CI^- type. Based on the phase stability diagrams of [Ca^2^+I/[H^+]^2, [Mg^2^^+I/[H^+]^2, and [Na^+I/[H^+] vs. [H_4SiO_4], spring water, groundwater and thermal water are mostly in equilibrium with kaolinite. The result of factor analysis shows three factors (factor 1,2 and factor 3) for the spring water, the groundwater and the thermal water which are represented by the influence of the dissolution of feldspar, calcite, anthropogenic sources (domestic and industrial wastes) and salt water.

TTT경화도표에 의한 에폭시 시스템의 경화반응 메카니즘과 반응속도에 대한 연구

최돈묵,인세진,오인석 경원전문대학 1999 論文集 Vol.21 No.-

Arbitrary cure temperatures were selected by using TGA (thermogravimetric analysis) for a uncured mixture of epoxy resins and anhydrides with accelerators. The TTT (time-temperature-transformation) cure diagram, including the iso-T_(g) contours, the vitrification curve, and the full cure line, was determinated by using a one-to-one relationship among the temperature of glass transition (T_(g)), the residual enthalpy (ΔHr), and the conversion ratio (α) which were obtained by using DSC (differential scanning calorimetry). And then an optimum cure cycle was considered within the region of the glass transition temperature, T_(g)∞, of a fully cured epoxy system. In order to accelerate cure reactions of an epoxy/anhydride system within the selected cure condition, a tertiary amine was used. TGA, DSC, and FT-IR(Fourier Transform-Infrared) were used to examine the effects of accelerators against epoxy resins and anhydride hardeners and to investigate cure reactions for an accelerators-added epoxy/anhydride system. Based on experimental results, the mechanisms of cure reaction were proposed, hereby the kinetics of cure reaction were calculated.

아세클로페낙 연질캡슬(클란자 에스 연질캡슬)의 개발

용철순,이경희,최진석,박병주,정세현,김용일,박상만,배명수,김귀자,김영식,유창훈,강성룡,유봉규,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1

To develop and aceclofenac soft capsule, four preparations with various solubilizers were prepared and their dissolution test was carried out. Among four preparations tested, a preparation with ethanolamine was selected a formula of aceclofenac soft capsule (Clanza S^(™), since it showed the fastest dissolution rate. Bioequivalence of aceclofenac tablet, Airtal^(™)(Dae-Woong Pharmaceutical Co., Ltd.) and aceclofenac soft capsule, Clanza S^(™)(Korea United Pharmaceutical Co., Ltd.) was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20-25 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After oral administration of one tablet or capsule containing 100 ㎎ of aceclofenac, blood ws taken at predetermined time intervals and the concentration of aceclofenac in plasma wa determined with an HPLC method under UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters using logarithmically transformed AUC_(t), C_(max) and T_(max) between Airtal tablet and Clanza soft capsule were 2.89%, 0.18% and 43.0%, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.250(e.g.log(0.81) - log(1.23) and log(0.89) - log(1.14)) for AUC_(t) and C_(max), respectively. Thus, the criteria of the KDFA guidelines for the equivalence was satisfied, indicating that Clanza S^(™) soft capsule is bioequivalent to Airtal^(™) tablet.

생체내 심근허혈-재관류 모델에서 멜라토닌의 재관류 부정맥에 대한 심근보호작용에 관한 연구

조규종,김원,홍정석,이미우,장성은,오세현,임경수 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Background: Recently, a few studies demonstrated that melatonin reduced the severity of myocardial reperfusion injuries, such as reperfusion arrhythmias. However, it is uncertain whether the melatonin reduces reperfusion arrhythmias in thus anesthetized animals because results were obtained using isolated hearts. Thus, to see whether melatonin reduces reperfusion arrhythmias in anesthetized animals, we examined the effect of melatonin on the incidence of reperfusion arrhythmias in an anesthetized-cat model of regional ischemia. Method: Adult mongrel male cats(n=30, 2.9∼4.2 kg) were anesthetized under positive-pressure artificial ventilation with room air. The animals of the control group(n=15) were subjected to 20-minute left anterior descending coronary artery(LAD) occlusion followed by abrupt reperfusion. The animals in experimental group(n=15) were divided into two. Group I(n=6) was pretreated with melatonin, 1 mg/kg, before occluding the LAD. Group II(n=9) was pretreated with melatonin, 10 mg/kg. The animals in experimental group were subjected to ischemia/reperfusion insult following drug treatment: melatonin was applied intra-peritoneally for 3 minutes just before LAD coronary artery ligation. The Fisher's exact test was used to compare the data from different animal groups. p<0.05 was considered significant. Results: The incidence of ventricular fibrillation(VF) during the reperfusion phase in group II(pretreated with melatonin, 10 mg) was significantly smaller than that in the control group(p-value = 0.0029). However, no statistically significant difference of VF incidence was found between group I(pretreated with melatonin, 1 mg) and the control group. Conclusion: Employing an anesthetized-cat model of regional cardiac ischemia, we investigated the dose-dependant effects of melatonin on reperfusion-induced arrhythmia. The cats pretreated with 10 mg/kg of melatonin before ischemia had a significantly reduced incidence of lethal reperfusion-induced arrhythmia, but there was no difference between the cats pretreated with 1 mg/kg of melatonin before ischemia and the control group.

양 하지의 근력저하를 주소로 응급실로 내원한 원발성 알도스테로증 1예

안력,김원,조규종,홍정석,이미우,장성은,오세현,임경수 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

A primary central nervous system lymphoma(PCNSL) is defined as a lymphoma limited to the cranial-spinal axis without systemic involvement. PCNSLs were formerly very rare, only 0.5∼ 1.2% of all intracranial neoplasms, and were usually associated with acquired immuno-deficiency syndrome(AIDS) and other immune-compromised states. Recently, there has been a clear rise in the incidence of this disease among normal individuals. We describe a 77-year-old female with hyponatremia who presented with a confused mental state. Computed tomography(CT) of the brain demonstrated a suprasellar mass with enhancement. We evaluated the basic hormonal studies and the magnetic resonance imaging(MRI). A ventricular biopsy was done, and the result was a diffuse, large, B-cell-type malignant lymphoma. She presented panhypopituitarism and partial central diabetes insipidus. She received chemotheraphy and was discharged in an improved condition. We report a case of panhypopituitarism due to PCNSL and give a review of the literature.

특발성 자발성 신장 파열 1예

윤재철,김원,조규종,홍정석,이미우,장성은,오세현,임경수 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Primary aldosteronism is a syndrome characterized by hypertension, hypokalemia, suppressed plasma renin activity, and elevated serum aldosterone levels. Conn first described it 1955 in association with adrenal cortical adenoma(Conn's syndrome). Today, it can be divided into at least six distinctive sub-groups. The diagnosis of primary aldosteronism is usually suspected when the patient presents with poorly controlled hypertension with hypokalemia. The main issues in the evaluation of primary aldosteronism are to differentiate an adenoma from hyperplasia and to localize the adenoma. Basic hormonal studies and computed tomographic(CT) scanning can be used effectively for that differentiation. An adenoma is one of a few potentially curable forms of hypertension, and it is best treated by removing the adrenal tumor. We experienced a case of a typical adrenal adenoma. The patient was a 37-year-old male who had experienced in both his legs over a period of several days a weakness due to hypokalemia. He was diagnosed using basic hormonal studies and adrenal CT scanning. After, he received laparoscopic adrenalectomy and was discharged with improved condition.

범하수체 기능저하증을 동반한 일차성 중추성 림프종의 1예

김원영,김원,조규종,홍정석,이미우,장성은,오세현,임경수 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

A primary central nervous system lymphoma(PCNSL) is defined as a lymphoma limited to the cranial-spinal axis without systemic involvement. PCNSLs were formerly very rare, only 0.5∼ 1.2% of all intracranial neoplasms, and were usually associated with acquired immuno-deficiency syndrome(AIDS) and other immune-compromised states. Recently, there has been a clear rise in the incidence of this disease among normal individuals. We describe a 77-year-old female with hyponatremia who presented with a confused mental state. Computed tomography(CT) of the brain demonstrated a suprasellar mass with enhancement. We evaluated the basic hormonal studies and the magnetic resonance imaging(MRI). A ventricular biopsy was done, and the result was a diffuse, large, B-cell-type malignant lymphoma. She presented panhypopituitarism and partial central diabetes insipidus. She received chemotheraphy and was discharged in an improved condition. We report a case of panhypopituitarism due to PCNSL and give a review of the literature.

프레탈정 (실로스타졸 100mg)에 대한 실로스탄정 (한국유나이티드 제약)의 생물학적 동등성

용철순,이경희,최진석,박병주,정세현,김용일,박상만,유봉규,이종달,최한곤 한국병원약사회 2003 병원약사회지 Vol.20 No.2

Bioequivalence of one cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and Cilostan^(R)(Korea united Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA. Sixteen normal male volunteers(age 20~30 years old)were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 100㎎ of cilostazol were orally administered, blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameter. The results showed that the differences in C_(max), T_(max) and AUC_(t) between one tablet were 16.08%, 18.88% and 17.57%, respectively. The powers (1-β) for C_(max), T_(max) and AUC_(t) were 85.03%, 83.92% and 80.12%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilostan^(R) tablet is bioequivalent to Pletaal^(R) tablet.