Evaluation of the Efficacy and Safety of DA-9601 versus Its New Formulation, DA-5204, in Patients with Gastritis: Phase III, Randomized, Double-Blind, Non-Inferiority Study

Choi, Yoon Jin,Lee, Dong Ho,Choi, Myung-Gyu,Lee, Sung Joon,Kim, Sung Kook,Song, Geun Am,Rhee, Poong-Lyul,Jung, Hwoon-Yong,Kang, Dae-Hwan,Lee, Yong Chan,Lee, Si Hyung,Choi, Suck Chei,Shim, Ki-Nam,Seol, KOREAN ACADEMY OF MEDICAL SCIENCE 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.11

<P>This study compared the efficacy of DA-9601 (Dong-A ST Co., Seoul, Korea) and its new formulation, DA-5204 (Dong-A ST Co.), for treating erosive gastritis. This phase III, randomized, multicenter, double-blind, non-inferiority trial randomly assigned 434 patients with endoscopically proven gastric mucosal erosions into two groups: DA-9601 3 times daily or DA-5,204 twice daily for 2 weeks. The final analysis included 421 patients (DA-5204, 209; DA-9601, 212). The primary endpoint (rate of effective gastric erosion healing) and secondary endpoints (cure rate of endoscopic erosion and gastrointestinal [GI] symptom relief) were assessed using endoscopy after the treatment. Drug-related adverse events (AEs), including GI symptoms, were also compared. At week 2, gastric healing rates with DA-5204 and DA-9601 were 42.1% (88/209) and 42.5% (90/212), respectively. The difference between the groups was −0.4% (95% confidence interval, −9.8% to 9.1%), which was above the non-inferiority margin of −14%. The cure rate of gastric erosion in both groups was 37.3%. The improvement rates of GI symptoms with DA-5204 and DA-9601 were 40.4% and 40.8%, respectively. There were no statistically significant differences between the two groups in both secondary endpoints. AEs were reported in 18 (8.4%) patients in the DA-5204 group and 19 (8.8%) in the DA-9601 group. Rates of AE were not different between the two groups. No serious AE or adverse drug reaction (ADR) occurred. These results demonstrate the non-inferiority of DA-5204 compared to DA-9601. DA-5204 is as effective as DA-9601 in the treatment of erosive gastritis. Registered randomized clinical trial at ClinicalTrials.gov (NCT02282670)</P>

플라즈마 표지소자의 제작

이상윤,라병욱,박동수,황인헌,이덕동,신영남,박성배,이동욱,박용석,박형근,손상호,권태근,채경락,정경득 慶北大學校 自然科學大學 1986 自然科學論文集 Vol.4 No.-

An Ac-type Plasma Display Panel (PDP) operating with Ne-Ar(0.1%) Penning mixture gas is fabicated. The characterics of the panel with electrodes covered with thin and thick dielectric layers are studied. The brightness of the Neon-orange light emitted by the panel measured as function of applied voltage and frequency. As an application, a graphic display system equipped with PDP showing still and moving pictures is made.

手話의 言語體制的 接近을 위한 基礎探索

石東一 又石大學校 特殊敎育硏究所 1988 特殊敎育學硏究 Vol.1 No.-

According to a tendency of content and method of education to meet individual competency and needs in the trend of current education of the deaf casting out one side of oral language, we analyzed the relational literatures, materials, and basic problems with manual language in Korea anticipating better effects in education with approach of systematic language of present manual language. The results are as follows: 1. Manual language doesn't arrest the development of oral language, but accelerates those of the deaf children. 2. It is not only ignorance of aspects of development of the hearing impaired to insisting use of continuous oral language by parents, teachers, and society, but also inconsistency with aspects of humanism and making psychological pressure, anxiety of language, resistence of oral language to them. 3. It is better to use manual language from early ages, and parents must educate their children with positive and emotional nature from learning sign language. 4. Linguistic characters of American Sign Language (ASL) are notable in an attempt for grammatical approach with sign markers and would continously make studies for diminishing a gap of bilangual.

特殊學校 敎育課程動向比較 硏究 : 聾學校 敎育課程을 中心으로 In the Point of the Curriculum for the Deaf Schools

石東一 又石大學校 1985 論文集 Vol.7 No.-

I have researched and compared the actual conditions and current tendency of the curriculum for the deaf students in foreign countries. My research will suggest some basic directions and contents in improving the textbooks for the deaf students in Korea and the teacher training programs in active service on the basis of the results of analyzing and comparing the deep structure of the main tendency. First, the object of the education for the deaf students must be set considering deaf students' psychological characteristics and self-realization on humanism. The contents of educational object for deaf students are as follows; 1. to improve scholastic ability. 2. harmonious development and adjustment of mind and body. 3. persistent will to overcome their physical handicap. 4. to strength their sensory and motor function. 5. to improve their communicatory function. 6. to maintain their harmonious human-relation. 7. citizen's duty. 8. to talk their responsibility. 9. to exercise their rights. 10. to increase their economic competency. 11. to develop their intellectual and cognitive competency. 12. to keep their self-esteem. Second, cure activity must be emphasized as subject-contents and their connection with other subjects must be considered with care. Third, structure and management of the curriculums should be adapted to the nongraded conception in order to reflect individual principle for each student's unique needs. 1. independent organization of curriculum. 2. enlargement of education opportunity for the severe handicapped. 3. integrated subjects, 4. systematic organization of inter-subjects. 5. flexible management of curriculum. 6. the earliest education. 7. consideration of integration of education. Fourth, teacher's special ability should be made the most use of. 1. Topic teaching, 2. collective responsibility of parents-teachers-learners. 3. learner' terminology. 4. maintenance of lingual environments. 5. emphasize relative services. Fifth, teaching method of language should be developed through total communication philosophy. In spite of various opinions about sign language, which is the core of total communication, we should reilluminate their extreme judgements. We should continue the study of the linguistic and systematic approach to establish sign markers and diminish the gap of bi-language because the tendency to teach sign language in combination with oral language from earlier yers can be found. Sixth, special program for the multihandicapped deaf students should be developed, and various mainstream programs for the severe def students should be improved. The selection of subjects would be made effectively for successful mainstream. Teachers' temperament for regular class should be cultivated.

手話의 言語體制的 接近을 위한 基礎探索

石東一 又石大學校 1984 論文集 Vol.6 No.-

According to a tendency of content and method of education to meet individual competency and needs in the trend of current education of the deaf casting out one side of oral language, we analyzed the relational literatures, materials, and basic problems with manual language in Korea anticipating better effects in education with approach of systematic language of present manual language. The results are as follows. 1. Manual language doesn't arrest the development of oral language, but accelerates those of the deaf children. 2. It is not only ignorance of aspects of development of the hearing impaired to insisting use of continuous oral language by parents, teachers, and society, but also inconsistency with aspects of humanism and making psychological pressure, anxiety of language, resistence of oral language to them. 3. It is better to use manual language from early ages, and parents must educate their children with positive and emotional nature from learning sign language. 4. Linguistic characters of American Sign Language(ASL) are notable in an attempt for grammatical approach with sign markers and would continously make studies for diminishing a gap of bilangual.

말초동맥질환에 있어서 혈장 호모시스테인 농도의 의미

최동현,이상목,고석환,홍성화,오수명,윤충,박호철 대한혈관외과학회 2004 Vascular Specialist International Vol.20 No.1

應答誤差의 減少를 위한 質問紙作成에 關한 硏究

金東奭 弘益大學校 1989 弘大論叢 Vol.21 No.2

키틴 분해균 Bacillus sp. LJ-25의 분리 및 효소생산 최적화

이정석,주동식,조만기,이응호 동서대학교부설연구소 1997 연구소 논문집 Vol.2 No.-

In order to produce functional chitin oligosaccharides, a chitinolytic becterium was newly screened from the viscera of Korean bony fish, and identified as Bacillus sp. LJ-25. For the production of chitinolytic enzyme, 1.0% nutrient broth and 0.3% colloical chitin was used as nitrogen and carbon source, respectively. The optimal temperature, initial pH and conentration of NaCl for the production of chitinase from Bacillus sp. LJ-25 were 30℃, 6.5-7.0 and 1.0%, rspectively. Chitinolytic activity of Bacillus sp. LJ-25 was increased until the incubation of 168 hours, but after 168 hours, the activity was decreased.

PPG와 MDI를 이용한 Polyurethane Ionomer의 합성과 전기전도성에 관한 연구

맹기석,송해영,김동철,백중현 忠南大學校 産業技術硏究所 1988 산업기술연구논문집 Vol.3 No.1

Hydroxyl-terminated polyether polyurethanes based on 4,4′-diphenyldiisocyanate(MDI), N-methyldiethanolamine(MDEA) and polypropylene glycol-2,000(PPG) were synthesized with constant level of hard segment. The tertiaryamine of MDEA was sulfonated with r-propane sultone thereby converting the polyether polyurethane to a polymeric Zwitterion. Electrically conducting polyurethane ionomer film was prepared by introducing copper sulfate. The CuxS-induced electrical conducting of polyurethane ionomer film was higher by order 10⁴ than that of the original film. The morphology of CuxS-induced PU, PUI film surface was investigated with SEM.

現代 漢語 零聲母 硏究

林東錫 건국대학교 1994 學術誌 Vol.38 No.1

現代漢語北京話裏使用的零聲母(Sro-또tial), 其來源不同而相當複雜. 醫如, 雖然 '五' '物' '烏' , 三個字的現代謠출均同爲(wu), 但是究以來源, 卽判然不同. 就 '五' 是從疑母(하來變的, 反切爲 '疑古切' ,'#O'是從明母(rn)再變成的微母(·T), 反切爲 '文弗切' , '烏' 是從影母(7)來源的, 反切爲 '哀都切'. 由此觀之, 可說古代漢語裏本身不是零聲母. 到現在就歸納零聲母的較多. 將現在讀音零聲母的分辯出來看, 就證明了古代五個勢璟(包括喩毋, 喩母就本來零勢母的)到今讀零聲母. 其五個是疑母(9) 影母(1) 瑞련) 微母(r) 蘿母). 但這五個變爲零勢辱的現況與剛嗚開, 齋, 合, 撮)有關, 所以포따分布內容穿鑿, 就得出了 斷母談譏爲開口單獨而已. 微母亦讀爲合口單獨, 喘母謫爲齋齒,合癲. 爆口 ,疑母與影母讀爲四吟全韻了. 硏究音韻, 可以駕助對了解漢語的古今變動, 而且在我們韓國漢字音方面, 也有領肋對把握其變化及固定的內容了.