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A SPITZER VIEW OF THE YOUNG OPEN CLUSTER NGC 2264
Sung, Hwankyung,Stauffer, John R.,Bessell, Michael S. American Institute of Physics 2009 The Astronomical journal Vol.138 No.4
<P>We have performed mid-IR photometry of the young open cluster NGC 2264 using the images obtained with the Spitzer Space Telescope Infrared Array Camera and Multiband Imaging Photometer for Spitzer instruments and presented a normalized classification scheme of young stellar objects in various color-color diagrams to make full use of the information from multicolor photometry. These results are compared with the classification scheme based on the slope of the spectral energy distribution (SED). From the spatial distributions of Class I and II stars, we have identified two subclusterings of Class I objects in the CONE region of Sung et al. The disked stars in the other star-forming region S Mon are mostly Class II objects. These three regions show a distinct difference in the fractional distribution of SED slopes as well as the mean value of SED slopes. The fraction of stars with primordial disks is nearly flat between log m = 0.2 and –0.5 and that of transition disks is very high for solar mass stars. In addition, we have derived a somewhat higher value of the primordial disk fraction for NGC 2264 members located below the main pre-main-sequence locus (so-called BMS stars). This result supports the idea that BMS stars are young stars with nearly edge-on disks. We have also found that the fraction of primordial disks is very low near the most massive star S Mon and increases with distance from S Mon.</P>
Kim, Bokyoung,An, Deokkeun,Stauffer, John R.,Lee, Young Sun,Terndrup, Donald M.,Johnson, Jennifer A. American Astronomical Society 2016 The Astrophysical journal Supplement series Vol.222 No.2
<P>The tension between the Hipparcos parallax of the Pleiades and other independent distance estimates continues even after the new reduction of the Hipparcos astrometric data and the development of a new geometric distance measurement for the cluster. A short Pleiades distance from the Hipparcos parallax predicts a number of stars in the solar neighborhood that are sub-luminous at a given photospheric abundance. We test this hypothesis using the spectroscopic abundances for a subset of stars in the Hipparcos catalog, which occupy the same region as the Pleiades in the color-magnitude diagram. We derive stellar parameters for 170 nearby G-and K-type field dwarfs in the Hipparcos catalog based on high-resolution spectra obtained using KPNO 4 m echelle spectrograph. Our analysis shows that, when the Hipparcos parallaxes are adopted, most of our sample stars follow empirical colormagnitude relations. A small fraction of stars are too faint compared to main-sequence fitting relations by Delta M-V greater than or similar to 0.3 mag, but the differences are marginal at a 2 sigma level, partly due to relatively large parallax errors. On the other hand, we find that the photometric distances of stars showing signatures of youth as determined from lithium absorption line strengths and R'(HK) chromospheric activity indices are consistent with the Hipparcos parallaxes. Our result is contradictory to a suggestion that the Pleiades distance from main-sequence fitting is significantly altered by stellar activity and/or the young age of its stars, and provides an additional supporting evidence for the longdistance scale of the Pleiades.</P>
Gotoh, Tetsuya,Kim, Jae Kyoung,Liu, Jingjing,Vila-Caballer, Marian,Stauffer, Philip E.,Tyson, John J.,Finkielstein, Carla V. National Academy of Sciences 2016 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.113 No.47
<P>The circadian clock and cell cycle networks are interlocked on the molecular level, with the core clock loop exerting a multilevel regulatory role over cell cycle components. This is particularly relevant to the circadian factor Period 2 (Per2), which modulates the stability of the tumor suppressor p53 in unstressed cells and transcriptional activity in response to genotoxic stress. Per2 binding prevents Mdm2-mediated ubiquitination of p53 and, therefore, its degradation, and oscillations in the peaks of Per2 and p53 were expected to correspond. However, our findings showed that Per2 and p53 rhythms were significantly out-of-phase relative to each other in cell lysates and in purified cytoplasmic fractions. These seemingly conflicting experimental data motivated the use of a combined theoretical and experimental approach focusing on the role played by Per2 in dictating the phase of p53 oscillations. Systematic modeling of all possible regulatory scenarios predicted that the observed phase relationship between Per2 and p53 could be simulated if (i) p53 was more stable in the nucleus than in the cytoplasm, (ii) Per2 associates to various ubiquitinated forms of p53, and (iii) Per2 mediated p53 nuclear import. These predictions were supported by a sevenfold increase in p53's half-life in the nucleus and by in vitro binding of Per2 to the various ubiquitinated forms of p53. Last, p53's nuclear shuttling was significantly favored by ectopic expression of Per2 and reduced because of Per2 down-regulation. Our combined theoretical/mathematical approach reveals how clock regulatory nodes can be inferred from oscillating time course data.</P>