患者에서 分離한 腸內細菌(大腸菌)에 대한 血淸型 및 抗生劑 耐性傳達에 관한 硏究

김승곤,최성민 서울保健大學 1994 論文集 Vol.14 No.1

This study was undertaken the biochemical characteristics, serotyping and antibiotics susceptibility to 79 strans of Escherichia coli isolated from patient from march in 1993 to December in 1993. Of 79 isolates, thirty one isolates(39.2%) were idenfied by pathogenic E. coli immune sera producted by Denka Seiken. Among them, 9 isolates(11.4%) were 06, followed by 015 and 044(4 isolates, 12.9%), respectively. 018, 0114, 0119, 0125, 0146, 0153 and 0164 were identified 1 isolate(3.2%), repectively. Resistance rate of E. coli isolated from patients against 12 antibiotics were 86.1%(68 isolates). Of them, resistance rate against TC was 68.3%(54 isolates), AM 64.4%(51 isolates), CB 62.0%(49 isolates), NN and NA 8.9%(7 isolates) and PB 1.3%(1 isolate), respectively. Of 68 resistant isolates, 59 isolates(86.8%) were resistant to more than 2 drug, followed by 2 drugs-resistance pattern01 isolates, 16.2%), 3 drug and 6 drig resistance pattern(9 isolates, 13.2%). Of multipleresistance pattern, AM-CB-SM and AM-CB-SM-TE pattern were most frequent(5 isolates, 7.4%, respectively) and more than 10 drugs resistance pattern was 1 isolate. Of 68 resistant isolates, 42(61.8%) were transferred their resistance to recipient cell (E. coli ML1410Na^(r)), Of them, the most frequently multiple transferred drugs was 2 drugs(40.5%, 17isolates) and the most frequently multiple transferred pattren was AM-CB(23.8%. 10 isolates).

연폭로 근로자들에서 적혈구 Pyrimidine 5'-Nucleotidase 활성도 및 요중 N-Acetyl-β-D-Glucosaminidase 활성도와의 상관관계 연구

서홍규,이병국,황천현,장성훈,이성수,이원진,최재욱 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.2

In this study, we measured the activity of the erythrocyte pyrimidin 5'-nuclectidase(P5N) and urinary N-acetyl-β-D-glucosaminidase(NAG) from 154 workers exposed to lead and 43 workers not exposed. We analyzed the correlation of the P5N activity and NAG activity with other biololgical exposure indices of lead such as blood lead(PbB) and zinc protoporphyrin(ZPP). The measurement was performed by using high performance liquid chromatography(HPLC), spectrophotometer and atomic absorption spectrophotometer. The results are as follows : 1. The mean value of P5N activity for workers exposed to lead was 9.50±3.13 μmol uridine/hr/g Hb and 11.60±2.2 μmol uridine/hr/g Hb for workers not exposed. The P5N activity showed a normal distribution, but the other indices of lead showed logarithmic normal distributions. 2. The P5N activity and ZPP were decreased as PbB was increased. But the NAG activity had no correlation with changes of PbB. 3. The correlation coefficients of the P5N activity with other biological exposure indices of lead such as PbB, ZPP, NAG activity were -0.72, -0.55, and 0.05, respectively. We speculated that the P5N activity can be used as a reliable biological exposure index of lead but NAG activity can be used as a biological management index of lead.

정보의 보존성과 자유의식 : For Integrate Understanding between Neuroscience and philosophy 신경과학과 철학의 통합적 이해를 위해

이성훈 大韓神經精神醫學會 1993 신경정신의학 Vol.32 No.3

This is written to elucidate relationship between neuroscientific and psychiatric approach to information and consciousness and philosophical approach to cognition and existence. Information endeavors to preserve itself through possession of a self of its own, and defensive information is added to pure information because such ability to preserve causes disturbance in proper information processing. What is needed to overcome this disturbance is consciousness. Consciousness is essentially an unpreserving and non-informative existence, and it is through such unpreserving function that conflict and irony of information processing are conquered. This process is analogous to that which tries to properly perceive phenomenon(information) itself through pure consciousness in the phenomenology. Moreover, pure informations obtained by way of unpreserving function of consciousness are developed into its own proper information through concentration and integration within consciousness, and this can be regarded as similar to the concept of the intentionality of consiousness of phenomenology. The domination relationship between the preservative self of information and the self of consciousness can be understood from the ontological viewpoint It can be viewed that the process of integration into being through nonbeing, where self of consciousness is freed from subordination to preservative self of information, presents a possibility of encountering ontology of philosophy. It is considered that a new possibility can be uncovered for the phenomena of neuroscience and psychiatry to meet with philosophical reasons through such relationship between information and consciousness.

충주시 농촌지역 주민의 건강행태 및 의료이용

장성훈,이건세,이원진,박종태 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.6 No.-

To evaluate the health behavior and medical utilization patterns of residents in Choongju rural area is useful for district health authority and health facilities in identifying the problems and setting the priorities. The reason is that rural area in Choongju city has a relatively few health resources except public health subcenters and public health posts. We evaluated the health behavior, health status, and medical utilization pattern of people in Choongju rural area using the household survey in summer, 1995. From 12 Myuns, randomly selected 6 Myuns first, and then applied convenient sample method. The residents had many health problems. 98(32%) out of the 307 respondents had some health problems, most of which were musculoskeletal and gastro-intestinal problems. A total of 218 persons(72%) thought that it was individual responsibility. Because the Lay referral system was poor and many of residents had to make the decisions about their health problems and medical seeking by themselves. When they were ill, 34% of respondents answered that they would visit hospitals first, and 24% would visit health-subcenter. But, when illness was severe, 72% of respondents answered that they would use hospitals at first. We suggest that public health facilities in rural area should be activated since they play the major role in promoting the health of rural residents. Health programmes such as health education, counseling, and disease prevention program, are also necessary especially for most of elderly persons.

모 중장비 제조 사업장의 유해작업요인 평가에 관한 연구

장성훈,이원진,서창호,김종규,이영신,황천현,서동윤 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.6 No.-

We evaluated the types and the amount of hazards in a heavy equipment factory and a plant factory to improve workers' health and to determine the priority in occupational health programs. We first inspected the working processes to find hazardous agents, measured them in each process environment, and compare the results with their TLVs(Threshold Level Value). This study was carried out from December 26, 1995 to January 30, 1996. The results are as follows: 1. In two factories, we identified the following hazardous agents: noise, dust, heavy metal fume, organic solvents, illumination, gases and ultraviolet light. 2. In the heavy equipment factory, some agents were over their TLVs in the following departments. 1) Preparation Department: dust, Pb, Mn, Fe₂O₃, NO₂ 2) Manufacture Department: noise, dust, Pb, Mn, Fe₂O₃, NO₂ 3) Assembly Department: noise 4) Technique Department: NO₂ 3. In the plant factory, some agents were over their TLVs in the following departments: 1) 1 Bay: illumination, Pb, Mn, Fe₂O₃ 2) 2 Bay: dust, illumination, Cu 3) 3 Bay: illumination 4) 4 Bay: noise, dust, Pb, Mn, Fe₂O₃, NO₂ 5) 5 Bay: noise, dust, Pb, Mn, Fe₂O₃, NO₂ 6) 6 Bay: Pb, Mn, NO₂ We concluded that the hazardous agents such as heavy metal fume, noise and noxious gas were required to be controlled at first.

울금의 유효성분 분리, 정제 및 항암시험 연구

류성렬,한기정,장향동 한국공업화학회 2005 응용화학 Vol.9 No.1

Curcumin (CUR), activation material, is extracted, separated, and purified from Curcuma longa, other effective substances are extracted and separated to conduct anti-cancer test on effective substance among these substances. In particular, Curcumin is used as anti-oxidation, anti-inflammation, and anti-cancer materials. Thus, to check for existence (non-existence) of cancer cells and morphological change, SK-HEP-1, which is adenocarcinoma cell line, was used on 6 well, and 30,000 cells and Chang cell, which is normal cell line, were also used. Curcumin among substances is subjected to processing so that its final concentration levelstands at 10M, 1 mM, and change in cell line was observed. Movement of target subject to observation is as follows, which are subject to verification and publication. A: Chang cell's normal cell, B: change in cell form after 24 hours after processing 10M curcumin onto Chang cell, C: SK-Hep-1 cell's normal cell,and D: growth andgrowth curtailing of cells subjected to 10M curcumin on SK-Hep-1 cell.

톨루엔, 크실렌 폭로량과 생물학적 지표들과의 상관성 연구

장성훈 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.2

In order to study the correlation of ambient toluene and xylene exposure with their biological monitoring indices, we measured the concentration of toluene and xylene in the workplace. We also measured their biological monitoring indices of workers from August to November in 1994. The exposed group consisted of 103 male workers and the non exposed group consisted of 34 male workers. The ambient concentration of toluene was 44.7±55.4 ppm and that of xylene was 2.35±2.15 ppm. The urinary concentration of hippuric acid in exposed group was 1.72±1.53 g/g creatinine and that of non-exposed group was 0.34±0.28 g/g creatinine. The difference was statistically significant between two groups(p<0.001). The urinary concentration of o-cresol in exposed group was 692.9±710.8㎍/g creatinine and that of non-exposed group was 184.7±167.6㎍/g creatinine. The difference was also statistically significant between two groups(p<0.001). The urinary concentration of methylhippuric acid which was compensated with urinary creatinine in exposed group was 62.7±104.6 mg/g creatinine and that of non-exposed group was 64.0±91.5 mg/g creatinine. However the difference was not statistically significant between two groups(p>0.05). When compensated with urinary creatinine, the correlation coefficient of ambient toluene with urinary hippuric acid and ocresol were 0.63(p=0.0001) and 0.65(p=0.0001), respectively. When compensated with urinary specific gravity, the correlation coefficient of ambient toluene with hippuric acid and ocresol were 0.525(p=0.0001) and 0.547(p=0.0001), respectively. The compensation method using urinary creatinine provided a higher correlation coefficient. We could not find any statistically significant differences between the duration of work and other variables(urinary hippuric acid, o-cresol and methylhippuric acid). In order to monitor biological indices of toluene-exposed workers, we suggest the measurement of urinary hippuric acid rather than o-cresol. As the compensation method, we suggest to use urinary creatinine rather than urinary specific gravity.

窒素 水準이 水耕토마토의 營養生長과 果實 收量에 미치는 影響

池性韓 호남대학교 1992 호남대학교 학술논문집 Vol.13 No.-

Tomato(Lycopersicon esculentum MILL. cv Ogatazuiko) plants were grown in the water culture solution at five levels of nitrogen (2∼32me) which were maintained by the addition of sodium nitrogen. The hignest fruit yield was obtained at 8∼16me N. In the rang 2∼16me N, the nitrogen level accelerated plant growth and increased nitrogen content of the leaves. There were no significant differences in vegetative growth and nitrogen content of the leaves between plants from the 16me and 32me N However, the fruit yield and potassium content of the leaves obtained from 32me N was 19% and 17% lower than those from 16me N respectively. The highest dry matter distribution of the leaf was achieved at 16∼32me N, but that of theroot was showed at 2me N. The results obtained here demonstrated that 8 me M is thought to be suitable for controlling excessive vegetative growth without the loss of fruit yield. The data presented suggest an optimum of 8∼16me N.

크루즈에 대한 은유적 표현 : 부산지역을 중심으로 하는 세미크루즈 활성화를 위한 제언

양승훈 신라대학교 부산학연구센터 2018 부산연구 Vol.16 No.1

본 연구는 지난 수년간 관광시장 중에서 가장 높은 성장세와 이에 따라 새로운 사업기회로 각광받아온 크루즈에 주목하고 본격적인 대규모, 해양크루즈를 운영하기에는 현실적으로 어려운 상황에서 이에 대한 대안으로서 세미크루즈의 이념형을 구성하고 이론적 실무적 시사점을 제공하는데 목적이 있다. 이를 위해서 부산에서 일본을 운항 중인 P크루즈에 탑승한 승객을 대상으로 심층인터뷰를 실시하고 세미크루즈에 대한 이념형을 도출하기 위해 은유적 표현을 유도하였다. 연구결과 세미크루즈는 과소한 탑승인원에서 나올수 있는 인간적인 교류와 선상이라는 친수성 욕구를 충족시키는 상품 및 서비스가 필요하며 초대형 해양크루즈에 대비하여 크기는 작지만 다양한 상품과 서비스를 추가하여 대접받는 욕구를 충족해야하는 것으로 나타났다. 이를 위해서 세미크루즈는 공통의 특수한 관심을 가지는 집단에게 소구하는 특정 테마를 주제로 하는 방향으로 나아가야 할 것이다. 연구의 시사점 및 한계점은 논문의 말미에 포함되었다.

軟膏基劑에 對한 小考

趙成珠 梨花女子大學校 藥學硏究所 1962 梨花藥學硏究 Vol.- No.3