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Kim, Juhyun,Jeong, Seonyeong,Kertsburg, Alexis,Soukup, Garrett A.,Lee, Seong-Wook American Chemical Society 2014 ACS CHEMICAL BIOLOGY Vol.9 No.11
<P>Gene therapeutic approaches are needed that can simultaneously induce the well-controlled expression of therapeutic genes and suppress the expression of disease-causing genes for maximization of their efficacy. To address this challenge, we designed an allosteric ribozyme that comprises a <I>Tetrahymena</I> group I-based trans-splicing ribozyme as an active domain for RNA replacement, a small molecule-specific RNA aptamer as a sensor domain, and a communication module as an active transfer domain. The effectiveness of this approach was assessed by constructing various ribozymes in combination with a theophylline-binding aptamer to identify an allosteric ribozyme, which is controlled by theophylline both <I>in vitro</I> and in cells. Moreover, we constructed adenoviral vectors encoding the ribozymes and validated allosteric regulation of trans-gene expression via theophylline-dependent RNA replacement in target RNA-expressing cells. Results demonstrate that an allosteric trans-splicing ribozyme is an applicable RNA-based framework for engineering external ligand-controlled gene expression regulatory systems that exhibit adjustable regulation, design modularity, and target specificity.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/acbcct/2014/acbcct.2014.9.issue-11/cb500567v/production/images/medium/cb-2014-00567v_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cb500567v'>ACS Electronic Supporting Info</A></P>
Verena Marterer,Michaela Radouchová,Radek Soukup,Susanne Hipp,Tomáš Blecha 한국의류학회 2024 Fashion and Textiles Vol.11 No.1
With the ongoing miniaturization of wireless devices, the importance of wearable textiles in the antenna segment has increased significantly in recent years. Due to the widespread utilization of wireless body sensor networks for healthcare and ubiquitous applications, the design of wearable antennas offers the possibility of comprehensive monitoring, communication, and energy harvesting and storage. This article reviews a number of properties and benefits to realize comprehensive background information and application ideas for the development of lightweight, compact and low-cost wearable patch antennas. Furthermore, problems and challenges that arise are addressed. Since both electromagnetic and mechanical specifications must be fulfilled, textile and flexible antennas require an appropriate trade-off between materials, antenna topologies, and fabrication methods—depending on the intended application and environmental factors. This overview covers each of the above issues, highlighting research to date while correlating antenna topology, feeding techniques, textile materials, and contacting options for the defined application of wearable planar patch antennas.
Kuca, Kamil,Cabal, Jiri,Jung, Yung Sik,Musilek, Kamil,Soukup, Ondrej,Jun, Daniel,Pohanka, Miroslav,Musilova, Lucie,Karasová,, Jana,Novotný,, Ladislav,Hrabinova, Martina Blackwell Publishing Ltd 2009 Basic & clinical pharmacology & toxicology Vol.105 No.3
<P>Abstract: </P><P>Newly developed acetylcholinesterase reactivators K117 [1,5-bis(4-hydroxyiminomethylpyridinium)-3-oxapentane dichloride] and K127 [(1-(4-hydroxyiminomethylpyridinium)-5-(4-carbamoylpyridinium)-3-oxapentane dibromide)] were tested for their potency to reactivate tabun-inhibited human brain cholinesterases. Pralidoxime and trimedoxime were chosen as standard reference reactivators. Human tissue was used, as that was closer on the real treatment of human beings. As a result, oxime K127 was found as the best tested reactivator according to the constant <I>k</I><SUB>r</SUB>, characterizing the overall reactivation process. On the contrary, the maximal reactivation ability expressed as percentage of reactivation was the best for trimedoxime. This differences were caused as a result of using the enzyme from different species. Due to this, experiments on human tissue should be conducted after <I>in vitro</I> and <I>in vivo</I> tests on animals to eliminate such important failures of promising oximes.</P>
장애학생의 개인적 요인 및 환경적 요인이 자기결정에 미치는 영향: 장애학생의 자기결정과 장애범주, 성별, 및 교육적 환경간의 관계 분석
서효정 ( Hyo Jeong Seo ),( Michael L. Wehmeyer ),( Susan B. Palmer ),( Jane H. Soukup ),( Kendra Williams Diehm ),( Karrie Shogren ) 한국특수교육문제연구소 2012 특수교육저널 : 이론과 실천 Vol.13 No.2
장애학생의 자기결정에 관한 미국 연구는 1990년 초반부터 활발하게 이루어졌다. 20년에 걸쳐 자기결정에 관한 연구가 활발하게 진행되는 동안, 자기결정의 이론을 구축하여 자기결정의 개념을 확립하려는 노력이 행해졌다. 이 이론들은 개인의 특성 요인과 환경적 영향 요인을 공통적으로 설명하여 자기결정의 개념을 구축하였다. 따라서, 이 연구에서는 개인적 요소(학생의 주요 장애 영역, 성별)와 학생이 배치된 교육적인 환경(일반학급, 특수학급, 특수학교)에 따라서 학생의 자기결정력이 어떻게 다른지를 살펴보고자 하였다. 이 연구는 학생의 자기결정을 향상시키기 위한 다양한 중재전략들의 효과를 살펴보고, 졸업 후 학생의 교육결과를 살펴보고자 한 5년 종단연구(2005년 ~ 2010년)의 한 부분으로, 학생들에게 자기결정 중재 전략을 실시하기 이전의 기초자료를 분석하였다. 구체적으로, 연구 참여자는 미국 6개의 주(Arkansas, Kansas, Missouri, Nebraska, Oklahoma, and Texas)에서 임의적으로 선별된 청소년기 장애학생 230명이고, 종속변수인 학생들의 자기결정을 측정하기 위해서 The Arc’s Self-determination scale과 The AIR Self-determination Scale (학생용)이 사용되었다. 연구 분석결과, 학생의 주요 장애영역에 따라서만 학생들의 자기결정 정도가 다른 것으로 나타났다. 본 연구 결과에 대한 논의와 함께, 교육현장에서 학생들의 자기결정을 증진시키기 위한 제안 및 향후 연구를 위한 제언들이 제공되었다. Self-determination for students with disabilities has gained increased attention in special education since the early 1990s. During this time, research has documented theoretical frameworks to provide a solid understanding of self-determination. Des Desppite different theoretical frameworks to consolidate the underlying construct of self-determination, each framework has common traits: the individual characteristics and environmental factors. This study examined individual characteristics (i.e., primary rimary disability and gender) and environmental characteristics (i.e., educational setting) to identify the impact on the levels of students’ self-determination. Results indicate that only disability categories have a significant impact on students’ relative levels of self-determination. Implications and future directions for research and are discussed.