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High Sodium Diet and Autoimmune Diseases
Soonjae Hwang,Hohyun Park,Ki-Jong Rhee 대한의생명과학회 2015 Biomedical Science Letters Vol.21 No.3
High sodium diet has been touted to be a major risk factor of disease in developed countries. The disease most closely associated with a high sodium diet is cardiovascular diseases. Autoimmune diseases are another broad spectrum of diseases that is associated with developed countries. In the past few years, several key scientific findings have revealed that a high sodium diet could also impact the pathogenicity of autoimmune diseases. In this review, we will highlight key results from such investigations and put it in context of high sodium diet and autoimmunity.
Integrated Framework for FUN on the Internet and Mobile Services
Soonjae Kwon,Emy Elyanee Mustapha 한국인터넷전자상거래학회 2016 인터넷전자상거래연구 Vol.16 No.2
This research was designed 1) to define and validate fun as a construct; 2) to compare two different applications(Internet and mobile services). The new four dimension of fun are introduced which are sociability, contentment, achievement and enthusiasm. Dimension of fun is critical to understand IS differentiated between new and established applications. The development of the new fun construct should be extended further to include bigger and wider range of sample especially during the content validation. The comparison study done for to compare usage of mobile service and Internet showed interesting results. These results are suggesting that application types do differentiate type of fun that users experience.
Asymmetrical change in the pelvis and the spine during cross-legged sitting postures
Soonjae Ahn,Seunghyeon Kim,강선영,전혜선,김영호 대한기계학회 2013 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.27 No.11
People spend much time with cross-legged sitting by increasing the time spent in the chair. Prolonged cross-legged sitting postures might cause spinal disorders and trunk asymmetry problems. We investigated the biomechanical effects of cross-legged sitting postures on the pelvic and spinal regions. 3D-motion analyses were performed on 26 healthy subjects. Data were collected while the subjects sat in four different postures: the control posture (without crossed legs) of sitting upright on the chair; the knee-on-knee (KoK) posture (the right knee on the left knee), the ankle-on-knee (AoK) posture (the right ankle on the left knee) and the ankle-on-ankle (AoA) posture (the right ankle on the left ankle). EMG signals were also collected for abdominal muscles. Cross-legged sitting postures showed significantly greater kyphotic curves in the lumbar and the thoracic spines and pelvic posterior tilting, when compared with the control posture. The pressure on the right buttock area was greater in the AoK posture than in the control posture, and the pressure on the left buttock area in the KoK posture was greater than in the control posture. Cross-legged sitting postures showed significantly greater external oblique muscle activation when compared with the control posture.
Targeting the Gut Microbiome to Ameliorate Cardiovascular Diseases
Soonjae Hwang,Chan Oh Park,Ki-Jong Rhee 대한의생명과학회 2017 Biomedical Science Letters Vol.23 No.3
The bacterial cells located within the gastrointestinal tract (GIT) outnumber the host"s cells by a factor of ten. These human digestive-tract microbes are referred to as the gut microbiota. During the last ten years, our understanding of gut microbiota composition and its relation with intra- and extra-intestinal diseases including risk factors of cardiovascular diseases (CVD) such as atherosclerosis and metabolic syndrome, have greatly increased. A question which frequently arises in the research community is whether one can modulate the gut microbial environment to "control" risk factors in CVD. In this review, we summarized promising intervention methods, based on our current knowledge of intestinal microbiota in modulating CVD. Furthermore, we explore how gut microbiota can be therapeutically exploited by targeting their metabolic program to control pathologic factors of CVD.
Soonjae Jung,Jae Yong Choi,Jung Young Kim,Sang-Jin Han,Youngbeom Seo,Kyo Chul Lee,Young Hoon Ryu 대한방사성의약품학회 2019 Journal of radiopharmaceuticals and molecular prob Vol.5 No.1
A bone metastasis is an important factor for prognosis and treatment of breast or prostate cancer patients. [18F]Sodium fluoride ([18F]NaF) is a PET radiopharmaceutical that can detect bone metastasis. Conventional[18F]NaF production process included radioactive metal impurities because the product was prepared byadding saline after beam irradiation to [18O]H2O. In this study, we apply the method of removing radionuclidicimpurities. To meet the criteria prescribed by GMP in quality control, we designed the custom-made [18F]NaFautomatic module. The mean radiochemical yield was 82.1 ± 4.4% (n = 32) productions for 3 years) and thetotal preparation time was 4 min. The final produced [18F]NaF solution meets the USP criteria for quality control. Thus, this fully automated system is validated for clinical use.
Soonjae Hwang,Min Ho Lee,Sun-Yeong Gwon,Seunghyung Lee,Dongju Jung,Ki-Jong Rhee 대한의생명과학회 2013 Biomedical Science Letters Vol.19 No.2
Enterotoxigenic Bacteroides fragilis (ETBF) causes inflammatory diarrhea in humans and animals and is also implicated in colorectal cancer. ETBF-infected mice exhibit a prominent large intestinal inflammation characterized by neutrophil infiltration and induction of the Th17 response. In this study, we examined differences in the secreted cytokine profile of the cecum and proximal colon of ETBF-infected mice using an antibody array. Of the cytokines examined, we found that the cecal tissues from ETBF-infected mice secreted elevated levels of G-CSF, IL-6, IL-17 and LIX compared to non-toxigenic Bacteroides fragilis (NTBF) and Mock infected mice. The proximal colon tissues from ETBF-infected mice secreted higher levels of G-CSF, IL-6, KC, LIX, MIP-1g and MCP-1. This study demonstrates that the cecum and colon should be considered separately when assays are used to determine immune responsiveness to enteric infections.