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Sooji Sirh,박혜란,박석규 대한뇌혈관외과학회 2018 Journal of Cerebrovascular and Endovascular Neuros Vol.20 No.1
Spontaneous chronic subdural hematoma (SDH) is a rare condition that could develop in association with hematologic disease. A 66-year-old male developed a chronic SDH as an initial manifestation of chronic myelomonocytic leukemia (CMML). He experienced recurrent chronic subdural hemorrhage and newly developed intracerebral hemorrhage. Considering the scheduled long-term chemotherapy, bilateral middle meningeal artery (MMA) embolization was performed to prevent recurrence of subdural hemorrhage. Although pancytopenia occurred during the 7 months’ follow- up period, residual chronic subdural hemorrhage was absorbed without recurrence. To our best knowledge, this is the first report of CMML with spontaneous chronic SDH. MMA embolization is potentially a useful and safe treatment option in the challenging clinical situations with underlying pathologies.
( Sooji Lee ),( Amanda W. Singer ),( Anu Osinusi ),( Diana M. Brainard ),( Anand P. Chokkalingam ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Chronic hepatitis C virus (HCV) infection has been associated with adverse cardiovascular and cerebrovascular outcomes. Viral eradication with direct-acting antiviral (DAA) therapy may decrease the risk of these events among HCV patients. We aimed to characterize the risk of cardiovascular and cerebrovascular events among HCV patients treated with DAA regimens compared to untreated patients in US claims data. Methods: 322,276 adults with chronic HCV were enrolled in the database between January 2006 and September 2015. We identified 8,342 HCV patients dispensed at least 12 weeks of DAA therapy (excluding boceprevir and telaprevir) and, for comparison, 76,423 untreated HCV patients who had follow-up time in the DAA era. Events were identified by diagnostic claims for acute and chronic ischemic heart disease, angina pectoris, cardiomyopathy, heart failure, subarachnoid hemorrhage, occlusion and stenosis of precerebral or cerebral arteries, cerebrovascular disease, cerebral atherosclerosis, intracerebral hemorrhage, and transient cerebral ischemia. Hazard ratios (HRs) estimating risk of incident cardiovascular and cerebrovascular events associated with completion of DAA therapy were calculated with adjustment for covariates using Cox proportional hazards methods. Results: HCV patients dispensed a full course of DAA therapy were more likely to be male, over 55 years-old, with baseline diagnoses of cirrhosis, diabetes, or hypertension, and on cardiovascular medications. After adjustment for covariates, there was a reduced risk of total cardiovascular and cerebrovascular events in patients completing DAA therapy compared to untreated patients (HR=0.86, 95% confidence interval [CI]: 0.74-0.99). Adjusted HRs were similar for cardiovascular disease (HR=0.90, 95%CI: 0.76-1.05) and cerebrovascular disease (HR=0.89, 95%CI: 0.74-1.08). Conclusions: In this real-world cohort, DAA therapy appeared to reduce the risk of cardiovascular and cerebrovascular events in HCV patients even within a short period following therapy. The benefits of curative DAA therapy in reducing extrahepatic complications of HCV may be even greater with longer follow-up.
Preventive effect of Lumbrokinase on post-surgical intra-abdominal adhesion
( Sooji Ham ),( Bo-ra Lee ),( Ji Hye Kim ),( Jin-a Oh ),( Dhan-ah Chae ),( Yeojin Lee ),( Hyun Jin Choi ),( Eun-ju Lee ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Objective: Postoperative adhesion is a major cause of chronic pain, infertility, bowel obstruction, and urinary dysfunction. Normally peritoneum is covered with monolayer of mesothelial cells which release plasminogen activator. Postoperative adhesion is provoked by increase of plasminogen activity inhibitors and decrease of fibrinolytic activity, which led to failure of fibrin exudate degradation and adhesion removal. This study is aimed to assess the effect of lumbrokinase (LK), a fibrinolytic enzyme extracted from earthworm, on prevention of postoperative adhesion. Methods: Intrabdominal injuries were induced with scratching until spot bleeding on peritoneum wall and cecum of Sprague-Dawley rats and lumbrokinase were intraperitoneally applied in injured area. Coagulation and hematological profiles were assessed after LK treatment. After 2 weeks after treatment, the severity and the area of intraabdominal adhesion were assessed with scoring system and immunohistochemical analysis. MTT assay and scratch migration assay were used to determine the effect of LK on fibroblast. Results: There is no adverse event after LK treatment. The severity and the area of adhesions were significantly reduced by LK (P=0.040 and P=0.009, respectively). Loosening and detachment of adhesion band between cecum and abdominal wall was observed in LK treated rats while tight attachment at adhesion site was observed in control. The peritoneal thickness of injured area in the LK treated rats was decreased in dose-dependent manner. The number of migrating cells in LK treated group was significantly low compared with that in control groups (P<0.01). Conclusion: LK prevents peritoneal thickening and reduces tissue adhesion by enhancing fibrinolytic activity and attenuating fibroblast invasion. Therefore, LK is a promising anti-adhesive material to prevent postoperative tissue adhesion.
Different Paths to Citizenship Development of Korean College Students by Academic Discipline
Sooji Kim,Byung Shik Rhee 한국교육학회 2016 敎育學硏究 Vol.54 No.1
This study was prompted by a consciousness of the need for today’s younger generations’ enhanced citizenship. Underlying assumptions are that higher education is essentially responsible for nurturing civic minds of the young and furthermore, that it is unquestionably capable of achieving this goal. In this regard, this research delved into college involvement predictors vital to students’ citizenship development and additionally, looked for different paths to development across academic disciplines. A stratified random sample of 5,093 juniors and seniors at 51 four-year Korean universities, was analyzed using hierarchical linear modeling (HLM 6.08). The findings indicated that students in Social Sciences reported the most development in citizenship during college, compared with those in Arts and Humanities, Business, Sciences, Engineering, and Professional fields. Another conclusive discovery was that ‘academic interaction with peers’ and ‘sense of belonging’ had positive effects on students’ citizenship development in all academic disciplines. Other college involvement predictors, however, had varying influences on students according to their affiliated academic disciplines. Finally, psychological factors such as sense of belonging had stronger impacts on students’ citizenship development than college involvement predictors in all academic fields except Business.
Optimal Surgical Timing of Aspiration for Spontaneous Supratentorial Intracerebral Hemorrhage
Sooji Sirh,Hye Ran Park 대한뇌혈관외과학회 2018 Journal of Cerebrovascular and Endovascular Neuros Vol.20 No.2
Objective : Minimally invasive techniques such as stereotactic aspiration have been regarded as promising alternative methods to replace craniotomy in the treatment of intracerebral hemorrhage (ICH). The aim of this study was to identify the optimal timing of stereotactic aspiration and analyze the factors affecting the clinical outcome. Materials and Methods : This retrospective study included 81 patients who underwent stereotactic aspiration for spontaneous supratentorial ICH at single institution. Volume of hematoma was calculated based on computed tomography scan at admission, just before aspiration, immediately after aspiration, and after continuous drainage. The neurologic outcome was compared with Glasgow outcome scale (GOS) score. Results : The mean volume ratio of residual hematoma was 59.5% and 17.6% immediately after aspiration and after continuous drainage for an average of 2.3 days, respectively. Delayed aspiration group showed significantly lower residual volume ratio immediately after aspiration. However, there was no significant difference in the residual volume ratio after continuous drainage. The favorable outcome of 1-month GOS 4 or 5 was significantly better in the group with delayed aspiration after more than 7 days (p = 0.029), despite no significant difference in postoperative 6-months GOS score. A factor which has significant correlation with postoperative 6-months favorable outcome was the final hematoma volume ratio after drainage (p = 0.028). Conclusion : There is no difference in final residual volume of hematoma or 6-months neurologic outcome according to the surgical timing of hematoma aspiration. The only factor affecting the postoperative 6-months neurologic outcome is the final volume of remaining hematoma after drainage.