유방암에서 종양의 크기와 액와림프절 전이의 상관성을 근거로 한 액와림프절 절제술의 생략

송근영,조현진,김권천 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Purpose: The aim of this study is evaluation of the relations between axillary lymph node status and tumor size, and then applied the omission criteria of axillary lymph node dissection in early breast cancer. Materials and Methods: We reviewed 110 patients underwent radical mastectomy and axillary lymph node dissection in breast cancer at Chosun university Hospital between Feb. 1996 and Mar. 2003. We evaluated the correlations between clinicopathologic factors, axillary lymph node status, and presence of metastasis. Results: Correlations between clinicopathologic factors and axillary lymph node status were statistically significant (p=0.01). Correlation between locoregional metastasis and distant metastasis and axillary lymph node status was significant (p=0.03). Results from the number of histologically-positive lymph nodes were significant (p=0.02) as that of lymph node status. Conclusions: The rate of axillary lymph node metastasis in Tla breast cancer is minute. And, preoperative evaluations and postoperative routine radiation therapy can control the axillary lymph node metastasis in Tla breast cancer. So, omission of the axillary lymph node dissection in Tla breast cancer may be considerable.

진행 위암환자에서 Lymphokine-Activated Killer (LAK) 활성의 저하

홍원선,김영환,송재관,강윤구,이진오,강태웅,김정룡 대한내과학회 1990 대한내과학회지 Vol.38 No.3

Natural killer(NK) and lymphokine-activated killer(LAK) activities were determined in 31 patients with unresectable stomach cancer before and immediately after chemotherapy with 5-fluorouracil, adriamycin and mitomycin C(FAM) and 31 healthy volunteers. The major purposes of the study were focused on whether peripheral blood lymphocytes(PBL) in stomach cancer patients had a similar ability in the generation of LAK activity to those in healthy volunteers and what the effect was of chemotherapy with FAM on the generation of LAK activity. LAK cells were generated in vitro by culturing human PBL with 100 U/㎖ of recombinant human interleukin-2(rH-IL-2) for 72 hours. K562(human myelogenous leukemia cell line) and MKN-45(human stomach adenocarcinoma cell line) were used as target cells for NK and LAK activities. NK activity against K562, a sensitive line, was significantly depressed in patients with stomach cancer compared with that in healthy volunteers(p<0.01). However, LAK activity against K562 was similar to that of the controls. Age, sex and performance status(ECOG 0-2 and 3-4) did not have an influence on both NK and LAK activities. LAK activity was significantly higher than NK activity, either against K562 or MKN-45, in both healthy volunteers and patients with stomach cancer(p<0.001). NK and LAK activities against MKN-45, a NK-resistant line, in patients with stomach cancer showed significantly lower levels than those in healthy volunteers. We also analyzed the effect of chemotherapy with FAM on NK and LAK activities, with no suppression of NK and LAK activities being observed. In this study, we have demonstrated that PBL of stomach cancer have a reduced ability to generate LAK activity in response to rH-IL-2. However, LAK activity generated from PBL receiving chemotherapy with FAM was similar to that of PBL without chemotherapy.

공초점 원리를 이용한 3차원 표면형상 측정에 관한 연구

강영준,송대호,유원재 한국비파괴검사학회 2001 한국비파괴검사학회지 Vol.21 No.2

근대 산업에서 기계 부품들의 정밀도와 표면 마무리 조건은 그 어느 때보다 더 절박하게 요구되고 있는 가운데, 표면 형상의 측정과 이해는 공학 기술자뿐만 아니라 물리학자나 화학자도 높은 관심을 갖게 되었다. 이런 상황에서 광학적 측정 방법은 opto-mechatronics의 이점을 가지고 진동 측정이나 균열, 결함의 검출 등의 분야에서 유용한 측정 방법으로 사용되고 있고, 표면 형상학의 분야에서 다시 한 번 중요한 역할을 할 것으로 기대를 받고 있다. 본 연구에서는 공초점 현미경의 원리에 대해 서술하였고, 기존의 스캔 방식 공초점 현미경보다 한 차원 개선된 3차원 표면형상 측정 시스템을 개발하였다. 그리고, 표면의 기하적인 형상에 대한 정보를 얻고 그 형상을 가시화하기 위해 컴퓨터 시스템과 통합하고 그에 필요한 소프트웨어를 개발하였다. In modern industry, the accuracy and the surface-finish requirements for machined parts have been becoming ever more stringent. In addition, the measurement and understanding of surface topography is rapidly attracting the attention of the physicist and chemist as well as the engineer. Optical measuring method is used in vibration measurement, crack and defect detection with the advent of opto-mechatronics, and it is expected to play an important role in surface topography. In this study, the principle of confocal microscope is described, and the advanced 3-D surface measuring system that has better performance than the traditional confocal microscope is developed. Suitable fixtures are developed and integrated with the computer system for generating 3-D surface and form data. Software for data acquistion and analysis of various parameters in surface geometrical features has been developed.

사람폐암세포주 (PC-14)에서 Cyclosporin A에 의한 Adriamycin 내성의 극복

김영환,홍원선,송재관,강윤구,이진오,강태웅,김건열,한용철 대한내과학회 1990 대한내과학회지 Vol.38 No.3

Cyclosporin A and verapamil were tested using MTT assay to evalute the modification effect on the resistance to adriamycin in a human lung cancer cell line(PC-14) and its resistant subline(PC-14/A). PC-14/A was derived by the continuous exposure of PC-14 to incremental concentrations of adriamycin. PC-14/A was 2.5 times more resistant to adriamycin in terms of ICso than PC-14. Cyclosporin A alone, at a concentration of 2.5㎍/㎖, inhibited the growth of PC-14 to 68.3%. 2.5㎍/ ㎖ and 5.0㎍/㎖ of cyclosporin A showed an increase in the cytotoxicity of adriamycin (p<0.01) with 5.0㎍/㎖ being greater than 2.5㎍/㎖(p<0.01). Excluding the direct cytotoxic effect, however, cyclosporin A did not increase in the sensitivity of PC-14 to adriamycin but only showed an additional cytotoxic effect with adriamycin. Verapamil (up to 6.0㎍/㎖) did not inhibit the growth of PC-14. 3.0㎍/㎖ of verapamil did not increase the cytotoxic effect of adriamycin. The combination of cyclosporin A and verapamil with adriamycin enhanced the cytotoxicity of adriamycin, but the result was similar to that of cyclosporin A with adriamycin. 5.0㎍/㎖ of cyclosporin A modified the adriamycin resistance of PC-14/A(SR, 3.2). However, 3.0㎍/㎖ of verapamil did not significantly reverse the adriamycin resistance of PC-14/A. The modified effect of the combination of 5.0㎍/㎖ of cyclosporin A and 3.0㎍/㎖ of verapamil was similar to that of 5.0㎍/㎖ of cyclosporin A alone in PC-14/A. These results demonstrate that cyclosporin A has an additional cytotoxic effect with adriamycin in PC-14 and PC-14/A and has overcome the acquired resistance to adriamycin in PC-14/A. They also suggest that cyclospoin A may have the therapeutic potential in the treatment of human lung cancer.

Reconstitution of Biologically Active FⅧ From Its Subunits

Song, Dong-Weon,Lee, Mi-Young,Oh, Sang-Hwan The Institute of Genetic ScienceYonsei Univ. Col 1998 Focus on genetic science Vol.6 No.-

Plant growth promotion and alleviation of salt stress by treatment of Sporosarcina globispora NBC126

Weon Jung SONG,Jung Hye EOM,Hyangmi KIM,Yeong-Su KIM,Sang-Mi YU 한국생물공학회 2019 한국생물공학회 학술대회 Vol.2019 No.4

The Effects of Internet-based English Practice on Listening and Reading

Song, Jeong-Weon The English Teachers Association in Korea 2006 영어어문교육 Vol.12 No.2

This study examines the effects of Internet-based English practice on listening and reading. Out of a total of 16 students who took part in pre- and post-tests, 11 who had frequently practiced listening and reading on the Internet showed greater improvement in these skills than the 5 who had practiced less. The findings also suggest that summarization of listening and reading on the Internet was useful as it made students concentrate specifically on the content. This study suggests that English language teachers use a bulletin board to complement the use of Internet sites for listening and reading practice outside of the classroom in an EFL context.

Stress Analysis of an Underground Steel Pipeline Considering Corrosion Defect

Weon-Keun Song,Jong-Woo Rhee 한국강구조학회 2006 International Journal of Steel Structures Vol.6 No.3

This paper examines a problem in the interaction betwen a soil medium that experiences frost heave and thaw settlementconsidering a corrosion pit on a pipe wal. The comparative analysis of the theory and the actual performances was valuablein that it established a level of confidence in the aplication of the introduced theory to the field. The numerical results showthe influence of frost heave and thaw settlement of a granite soil medium on a temperature-dependent stress field on a wallof a pipeline buried in South Korea.

김해 도자 문화의 전통과 계승, 발전

Weon Young Song 경남대학교 신소재연구소 2011 신소재연구 Vol.23 No.-

Effects of carbon content on the tensile and fatigue properties in hydrogen-charged Fe-17Mn-<i>x</i>C steels: The opposing trends

Song, Seok Weon,Kim, Jae-Nam,Seo, Hyun Joo,Lee, Taekyung,Lee, Chong Soo Elsevier 2018 Materials science & engineering. properties, micro Vol.724 No.-

<P><B>Abstract</B></P> <P>This study investigated the effects of carbon content on the tensile and low-cycle fatigue (LCF) properties of hydrogen-charged high-Mn steels. Fe-17Mn-<I>x</I>C (<I>x</I> = 0.5, 0.7, and 0.9 wt%) steels were electrochemically hydrogen-charged for this purpose. Interestingly, the carbon content gave rise to opposite hydrogen embrittlement (HE)-resistance trends between monotonic and cyclic loadings; with increasing carbon content, tensile properties deteriorated, while LCF life showed a positive correlation. Such differences were interpreted in terms of primary deformation mechanisms under each loading condition. Increasing carbon contents accompanied an increasing number of thin mechanical twins as well as a higher density of sessile dislocations in monotonic tensile deformation. However, stacking fault energy, which is closely related to carbon content, changed the slip mode during cyclic deformation, thus resulting in the opposing trends found in this work.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>