생약으로부터 산화적 결합 효소인 갑상선 peroxidase의 저해제 검색

이현정,장미영,김미리,배기환,석대은 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-

Thyroid peroxidase is a biochemical target protein for the antithyroid drugs. Ethanol extracts from one hundred and thirty seven natural products were screened for the inhibition of thyroid peroxidase activity. Thyroid peroxidase was purified from porcine thyroids, and the inhibition of peroxidase activity was evaluated using guaiacol oxidation (C-C coupling) assay. Twenty one natural products expressed a remarkable inhibition (>50%) of peroxidase activity at 330㎍ solid weight/ml. The 50% inhibitory concentration (IC50) of 70% ethanol extract from six potent natural products ranged from 3.1 to 31.2㎍ solid weight/ml, in contrast to the range (0.33∼0.54㎍/ml) of IC50, values for catechin and epigallocatechin gallate as positive controls. Noteworthy, the extract of Camellia taliensis showed an irreversible inhibition of the enzyme. It is suggested that extract from some natural products such as Camellia taliensis, Rheum undulatum or Euphorbia pekinsis, exhibiting a potent inhibition of peroxidase activity, may be developed as sources of potent antithyroid agents.

외상성 주관절 구축의 수술적 치료

신현대,이원석 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

The eleven consecutive patients who had contracture of the elbow joint were treated by anterior capsulectomy and distraction arthroplasty without fascial interposition or anterior capsulectomy only. The ten elbows were post-traumatic contracture, and the one elbow was the ankylosis due to prolonged immoobilization after rain injury. Five patients were treated with distraction arthroplasty by modified Mayo Clinic Device and six patients underwent anterior capsulectomy under general or regional anesthesia. The mean preoperative arc of the total motion was 52 degrees(from 44 to 92 degrees of flexion). At follow-up examination, twelve to forty months postoperatively, of eleven patients, the mean arc of the total motion was 108 degrees (from 14 to 122 degrees of flexion). There were seven complications in seven of the eleven patients. Of these, the two were heterotopic ossification recurred in the posterior capsule of the elbow joint, so subsequently the ulnohumeral arthroplasty was performed at postoperative 8 months and 30 months later. The transient ulnar nerve injuries were occurred in two patients. The injured nerve dysfunction was resolved spontaneously. Two patients occured superficial wound infection. The pin site infection was occurred in one patient. The infection was subsided by dressing and antibiotics. Nine of the eleven patients who were followed for average 19 months satisfied with the results of the procedure because of the improved activity in carrying out daily life. No patients showed aggravation of pain. The three severely unstable elbow was improved from 3 points to 1 point on stability points. It was concluded that results of distraction arthroplasty and anterior capsulectomy could be gratifying and the range of motion of elbow was improved Significantly. But the technique is demanding and the rate of complications such as ulnar paresthesia or pin site infection is high especially distraction arthroplasty.

노인의 갑상선기능저하증에 대한 임상적 연구

정윤석,남문석,이은직,김경래,이현철,김현승,허갑범 한국노화학회 1993 한국노화학회지 Vol.3 No.1

프랑스 여성 사회학의 연구 동향: 문제 인식과 쟁점을 중심으로

전석현 서울여자대학교 여성연구소 1998 여성연구논총 Vol.13 No.-

人口豫測模型에 관한 硏究(1985)

崔鍾碩,申鉉山,姜正求 충남대학교 자연과학연구소 1986 忠南科學硏究誌 Vol.13 No.1

In this paper, the population projection is estimated by the method of extrapolation which is based on logistic curve. It is required that each time interval of input data is one year. But census is not usually done punctually. So we try to use the raw census data and corrected them by appropriate transformation. For the population projection, we use four kinds of data : Model Ⅰ annual report from 1955 to 1985, Model Ⅱ linear correction of inter census population from 1955 to 1985, Model Ⅲ Compound interest correction on inter census population from 1955 to 1985, Model Ⅳ five years moving average correction of all inter census population. Estimation by model Ⅰ is not good because of large error caused from wrong estimation of population between census. We get a low projection model Model Ⅱ P=5,314/(1+1.4904 EXP (-0.050756t)) × 10 exp((4) from the second try, a high projection model Model Ⅲ P=5,429/(1+1.5438 EXP (-0.04973t)) × 10 exp(4) from the third try and a medium projection model Model Ⅳ P=5,379/(1+1.5190 EXP (-0.050392t)) × 10 exp((4) from the fourth try. We can guess at a saturation population and at a demographic transition point by virtue of an estimation of this logistic curve. The saturation population of Korea is estimated as 5,314×10 exp (4) by model Ⅱ in this paper. We have found the fact that the domographic transition point of Korea has been rapidly advancing since 1963.

2006년 경상북도 일부 지역에서 발생한 쯔쯔가무시병의 역학적 특성

임현술,유석주 동국대학교 의학연구소 2008 東國醫學 Vol.15 No.1

쯔쯔가무시병은 국내에서 최근 그 발생이 증가추세에 있다. 이 연구는 쯔쯔가무시병 사례군의 발생 원인을 추적하여 보다 효과적인 예방대책을 마련하기 위하여 수행하였다. 2006년 10월 1일부터 12월 31일까지 경상북도 경주시, 영천시, 청도군 보건소에서 확진된 쯔쯔가무시병 사례를 직접 방문하여 연령, 성별, 직업, 작업행태, 가피위치, 방문 및 진단기관 등에 대해 설문조사를 실시하였다. 이 결과를 토대로 성별, 연령별로 환자를 분류하고 작업행태별로 가피의 위치를 분류해 보았고, 발생일별 분포와 진단기관, 방문기관별 입원 여부 등을 분석하였다. 성별 분포는 남자 28명(45.2%), 여자 34명(54.8%)이었고, 연령별 분포는 60대 19명(30.6%), 70대 17명(27.4%), 50대 13명(21.0%) 등의 순이었다. 사례군의 발생일은 10월과 11월에 집중되어 있었다. 작업행태별로 분류해 보면, 농사관련 작업이 41명(66.1%), 과수재배 작업이 13명(21.0%), 성묘 작업이 3명(6.5%), 실내에 쥐가 있던 경우가 3명(6.5%), 등산과 기타 외부활동이 각각 1명이었다. 농사관련 작업은 다시 세부적으로 다양한 농사활동 17명(41.5%), 논농사 11명(26.8%), 텃밭농사 8명(19.5%), 밭농사 5명(12.2%)이었다. 사례들의 첫 번째 방문기관은 의원이 40명, 병원 6명, 보건소 4명, 보건지소 3명, 한의원 1명, 약국 8명이었으며, 첫 방문기관에서 3명이 입원하였고, 그 후 둘째, 셋째, 넷째 방문기관을 거치면서 최종적으로 47명(75.8%)이 입원하였다. 가피는 52명(83.9%)에서 55건 관찰되었고, 그 위치는 겨드랑이가 15건(27.3%)으로 가장 많았고, 옆구리와 서혜부가 각각 6건, 배꼽근처와 흥부가 각각 5건 등의 순이었다. 일부에서 작업행태를 재연해 본 결과, 가피의 위치와 위험작업 간 관련성을 관찰할 수 있었다. 이 연구는 쯔쯔가무시병 사례군을 대상으로 작업행태를 재연하여 위험작업을 추정할 수 있었던 점에서 의의를 찾을 수 있다. Currently, the incidence of scrub typhus is increasing in Korea. The objective of this study was to enhance the efficiency of management and prevention of scrub typhus. The authors reviewed 62 cases reported by the local public health centers. The cases had the newly developed scrub typhus patients in Gyeongju-si, Yeongcheon-si and Cheongdo-gun from October 1 to December 31, 2006. We conducted a questionnaire survey and reviewed the characteristics of the reported cases. Determination of the cause of disease was evaluated. The occurrence of disease varied with gender, age, working attitude and the date of onset. Twenty-eight patients (45.2%) were male, and 34 patients (54.8%) were female. The most of cases occurred between October and November. The probable causes were fruit harvesting (13 cases), mowing around grave yard (3 cases), indoor activity near mice (3 cases), climbing (1 case), other outdoor activity (1 case), and farming activities (41 cases) such as various farm works (17 cases), rice field farming (11 cases), house garden farming (8 cases), and dry-field farming (5 cases). Total 47 cases (75.8%) were admitted to hospitals at last. The sites of eschar were axilla (15 spells), flank (6 spells), groin (6 spells), and around umbilicus (5 spells). Some of cases reacted to their working, indicating that the site of the eschar had some correlation with the cause of infection. The results of this report provide meaningful information on scrub typhus about etiology and high-risk behavior that can be used for establishing effective prevention programs.

표면근전도의 근육 긴장도를 이용한 컴퓨터 단말기 작업자세 평가

임상혁,박희석,김현욱 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.4

목 적 : 본 연구는 VDT작업에서 작업동안 영향을 받는다고 알려진 5개의 근육을 표면근전도를 이용하여 근육의 긴장도를 측정, 평가하고자 하였다. 방 법 : 전화교환 및 고객상담 업무를 담당하고 있는 여성 작업자 11명을 대상으로, 책상의 높이, 모니터의 위치, 키보드의 거리를 달리하여 근육의 긴장도를 측정하였다. 실험장(workstation) 설계에서 높은 책상은 대상자가 속한 사업장의 책상으로 하였으며 높이는 72.8 cm이었고, 미국 국립표준원의 기준에 맞게 제작한 표준 책상의 높이는 65.0 cm이었다. 모니터의 위치는 목을 비틀지 않고 모니터를 주시하고 있는 경우와 약 45도 비틀면서 주시하는 경우로 나누어서 실험하였고, 키보드의 거리는 책상의 끝에서 15 cm 떨어진 것과 30 cm 떨어진 경우로 실험하였다. 실험에 사용된 근육은 paraspinal muscles, upper trapezium muscle, supraspinatus muscle, infrasplnatus muscle, rhomboid muscle이었으며, 실험은 하나의 조건에 대해 각각 5분씩 수행하였고, 각 실험후 10분간 손을 다리 위에 올려놓고 쉬게 하였다. 결 과 : Paraspinal muscles의 표면근전도 값은 모니터가 작업자로부터 45˚측면에 위치할 때가 작업자 중앙에 위치할 때보다 유의하게 높게 나타났다. Upper trapezium muscle, supraspinatus musscle, infraspinatus muscle의 표면근전도 값은 높은 책상에서 미국 국립표준연구원이 제시한 표준책상보다 유의하게 높게 나타났다. Rhomboid musscle은 책상의 높낮이에 따라 표면근전도 값이 차이가 있었으나 통계적 인 의미는 없었다. 결 론 : 이러한 결과로 볼 때 책상의 높낮이가 VDT 작업에서의 어깨 근육 긴장도에 중요한 영향을 미친다고 생각되며, 또한 표면근전도를 이용한 근육 긴장도의 평가가 인간공학적으로 적합한 VDT작업장 설계에 유용할 것으로 생각된다. Objects : Thls study was designed to assess muscle tensions while working at a YDT workstation with surface electromyography (SEMG). Methods : Variables texted were desk height, monitor positon on the desk, distance from edge of the desk to the keyboard. Eleven female volunteers working in the tele-com munication company were seated at an ergonomically adjusted workstation. They were assigned to a task of typing for 5 minutes and were given a 10 minutes resting with hands in their lap. For the initial experiment, the desk height was fixed to standard desk height(65.0 cm) recommended by ANSI and latter adjusted to a higher desk height (72.8 cm) for this study such that the subjects experienced slight elevation of shoulders. The monitor position initially at the center on the desk and latter left site of the desk (45o from monitorneck axles). The keyboard was positioned to an optimal distance (15 cm from the desk edge) and an abnormal distance (30 cm). Five muscle groups (paraspinal muscles, upper trapezium muscle, supraspinatus muscle, infraspinatus muscle, and rhomboid muscle) were selected for the study. The data of SEMG were analyzed by 2×2×2xs mixed factorial design. Results : The results were as follows: 1. SEMG activity recorded from the paraspinal muscles were significantly higher when the angle of the monitor adjusted to 45 degree from the center of the desk.. 2. SEMG activity recorded from the upper trapezius/supraspinatus/infraspinatus muscles were significantly higher when the hight of the desk was elevated from the recommended height. 3. SEMG activity from the rhomboid muscle showed no significantiy difference in all test conditions. Conclusions : The results of thls study confirm that the helght of a VDT workstation and the angle of the monitor are risk factors of upper extremity cumulative trauma disorders. Also SEMG would be useful for measuring muscle activities during workstation assessment.

아침결식이 여고생의 체력과 신체조성에 미치는 영향

이동옥,김현숙,송애경 建國大學校 敎育硏究所 2003 論文集 Vol.27 No.-

This study was intended to make a comparative analysis of the effect of female high school students' absence of breakfast on the composition of physical strength and body. This study was conducted for 30 subjects in the group of female high school students omitting breakfast, those female students enrolled in the high school attached to ´K´University. As the research method, this study made a measurement and comparison of body fat by group, conducted the physical strength test on six items and conducted the questionnaire research and analyzed its results. As a result, it was found that there was not a overall significant difference in body fat, physical strength and that breakfast did not have an effect on body composition and scholastic achievement as well. This run counter to the findings of previous studies and expectation of this study. Accordingly, it is necessary to male a systematic study of the effect of female high school students' absence of breakfast on the composition of physical strength and body for more subjects for a longer period of research.

ATHB12, an ABA-lnducible Homeodomain-Leucine Zipper (HD-Zip) Protein of Arabidopsis, Negatively Regulates the Growth of the Inflorescence Stem by Decreasing the Expression of a Gibberellin 20-Oxidase Gene

Ora Son,허윤선,김윤경,이현정,김성한,김미란,남경희,이명석,김부용,박종범,박정안,이석찬,Atsushi Hanada,Shinjiro Yamaguchi,이인정,김승기,윤대진,Eva So¨derman,천충일 Sookmyung Women's University Research Institute of 2010 여성과 건강 Vol.6 No.1

ATHB12, an ABA-lnducible Homeodomain-Leucine Zipper (HD-Zip) Protein of Arabidopsis, Negatively Regulates the Growth of the Inflorescence Stem by Decreasing the Expression of a Gibberellin 20-Oxidase Gene

Ora Son,허윤선,김윤경,이현정,김성한,김미란,남경희,이명석,김부용,박종범,박정안,이석찬,Atsushi Hanada,Shinjiro Yamaguchi,이인정,김승기,윤대진,Eva So¨derman,천충일 Sookmyung Women's University Research Institute of 2010 여성과 건강 Vol.6 No.1