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Soad Taha,Moniur El Abd,Cristian De Gobba,Mahmoud Abdel-Hamid,Ensaf Khalil,Doaa Hassan 한국식품과학회 2017 Food Science and Biotechnology Vol.26 No.5
The effect of Lactobacillus acidophilus 20552 ATCC (T2) or Lactobacillus helveticus CH 5 (T3) in combination with yoghurt starter (1:1) on the antioxidant and antibacterial activities of the bioactive peptides present in buffalo’s yoghurt was studied. The SDS-PAGE results indicate that all caseins were completely hydrolyzed by both strains, whereas whey protein fractions were still present. All starter cultures have the ability to produce lowmolecular- weight bioactive peptides, most of which were originated from b-casein and fewer from as1 casein. The antioxidant activity (%) of the water-soluble peptide extract from yoghurt samples increased in all samples during storage. Samples containing Lb. helveticus CH 5 showed the highest values. All yoghurt treatments displayed antibacterial activity against Escherichia coli. Control yoghurt and T3 showed higher antibacterial activity on E. coli, Staphylococcus aureus, and Bacillus cereus as compared to T2.
Samia M. Rida,Soad A. M. El-Hawash,Hesham T. Y. Fahmy,Aly A. Hazza,Mostafa M. M. El-Meligy 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.1
A novel series of 1-(1-benzofuran-2-yl-ethylidene)-4-substituted thiosemicarbazides (2a-d) along with some derived ring systems: substituted-2,3-dihydro-thiazoles (3a-c, 4a-f) and thiazolidin- 4-ones (5a-d and 6a-d), were synthesized. In addition, cyanoacetic acid-(1-benzofuran- 2-yl-ethylidene) hydrazide (7) was used to prepare another new series of compounds consisting of substituted pyridin-2(1H)-ones (8a-c); 2-thioxo-2,3-dihydro-thiazoles (9a-d) and 2-thioxo-2,3-dihydro-6H-thiazolo[4,5-d]pyrimidin-7-ones (10a-c, 11a-c). The absolute configuration of compound 5c was determined by X-ray crystallography. The compounds prepared were evaluated for their in vitro anti-HIV, anticancer, antibacterial, and antifungal activities. Among the tested compounds, compounds 5c and 9a produced a significant reduction ㅐㄹ the viral cytopathic effect (93.19% and 59.55%) at concentrations >2.0×10-4 M and 2.5×10-5 M respectively. Compound 9a was confirmed to have moderate anti-HIV activity. Compounds 2a, 2d, and 5c showed mild antifungal activity. However, none of the tested compounds showed any significant anticancer activity.
Samia M. Rida,Soad A. M. El-Hawash,Hesham T. Y. Fahmy,Aly A. Hazzaa,Mostafa M. M. El-Meligy 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.10
Previously, we synthesized and evaluated several benzofuran derivatives containing heterocyclic ring substituents linked to the benzofuran nucleus at C-2 by a two- to four-atom spacer as potential anti-HIV-1, anticancer and antimicrobial agents. Among these derivatives, NSC 725612 and NSC 725716 exhibited interesting anti-HIV-1 activity. To further investigate the structure-activity relationship, we synthesized several new benzofuran derivatives derived from 2-acetylbenzofuran (2, 3a-c) and 2-bromoacetylbenzofuran (6; 7a,b; 8a,b). The compounds were designed to comprise the heterocyclic substituents directly linked to the benzofuran nucleus at C-2. Moreover, various related benzimidazoles derived from 2-acetylbenzimidazole and from 2-cyanomethylbenzimidazole (12a,b; 13a,b; 15; 16a,b) were also prepared as isosteres. The synthesized compounds were preliminarily evaluated for their in vitro anti-HIV-1, anticancer and antimicrobial activity. Compounds 2, 3a, 3b, and 12b showed weak anti-HIV-1 activity. Compound 6 exhibited mild activity against S. aureus, while compound 15 had mild activity towards S. aureus and C. albicans. However, no significant anticancer activity was observed with any of the tested compounds. From these results, we conclude that the presence of the spacer between the heterocyclic substituent and the benzofuran nucleus may be essential for the biological activity.
Middle Eastern Plants with Potent Cytotoxic Effect Against Lung Cancer Cells
Jilan A. Nazeam,Soad Z. EL-Emam 한국식품영양과학회 2024 Journal of medicinal food Vol.27 No.2
Cancer is one of the leading causes of increasing global mortality with uprising health concerns and threats. Unfortunately, conventional chemotherapy has substantial side effects, limiting its relevance and prompting a quest for safe andefficient alternatives. For thousands of years, plants have provided a rich reservoir for curing a variety of ailments, includingcancer. According to the World Health Organization, medicinal plants would be the best source of medications. However, only25% of drugs in the present pharmacopoeia are derived from plants. Hence, further research into different plants is required tobetter understand their efficacy. Twenty extracts of widely distributed Middle Eastern plants were screened for the cytotoxiceffect against lung cancer cell lines (A549). Eleven plants showed IC50 below 25 lg/mL, consequently, the bioactive extractswere further fractionated by graded precipitation using absolute ethanol. All fraction A (FA; crude polysaccharides precipitate)showed potent IC50, 0.2–5.5 lg/mL except the FA of Brassica juncea, Silybum marianum, and Phaseolus vulgaris, whereas FBfractions (filtrate) of Anastatica hierochuntica, Plantago ovate, Tussilago farfara, and Cucurbita moschata had lower efficacythan other fractions with IC50 values in the range of 0.1–7.7 lg/mL. The fractions of FA Taraxacum officinale and FB Ziziphusspina possess the most potent cytotoxic activity with IC50, 0.2 and 0.1 lg/mL, respectively. Moreover, cell cycle analysis of bothfractions revealed an arrest at G1/S-phase and activation of apoptosis rather than necrosis as the mode of cell death. Therefore, T. officinale and Z. spina fractions may pave the way to manage lung carcinoma as an alternative and complementary food regimen.
Rida, Samia M.,El-Hawash, Soad A.M.,Fahmy, Hesham T.Y.,Hazzaa, Aly A.,El-Meligy, Mostafa M.M. The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.10
Previously, we synthesized and evaluated several benzofuran derivatives containing heterocyclic ring substituents linked to the benzofuran nucleus at C-2 by a two- to four-atom spacer as potential anti-HIV-1, anticancer and antimicrobial agents. Among these derivatives, NSC 725612 and NSC 725716 exhibited interesting anti-HIV-1 activity. To further investigate the structure-activity relationship, we synthesized several new benzofuran derivatives derived from 2-acetylbenzofuran (2, 3a-c) and 2-bromoacetylbenzofuran (6; 7a,b; 8a,b). The compounds were designed to comprise the heterocyclic substituents directly linked to the benzofuran nucleus at C-2. Moreover, various related benzimidazoles derived from 2-acetylbenzimidazole and from 2-cyanomethylbenzimidazole (12a,b; 13a,b; 15; 16a,b) were also prepared as isosteres. The synthesized compounds were preliminarily evaluated for their in vitro anti-HIV-1, anticancer and antimicrobial activity. Compounds 2, 3a, 3b, and 12b showed weak anti-HIV-1 activity. Compound 6 exhibited mild activity against S. aureus, while compound 15 had mild activity towards S. aureus and C. albicans. However, no significant anticancer activity was observed with any of the tested compounds. From these results, we conclude that the presence of the spacer between the heterocyclic substituent and the benzofuran nucleus may be essential for the biological activity.
Rida, Samia M.,EI-Hawash, Soad A.M.,Fahmy, Hesham T.Y.,Hazza, Aly A.,EI-Meligy, Mostafa M.M. The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.1
A novel series of 1-(1-benzofuran-2-yl-ethylidene)-4-substituted thiosemicarbazides (2a-d) along with some derived ring systems: substituted-2,3-dihydro-thiazoles(3a-c, 4a-f) and thiazolidin-4-ones(5a-d and 6a-d), were synthesized. In addition, cyanoacetic acid-(1-benzofuran-2-yl-ethylidene) hydrazide(7) was used to prepare another new series of compounds consisting of substituted pyridin-2(1H)-ones(8a-c); 2-thioxo-2,3-dihydro-thiazoles(9a-d) and 2-thioxo-2,3-dihydro-6H-thiazolo[4,5-d]pyrimidin-7-ones (10a-c, 11a-c). The absolute configuration of compound 5c was determined by X-ray crystallography. The compounds prepared were evaluated for their in vitro anti-HIV, anticancer, antibacterial, and antifungal activities. Among the tested compounds, compounds 5c and 9a produced a significant reduction ㅐ ㄹ the viral cytopathic effect (93.19% and 59.55%) at concentrations $>2.0{\times}10^{-4}\;M\;and\;2.5{\times}10^{-5}\;M$respectively. Compound 9a was confirmed to have moderate anti-HIV activity. Compounds 2a, 2d, and 5c showed mild antifungal activity. However, none of the tested compounds showed any significant anticancer activity.
Synthesis of Thiazolo[4,5-d]pyrimidine Derivatives as Potential Antimicrobial Agents
Habib, Nargues S.,Soliman, Raafat,El-Tombary, Alaa A.,El-Hawash, Soad A.,Shaaban, Omaima G. 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.12
In this study, we report the synthesis and antimicrobial evaluation of several new thiazolo[4,5-d]pyrimidine derivatives, namely 7-substituted amino-5-methyl-3-phenylthiazolo[4,5-d]pyrimidine-2(3H)-thiones 4a-e, 8, 13, 15, ethyl 2-cyano-2-(7-substituted-5-methyl-3-phenylthiazolo [4,5-d]-pyrimidin-2(3H)-ylidene)acetates 5a-b, 2-(7 -substituted-5-methyl-3-phenylthiazolo[4,5-d]pyrimidin-2(3H)-ylidene)malononitriles 6a-b, 5-methyl-7-morpholino-3-phenylthiazolo[4,5-d]pyrimidine-2(3H)-one 7, and 7-[4-(1-substituted-5-phenyl-4,5-dihydro-1H-pyrazolin-3-yl)anilino]-5-methyl-3-phenylthiazolo[4,5-d]pyrimidine-2(3H)-thiones 10-12. Some of the tested compounds were more active against C. albicans than E. coli and P. aeruginosa, and all were inactive against S. aureus.
Synthesis of Thiazolo[4,5-d]pyrimidine Derivatives as Potential Antimicrobial Agents
Nargues S. Habib,Raafat Soliman,Alaa A. El-Tombary,Soad A. El-Hawash,Omaima G. Shaaban 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.12
In this study, we report the synthesis and antimicrobial evaluation of several new thiazolo[4,5- d]pyrimidine derivatives, namely 7-substituted amino-5-methyl-3-phenylthiazolo[4,5-d]pyrimidine- 2(3H)-thiones 4a-e, 8, 13, 15, ethyl 2-cyano-2-(7-substituted-5-methyl-3-phenylthiazolo [4,5-d]-pyrimidin-2(3H)-ylidene)acetates 5a-b, 2-(7-substituted-5-methyl-3-phenylthiazolo[4,5- d]pyrimidin-2(3H)-ylidene)malononitriles 6a-b, 5-methyl-7-morpholino-3-phenylthiazolo[4,5-d] pyrimidine-2(3H)-one 7, and 7-[4-(1-substituted-5-phenyl-4,5-dihydro-1H-pyrazolin-3-yl)anilino]-5- methyl-3-phenylthiazolo[4,5-d]pyrimidine-2(3H)-thiones 10-12. Some of the tested compounds were more active against C. albicans than E. coli and P. aeruginosa, and all were inactive against S. aureus.
Mahmoud K.G.,Sayyed M.I.,Hashim S.,Almuqrin Aljawhara H.,El-Soad A.M Abu 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.4
In this study, halloysite nanoparticles-doped epoxy resin was synthesised using the casting method. The MH-300A density metre revealed that the density of the fabricated composites changed from 1.132 to 1.317 g/cm3 as the halloysite nanoparticle concentration increased. The Fourier transform infrared was recorded for the synthesised composites. Furthermore, the γ-ray shielding properties of the synthesised composites were evaluated using Monte Carlo simulation and a theoretical programme, XCOM. The linear attenuation coefficient of the epoxy resin increased by 43% (at γ-energy of 15 keV) and 14% (at γ-photon energy of 662 keV) when the concentration of the halloysite nanoparticles was increased from 0 wt% to 40 wt%, respectively.
Sweed Nabila M.,Fayez Ahmed M.,El-Emam Soad Z.,Dawoud Marwa H. S. 한국약제학회 2021 Journal of Pharmaceutical Investigation Vol.51 No.1
Purpose Rosuvastatin calcium (RSC) is a statin which, in addition to its anti-hypercholesteremic effects, was found to have a potential anticancer activity. The target of the present study is to develop self nano-emulsifying drug delivery systems (SNEDDS) loaded with RSC to overcome its poor solubility, and augment its anticancer activity. Methods A combined mixture-process experimental design was chosen for the optimization of SNEDDS by changing its mixture and process components, where the mixture components were the percentage of Smixture (surfactant and co-surfactant) ( X1) and the percentage of oil ( X2). The process components were the ratio of surfactant to co-surfactant ( X3), and the type of surfactant ( X4). Twenty-four formulae were evaluated for % transmittance and saturated solubility. Results The optimized formula ( O1) was selected based on the highest % transmittance and highest drug solubility, where the % transmittance was 99.05 ± 0.09% and the saturated solubility was 80.52 ± 2.57 mg/ml. The optimized formula has a globule size of 17.53 ± 0.89 nm, a zeta potential of − 10.2 ± 0.21 mV, and a cloud point of 88.5 ± 0.54 °C. Transmission electron microscopy demonstrated spherical droplet morphology. In vitro drug release showed remarkable increase in the drug release from the optimized formula as compared to the corresponding standard RSC. The anticancer activity of O1 was evaluated in HepG2 cell-line, where the IC50 value was 16.2 ± 0.23 μg/ml. The optimized formula increased cell death by both apoptosis and necrosis. Conclusion Our results show that the optimized SNEDDS formula is promising for enhancing the anticancer effect of RSC.