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정신분열병환자와 가족을 위한 행동적 가족치료의 효과성에 관한 연구
전석균,박소라,이현주 한국 정신보건 사회사업학회 1999 정신보건과 사회사업 Vol.8 No.-
The purpose of this study is on developing the Integrated therapeutic model for the patients with schizophrenia and the families in the process of the rehabilitation by examining the effectiveness of the behavioral family therapy program. The participants in this program were 19 patients and families who currently enrolle in the day care center in a university hospital. To evaluate the effectiveness of this program, four measurement tools were used; the Social Problem Solving Inventory(SPSI), Index of Family Relationship(IFR), Aggression Questionnaire(AQ), and SCL-90R. The content of this behavioral family therapy program consisted of 15 sessions: 2 sessions of family psycho-education, 6 sessions of communication skill training and 7 sessions of problem solving skill training. The results have shown significant differences in the score of the SPSI for the patients and families and IFR. The total score on the AQ didn't show any significant difference, while the subscale of Hostility showed significant difference. The pre and post scores on the SCL-90R of the patients were significantly different. On the basis of these findings, some of the recommendations were suggested for the future study.
한국 재래산양에서 Bovine Viral Diarrhea, Bovine Herpesvirus-1, Parainfluenza Type-3 바이러스에 대한 혈청학적 연구
한동운,권용국,문진산,윤소라,위성환,장환,탁동섭,이태욱,강문일 한국수의공중보건학회 2003 예방수의학회지 Vol.27 No.3
The 948 goat sera were serologically tested for ten pathogens including bovine viral diarrhea (BVD), bovine herpes virus type-1 (BHV-1) and parainfluenza virus type-3 (PI-3). By viral neutralizaion test, three pathogens including BVD virus, BHV-1, PI-3 were applied for screening each neutralizing antibody and its titration. Among 948 sera, there were 215 seropositives (22.7%) against BVD virus, 25 (2.6%) against BHV-1 virus, and 161 (17.0%) against PI-3 virus, respectively. In the seropositive cases to BVD virus, provincial prevalence of them were recorded as Gyeongnam(30.8%) for the highest one, while as Jeonbuk (15.8%) and Gyeongbuk(l6.7%) relatively for the lower ones. Among them, higher than 1:8 in antibody titration was classified as 74 cases (34.4%) which were suspected the cycle of its infection in their herds. Among the seropositives to BHV-1, it was relatively lower prevalence rate ranging from 1.7% to 6.7% that those of BVD virus and PI-3, but more importantly they were prevailing across the country. Most of the seropositive cases (42.9%) to PI-3 were classified as 1:4-1:16 in titration, but also distributed all around the country. The prevalence in goats varied according to areas (15.8 to 30.8%). Related to the provincial prevalence of three viral agents in Korean goats, it seemed that three viral pathogens would be directly or indirectly involving in various disorders as primary or secondary causative agents resulting in decreased productivity.
한국 재래 산양에서 Leptospira spp.에 대한 혈청역학적 연구
한동운,권용국,문진산,윤소라,위성환,장환,탁동섭,이태욱,강문일 한국수의공중보건학회 2003 예방수의학회지 Vol.27 No.3
Between January 1999 and September 2001, 948 sera (120 from each province except 108 from Chungbuk) from 8 provinces were sampled from Korean goats. All the samples were serologically tested for Leptospira spp. By the microscopic agglutination test against four L. interrogans serovars including canicola, icterohaemorrhagiae, pomona and hardjo, 948 Korean goats were confirmed as 11 seropositives (1.2%) only infected with L. icterohemorrhagiae. All positive sera were collected from Gyeonggi (5), Gangwon (4) and Chungbuk (2). Titration of them were classified as 1:100 of 10 sera except one case with 1:200 from Gyeonggi. It was meaningful that the pathogen in Korean goats was mainly distributed in the northen part of the country. Consequently, the results in the study were confirmed and analyzed the recent status of infection of leptospirosisas zoonotic agentsome in Korean goats.
Rah, So-Young,Lee, Young-Hoon,Kim, Uh-Hyun Federation of American Societies for Experimental 2017 The FASEB Journal Vol.31 No.7
<P>LPS has been shown to induce hepatocyte autophagy, but little is known about how LPS is able to do this during acute toxic liver injury. Our aim was to determine the existence of any selective Ca<SUP>2+</SUP> signaling coupling to hepatocyte autophagy in response to LPS. LPS increased the autophagic process in hepatocytes, and CD38 knockdown prevented this response. Ned19, a specific inhibitor for nicotinic acid adenine dinucleotide phosphate (NAADP), prevented LPS-mediated Ca<SUP>2+</SUP> signaling and autophagosome formation in hepatocytes. CD38 overexpression protected the liver from LPS/<SMALL>D</SMALL>-galactosamine (GalN)-induced injury, and NAADP administration promoted autophagosome formation and protected hepatocytes from injury induced by LPS/GalN. Autophagy was promoted by the up-regulation of autophagy-related gene expression <I>via</I> NAADP-mediated Ca<SUP>2+</SUP> signaling in response to LPS. However, CD38-knockout mice displayed down-regulation in hepatocyte gene expression. Ned19 also inhibited the NAADP-stimulated induction of gene expression by inhibiting the LPS-induced nuclear translocation of transcription factor EB (TFEB). Hepatocyte autophagy protects against LPS-induced liver injury <I>via</I> the CD38/NAADP/Ca<SUP>2+</SUP>/TFEB pathway. The role of NAADP-mediated Ca<SUP>2+</SUP> signaling in the autophagic process will help elucidate the complexities of autophagy regulation, which is essential toward the discovery of new therapeutic tools against acute liver injury.—Rah, S.-Y., Lee, Y.-H., Kim, U.-H. NAADP-mediated Ca<SUP>2+</SUP> signaling promotes autophagy and protects against LPS-induced liver injury.</P>
Rah So-Young,Joe Yeonsoo,Park Jeongmin,Ryter Stefan W.,Park Chansu,Chung Hun Taeg,Kim Uh-Hyun 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Hepatic glucose production by glucagon is crucial for glucose homeostasis during fasting, yet the underlying mechanisms remain incompletely delineated. Although CD38 has been detected in the nucleus, its function in this compartment is unknown. Here, we demonstrate that nuclear CD38 (nCD38) controls glucagon-induced gluconeogenesis in primary hepatocytes and liver in a manner distinct from CD38 occurring in the cytoplasm and lysosomal compartments. We found that the localization of CD38 in the nucleus is required for glucose production by glucagon and that nCD38 activation requires NAD+ supplied by PKCδ-phosphorylated connexin 43. In fasting and diabetes, nCD38 promotes sustained Ca2+ signals via transient receptor potential melastatin 2 (TRPM2) activation by ADP-ribose, which enhances the transcription of glucose-6 phosphatase and phosphoenolpyruvate carboxykinase 1. These findings shed light on the role of nCD38 in glucagon-induced gluconeogenesis and provide insight into nuclear Ca2+ signals that mediate the transcription of key genes in gluconeogenesis under physiological conditions.