Canine Renal Failure Caused by Ochratoxin A and Citrinin in the Commercial Dog Food

So-Jeo Ahn,Seok-Young Jeoung,Man-su Lim,Son-Il Pak,Jeong-hee Han,Doo Kim 한국임상수의학회 2007 한국임상수의학회지 Vol.24 No.2

Five dogs with renal failure were refered to the Veterinary Medical Teaching Hospital at Kangwon Nationalfor over 1 month. The dogs showed anorexia, emaciation, vomiting, and polydipsia/polyuria. And in one severelyaffected dog, bloody diarrhea and hypothermia were seen. The remarkable clinicopathological signs were high valueof BUN and creatinine. In some dogs, GGT, phosphorus and lipase were increased. However, no significant changesof complete blood count were found. In urinalysis, hematuria, low specific gravity urine, proteinuria, and calciumoxalate-like crystals were observed. Two severely affected dogs were died. The remained dogs were recovered graduallyafter change of dog food and supportive therapy. Pathological findings were seen typically in kidneys. Renal atrophy,tion, necrosis, dystrophic calcification and regeneration inthe tubular epithelium were seen. Yellowish brown fluorolucent laminated materials or particles were quite often foundin the lumina of the necrotizing renal tubules of cortex and medulla. Proliferation of fibrous tissue in the interstitiumwas also seen. By the mycotoxin analysis of the Pedigree dry dog fod, ochratoxin A (OTA) and citrinin were detectedas much as the concentration of 372.8 ppb and 8.3 ppb, respectively. The final diagnosis of renal failure caused byOTA and citrinin toxicosis was made on the basis of history takings, clinical signs, clinicopathological and pathologicalfindings, and analysis of mycotoxins.

Serologic Survey for Canine Coronavirus in Adult Dogs

So-Jeo Ahn,Seok-Young Jeoung,Son-Il Pak,Doo Kim 한국임상수의학회 2007 한국임상수의학회지 Vol.24 No.4

The purposes of this study were to survey the seroprevalence of canine coronavirus (CCV) in healthy adultdogs and to determine whether there was any relationship between seroprevalence and the host parameters. Serumsamples for determination of serum neutralization antibody titers against CCV were obtained from 812 healthy adultdogs over 1 year old brought to veterinary clinics for routine health care visit in 4 provinces from January 2003 toApril 2004. Of the 812 dogs, 714 (87.9%) had positive antibody titers (more than 1 : 4) against CCV. The prevalenceof positive CCV antibody titers were not significantly associated with age, sex, rearing province and environment,and vaccination status. However, the positive CCV antibody titers were increasing with the age. These serologicalfindings have shown that prevalence of positive CCV antibody titers in Korean dogs were a relatively high and thatagainst infection with CCV as it is to vaccinate against canine parvovirus.

Genetic Analysis of VP2 Gene of Canine Parvovirus Isolates in Korea

JEOUNG, Seok-Young,AHN, So-Jeo,KIM, Doo Japanese Society of Veterinary Science 2008 The Journal of veterinary medical science Vol.70 No.7

<P>The purpose of this study was to genetically characterize CPV isolates from Korea. The VP2 gene of 31 isolates was characterized by DNA sequencing and their phylogeny. Among the 31 field CPV isolates, 28 isolates were classified as type 2a and other 3 isolates as type 2b. The isolates in 2a-I, II and III subclusters have unique mutations. The isolates in 2a-IV and V subclusters had similar amino acid sequences to type 2a isolates from other parts of the world. The isolates in type 2b had similar amino acid sequences to type 2b isolates from Asia, Italy, and U.S.A. The molecular analysis of VP2 gene of CPV provided the useful information for the identification of CPV types and the understanding of their genetic relationship.</P>

Characteristics of nitrogen-doped carbon nanotubes synthesized by using PECVD and Thermal CVD

Kim, Jae-Bum,Kong, So-Jeo,Lee, Sung-Youp,Kim, Je-Han,Lee, Hyeong-Rag,Kim, Chang-Duk,Min, Bong-Ki Korean Physical Society 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.60 No.7

두풍(頭風)과 편두통(Migraine)에 대(對)한 동서의학적(東西醫學的) 문헌고찰(文獻考察)

오소조,정지천,이원철,Oh, So-Jeo,Jeong, Ji-Cheon,Lee, Won-Chul 대한한방내과학회 1993 大韓韓方內科學會誌 Vol.14 No.1

This report on the $T{\acute{o}}u\;f{\bar{e}}ng$ and Migraine comes to conclude, through the study of the Oriental- Western medical references, as follow; 1. First, $T{\acute{o}}u\;f{\bar{e}}ng$ and Migraine had some concurrencies that both the two symptoms have appeared severe and recurrent headache and more often to the female. 2 Many of them e.g. Sensory disturbance, Vertigo, Nausea, Vomiting, Tinnitus etc. in the prodrome and main symptom of $T{\acute{o}}u\;f{\bar{e}}ng$ and Migraine were identical, especially the symptom of the $f{\bar{e}}ng\;t{\acute{a}}n\;t{\acute{o}}u\;t{\grave{o}}ng$ was similar to the prodrome of the Migraine. We could find out the semilarity of the symptoms through that Migraine is proximately set in unilateral, and $Pi{\bar{a}}nT{\acute{o}}u\;f{\bar{e}}ng$ is so called alias $B{\grave{a}}n\;bi{\bar{a}}n\;t{\acute{o}}u\;t{\grave{o}}ng$. 3. The pathogeny of $T{\acute{o}}u\;f{\bar{e}}ng$ include the case of ‘$f{\bar{e}}ng\;xi{\acute{e}}\;r{\grave{u}}\;n{\bar{a}}o$’, the patient feeling weak condition, $T{\acute{a}}n,\;T{\acute{a}}nshi,\;T{\acute{a}}nhu{\breve{o}},\;Y{\grave{u}}q{\grave{i}}$, etc. and, ‘$t{\acute{a}}n\;zhu{\grave{o}}\;sh{\grave{a}}ng\;y{\acute{a}}o$’, ‘$G{\bar{a}}n\;y{\acute{a}}ng\;hu{\grave{a}}\;f{\bar{e}}ng$’. There were variable that $F{\bar{e}}ng,\;Xu{\grave{e}},\;F{\bar{e}}ngr{\grave{a}},\;F{\bar{e}}ngx{\bar{u}},\;Xu{\grave{e}}x{\bar{u}},\;Hu{\check{o}}$ in the left, and $t{\acute{a}}n,\;R{\grave{e}},\;t{\acute{a}}nr{\grave{e}},\;Qir{\acute{a}}$ in the right partial pathogeny. It was referred $Sh{\grave{a}}o\;y{\acute{a}}ng\;j{\bar{i}}ng$, $Ju{\acute{e}}\;y{\bar{i}}n\;j{\bar{i}}ng$, $Y{\acute{a}}ng\;m{\acute{i}}ng\;j{\bar{i}}ng$, $T{\grave{a}}i\;y{\acute{a}}ng\;j{\bar{i}}ng$ in connection with the Meridian system. And otherwise the primary cause of Migraine is still unknown to us. Heredity is probably important, but the mode of transmission is uncertain. Recently, the important assumption is the vasomotor change caused by vasoconstrictors like that norepinephrine, epinephrine, and serotonin etc.

Epidemiological Observation on Recent Outbreaks of Canine Parvoviral Enteritis in Korea

Seok-Young Jeoung,Doo Kim,So-Jeo Ahn,Son-Il Pak 한국임상수의학회 2006 한국임상수의학회지 Vol.23 No.3

ontrolled successfully by the use of low-passage hightiter modified live CPV vaccines. However, outbreaks of CPV enteritis have been continued in Korea. In this study,we carried out epidemiological investigation on the recent outbreaks of CPV enteritis of dogs and determined thepotential prognostic factors affecting the survival of dogs. The total of 140 dogs diagnosed for CPV enteritis werestatistically analysed. The majority of dogs were from 6 to 18 weeks of age and were not vaccinated or incompletelyvacinated. There were significant difference in the survival rate between male and female dogs with CPV enteritisand among the age groups (PHI titer <80 group and HI titer 160 group (P<0.05). The majority of dogs had a history of diarrhea, vomiting, lethargyand dehydration. It was considered that recent outbreak of CPV enteritis in Korea caused by the failure of vaccinationand/or by the inadequate antibody responses to CPV vaccines. Prophylactic measures should include isolation of youngdogs from the dog population until the vaccination can be expected to provide protection.

불안정 지지면에서의 유산소 운동이 심폐기능과 균형능력에 미치는 영향

권효륜(Hyo-Ryun Kwon),김미소(Mi-So Kim),남유정(Yu-Jung Nam),박혜민(Hye-Min Park),이경선(Kyeong-Sun Lee),조홍덕(Hong-Deok Jo),최동원(Dong-Won Choi),양회송(Heo-Song Yang),유영대(Young-Dae Yoo),강효정(Hyo-jeong Kang),정찬주(Chan-Joo Jeo 대한심장호흡물리치료학회 2018 대한심장호흡물리치료학회지 Vol.6 No.1

The purpose of this study was to investigate the effects of aerobic exercise with unstable supporting surface on cardio-pulmonary function and balance ability. Methods : This study was performed on 20 subjects. The subjects were divided into two groups; stable supporting surface group(Group Ⅰ, n=10), unstable supporting surface group(Group Ⅱ, n=10). The groups performed the aerobic exercise, which is jump rope exercise, 2 times a week for 4 weeks. Results : The results were as follows. There was statistically significant difference of cardiovascular endurance in Group Ⅰ(p<0.05), and there were statistically significant difference of cardiovascular endurancedynamic, OSI and dynamic APSI in Group Ⅱ (p<0.05). However, there were no statistically significant difference in pulmonary functions which were FVC and FEV1 in Group Ⅰand Group Ⅱ. Conclusion : As a result of this study, aerobic exercise with unstable supporting surface have a potential to induce positive responses in cardiovascular endurance and dynamic balance ability of healthy adults.

Molecular Phylogenetic Classification of Dermatophytes Isolated from Dogs and Cats

Doo Kim,Seok-Young Jeoung,So-Jeo Ahn 한국임상수의학회 2006 한국임상수의학회지 Vol.23 No.4

Using internal transcribed spacer 1 (ITS1) region ribosomal DNA sequences from 9 strains of Microsporumcanis and 5 strains of Microsporum gypseum isolated from dogs and a cat with dermatophytosis, we demonstratedthe mutual phylogenetic relationship of these strains. Nucleotide sequence analysis of the ITS1 gene fragments fromthe 9 strains of M canis had the 100% nucleotide sequence similarities and the 5 strains of M gypseum also hadthe 100% nucleotide sequence similarities. The phylogenetic analysis of the nucleotide sequences of the 9 strains ofM canis formed a nested cluster with the reference strains of M canisEurope. M canis were genetically distinct from the other reference strains of Microsporum spp, but M distortum, Mequinum, and M ferrugineum were genetically very close to M canis. M gypseum form a cluster in the phylogenetictree with M canis as an outgroup. The molecular analysis of ITS1 genes provided the useful information for theidentification of these Microsporum species and the understanding of their relationship.

Development of Rapid Detection Technique for Canine Distemper Virus

김두,안소저,권혁무,Kim, Doo,Ahn, So-Jeo,Kwon, Hyuk-Moo The Korean Society of Veterinary Clinics 2000 한국임상수의학회지 Vol.17 No.1

Recently cases of canine distemper have occurred in Korea despite vaccination was carried out nationwidely. This study was performed to establish rapid diagnosis of canine distemper by RT-PCR, nested PCR, and serological test. A total of 30 dogs, which were suspected canine distemper clinically, was examined. RT-PCR and nested PCR were specific for the amplification of CDV H gene and sensitive to detect 7 TCID50 of Onderstepoort strain. By RT-PCR, H gene was detected in 6(20%) of 30 peripheral bloods from dogs. And H gene was detected in 10(33.3%) of 30 samples by nested PCR. H gene was detected from 1 brain of 6 years-old Beagle dog and 1 lung of 2 months-old Shihtzu dog, in which peripheral blood H gene was not detected. Serum neutralizing antibody titer against Onderstepoort strain ranged from 4 to 1,024 in 30 patients. No correlation was observed between the results of nested PCR and titiers of neutralizing antibody.

Epidemiological Observation on Recent Outbreaks of Canine Distemper in Korea

Doo Kim,Son-il Pak,Ji-young Park,So-jeo Ahn,Seok-young Jeoung 한국임상수의학회 2004 한국임상수의학회지 Vol.21 No.3

To characterize the recent outbreaks of canine distemper (CD) in Korea, we carried out epidemiologicalinvestigations by clinical observations, serum neutralizing (SN) antibody titer determination and RT-PCR on the 315 dogswere infected with CDV. Breed or gender did not sem to have effects on the prevalence of CD. The major part ofdogs were in young age from 6 weeks to 18 weeks of age, and were not vaccinated or incompletely vaccinated. Clinicalsigns of dogs with CD were multisystemic and extremely variable. Dogs died from CD had significantly more ocularsigns and neurologic signs than those of dogs survived (p<0.05). The SN titers against CDV of 157 (96.9%) dogs wereunder 1:16, which is less than protective level. One possible explanation for recent outbreaks of CD in Korea mightbe low antibody titers against CDV because of vacination failure. Therefore, to reduce the impact of virulent infectionin the dog population, dogs should be vacinated adequately and prophylactic measures should include isolation of youngdogs from the dog population until vaccination can be expected to provide protection. 본 연구에서는 최근 국내에서 발병하는 개 디스템퍼(CD)의 역학적 조사를 위하여 2002년 2월부터 2002년 10월까지 강원도, 경기도와 서울특별시의 10개 동물병원 수의사에 의하여 CD에 감염된 것으로 잠정진단된 315마리의 개를 대상으로 하였다. 개체의 신상자료와 임상증상을 조사하였으며 CD를 확진하기 위하여 혈액의 단핵구나 결막 상피세포에서 CDV의 NP gene을 RT-PCR로 증폭하였다. CD로 의심되는 총 315마리 중 162마리가 CD 양성으로 진단 되었으며 성별과 종에 따른 발병율에는 차이가 없었다. 나이별 분포는 백신을 접종해야 하는 기간인 6-18주에 가장 높은 분포를 보였으며 1세 이상에서도 소수 발병하였다. CD 환축은 호흡기 증상, 위장관 증상, 눈의 증상 등 다양한 증상이 나타나 임상증상에 근거하여 CD를 진단하기에 어려움이 있었다. CD 양성의 개 중 84.6%가 백신을 한번도 맞지 않았거나 예방접종을 제대로 실시되지 않은 상태였으며 CDV에 대한 혈청 중화 항체가는 96.9%의 개가 방어수준 이하인 1:16 이하를 나타내었다. CD 양성 162마리와 CD음성으로 진단 된 153마리의 혈청 중화 항체가 사이에는 통계적인 유의차가 인정되었으며 (P< 0.05), CD 양성 개 중에 생존 한 개들은 폐사한 개들보다 중화 항체가 높은 경향을 보였다. 눈의 증상과 신경증상을 보인 개체들은 다른 개체들에 비해 생존율이 유의하게 낮은 것으로 나타났다 (P< 0.05). 본 연구의 결과 현재 국내에서 발병하고 있는 개 디스템퍼는 예방접종의 실패에 따라 개들의 항체 수준이 전반적으로 낮은 것에 기인하는 것으로 판단되므로 예방접종에 대한 전반적인 검토가 필요하며 예방을 위하여 감염에 취약한 시기에는 감염원에 접촉을 최소화하는 것이 중요할 것으로 판단되었다.