Effects of Phenytoin and Diazepam on the Seizure Activity in the Cortical Dysplasia Animal Models

Kim, Si-Hyung,Choi, In-Sun,Cho, Jin-Hwa,Park, Eun-Ju,Jang, Il-Sung,Choi, Byung-Ju,Kim, Hyun-Jung,Kim, Young-Jin,Nam, Soon-Hyeun The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2

Dysplasia-associated seizure disorders are markedly resistant to pharmacological intervention. Relatively little research has been conducted studying the effects of antiepileptic drugs(AEDs) on seizure activity in a rat model of dysplasia. We have used rats exposed to methylazoxymethanol acetate(MAM) in utero, an animal model featuring nodular heterotopia, to investigate the effects of AEDs in the dysplastic brain. Pilocarpine was used to induce acute seizure in MAM-exposed and age-matched vehicle-injucted control animals. Field potential recordings were used to monitor amplitude and numbers population spikes, and paired pulse inhibition in response to stimulation of commissural pathway. Two commonly used AEDs were tested: diazepam 5, 2.5mg/kg;phenytoin 40, 60mg/kg. Diazepam(DZP) and phenytoin(PHT) reduced the amplitude of population spike in control and MAM-exposed rats. However, the amplitude of population spike was nearly eliminated in control rats as compared to the MAM-exposed rats. Pharmaco-resistance was tested by measuring seizure latencies in awake rats after pilocarpine administration(320mg/kg, i.p.) with and without pretreatment with AEDs. Pre-treatment with PHT 60 mg prolonged seizure latency in control rats, but not in MAM-exposed animals. The main findings of this study are that acute seizures initiated in MAM-exposed rats are relatively resistant to standard AEDs assessed in vivo. These data suggest that animal model with cortical dysplasia can be used to screen the effects of potential AEDs.

Improved Adhesion of Metal Electrode Layer on Si₃N₄ Substrate through an All-Wet Process

Kim, Danbi,Eom, Nu Si A,Kim, Jiwon,Lee, Kyu Hyoung,Park, Sung Heum,Lee, Ju Ho,Chao, Yong-Ho,Lim, Jae-Hong Electrochemical Society 2019 ECS journal of solid state science and technology Vol.8 No.2

<P>Electroless deposition requires preliminary surface treatment to effectively adsorb a metal electrode layer onto a ceramic substrate. Herein, a simple surface treatment using an all-wet process was performed to achieve adhesion stability between a Si<SUB>3</SUB>N<SUB>4</SUB> substrate and Ni film. The method involved deposition of an interfacial Pd-TiO<SUB>2</SUB> buffer between the two layers. Surface pretreatment via silanization was initially performed to improve surface wettability, thereby enhancing uniform deposition of Pd-TiO<SUB>2</SUB>. Subsequently, a thin Ni layer was directly deposited onto the Pd-TiO<SUB>2</SUB> layer without necessitating sensitization or activation. The synthesized Ni/Pd-TiO<SUB>2</SUB>/Si<SUB>3</SUB>N<SUB>4</SUB> heat sink exhibited excellent adhesion property in the cross-hatch, scratch, and thermal shock tests. The mechanism of adhesion enhancement involved chemical bonding of Pd-TiO<SUB>2</SUB> with the self-assembled monolayer on the substrate and reduced internal stress due to removal of residual hydrogen between the layers of the heat sink. Thus, the fabricated heat sink has a promising application in electronic devices operated at high temperatures.</P>

흉부 둔상 후 8년간 지속된 삼첨판폐쇄부전의 치료 1예

송현주,남승현,최영주,박성훈,박시훈,한재진 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.4

지문영상으로부터 개선된 세선화 영상 추출에 관한 연구

金源周,南侍秉 三陟大學校 2000 論文集 Vol.33 No.1

자동 지문 패턴 인식에 있어서 가장 중요한 단계는 입력된 지문영상에서 신뢰할 수 있는 특징을 추출해 내는 것이다. 그렇지만, 특징 추출의 전 단계인 전처리 과정에서 영상개선과 세선화 과정 역시 중요하다. 본 연구에서는 256 그레이 레벨로 입력된 지문영상으로부터 잡음제거 및 영상 개선하기 위한 Over Lapping Histogram 알고리즘과 Parallel thinning 알고리즘을 적용하여 개선된 세선화 영상을 추출하는 방법을 제안 하였다. 그리고, 기존의 알려진 방법들과 비교 실험한 결과 제안된 알고리즘의 영상이 기존의 알고리즘에 적용했을 때 보다 개선된 세선화 영상 추출이 가능하였으며, 영상품질 역시 우수함을 나타내었다. An Important process of Automatic Fingerprint Pattern Recognition is to extract relible feature from the input fingerprint image. However, It is important to image enhancement and thining progress from preprocess of previous step of feature extraction. Now, In this using Over lapping Histrogram. And we get image at this progress and adaptive of parallel thining algorithm that extracted improve thining image. The experimental results are confirmed that the improvement of quality of 256 gray level fingerprint images comparision with the existing well known methods.

瀉白散의 肥滿細胞 嫫介性 炎症性 細胞活性物質 分泌 抑制 效果

이병주,신조영,이시형,홍재의,박병민,이승언 한국전통의학연구소 2003 한국전통의학지 Vol.13 No.1

Ocjective : Sabaeksan has been used for the purpose of prevention and treatment of bronchial asthma and allergic asthma in korea. Methods : To investigate the biological effect of Sabaeksan, the author examined cytotoxicity and inflammatory cytokines secretion with human leukemic mast cell line, HMC-1. HMC-1 was stimulated with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187. Sabaeksan by itself had no effect on viability of HMC-1. Result : The effects of Sabaeksan on the secretion of tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6 from HMC-1 were evaluated with enzyme-linked immunosorbent assay. Sabaeksan (1 mg/㎖) inhibited PMA plus A23187-stimulated TNF-α and IL-6 secretion, by 43.86 ± 5.26%, 56.39 ± 3.65%, respectively. Sabaeksan also inhibited the NF-κB (p50/p65) expression. Conclusion : Taken together, these results suggest that Sabaeksan inhibit the production of inflammatory cytokines in HMC-1 cells through blockade of NF-κB activation.

건강정보학 학사교육과정개발

전시자,주혜경,강수진 적십자간호전문대학 2000 적십자간호전문대학논문집 Vol.22 No.-

능력별 과제학습이 수학과 학업성취와 태도에 미치는 효과

김시주,강석호 안동대학교 사범대학부속 과학교육연구소 1998 과학교육연구소논문집 Vol.1 No.-

본 연구는 수준별 교육 과정의 도입이 주요 골자인 제7차 교육과정의 시행을 앞두고 농어촌지역의 소규모 학교에서 시도할 수 있는 수업 모형을 개발하고, 능력별 과제학습 카드의 활용을 통한 수업이 학생들의 학업 성취 수준과 수학과 학습 태도에 미치는 효과를 검증하기 위한 연구로서 능력별 과제학습 카드를 활용한 지도가 전통적인 수업 방식에 비해 학생들의 학업 성취 수준과 향상과 학습태도의 변화에 효과적임을 입증할 수 있었다. 특히 상위 집단의 학생들 보다 중위 집단과 하위 집단의 학생들에게 더욱 효과적임을 알 수 있었다. In 7-th curriculum put in force in 2000, we will apply the curriculum according to the level to enlarge the growth potentiality and the efficiency of an education greatest. The purpose of this study is to develop the teaching model applicable in a small school, and for the students to learn according to their ability. Consequently the subject learning according to the ability was more effective to the advancement of the scholastic attainment than a traditional teaching method.

안구길이, 수정체전낭-망막길이, 굴절상태 및 각막굴절력간의 상호관계

최시환,박주희,박우찬 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2

Axial length is major determinant of ocular refractive power. The purpose of this study was to establish the interrelationship among axial length, anterior lens capsule to retina length(ACRL), refractive states, and corneal refractive power. We measured above four variables of 364 normal adult eyes. The results were as follows: 1. The mean axial length and ACRL of all 364 eyes were 24.93(±1.25mm) and 21.59(±1.20mm) respectively. 2. The mean axial length and ACRL of 63 eyes within ±1 diopter were 23.64(±0.82mm) and 20.34(±0.79mm) respectively. 3. Refractive states, axial length, and ACRL were closely associated. The coefficient of correlation between refractive states and axial length is r=-0.7542(p<0.001), the one between refractive states and ACRL is r=-0.7526(p<0.001). 4. The coefficient of correlation between corneal refractive power and axial length is r=-0.3589(p<0.001), the one between corneal refractive power and ACRL is r=-0.3727(p<0.001). 5. Axial length/ACRL ratio of 63 eyes within ±1 diopter is 1.16(±0.02).

마크로-고리 화합물을 함유한 액체막의 특성에 관한 연구 : 칼륨 이온 운반에 미치는 음이온 효과

김시중,이심성,이선혜,윤창주 聖心女子大學校 1982 論文集 Vol.13 No.2

디벤조-18-크라운-6가 함유된 액체막을 통한 피크린산칼륨과 요오드화칼륨의 운반속도를 각 칼륨염의 농도 변화에 따라 측정하였다. 음이온의 종류에 따라 운반 메카니즘이 크게 다르게 나타나고 있다. 피크린산칼륨은 이온 확산에 가깝고, 요오드화칼륨은 이온 쌍 확산으로 운반되는 것 같다. The transport mechani는 of potassium picrate and potassium iodide across the liquid membrane containing dibenzo-18-crown-6 were studied by measuring the transport rate of the potassium salts. Potassium picrate seems to be transposted by the ionic diffusion but potassium iodide by the ion-pair.

일부 소규모 시계조립 사업장의 상지 누적외상성장애의 유병률

장은철,김현주,권영준,박시복,이수진,송재철 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.4

목적 : 단순 반복작업을 하는 시계조립 사업장 근로자를 대상으로 상지 누적외상성장애의 자각증상 유병률과 상지 누적외상성장애 유병률을 파악하고자 하였다. 방 법 : 인구학적 특성, 상지의 자각증상, 사회심리적 요인은 자가 설문지법으로, 인간공학적 특성은 점검표를 이용한 면담법으로 조사하였다. 상지의 자각증상 조사와 사회심리적 요인은 각각, N10SH (1993) 설문지와 Karasek(1979)의 Job strain model을 번역하여 조사하였다. 상지 누적외상성장애 판정은 의사가 작업 현장에서 직접 환자 면담과 이학적 검사를 수행한 후, 연구에서 규정한 증례정의에 의해 수행하였다. 수집된 자료는 x2 teat와 exact test로 단별량 분석을 하였고, 이중 의미있는 변수와 위험 인자로 알려진 변수들로 다중 로지스틱 회귀분석을 시행하였다. 결 과 : 대상자들의 자각증상 유병률은 54.2 %였고, 부위별로는 목 34.9 %, 손/손목 31.3 %, 어깨 30.1 %, 팔/팔꿈치 18.0 %순이었다. 상지 누적외상성장애의 유병률은 45.8 %였고, 근막동통증후군이 26명으로 가장 많았고, De Quervain씨 병 8명, 수부/전완부의 건염 및 건활막영 8명, 수근관 증후군 5명, 이두건염 5명, 척골 신경병증 5명, 내상과 염 4명, 외상과염 2명, 경추 디스크 질환 2명, 흥곽 출구 증후군 1명순으로 나타났다. 단변량 분석시 자각증상 유병률은 작업부서 중 완성 부에서, 상지 누적외상성장애 유병률은 여자와 완성 부에서 통계학적으로 유의하게 높았다. 다중 로지스틱 회귀분석 결과 완성부와 근무긴장도가 높은 군이 상지 누적외상 성장애와 통계학적으로 유의한 결과를 보였다. 결 론 : 이 연구에서 상지 누적외상성장애 유병률은 45.8 %으로서 저강도의 단순 반복작업을 하는 시계조립 사업장 근로자에서도 누적외상성장애의 위험이 있는 것으로 생각된다. 또한, 사회심리적 요인과 작업 부서별 공정 및 환경이 유병률에 영향을 미치는 주요 요인으로 생각되며, 향후 이들에 관한 다양한 연구가 진행되어야 할 것이다. 산업보건 현장에서는 시계조립 사업장과 같이 저 강도의 단순 반복작업을 위주로 하는 사업장에 대한 지속적인 관심과 각 사업장별 위험요인을 파악하여 적절한 예방 및 관리 대책을 세워야 할 것이다. Objectives : The prevalence of cumulative trauma disorders of upper extremities mons watch assembly workers in small-scaled industry was studied. Methods. In 83 workers at five watch assembly factories, symptoms and psychosocial questionnaire, ergonomic Interview, physical examination were conducted. Results : Prevalence of self-reported symptoms was 54.2% and neck 34.9%, wrist/hand 31.3%, shoulder 30.1%, elbow/arm 18.0% by anatomical site. Prevalence of cumulative trauma disorders was 45.8%. Most common disease was myofascial pain syndrome (31.3%). The other diseases were De Quervain disease (9.6%), tenosynovitis/tendinitis at wrist/hand (9.6%), bicipital tendinitis(6.0%), fat. epicondylitis(4.8%), meIn. epicondylitis(2.4%), and cervical disc disease(2.4%). As result of ergonomic interview, repetitiveness was 79(98.8%). There were no differences in the prevalence of self-reported symptoms and cumulative trauma disorders for age, sex, marital status, duration of work In the study, The significant factors of cumulative trauma disorders were occupational task and psychosocial stress in the study. The prevalence of cumulative trauma disorders in high strain group was hlgher (68.4%) than other three groups. The prevalence of self-reported symptoms and cumulative trauma disorders in assembly task was higher (70.0%, 64.0%) than other two tasks. Conclusions : Prevalence of self-reported symptoms was 54.2%, prevalence of cumulative trauma disorders was 45.8% in watch assembly workers. In this study, factor related to self-reported symptoms was occupational task and factors relaxed to cumulative trauma disorders were occupational task and psychosocial stress. This results suggest that differences of ergonomics and environment in occupational task cause differences of prevalence of self-reported symptoms and cumulatlve trauma disorders.