한국 재래산양의 위장관에 분포하는 내분비세포의 면역조직화학적 연구

조성환,김무강,류시윤,허민도 대한해부학회 1992 Anatomy & Cell Biology Vol.25 No.1

저신장을 주소로 내원한 환아에서 발견된 기질성 원인 질환에 대한 임상적 고찰

고시환,이동환 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

Background: Growth is a sensitive index, which reflects the health status, nutrition and hereditary background of children. If a growth pace deviates from the normal, it could be a warning that represent s congenital or secondary diseases. A lot of research and clinical have been done since Raben reported the treatment of dwarfism using growth hormone for the first time in 1958. Recently, the interest in the growth is more and more increasing, which results in a lot of request. It is usually known that it is rare most children with short stature have abnormality in other internal organs except endocrine or congenital problems . Sometimes, however, the short height itself could be manifestation of major diseases caused by the problem of other internal organs. Accordingly, this study reports the cases of unexpected major diseases found in patients with short stature who have been observed in the outpation clinic and emphasizes the importance of early diagnosis of the diseases. Methods: The retrospective study has been done with the records of patients who were diagnosed as short sture with a basis of below 2 SD (Standard Deviation) or 3 percentile in the pediatric clinic of the Samsung seoul hospital from January of 1996 to July of 1997. The study excludes children patients who indicated vomiting, headache and other nervous diseases-related symptoms except short stature among brain tumor patients. Results : The results were as follows 1) Major internal organ problems have been found in 5 of 52 cases which were diagnosed as short stature after visiting the outpatient clinic with the chief complaint of growth retardation. 2) 2 of the 5 cases were diagnosed chronic renal failure and started dialysis treatment after several months. No specific problems were found in the urinalysis till the term of renal failure. 3) The problems on the Sella MRI test were found in 3 cases of 1 case craniopharyngioma, 1 case histiocytosis X and 1 case focal mass in the pituitary body. Conclusion: Although a few children have the problems in the major internal organs among patients who were diagnosed as short stature, major diseases were found in all 5 cases who have problem Accordingly, it is considered to be necessary to estimate other internal organs minutely.

연쇄상구균을 실험감염시킨 넙치치어의 병리조직학적 관찰

조성환,류시윤,김현수,박배근,김덕환,손화영,윤원기,신창호 충남대학교 수의과대학 동물의과학연구소 1999 動物醫科學硏究誌 Vol.7 No.-

Pathological observations were examined after abdominal inoculation in 7∼8㎝ sized flounder (Paralichthys olivaceus) with 1X10^7 cfu/㎖ of Streptococcus faecalis. The infected flounder were clinically observed and weighed a fish body at 0, 5, 10, 15, 20, 25, 30 days post inoculation. In infected group, mortality were 70% and feed efficiency were 7.2%. In non-infected group, mortality were 10% and feed efficiency were 18.2%. Macroscopically, the significant lesions were characterized by protrusions and opacity of the eyes and ulcer of the caudal pecuncle. Histopathologically, the lesions were observed a degeneration. necrosis and inflammatory cells in muscle of the caudal peduncle and a degeneration and necrosis of the rod cells and detached retina from the black pigmented layer

생쥐 鼻中隔 各種 粘膜上皮 및 粘膜下腺의 分布樣狀과 그 表面積에 관한 硏究

金東煥,金武剛,申台均,金弘善,柳時潤,李永浩 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.1

In order to set the distribution pattern and surface area of the mucosal epithelium and submucosal gland in the mice nasal septum. 3-month-old healthy 6 mice weighing 25gm approximately have been contributed for this research. For the mapping of the each nasal epithelium and submucosal gland in the submicroscopic level, the routine paraffin block of the mice nasal septum were cut as the 10㎛ thick at 110㎛ intervals. Consecutive 2 slides were stained with H-E and PAS and reconstructed in form of maps representing the structure in a sagittal plane. The results obtained from this research were summarized as follows. 1. The unilateral nasal surface epithelial area of the mice nasal cavity was 31.23㎟ 2. The areas of the stratified squamous epithelium, respiratory epithelium and olfactory epithelium which compose the unilateral nasal epithelium were 4.47㎟(14.3%), 12.7㎟(40.8%), and 14.02㎟(44.9%), respectively. 3. Submucosal glands in the mice nasal septum were divided into the PAS-positive, PAS-negative and Bowman's glands by the PAS staining. 4. The surface area of the PAS-positive glands in the nasal unilateral septum was 5.23㎟ which is located in the central area of the respiratory portion. 5. The surface area of the PAS-negative glands in the nasal unilateral septum was 5.05㎟ which is located above and below the PAS-positive gland. 6. The surface area of the Bowman's glands was 12.1 ㎟ which was located in the olfactory region. 7. In the vestibular region., 3 ducts of PAS-negative glands of the respiratory region are found, and below the nasal septum there is the infraseptal gland(PAS-negative).

좌심실내 혈류 전파 속도에 관한 연구

최시완,정진옥,강승식,성인환,박종훈 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.1

Background : Noninvasive attemps to identify left ventricular relaxation have been hampered because relaxation rate, left atrial filling pressure, and chamber compliance are the major determinants of peak early velocity and filling rate. This study was perfomed to evaluate the relation between the velocity of flow propagation and left ventricular relaxation by using pulsed doppler echocardiography to analize flow propagation in the left ventricle. Method : By using pulsed Doppler echocardiography, the velocity of left ventricular flow propagation was measured from the distance and time difference of flow wave along the long axis propagation of left ventricular inflow during early filling in normal subjects (n=30), and M-mode echocardiographic data were obtained to evaluate mitral annulus long axis movement (mitral annulus relaxation rate) which represents left ventricular relaxation. Results : the peak early velocity was not related to mitral annulus relaxation rate, but, the velocity of flow propagation was related to mitral annulus relaxarate (P<0.005) in normal subjects. Conclusion : the velocity of flow propagation during early filling seems to be highly dependent on the mitral annulus relaxation rate and could be an important noninvasive tool in studying diastolic function.

스마트폰 부재와 분실을 대비한 어플리케이션

조시현;문상수;김기환;도민균;서재현;김태공 인제대학교 2012 仁濟論叢 Vol.27 No.1

Recently, as the Smart Phone is rapidly disseminated worldwide, it is emerging as an important digital communication media changing the communication types of users. We use the Smart Phone in all aspect of daily life besides communication. The Smart Phone is indispensible tool that has a great ripple effect on our daily life. Therefore, if the Smart Phone users lose or do not bring their phones, they were troubled. In this paper, we make users available to use the Smart Phone, even if they lose or do not bring their phones. To do this end, we develop features that search the phone in case of not knowing where it is, that contact another phone in case of not bringing their phone, that lock the phone in case of losing it. We expect these features promote a expansion and a vitality of the Smart Phone market.

Prostacyclin synthase 유전자의 C1117A 다형성과 이형협심증과의 관련성

성인환,임대승,김정희,이재환,최시완,정진옥 대한내과학회 2004 대한내과학회지 Vol.66 No.4

목적 : Thromboxan A2의 혀관수축반응을 저해하는 prostacylin synthase exon 8 C117A의 변이가 관동맥 연축과 관련성이 있는지를 알아보고자 하였다. 방법 : 1998년 1월 1일부터 2000년 12월 31일까지 충남대학교병원 순환기내과에서 관동맥조형술과정맥내 에르고노빈 유발검사를 시행하여 관동맥 연축이 확진된 이형협심증 환자군(45예)과 정상 대조군(59예)을 대상으로 중합효소 연쇄반응법 및 restriction fragment length polymorphism을 이용하여 분석하였다. 결과 : Prostacyclin synthase exon 8 C117A 유전자형의 빈도는 대조군에서 A/A : A/C : C/C =3.4% : 30.5% : 66.1%, 이형협심증 환자군에서 A/A : A/C : C/C = 8.9% : 42.4% : 48.9%로 두 군간에 유의한 차이가 없었다. 대조군에 비해 변이형 협심증 환자군에서 남자의 비율과 흡연률이 높았지만, prostacyclin synthase exon 8 C117A 유전자형에 따른 군에서 당뇨병, 고혈압, 흡연, 고지혈증, 비만 등의 유의한 차이는 없었다. 결론 : 한국인에서 prostacyclin synthase exon 8 C117A 유전자 다형성과 관동맥 연축이 있는 이형협심증과의 유의한 연관성은 발견할 수 없었다. Backround : Coronary artery spasm plays an important role in the pathogenesis of variant angina(VA). Prostacyclin is one of the endothelium derived relaxing factors. The association between the novel single nucleotide polymorphism in the prostacyclin synthase gene and VA is not known. Therefore, we investigated the association between VA and the polymorphysm in the prostacyclin synthase gene. Methods : We compared 45 variant angina patients who had positive intravenous ergonovine test by coronary angiography with 59 control subjects who had negative intravenouis ergonovine test and normal coronary angiogram. Using the polymerase chain reaction-single-strand conformation polymorphism analysis, we identified a single nucleotide polymorphism, C117A, in exon 8. This nucleotide change did not cause an amino acid change in codon 373. Results : There was no significant difference in characteristics between the control group and the VA group, and there was no significant difference in the genotype distributions between the control group and the VA group. Conclusion : The C117A polymorphism in exon 8 of the prostacyclin synthase gene is not associated with variant angina.

개에서 관찰된 모기질세포종의 증례보고

조성환,손화영,김혜성,최종윤,류시윤,박배근,윤원기,홍성혁,김덕환 충남대학교 수의과대학 동물의과학연구소 2002 動物醫科學硏究誌 Vol.10 No.-

Pilomatricoma was histopathologically diagnosed in a 2.5-year-old male Alaskan malamute. The patient was referred to Chungnam National University, Veterinary Medical Teaching Hospital with solitary, firm and well-circumscribed mass at shoulder. Grossly, the mass was dome shaped to tumor like and 10 x 8 x 5㎝ in size. Some lesions had gritty or bony consistency and was chalky when sectioned Histopathologic feature included mumerous clusters of tightly arranged, basaloid cells with evenly distributed chromatin and ghost cells were characterized by a central unstained zone. The ghost cells often become calcified and osseous metaplasia was also present.

금속-도재 수복물에서 비귀금속 합금의 재사용에 따른 결합강도에 관한 연구

임시덕,이은경,장기환 한국위생과학회 2001 한국위생과학회지 Vol.7 No.2

치과용 비귀금속 합금 중 Verabond와 RecilliumⅢ,Ⅴ를 사용하여, 새 금속만 사용한 group(Ver-1, Rex3-1, Rex5-1)과 재사용한 group(Ver-2, Rex3-2, Rex5-2)의 경도측정을 한 결과 새금속만을 사용한 group에서는 Ver-1이 경도측정치가 가장 높았으며, 재사용한 group에서는 Rex5-2가 가장 높은 경도 측정치를 나타내었고 Rex3에서는 Rex3-1과 Rex3-2간의 경도 차이는 없었다. Verabond와 RexolloumⅢ,Ⅴ를 사용한 것과, 새 금속만을 사용하여 Vita Omega Porcelain을 올려서 소성하고, 금속과 도재간의 결합강도를 측정 한 것과, 한번 주조된 비귀금속 합금에 50%의 새로운 합금을 사용하여 Vita Omega Porcelain을 올려서 소성하고, 금속과 도재간의 결합강도를 측정한 결과 재 사용한 금속 중 Rex5-1이 금속과 도재간의 결합강도가 가장 좋은 것으로 나타났고, 주조된 합금에 새 금속 50%를 섞은 group에서는 Rex5-2가 결함강도가 가장 낮은 것으로 나타났다. 그러나 Ver-1과 Ver-2는 금속과 도재간의 결합강도는 큰 차이점이 없는 것으로 보인다. The hardness of non-precious dental alloy was measured using Verabond and Rexillium Ⅲ,Ⅴ, The dental alloy was group into a new alloy group (Ver-1, Rex5-1) and used alloy (Ver-2, Rex5-2). As a result, Ver-1 showed the highest hardness value in a new alloy group. and Rex5-2 showed the highest hardness value in a used alloy group. However, Rex3-1 and Rex3-2 did not show any difference in hardness. The bonding strength between alloys used Verabond and Rexillium Ⅲ,Ⅴ was tested; The bonding strength between porcelain and a new alloy, which was firing after build up weth Vita Omega porcelain; was tested; Also, the bonding strength between porcelain and metal, which was casted and firing after build up with vita Omega pocelain was tested. I this case, the casted alloy was mixed with a new alloy by hay in weight. As a result, Rex5-1 yielded the highest strength among the used alloy group. Rex5-2 was the lowest in bonding strength among the alloy mixed with casted alloy and a new alloy by hay in weight. On the other hand, Ver-1 and Ver-2 did not show apparent difference in bounding strength.

돼지생식기호흡기 증후군(PRRS) 바이러스 감염시킨 돼지 기관의 병리학적 관찰

조성환,김현수,윤원기,전무형,류시윤,박배근,손화영,김무강 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-

The porcine reproductive and respiratory syndrome virus was inoculated into swine tracheal organ culture. The ballooning degeneration of the tracheal ciliated epithelium and a decrease of ciliary activity from the tracheal organs infected with PRRS virus were observed one day post-infection(PI). Tracheal epithelium showed degeneration and focal necrosis 2 days PI. Epithelial necrosis and loss of cilia and epithelial cells became more severe 3 and 4 days PI. An entire loss of cilia and epithelial cells were recognized 4 days PI, however, control tracheal organs were normal during the period of the experiment except a little decrease of ciliary activities with time..