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Si-si Qi,Ying Miao,You-yu Sheng,Rui-ming Hu,Jun Zhao,Qin-ping Yang 대한피부과학회 2023 Annals of Dermatology Vol.35 No.1
Background: We found microRNA (miR)-1246 to be significantly differentially expressedbetween severe active alopecia areata (AA) patients and healthy individuals. Objective: To explore the role and mechanism of miR-1246 in severe AA. Methods: Expression of miR-1246, dual-specific tyrosine phosphorylation-regulated kinase1A (DYRK1A), and nuclear factor of activated T cells 1c (NFATc1) in peripheral CD4+ Tcells and in scalp tissues of patients were detected using RT-qPCR, Western blot, and immunohistochemistryassays. Peripheral CD4+ T cells from the AA patients were transfectedwith lentiviral vectors overexpressing miR-1246. RT-qPCR and Western blot analysis wereused to measure mRNA or protein expression of retinoic-acid-receptor-related orphan nuclearreceptor gamma (ROR-γt), interleukin (IL)-17, DYRK1A, NFATc1, and phosphorylatedNFATc1. Flow cytometry was used to assay the CD4+IL-17+ cells proportion. ELISA wasused to measure cytokine levels. Results: miR-1246 levels decreased and DYRK1A and NFATc1 mRNA levels significantlyincreased in the peripheral CD4+ T cells and scalp tissues of severe active AA samples. NFATc1 protein expression was also significantly increased in the peripheral CD4+ T cellsbut not in the scalp tissues. NFATc1 positive cells were mainly distributed among infiltratinginflammatory cells around hair follicles. In peripheral CD4+ T cells of severe active AA,overexpression of miR-1246 resulted in significant downregulation of DYRK1A, NFATc1,ROR-γt, and IL-17 mRNA and phosphorylated NFATc1 protein, as well as a decrease in theCD4+IL-17+ cells proportion and the IL-17F level. Conclusion: miR-1246 can inhibit NFAT signaling and Th17 cell activation, which may bebeneficial in the severe AA treatment.
Fu, Si-Rui,Zhang, Ying-Qiang,Li, Yong,Hu, Bao-Shan,He, Xu,Huang, Jian-Wen,Zhan, Mei-Xiao,Lu, Li-Gong,Li, Jia-Ping Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
Background: Sorafenib is a promising drug for advanced hepatocellular carcinoma (HCC); however, treatment may be discontinued for multiple reasons, such as progressive disease, adverse events, or the cost of treatment. The consequences of sorafenib discontinuation and continuation are uncertain. Materials and Methods: We retrospectively analyzed 88 HCC patients treated with sorafenib from July 2007 to January 2013. Overall survival (OS), post-disease progression overall survival (pOS), and time to disease progression (TTP) were compared for survival analysis. Cox proportional hazard regression was performed to assess the effect of important factors on OS in the overall patient population and on pOS in patients who continued sorafenib treatment. Results: Sorafenib was discontinued and continued in 24 and 64 patients, respectively. The median OS (355 vs 517 days respectively; p=0.015) and median post-PD OS (260 vs 317 days, respectively; p=0.020) were statistically different between the discontinuation and continuation groups. Neither the median time to first PD nor the time to second PD were significantly different between the 2 groups. In the discontinuation group, 3 of the 24 patients (12.5%) suffered disease outbreaks. In Cox proportional hazard regression analysis after correction for confounding factors, BCLC stage (p=0.002) and PD site (p=0.024) were significantly correlated with pOS in patients who continued sorafenib treatment. Conclusions: Sorafenib discontinuation may cause HCC flares or outbreaks. It is advisable to continue sorafenib treatment after first PD, particularly in patients with Barcelona Clinic Liver Cancer stage B disease or only intrahepatic PD.
Comparison of carcass and meat quality traits between lean and fat Pekin ducks
Ding, Si-Ran,Li, Guang-Sheng,Chen, Si-Rui,Zhu, Feng,Hao, Jin-Ping,Yang, Fang-Xi,Hou, Zhuo-Cheng Asian Australasian Association of Animal Productio 2021 Animal Bioscience Vol.34 No.7
Objective: According to market demand, meat duck breeding mainly includes 2 breeding directions: lean Pekin duck (LPD) and fat Pekin duck (FPD). The aim of the present study was to compare carcass and meat quality traits between 2 strains, and to provide basic data for guidelines of processing and meat quality improvement. Methods: A total of 62 female Pekin ducks (32 LPDs and 30 FPDs) were slaughtered at the age of 42 days. The live body weight and carcass traits were measured and calculated. Physical properties of breast muscle were determined by texture analyzer and muscle fibers were measured by paraffin sections. The content of inosine monophosphate (IMP), intramuscular fat (IMF) and fatty acids composition were measured by high-performance liquid chromatography, Soxhlet extraction method and automated gas chromatography respectively. Results: The results showed that the bodyweight of LPDs was higher than that of FPDs. FPDs were significantly higher than LPDs in subcutaneous fat thickness, subcutaneous fat weight, subcutaneous fat percentage, abdominal fat percentage and abdominal fat shear force (p<0.01). LPDs were significantly higher than FPDs in breast muscle thickness, breast muscle weight, breast muscle rate and breast muscle shear force (p<0.01). The muscle fiber average area and fiber diameter of LPDs were significantly higher than those of FPDs (p<0.01). The muscle fiber density of LPDs was significantly lower than that of FPDs (p<0.01). The IMF of LPDs in the breast muscle was significantly higher than that in the FPDs (p<0.01). There was no significant difference between the 2 strains in IMP content (p>0.05). The polyunsaturated fatty acid content of LPDs was significantly higher than that of FPDs (p<0.01), and FPDs had higher saturated fatty acid and monounsaturated fatty acid levels (p<0.05). Conclusion: Long-term breeding work resulted in vast differences between the two strains Pekin ducks. This study provides a reference for differences between LPD and FPD that manifest as a result of long-term selection.
패킹모델 이용한 초고성능 콘크리트 배합설계 및 성능 평가
옌스뤠이 ( Yan Si-rui ),장종민 ( Jang Jong-min ),이한승 ( Lee Han-seung ) 한국건축시공학회 2020 한국건축시공학회 학술발표대회 논문집 Vol.20 No.1
This paper introduces the mix design and performance evaluation of Ultra-High Performance Concrete (UHPC). The concrete mixture is designed to achieve a densely compacted cementitious matrix via the modified Andreasen & Andersen particle packing model. The compressive strengths of UHPC designed by this method reached 154MPa. The relationship between packing theory and compressive strength of UHPC is discussed in this paper.
Curved-quartic-function elements with end-springs in series for direct analysis of steel frames
Si-Wei Liu,Jake Lok Yan Chan,Rui Bai,Siu-Lai Chan 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.29 No.5
A robust element is essential for successful design of steel frames with Direct analysis (DA) method. To this end, an innovative and efficient curved-quartic-function (CQF) beam-column element using the fourth-order polynomial shape function with end-springs in series is proposed for practical applications of DA. The member initial imperfection is explicitly integrated into the element formulation, and, therefore, the <i>P</i>-<i>δ</i> effect can be directly captured in the analysis. The series of zero-length springs are placed at the element ends to model the effects of semi-rigid joints and material yielding. One-element-per-member model is adopted for design bringing considerable savings in computer expense. The incremental secant stiffness method allowing for large deflections is used to describe the kinematic motion. Finally, several problems are studied in this paper for examining and validating the accuracy of the present formulations. The proposed element is believed to make DA simpler to use than existing elements, which is essential for its successful and widespread adoption by engineers.
Rui Guo(곽뢰),Zuliyati Rohmah(쥴리야티 로마),Kwang-Soo Choi(최광수),Si-Hyang Park(박시향),Yeong-Lae Ha(하영래),Seok-Joong Kang(강석중),Byeong-Dae Choi(최병대) 한국생명과학회 2015 생명과학회지 Vol.25 No.5
공액리놀레산(CLA)과 카로테노이드 일정량을 함유하는 두 가지 사료구와 대조구를 감성돔(Acanthopagrus schlegeli)에 급여하였다. 대조구에는 CLA와 카로테노이드가 포함되지 않았고, CP10구에는 CLA 1%와 카로테노이드 0.1%가 포함되었고, CP25구에는 CLA 2.5%와 카로테노이드 0.1%가 포함되었다. 대조구, CP10 및 CP25구의 일일성장률(SGR)은 0.74, 0.81, 0.97이었고, 사료요구율은 2.65, 2.46 및 2.04이었다. 사육 후 근육 내에 축적된 CLA 함량은 CP10 및 CP25구에서 각각 2.8% 및 5.6%였으며, 내장에 축적된 CLA 함량은 4.0% 및 8.3%였다. 한편, CP25구의 내장에서 추출된 지용성 물질(VLE)을 첨가한 3T3-L1 지방세포 생존율은 대조구와 비교하였을 때 처리량에 따라 영향을 받는 것으로 나타났다. 따라서 CP25구의 VLE 추출물 농도를 1, 10, 50 및 100 μg/ml으로 처리하였을 때 각각 85.9±0.8%, 74.8±0.9%, 75.5±0.6% 및 72.1±0.7% 감소시켰다. 이와 같은 사료로 감성돔을 사육하는 경우 CP10 및 CP25구의 내장에서 추출한 지질함량 중 CLA함량은 각각 4.0% 및 8.5%, 카로테노이드는 각각 0.62 mg/g 및 0.56 mg/g, EPA 및 DHA는 각각 11.7%와 10.8% 및 11.8%와 12.7%로 증가하였고, 총 PUFA 함량도 각각 48.4% 및 50.5%로 증가하여 인체에 긍정적인 영향을 미치는 성분을 동시에 섭취할 수 있어 기능성 어류의 생산이 가능한 것으로 나타났다. Three groups of black seabream (Acanthopagrus schlegeli) were fed with treatment diets containing certain concentrations of conjugated linoleic acid (CLA) and carotenoids. The control group feed contained 0% CLA and 0% carotenoids, the CP10 group feed contained 1% CLA and 0.1% carotenoids, and the CP25 group feed contained 2.5% CLA and 0.1% carotenoids. The CP10 and CP25 groups demonstrated the enhanced growth and increased feed conversion efficiency of black seabream. The specific growth rates (SGRs) were 0.74, 0.81, and 0.97, while the feed conversion ratios (FCRs) were 2.65, 2.46, and 2.04 for the control, CP10, and CP25 groups, respectively. The total contents of high unsaturated fatty acid (HUFA) for the control, CP10, and CP25 groups were 41.0%, 41.7%, and 43.5%, respectively. CLA was deposited to the extent of 2.8% and 5.6% in the muscle, and 4.0% and 8.3% in the viscera of the CP10 and CP25 groups, respectively. Meanwhile, treatment with the viscera lipid extract (VLE) from CP25 fish evidently lowered 3T3-L1 adipocytes viability. The lipid extract from the muscle and viscera of black seabream contained ample amounts of beneficial substances, such as CLA, carotenoids, EPA, and DHA. CLA, which enriched black seabream muscle, could be categorized as a functional food and serve as a well-being food. Meanwhile, the fish oil from its viscera could serve as a high function supplement.
Rui-Le Pan,Di-Hua Chen,Jian-Yong Si,Xiao-Hong Zhao,Zhan Li,Li Cao 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.2
Two new cyclolanostane diglycosides, cimifoetiside A (1) and cimifoetiside B (2), were isolated from an 80% ethanolic extract of the aerial part of Cimicifuga foetida L. (Ranuculaceae). Using spectral data and chemical analysis, the structures of 1 and 2 were identified as (23R, 24S) cimicigenol 3-O-β-D-glucopyranosyl-(1"→3')-β-D-xylopyranoside and (23R, 24S) cimicigenol 3-O-β-D-glucopyranosyl-(1"→2')-β-D-xylopyranoside, respectively. The in vitro immunosuppressive effects of the two new compounds 1 and 2, as well as four other known cyclolanostane saponins 3-6 on T cells were evaluated. All the agents tested effectively inhibited the proliferation of murine splenocytes induced by Concanavalin A (ConA), with IC50 values ranging from 12.7 nM to 33.3 nM.