라벤더 에탄올 추출물의 피지생성 억제효과

박시준,김호민,한규수,성금수,신미란,문연자,우원홍 한국전통의학연구소 2006 한국전통의학지 Vol.15 No.1

Lavandula vera is indispensable member of the herb family, used for perfumes and potpourri. Androgens have profound effects on the physiology of the sebaceous gland. Sebum is secreted due to the effect of androgen, which starts to be secreted at puberty. Using the human sebocyte cell line SZ95, the author investigated the inhibitory effect of Lavandula vera on the lipid production. Light microscopic finding were examined numerous cytoplasmic lipid droplets SZ95 cells by Oil red staining and lipid droplets were increased markedly by testosterone. On the other hand, combined treatment with Lavandula vera and testosterone resulted in a lower lipid droplets than with testosterone alone in a dose-dependent manner. These findings indicate that Lavandula vera acts antagonistically to testosterone and inhibits the lipid synthesis of SZ95 cells at the cellular level.

류마티성 승모판 협착증 환자에서 Inoue 풍선을 이용한 경피적 승모판 풍선 성형술의 임상 경험

박시훈,신길자 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.1

Object : Percutaneous mitral balloon valvuloplasty was introduced by Dr. Inoue in 1984 and it is now widely used in the treatment of mitral stenosis due to its simple design to use. Method : From September 1993 to January 1996, 11 cases of percutaneous mitral balloon valvuloplasty were performed at the Ewha Womans University Hospital. Result : Following the percutaneous mitral balloon valvuloplasty, the mitral valve opening area was increased from 1.18±0.34㎠ to 1.91±0.62㎠(p<0.001). The mean mitral valve diastolic pressure gradient was decreased from 14.35±6.00mmHg to 5.41±4.03mmHg.(p<0.001) The NYHA functional class was improved significantly. Among 11 cases, 1 case(9%) was failed to expand mitral valve opening area and another 1 case developed grade 2 of mitral regurgitation. But there was no life threatening complication such as cardiac tamponade. Conclusion : It is concluded that percutaneous mitral balloon valvuloplasty with Inoue alloon is an effective and simple method for most patient with mitral stenosis who do not have thrombi.

건강정보학 학사교육과정개발

전시자,주혜경,강수진 적십자간호전문대학 2000 적십자간호전문대학논문집 Vol.22 No.-

내산성 및 내담즙성이 우수한 양돈용 유산균의 선발

유자영,양시용,송민동 建國大學校 自然科學硏究所 2002 建國自然科學硏究誌 Vol.13 No.1

본 연구는 가축의 장내에서 유익한 영향을 주는 유산균을 돼지의 분변으로부터 분리하고 내산성과 내담즙성이 뛰어난 균을 선별하여 유산균 생균체를 준비하고자 실시하였다. 분변에 섞여 있는 다른 균들과 산이나 담즙액에 약한 균들은 처음부터 분리하기 위하여 pH를 2.0으로 맞춘 MRS broth에 배양시키고 oxgall이 첨가된 배지에 도말하여 40개의 균주를 분리하였다. BCP배지를 이용해서 유산의 생성여부를 확인하고, O.D값과 pH를 측정하였으며, 그람염색과 형태관찰을 통하여 33개의 균주를 분리하였다. 분리된 균주중에서 산에 대한 내성이 있다고 판단되는 12개의 균주를 분리해냈고, 12개의 균주의 내산성 및 내담즙성을 3회에 걸쳐 시험하고 내산성과 내담즙성이 우수한 3개의 균주를 선별하였다. 마지막으로 담즙산 농도별 시험을 행함으로써 가축의 장까지 살아서 도달하기 위해 꼭 갖추어야 할 조건인 내산성과 내담즙성이 가장 좋은 #32-1 균주를 최종 선발하였다. 유산균이 생균제로서의 기능을 수해하려면 oxgall이 0.3% 함유된 배지에서 성장할 수 있을 정도의 내성을 갖고 있어야 한다는 보고가 있는데 #32-1 균주의 경우 담즙액의 농도가 3%인 배양액에서도 높은 생존률을 보임으로써 생균제로서 사용하기위해 갖고 있어야 할 담즙에 대한 내성이 우수하다고 판단하였다. This study was performed to screen lactic acid bacteria for the direct-fed-microbials. A lactic acid bacteria which has resistant to acid and bile salts were isolated from swine feces. Among the previously obtained acid tolerant strains, three of them show resistant to artifical gastric juice and bile. Finally, 321- stain was selected for good growth an high survival rate. The finally selected 32-1 stain was identified as Lactobacillus salivarius. The strain, which named L. salivarius JY 32-1, was able to tolerate acid condition down to pH 2.5 and could also tolerate bile at 3%.

D. D. T. 의 合成

柳時子 梨花女子大學校 藥學硏究所 1961 梨花藥學硏究 Vol.- No.2

기능성 위장관 장애에서 혈청 IL-1β, IL-2,IL-6의 변화 : 우울증 및 스트레스와의 상관성

박시성,이상신,박무인,구자영,박제민,김명정 한국정신신체의학회 2002 정신신체의학 Vol.10 No.2

관상동맥 환자에서 관상동맥 스텐트 삽입술에 관한 임상경험

박시훈,신길자 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.2

Objective : The placement of stents in coronary arteries has been shown to be effective bail out procedure and reduce restenosis in comparison to balloon angioplasty. We experienced coronary stenting in 8 patients with coronary artery disease and report our results. Method : From October 1995 to April 1996, 8 cases of coronary artery stenting were per-formed at the Ewha Womans University Hospital. We evaluated results of the procedure, in-hospital complications, follow-up coronary angiography and follow-up clinical events. Result : All lesions were successfully stented without in-hospital complications including death, myocardial infarction, repeat coronary angioplasty, or CABG. During 2 months of fol-low-up, there was no clinical events. Follow-up coronary angiography was performed in one case, showing no restenosis. Conclusion : Acute procedural results and angiographic and follow-up clinical outcomes were favorable, so coronary stenting seemed to be good therapeutic tool in treatment of coronary artery disease.

본태성 고혈압환자의 좌심실 비대 평가에 있어서 심전도와 심초음파도의 비교에 대한 연구 : 표준 12극 심전도 총QRS 전위를 중심으로

신길자,박시훈,이우형 梨花女子大學校 醫科大學 醫科學硏究所 1995 EMJ (Ewha medical journal) Vol.18 No.1

연구배경 : 본태성 고혈압환자에 있어서 좌심실 비대는 환자의 예후에 중요한 영향을 미친다. 그러나 종전의 심전도에 의한 좌심실 비대의 진단은 비교적 정확하지 못하며, 심초음파도 개발된 이후 좌심실질량의 측정이 가능하게 되었다. 이에 저자들은 심전도와 심초음파도로 진단된 좌심실 비대를 비교 관찰함으로써 정확도를 평가하였다. 방법 : 좌심실 비대를 진단하기 위하여 본태성 고혈압환자 50예와 정상인 50예에 대하여 심전도 및 심초음파검사를 시행하였다. 결과 : 심전도로 측정한 좌심실비대의 평가에 있어서 총 QRS 전위는 고혈압환자군에서 205.6±51.3mm, 정상대조군에서 149.6±42.4mm였고(p<0.01), SV_1+RV_5 or V_6는 고혈압환자군에서 0.86+0.47, 정상대조군에서 0.83±0.20(p>0.05)였다. 심초음파도로 측정한 좌심실 질량지수는 고혈압환자군에서 209±60gm/m^2, 정상대조군에서 117±30gm/m^2(p<0.01)이었다. 심전도상의 좌심실비대의 진단기준은 심에코도와 비교해 볼 때, 총 QRS 전위의 합은 민감도와 특이도가 65.0%, 78%였고, 정확도는 61.4%였으며, SV_1+RV_5 or V_6는 45.0%, 85.0%로써 정확도는 68.8% 였으며, RV_6 : RV_5는 10.0%, 78,2% 였고 정확도는 85.6%였다. 결론 : 이상의 결과 좌심실비대 평가에 있어서 심전도상 좌심실비대 평가는 총 QRS 전위의 합을 이용하는 것이 SV_1+RV-5 or RV_6 : RV_5를 이용하는 것보다 민감도 및 정확도가 높았다. Background : Left ventricular hypertrophy(LVH) is an important prognostic factor in essential hypertersion. But the method of diagnosis of LVH by electrocardiography has limitations. In this study, we compared the sensitivity of the total 12-lead QRS amplitude with the sensitivity of certain standard electrocardiographic criteria for left ventriculart hyterthophy in patients with essential hypertension. Materials & Method : Atotal of 50 hypertrophy patients and 50 normal adults were studied. For diagnosis fo left ventricular hypertrophy by electrocardiography, we use Sokoliw and Lyon index, the ratio of RV_6 : RV_5 and a method using the total QRS complex voltage of standard 12-lwads. By echocardiography, we calculated left ventricular mass index. Results : The total QRS voltage ranged from 127mm to 332mm(mean : 205±51mm) in hypertensives, 86mm to 308mm(mean : 149±42mm) in nonmal group. Using 175mm as the upper limit of normal, this method gave a sensitivity of 80% show reasonable sensitivity of any criteria tested. The Sokolow-Lyon index gave a sensitivity of 45%, the RV_6/RV_5 ratio gave only 10% of sensitivity. Conclusion : Total 12-lead QRS voltage more than 175mm is a useful indicator of left ventriculat hypertrophy in patients with essential hypertension.

발관리 교육프로그램이 노인 당뇨병 환자의 발관리 이행과 족부합병증에 미치는 효과

노영숙,전시자,권연숙,임미숙,심강희 노인간호학회 2007 노인간호학회지 Vol.9 No.2

Purpose : Diabetic foot complications are significant problems in diabetes mellitus and often result in lower extremity amputation. This study was conducted to verify the effects of foot care education on compliance with foot care and diabetic foot complications when the patient is an elder with diabetes. Method: A group pretest-posttest design was used to examine the effects of 6 months of foot care education with a group of 13 elders with diabetes. The major dependent variables including foot care compliance and diabetic foot complications were measured at the beginning and end of the treatment period to examine the effects of foot care education. Result : There were no significant differences in total foot care compliance scores and presence of diabetic foot complication after 6 months, Conclusion : Interventions involving problem based education and pursuing long-time effects may be more effective in implementing and sustaining improvements than just group education or one time interventions for elders with diabetes.

대퇴동맥을 이용한 도자술에 합병된 대퇴 가성 동맥류의 비수술적 치료 : 수기 압박과 C-clamp의 병용사용

박사영,박시훈,신길자,이우형 梨花女子大學校 醫科大學 醫科學硏究所 1995 EMJ (Ewha medical journal) Vol.18 No.3

Femoral pseudoaneurysm is important complication after diagnostic femoral catheterizationor more complex procedure. With the increasing use of larger-size percutaneous instruments and periprocedual anticoagulant or antiplatelet agent the incidence of postcatheterization femorl artery injuries ncluding pseudoaneuiysm has increased in the past few years. Duplex ultrasonography and addition of color- flow Doppler provides an accurate, noninvasive. risk-free diagnosis and faster detection of intraaneurysrnal blood flow and the track betweenthe injured artery and the pseudoaneurysm. Though early surgical repair of the arterial defect is usually recommended because of severeand life-threatening complication such as rupture, fhrornboembolism, compression neuropathyetc, Ultrasono-Guided Compression Repair(UGCR) is to be first-line treatment for its advantagesuch as high success rate, low morbidity and cost-effectiveness. The authors report 2 cases of femoral psoudoaneurysrns treated using UGCR with nlanualcompression with C-clamp at the same time as a nonsurgical treatment.