증식당뇨망막증에서 아르곤레이저 광응고술의 치료 효과

안병헌,민병무,최시환,서병로,박우찬 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2

Vitreous hemorrhage, which is the major cause of blindness in proliferative diabetic retinopathy, has been prevented clinically with laser photocoagulation. We reviewed 57 cases(98 eyes) of proliferative diabetic retinopathy which were treated by argon laser and followed up for more than 6 months. Of these 98 eyes, 81 eyes(83%) showed a satisfactory response after standard panretinal photocoagulation. 14 eyes(14%) revealed the vitreous hemorrhage after panretinal photocoagulation and higher incidence of vitreous hemorrhage in the cases of new vessel on the optic disc. In the cases(26 eyes) of new vessel on the optic disc, 2000 laser burns revealed lower incidence of vitreous hemorrhage(1/5, 20%) in comparison with 1500 laser burns(8/21, 38%). These results indicate that initial augmented laser therapy prevented the vitreous hemorrhage effectively.

폐암과 동반되어 나타난 기관기관지병증 골연골형성증 1예

이영진,전현수,박시형,김모세,김현주,이승헌,이영민,이현욱,이현경 仁濟大學校 白病院 2010 仁濟醫學 Vol.31 No.-

Tracheobronchopathia osteochondroplastica (TPO) is a rare benign disease of unknown etiology characterized by multiple cartilaginous or bony submucosal nodules, which project into the tracheobronchial lumen. Although some disorders were reported combined with TPO, these seemed to be considered casual. We report a case of TPO that combined with adenocarcinoma of lung. She was 50-year-old non smoking woman presented with chronic cough with right chest pain. Lung mass on right lower lobe was found on chest x-ray, so lung cancer was suspected. Multiple scattered whitish small elevations from trachea to bronchial trees were found on bronchoscopic exam. We mistook these lesions for metastases from lung cancer and biopsies of these lesions were done. Transbronchial biopsy for right lower lobe mass lesion was also done. But biopsies from trachea and bronchus revealed TPO rather than lung cancer. Transbronchial lung biopsy of right lower lobe mass was diagnosed adenocarcinoma of lung. So TPO combined with adenocarcinoma of lung was diagnosed.

중증 미만성 뇌축색손상 환자의 MRI소견 및 임상적 고찰

김한겸,김성호,송시헌,김관태,김윤 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.1

The distribution and extent of traumatic lesions were evaluated with MRI in 31 patients with diffuse axonal injuries(DAI). Authors also analyzed patients with diffuse axonal injury, clinically. The patients with DAI showed statistically significant lower incidence of lucid interval, fracture of the skull and intracranial hematoma. Combined injuries, intracrnial hematomas and distribution of lisions were porved to be poor prognostic factors of DAI. Diffuse axonal injury is most commonly involved in the white matter of the frontal and temporal loves and the splenium of the corpus callosum. Patients with lisions in brainstem and cerebellum revealed worst prognoses. In our studies, the sensitivities of the imaging techniques for diffuse axonal injures were 7.3% with CT scan, 75.6% with T1WI, and with 97.6% in T2WI of MRI, respectively. The authors concluded that MRI has clear advantages over CT in evaluating diffuse axonal injuries.

Bowen`s disease partially responded to photodynamic therapy

( Si Heon Lee ),( Sang Won Kim ) 대한피부과학회 2000 초록집 Vol.38 No.10

Poster Session : PS 0780 ; Upper GI Tract : Clinical Outcomes of Individuals with Forrest Type IIB Peptic Ulcer: A Comparison Betweeen Endoscopic Therapy and Medical Therapy in a Multicenter Study

( Si Hye Kim ),( Jin Tae Jung ),( Joong Goo Kwon ),( Eun Young Kim ),( Seong Woo Jeon ),( Kyung Sik Park ),( Kwang Bum Cho ),( Si Hyung Lee ),( Byung Ik Jang ),( Chang Heon Yang ),( Dong Wook Lee ),( 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: The optimal management of bleeding peptic ulcer with adherent clot remains controversial. The purpose of this study was to compare clinical outcome between endoscopic therapy and medical therapy. Also, we evaluate the risk factors of rebleeding in Forrest type IIb peptic ulcer. Methods: UGI bleeding registry data from 8 hospitals in Korea between February 2011 and December 2013 were reviewed and categorized according to the Forrest classifi cation. Patients with acute upper gastrointestinal(UGI) bleeding from peptic ulcer with adherent clots were enrolled. Results: In total, 954 patients diagnosed with peptic ulcer bleeding, with 126 bleedings (13.2%) being classifi ed as Forrest type IIb. Of 126 patients with adherent clots, 84 (66.7%) had endoscopic therapy and 42 (33.3%) were managed with medical therapy alone. The basic characteristics of patients in two groups were similar except for higher Glasgow Blatchford Score and pre Rockall score in medical therapy group. Bleeding related mortality(1% vs 3%; p=0.0018), bleeding non-related mortality(2% vs 3%; p=0.0018) and all cause mortality(3.7% vs 20%; p=0.005) were signifi cantly lower in the endoscopic therapy group. Also, endoscopic therapy was safe compared with medical therapy alone(3.57% vs.11.90%; p=0.284). But, there was no difference between endoscopic therapy and medical therapy in rebleeding (7.14% vs.9.52%; p=0.641). In multivariate analysis, the independent risk factors of rebleeding are previous medication with aspirin and/or nonsteroidal anti-infl ammatory drugs(NSAIDs)(odds ratio,13.052; p=0.025) and higher full Rockall score(odds ratio, 0.348; p=0.048). Conclusions: In patients with Forrest type IIb peptic ulcer bleeding, endoscopic therapy was associated with a signifi cant reduction in bleeding related mortality and all cause mortality compared with medical therapy alone. Endoscopic therapy should be considered for patients with medication of aspirin and/or NSAIDs, higher full Rockall score.

Attributable risk of lung cancer deaths due to indoor radon exposure

Si-Heon Kim,Won Ju Hwang,Jeong-Sook Cho,Dae Ryong Kang 대한직업환경의학회 2016 대한직업환경의학회지 Vol.28 No.-

Exposure to radon gas is the second most common cause of lung cancer after smoking. A large number of studies have reported that exposure to indoor radon, even at low concentrations, is associated with lung cancer in the general population. This paper reviewed studies from several countries to assess the attributable risk (AR) of lung cancer death due to indoor radon exposure and the effect of radon mitigation thereon. Worldwide, 3–20 % of all lung cancer deaths are likely caused by indoor radon exposure. These values tend to be higher in countries reporting high radon concentrations, which can depend on the estimation method. The estimated number of lung cancer deaths due to radon exposure in several countries varied from 150 to 40,477 annually. In general, the percent ARs were higher among never-smokers than among ever-smokers, whereas much more lung cancer deaths attributable to radon occurred among ever-smokers because of the higher rate of lung cancers among smokers. Regardless of smoking status, the proportion of lung cancer deaths induced by radon was slightly higher among females than males. However, after stratifying populations according to smoking status, the percent ARs were similar between genders. If all homes with radon above 100 ㏃/㎥ were effectively remediated, studies in Germany and Canada found that 302 and 1704 lung cancer deaths could be prevented each year, respectively. These estimates, however, are subject to varying degrees of uncertainty related to the weakness of the models used and a number of factors influencing indoor radon concentrations.

A Case of Bowen`s Disease Partially Responded to Photodynamic Therapy

(Si Heon Lee),(Byung Cheol Jung),(Min Jung Woo),(Dong Seok Kim),(Sang Won Kim) 대한피부과학회 2002 Annals of Dermatology Vol.14 No.1

N/A Photodynamic therapy(PDT)is designed to kill targeted tumor cells of various cutaneous and noncutaneous malignancies by highly reactive oxygen intermediates generated through the interaction of light with a photosensitizer1. It is particularly effective in treating in situ or early invasive tumors. Several non-neoplastic dermatological conditions may also respond to PDT,including psoriasis and alopecia areata2-4.Single lesion of Bowen`s disease can be satisfactorily treated by surgical excision, curettage, cautery, cryotherapy or topical application of 5-fluorouracil5,7.However,these therapies may be impractical for patients with widespread or large lesions located on anatomiPhotodynamic therapy(PDT)is a treatment modality by highly reactive oxygen intermediates generated through the interaction of light with a photosensiziter.It has been shown to be an effective treatment for various cutaneous and noncutaneous malignancies.It is efficient for the curative and palliative treatment of epithelial skin tumor in situ or early invasive lesions. In effect, it is a useful alternative treatment for the lesions located on anatomically difficult areas or the large-sized lesions. We treated a case of Bowen`s disease arising on the plantar area and 3rd and 4th toewebs of left forefoot in a 61-year-old man with PDT using the hematoporphyrin derivative,porfirmer sodium(Photofrin, Russia)as a photosensitizer and gold vapor laser as a visible light source. The outcome showed partial clinical improvement after about 2 months` follow-up.(Ann Dermatol 14(1)

Indoor Radon and Lung Cancer: Estimation of Attributable Risk, Disease Burden, and Effects of Mitigation

Kim, Si-Heon,Koh, Sang-Baek,Lee, Cheol-Min,Kim, Changsoo,Kang, Dae Ryong Yonsei University College of Medicine 2018 Yonsei medical journal Vol.59 No.9

<P><B>Purpose</B></P><P>Exposure to indoor radon is associated with lung cancer. This study aimed to estimate the number of lung cancer deaths attributable to indoor radon exposure, its burden of disease, and the effects of radon mitigation in Korea in 2010.</P><P><B>Materials and Methods</B></P><P>Lung cancer deaths due to indoor radon exposure were estimated using exposure-response relations reported in previous studies. Years of life lost (YLLs) were calculated to quantify disease burden in relation to premature deaths. Mitigation effects were examined under scenarios in which all homes with indoor radon concentrations above a specified level were remediated below the level.</P><P><B>Results</B></P><P>The estimated number of lung cancer deaths attributable to indoor radon exposure ranged from 1946 to 3863, accounting for 12.5–24.7% of 15623 total lung cancer deaths in 2010. YLLs due to premature deaths were estimated at 43140–101855 years (90–212 years per 100000 population). If all homes with radon levels above 148 Bq/m<SUP>3</SUP> are effectively remediated, 502–732 lung cancer deaths and 10972–18479 YLLs could be prevented.</P><P><B>Conclusion</B></P><P>These findings suggest that indoor radon exposure contributes considerably to lung cancer, and that reducing indoor radon concentration would be helpful for decreasing the disease burden from lung cancer deaths.</P>

하수이용 냉난방시스템

김시헌(Si-Heon Kim),정영혁(Young-Hyuk Jung) 대한설비공학회 2009 대한설비공학회 학술발표대회논문집 Vol.2009 No.-

A Case of Bowen's Disease Partially Responded to Photodynamic Therapy

Lee, Si Heon,Jung, Byung Cheol,Woo, Min Jung,Kim, Dong Seok,Kim, Sang Won Korean Dermatological Association 2002 Annals of Dermatology Vol.14 No.1