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Shunyao Liao,Yunqiang Liu,Bing Zheng,Pyo Yun Cho,Hyun Ok Song,Yun-Seok Lee,Suk-Yul Jung,Hyun Park 대한기생충학열대의학회 2011 The Korean Journal of Parasitology Vol.49 No.4
The onset, severity, and ultimate outcome of malaria infection are influenced by parasite-expressed virulence factors as well as by individual host responses to these determinants. In both humans and mice, liver injury follows parasite entry, persisting to the erythrocytic stage in the case of infection with the fatal strain of Plasmodium falciparum. Hepatic nuclear factor (HNF)-1α is a master regulator of not only the liver damage and adaptive responses but also diverse metabolic functions. In this study, we analyzed the expression of host HNF-1α in relation to malaria infection and evaluated its interaction with the 5´-untranslated region of subtilisin-like protease 2 (subtilase, Sub2). Recombinant human HNF-1α expressed by a lentiviral vector (LV HNF-1α) was introduced into mice. Interestingly, differences in the activity of the 5´-untranslated region of the Pf-Sub2 promoter were detected in 293T cells, and LV HNF-1α was observed to influence promoter activity, suggesting that host HNF-1α interacts with the Sub2 gene.
Cheng, He,Chen, Hao,Xu, Shaohui,Yang, Shunyao The Korean Institute of Power Electronics 2017 JOURNAL OF POWER ELECTRONICS Vol.17 No.6
Switched reluctance motor (SRM) is suitable for electric vehicle (EV) applications with the advantages of simple structure, good overload capability, and inherent fault-tolerance performance. The SRM dynamic simulation model is built based on torque, voltage, and flux linkage equations. The EV model is built on the basis of the analysis of forces acting on a vehicle. The entire speed range of the SRM drive is then divided into constant torque and constant power areas. The command torque of the motor drive system is given according to the accelerator pedal coefficient and motor operation areas. A novel adaptive variable angle control is proposed to avoid the switching chattering between the current chopping control and angle position control modes in SRM drives for EV applications. Finally, simulation analysis and experimental results are conducted to verify the accuracy of the proposed simulation model and control strategy.
He Cheng,Hao Chen,Shaohui Xu,Shunyao Yang 전력전자학회 2017 JOURNAL OF POWER ELECTRONICS Vol.17 No.6
Switched reluctance motor (SRM) is suitable for electric vehicle (EV) applications with the advantages of simple structure, good overload capability, and inherent fault-tolerance performance. The SRM dynamic simulation model is built based on torque, voltage, and flux linkage equations. The EV model is built on the basis of the analysis of forces acting on a vehicle. The entire speed range of the SRM drive is then divided into constant torque and constant power areas. The command torque of the motor drive system is given according to the accelerator pedal coefficient and motor operation areas. A novel adaptive variable angle control is proposed to avoid the switching chattering between the current chopping control and angle position control modes in SRM drives for EV applications. Finally, simulation analysis and experimental results are conducted to verify the accuracy of the proposed simulation model and control strategy.