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Development of Lactobacillus casei Resistant to Rifampicin
Shung Hee Lee,Eung Chil Choi,Byong Kak Kim 한국생약학회 1985 생약학회지 Vol.16 No.4
Lactobacillus casei was treated with N-methyl-N`-nitro-N-nitrosoguanidine (NTG) to obtain resistant mutants to rifampicin. Freshly grown cells of the strain suspended in tris-malec acid buffer were exposed to NTG of 50㎍/㎖ for 30 min. Five colonies of the NTG-induced mutants showed distinct resistance to rifampicin. They also exhibited identical characteristics with those of the original Lactobacillus casei when they were tested for growth, titrable acidity and sugar fermentation. It is suggested that they can be utilized as efficient starter cultures for fermented milk.
Lee, Chan-Hee,Lee, Sang-Hee,Park, Jong-Seon,Kim, Young-Jo,Kim, Kee-Sik,Chae, Shung-Chull,Kim, Hyo-Soo,Choi, Dong-Ju,Cho, Myeong-Chan,Rha, Seung-Woon,Jeong, Myung-Ho Science Press 2014 Journal of geriatric cardiology Vol.11 No.2
<P><B>Background</B></P><P>The benefit of statin use after acute ST-segment elevation myocardial infarction (STEMI) has been well established, however, the influence of the timing of statin administration has not been elucidated. The objective of this study focused on early clinical outcomes after percutaneous coronary intervention (PCI).</P><P><B>Methods</B></P><P>This analysis of the Korea Working Group on Myocardial Infarction registry (KorMI) study included 3,584 STEMI patients (mean age, 63 ± 13 years; male, 2,684, 74.9%) undergoing PCI from January 2008 to June 2009. Rates of major adverse cardiac events (MACE: all-cause death, recurrent MI, and target lesion revascularization) were compared among patients grouped according to statin therapy timing: I, both during and after hospitalization (<I>n</I> = 2,653, 74%); II, only during hospitalization (<I>n</I> = 309, 8.6%); III, only after discharge (<I>n</I> = 157, 4.4%); and IV, no statin therapy (<I>n</I> = 465, 13%). Mean follow-up duration was 234 ± 113 days.</P><P><B>Results</B></P><P>Multivariate factors of statin use during hospitalization included prior statin use, multiple diseased vessels, final thrombolysis in myocardial infarction flow grade III, and low-density lipoprotein cholesterol level. At 6-month follow-up, groups III and IV had the highest MACE rates (2.3%, 3.9%, 5.1%, and 4.9% for groups I-IV, respectively, <I>P</I> = 0.004). After adjusting for confounders, groups II-IV had a higher MACE risk than group I [hazard ratio (HR): 3.20, 95% confidence interval (95%CI): 1.31–7.86, <I>P</I> = 0.011; HR: 3.84, 95%CI: 1.47–10.02, <I>P</I> = 0.006; and HR: 3.17, 95%CI: 1.59–6.40, <I>P</I> = 0.001; respectively].</P><P><B>Conclusions</B></P><P>This study, based on the national registry database, shows early and continuous statin therapy improvs early outcomes of STEMI patients after PCI in real-world clinical practice.</P>
The rate of ischemia-driven target Lesion revascularization of paclitaxel-eluting stents (초)
( Sun Hee Park ),( Hun Sik Park ),( Jang Hoon Lee ),( Hyeon Min Ryu ),( Myung Hwan Bae ),( Yong Seop Kwon ),( Dong Heon Yang ),( Yong Keun Cho ),( Shung Chull Chae ),( Jae Eun Jun ),( Wee Hyun Park ) 대한내과학회 2008 대한내과학회지 Vol.75 No.1S