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      • KCI등재

        Dormant Season Fertigation Promotes Photosynthesis, Growth, and Flowering of ‘Blueshower’ Rabbiteye Blueberry in Warm Climates

        Shun-Hsin Huang,Kuo-Tan Li 한국원예학회 2015 Horticulture, Environment, and Biotechnology Vol.56 No.6

        In the subtropical lowland of Taiwan with a warm winter climate, most rabbiteye blueberry cultivars (Vaccinium ashei) are semi-deciduous, and their leaves remain green through the winter. We investigated whether fertigation with nitrogen (N) and phosphorus (P) during the dormant season had any subsequent effects on vegetative growth and flowering of rabbiteye blueberry in this region. Potted 3-year-old ‘Blueshower’ plants were fertigated weekly from November 2012 to March 2013 with combinations of 100, 200, or 400 mg·L-1 N and 200 or 400 mg·L-1 P. Plants fertigated without N and P served as the control. Fertigation with any N and P treatment during the dormant season significantly increased photosynthesis (Pn) of overwintered leaves relative to the control, but had no effect on Pn ofthe new leaves. N at 100 mg·L-1 increased the total chlorophyll content in overwintered leaves more than two-fold compared to the control; total chlorophyll content in overwintered leaves increased with N rate, but was not affected by P rate. Dormant-season N and P fertigation advanced vegetative budburst. However, new shoot growth was negatively affected by dormant-season P fertigation. The number of flowers increased with N rate. We concluded that in the subtropical lowland with a warm winter climate, dormant-season fertigations, especially to supply N, can improve flowering and canopy development in the following spring.

      • KCI등재

        Acupuncture-Related Rapid Dermal Spread of Breast Cancer: A Rare Case

        Hsin-Shun Tseng,Szu-Erh Chan,Shou-Jen Kuo,Dar-Ren Chen 한국유방암학회 2011 Journal of breast cancer Vol.14 No.4

        Many ethnic Chinese patients seek second or adjuvant alternative therapies after breast cancer is diagnosed. Chinese herbs and acupuncture are the most popular methods in East Asia. We present a case of acupuncture manipulation-related cutaneous spread that no literature reported before. Post-acupuncture cutaneous spread was noted in a 54-year-old woman with left neck lymph node recurrence after complete surgery, chemotherapy and radiotherapy treatment. The results of chest computed tomography and skin biopsy showed the metastatic breast cancer in the dermis. Six courses of paclitaxel and gemcitabine followed by trastuzumab were given as therapeutic chemotherapy. The neck mass and cutaneous lesions subsided after 2 courses of chemotherapy. Direct puncture of a metastatic lymph node might increase the incidence of tumor spread on the skin. Therefore, despite the efficacy of complementary and alternative medicine, its safety and possible side effects should be more emphasized.

      • THE EFFECT OF IPO LOCKUP AGREEMENTS ON STOCK PRICES: AN EMPIRICAL ANALYSIS ON THE TAIWAN STOCK EXCHANGE

        Dar Hsin Chen,Chun Da Chen,Lloyd P Blenman,Feng Shun Bin People&Global Business Association 2005 Global Business and Finance Review Vol.10 No.1

        We examine the performance of Taiwanese IPOs surrounding lockup expiration. We find some evidence that investors in IT-IPOs could suffer significant wealth losses, in the days just prior to the lockup expiration. Non-IT IPO investors are not similarly affected. However, contrary to previous research, we find significant return reversals for both IT and non-IT stocks. After the lockup expiration dates trading volumes are also abnormally high. The returns to IT firms and firms with larger market capitalizations, exhibit greater sensitivity to lockup expiration dates than those of non-IT firms and small-cap firms.

      • KCI등재

        Survival Benefit of Tamoxifen in Estrogen Receptor-Negative and Progesterone Receptor-Positive Low Grade Breast Cancer Patients

        Li-Heng Yang,Hsin-Shun Tseng,Che Lin,Li-Sheng Chen,Shou-Tung Chen,Shou-Jen Kuo,Dar-Ren Chen 한국유방암학회 2012 Journal of breast cancer Vol.15 No.3

        Purpose: This study aimed to analyze the efficacy and prognostic significance of adjuvant tamoxifen in breast cancer patients with various hormone receptor statuses. Methods: Typically, 1,260 female breast cancer patients were recruited in this study. The correlation between estrogen receptor (ER)/progesterone receptor (PR) phenotypes and clinical characteristics was investigated, and the survival rate was assessed after 5-year follow-up. Results: The 5-year overall survival (85%) was better in women under the age of 50 years. Patients with ER+/PR+ tumors had a better 5-year survival rate (94%); those with ER-/PR- tumors experienced the worst outcome (74% survival rate); whereas singlepositive cases were in between. In 97 out of 128 patients with ER-/PR+ tumors, tamoxifen was given as adjuvant hormonal therapy, and it increased the survival benefit in the lower grade group in terms of overall survival and disease-free survival (p=0.01 and p=0.03, respectively). Conclusion: For high-grade tumors with ER-/PR+, adjuvant tamoxifen therapy may have no survival benefit, whereas for the patients with low-grade ER-/PR+ tumors, adjuvant tamoxifen therapy is highly suggestive.

      • KCI등재

        Comparative Analysis of Logistic Regression, Support Vector Machine and Artificial Neural Network for the Differential Diagnosis of Benign and Malignant Solid Breast Tumors by the Use of Three-Dimensional Power Doppler Imaging

        Shou-Tung Chen,Yi-Hsuan Hsiao,Yu-Len Huang,Shou-Jen Kuo,Hsin-Shun Tseng,Hwa-Koon Wu,Dar-Ren Chen 대한영상의학회 2009 Korean Journal of Radiology Vol.10 No.5

        Objective: Logistic regression analysis (LRA), Support Vector Machine (SVM) and a neural network (NN) are commonly used statistical models in computeraided diagnostic (CAD) systems for breast ultrasonography (US). The aim of this study was to clarify the diagnostic ability of the use of these statistical models for future applications of CAD systems, such as three-dimensional (3D) power Doppler imaging, vascularity evaluation and the differentiation of a solid mass. Materials and Methods: A database that contained 3D power Doppler imaging pairs of non-harmonic and tissue harmonic images for 97 benign and 86 malignant solid tumors was utilized. The virtual organ computer-aided analysis-imaging program was used to analyze the stored volumes of the 183 solid breast tumors. LRA, an SVM and NN were employed in comparative analyses for the characterization of benign and malignant solid breast masses from the database. Results: The values of area under receiver operating characteristic (ROC) curve, referred to as Az values for the use of non-harmonic 3D power Doppler US with LRA, SVM and NN were 0.9341, 0.9185 and 0.9086, respectively. The Az values for the use of harmonic 3D power Doppler US with LRA, SVM and NN were 0.9286, 0.8979 and 0.9009, respectively. The Az values of six ROC curves for the use of LRA, SVM and NN for non-harmonic or harmonic 3D power Doppler imaging were similar. Conclusion: The diagnostic performances of these three models (LRA, SVM and NN) are not different as demonstrated by ROC curve analysis. Depending on user emphasis for the use of ROC curve findings, the use of LRA appears to provide better sensitivity as compared to the other statistical models. Objective: Logistic regression analysis (LRA), Support Vector Machine (SVM) and a neural network (NN) are commonly used statistical models in computeraided diagnostic (CAD) systems for breast ultrasonography (US). The aim of this study was to clarify the diagnostic ability of the use of these statistical models for future applications of CAD systems, such as three-dimensional (3D) power Doppler imaging, vascularity evaluation and the differentiation of a solid mass. Materials and Methods: A database that contained 3D power Doppler imaging pairs of non-harmonic and tissue harmonic images for 97 benign and 86 malignant solid tumors was utilized. The virtual organ computer-aided analysis-imaging program was used to analyze the stored volumes of the 183 solid breast tumors. LRA, an SVM and NN were employed in comparative analyses for the characterization of benign and malignant solid breast masses from the database. Results: The values of area under receiver operating characteristic (ROC) curve, referred to as Az values for the use of non-harmonic 3D power Doppler US with LRA, SVM and NN were 0.9341, 0.9185 and 0.9086, respectively. The Az values for the use of harmonic 3D power Doppler US with LRA, SVM and NN were 0.9286, 0.8979 and 0.9009, respectively. The Az values of six ROC curves for the use of LRA, SVM and NN for non-harmonic or harmonic 3D power Doppler imaging were similar. Conclusion: The diagnostic performances of these three models (LRA, SVM and NN) are not different as demonstrated by ROC curve analysis. Depending on user emphasis for the use of ROC curve findings, the use of LRA appears to provide better sensitivity as compared to the other statistical models.

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