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        • KCI등재SCIE

          Cordblood-Based High-Throughput Screening for Deafness Gene of 646 Newborns in Jinan Area of China

          Shou-Xia,Li,Ding-Li,Chen,Su-Bin,Zhao,Li-Li,Guo,Hai-Qin,Feng,Xiao-Fang,Zhang,Li-Li,Ping,Zhi-Ming,Yang,Cai-Xia,Sun,Gen-Dong,Yao 대한이비인후과학회 2015 Clinical and Experimental Otorhinolaryngology Vol.8 No.3

          Objectives. Infants with slight/mild or late-onset hearing impairment might be missed in universal newborn hearing screening (UNHS). We identified the mutation hot spot of common deaf gene in the newborns in Jinan area population by screening the mutation spot with neonate cord blood, in order to make clear whether the neonate cord blood for screening is feasible. Methods. Six hundred and forty-six newborns were subjected to both UNHS and genetic screening for deafness by using neonate cord blood. The newborn genetic screening targeted four deafness-associated genes, which were commonly found in the Chinese population including gap junction beta-2 protein (GJB2), gap junction beta-3 protein (GJB3), solute carrier family 26 member 4 (SLC26A4), and mtDNA 12S rRNA. The most common 20 spot mutations in 4 deaf genes were detected by MassARRAY iPLEX platform and mitochondrial 12S rRNA A1555G and C1494T mutations were sequenced using Sanger sequencing. Results. Among the 646 newborns, 635 cases passed the UNHS and the other 11 cases (1.7%) did not. Of the 11 failures, two cases were found to carry homozygous GJB2 p.R143W pathogenic mutation, one case was found to have heterozygous GJB2 235delC mutation, and another one case carried heterozygous GJB3 p.R180X pathogenic mutation. Six hundred and thirty-five babies passed the newborn hearing screening, in which 25 babies were identified to carry pathogenic mutations, including 12 heterozygotes (1.9%) for GJB2 235delC, eight heterozygotes (1.3%) for SLC26A4 IVS7-2A>G, one heterozygote (0.2%) for p.R409H, two homozygotes (0.3%) for m.1494C>T, and two homozygotes (0.3%) for m.1555A>G. Conclusion. Newborn genetic screening through the umbilical cord blood for common deafness-associated mutations may identify carriers sensitive to aminoglycoside antibiotic, and can effectively prevent or delay hearing loss occurs.

        • KCI등재SCOPUS

          An Improved Interval AHP Method for Assessment of Cloud Platform-based Electrical Safety Monitoring System

          Shou-Xiang,Wang,Lei-Jiao,Ge,Sheng-Xia,Cai,Dong,Zhang 대한전기학회 2017 Journal of Electrical Engineering & Technology Vol.12 No.2

          Electrical safety monitoring System (ESMS) is a critical component in modern power systems, which is characterized by large-scale access points, massive users and versatile requirements. For convenience of the information integration and analysis, the software development, maintenance, and application in the system, the cloud platform based ESMS is established and assessed in this paper. Firstly the framework of the system is proposed, and then the assessment scheme with a set of evaluation indices are presented, by which the appropriate cloud product can be chosen to meet the requirements of a specific application. Moreover, to calculate the weights of the evaluation indices under uncertainty, an improved interval AHP method is adopted to take into consideration of the fuzziness of expert scoring, the qualitative consistency test, and the two normalizations in the process of eigenvectors. Case studies have been made to verify the feasibility of the assessment approach for ESMS.

        • KCI등재SCOPUS
        • SCIESCOPUSKCI등재

          An Improved Interval AHP Method for Assessment of Cloud Platform-based Electrical Safety Monitoring System

          Wang,,Shou-Xiang,Ge,,Lei-Jiao,Cai,,Sheng-Xia,Zhang,,Dong The Korean Institute of Electrical Engineers 2017 Journal of Electrical Engineering & Technology Vol.12 No.2

          Electrical safety monitoring System (ESMS) is a critical component in modern power systems, which is characterized by large-scale access points, massive users and versatile requirements. For convenience of the information integration and analysis, the software development, maintenance, and application in the system, the cloud platform based ESMS is established and assessed in this paper. Firstly the framework of the system is proposed, and then the assessment scheme with a set of evaluation indices are presented, by which the appropriate cloud product can be chosen to meet the requirements of a specific application. Moreover, to calculate the weights of the evaluation indices under uncertainty, an improved interval AHP method is adopted to take into consideration of the fuzziness of expert scoring, the qualitative consistency test, and the two normalizations in the process of eigenvectors. Case studies have been made to verify the feasibility of the assessment approach for ESMS.

        • KCI등재SCIESCOPUS

          Quantum Dialogue by Using the GHZ State

          Yan,XIA,Shou,ZHANG,Chang-Bao,FU,엄정인,연규황,홍석경 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.I

          We present a quantum dialogue protocol by using the Greenberger-Horne-Zeilinger (GHZ) state. In this paper, we point out that the ‘quantum dialogue' communication scheme recently introduced by Nguyen can be eavesdropped on under an intercept-and-resend attack. We also give a revised control mode to detect this attack. Hence, within the present version two users can exchange their secret messages securely and simultaneously, and the efficiency of information transmission can be successfully increased. We present a quantum dialogue protocol by using the Greenberger-Horne-Zeilinger (GHZ) state. In this paper, we point out that the ‘quantum dialogue' communication scheme recently introduced by Nguyen can be eavesdropped on under an intercept-and-resend attack. We also give a revised control mode to detect this attack. Hence, within the present version two users can exchange their secret messages securely and simultaneously, and the efficiency of information transmission can be successfully increased.

        • KCI등재SCIESCOPUS

          Probabilistic teleportation of an arbitrary three-particle state via a partial entangled four-particle state and a three-particle GHZ state

          Yan,Xia,Shou,Zhang,Chang-bao,Fu,엄정인,연규황 한국물리학회 2005 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.46 No.2

          We propose a scheme to teleport an arbitrary and unknown three-particle state by using a nonmaximally four-particle entangled state and a non-maximally three-particle GHZ state from a sender to either one of two receivers. We show that teleportation can be successfully realized with a certain probability by performing three Bell-states measurements on the sender's side and by introducing a Hadamard operation on the receiver's side conditioned on an appropriate unitary transformation on the other possible receiver's side We propose a scheme to teleport an arbitrary and unknown three-particle state by using a nonmaximally four-particle entangled state and a non-maximally three-particle GHZ state from a sender to either one of two receivers. We show that teleportation can be successfully realized with a certain probability by performing three Bell-states measurements on the sender's side and by introducing a Hadamard operation on the receiver's side conditioned on an appropriate unitary transformation on the other possible receiver's side.

        • KCI등재SCIESCOPUS

          Controlled Secure Direct Communication by Using GHZ Entangled State

          Yan,XIA,Shou,ZHANG,Chang-Bao,FU,엄정인,Feng-Yue,LI,연규황 한국물리학회 2005 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.47 No.3

          We present a controlled secure direct communication protocol by using Greenberger-Horne-Zeilinger (GHZ) entangled state via swapping quantum entanglement and local unitary operations. Since messages transferred only by using local operations and a public channel after entangled states are successfully distributed, this protocol can protect the communication against a destroying-travel-qubit-type attack. This scheme can also be generalized to a multi-party controlsystem.

        • Clinical Significance of Upregulation of mir-196a-5p in Gastric Cancer and Enriched KEGG Pathway Analysis of Target Genes

          Li,,Hai-Long,Xie,,Shou-Pin,Yang,,Ya-Li,Cheng,,Ying-Xia,Zhang,,Ying,Wang,,Jing,Wang,,Yong,Liu,,Da-Long,Chen,,Zhao-Feng,Zhou,,Yong-Ning,Wu,,Hong-Yan Asian Pacific Organization for Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5

          Background: miRNAs are relatively recently discovered cancer biomarkers which have important implications for cancer early diagnosis, treatment and estimation of prognosis. Here we focussed on expression of mir-196a-5p in gastric cancer tissues and cell lines so as to analyse its significance for clinicopathologic characteristics and generate enriched KEGG pathways clustered by target genes for exploring its potential roles as a biomarker in gastric cancer. Materials and Methods: The expression of mir-196a-5p in poorly, moderate and well differentiated gastric cancer cell lines compared with GES-1 was detected by RT-qPCR, and the expression of mir-196a-5p in gastric cancer tissues comparing with adjacent non cancer tissues of 58 cases were also assessed by RT-qPCR. Subsequently, an analysis of clinical significance of mir-196a-5p in gastric cancer and enriched KEGG pathways was executed based on the miRWalk prediction database combined with bioinformatics tools DAVID 6.7 and Mirfocus 3.0. Results: RT-qPCR showed that mir-196a-5p was up-regulated in 6 poorly and moderate differentiated gastric cancer cell lines SGC-7901, MKN-45, MKN-28, MGC-803, BGC-823, HGC-27 compared with GES-1, but down-regulated in the highly differentiated gastric cancer cell line AGS. Clinical data indicated mir-196a-5p to beup-regulated in gastric cancer tissues (47/58). Overexpression of mir-196a-5p was associated with more extensive degree of lymph node metastasis and clinical stage (P < 0.05; x2 test). Enriched KEGG pathway analyses of predicted and validated targets in miRWalk combined with DAVID 6.7 and Mirfocus 3.0 showed that the targeted genes regulated by mir-196a-5p were involved in malignancy associated biology. Conclusions: Overexpression of mir-196a-5p is associated with lymph node metastasis and clinical stage, and enriched KEGG pathway analyses showed that targeted genes regulated by mir-196a-5p may contribute to tumorgenesis, suggesting roles as an oncogenic miRNA biomarker in gastric cancer.

        • SCIESCOPUSKCI등재

          Anthocyanins in 'Cabernet Gernischet' (Vitis vinifera L. cv.) Aged Red Wine and Their Color in Aqueous Solution Analyzed by Partial Least Square Regression

          Han,,Fu-Liang,Jiang,,Shou-Mei,He,,Jian-Jun,Pan,,Qiu-Hong,Duan,,Chang-Qing,Zhang,,Ming-Xia Korean Society of Food Science and Technology 2009 Food Science and Biotechnology Vol.18 No.3

          Anthocyanins are considered one of the main color determinants in aged red wine. The anthocyanins in aged red wine made from 'Cabernet Gernischet' (Vitis vinifera L. cv.) grape were investigated by high performance liquid chromatography- electronic spray ionization- mass spectrometry (HPLC-ESI-MS) and their color presented in aqueous solution were evaluated using partial least square regression (PLS). The results showed that there were 37 anthocyanins identified in this wine, including 22 pyranoanthocyanins. The analysis of PLS indicated that different anthocyanins showed distinct color values: malvidin 3-O-(6-O-acetyl)-glucoside-4-vinylguaiacol (Mv3-acet-glu-vg) presented the highest color values, while malvidin 3-O-glucoside (Mv3-glu) showed least. Among the free non-acylated anthocyanins, peonidin 3-O-oglucoside (Pn3-glu) showed the highest color values; the coumarylated anthocyanins presented higher color values than their corresponding acetylated anthocyanins and parent anthocyanins; pyranoanthocyanins presented also higher color values than their original anthocyanins; the color of anthocyanins depended on their structure. This work will be helpful to reveal evolution in aged red wine.

        • KCI등재SCOPUS

          Anthocyanins in ‘Cabernet Gernischet' (Vitis vinifera L. cv.) Aged Red Wine and Their Color in Aqueous Solution Analyzed by Partial Least Square Regression

          Fu-Liang,Han,Shou-Mei,Jiang,Jian-Jun,He,Qiu-Hong,Pan,Chang-Qing,Duan,Ming-Xia,Zhang 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.3

          Anthocyanins are considered one of the main color determinants in aged red wine. The anthocyanins in aged red wine made from ‘Cabernet Gernischet' (Vitis vinifera L. cv.) grape were investigated by high performance liquid chromatography- electronic spray ionization- mass spectrometry (HPLC-ESI-MS) and their color presented in aqueous solution were evaluated using partial least square regression (PLS). The results showed that there were 37 anthocyanins identified in this wine, including 22 pyranoanthocyanins. The analysis of PLS indicated that different anthocyanins showed distinct color values: malvidin 3-O-(6-O-acetyl)-glucoside-4-vinylguaiacol (Mv3-acet-glu-vg) presented the highest color values, while malvidin 3-O-glucoside (Mv3-glu) showed least. Among the free non-acylated anthocyanins, peonidin 3-Oglucoside (Pn3-glu) showed the highest color values; the coumarylated anthocyanins presented higher color values than their corresponding acetylated anthocyanins and parent anthocyanins; pyranoanthocyanins presented also higher color values than their original anthocyanins; the color of anthocyanins depended on their structure. This work will be helpful to reveal evolution in aged red wine.

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