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Parastic Infections among Long-term Overseas Japanese Residents in Tropical Areas
Shirasaka, Ryukoh INSTITUTE OF TROPICAL MEDICINE YONSEI UNIVERSITY 1982 YONSEI REPORTS ON TROPICAL MEDICINE Vol.13 No.1
現在 約 20萬名 以上의 日本人이 여러가지 目的으로 外國에 나가 長期滯留 또는 居住하고 있으며 앞으로 더 많은 數가 外國 特히 開發途上國 및 熱帶地域 여러나라에 進出할 것이 展望된다. 따라서 이들은 熱帶性疾病의 80%以上을 占하고 있는 無數한 寄生蟲病의 危險에 露出되게 될 것이다. 또한 이들은 歸國과 함께 여러 種類의 寄生蟲病을 流入할 可能性을 內包하고 있어 매우 重要한 管理의 對象이 되고 있다. 이에 이들의 日常生活에 있어 必要로하는 充分한 知識의 習得이 要求되고 있어 感染에 關與하는 諸要件, 居住期間과 寄生蟲性 疾病, 地域別 寄生蟲性 疾病, 生活還境, 感染經路等을 槪觀하고 歸國 日本人들의 寄生蟲感染狀態를 要約 考察하였다.
Synthesis of gadolinium-doped ceria nanoparticles by electrolysis of aqueous solutions
Hatsuki Shirasaka 한양대학교 세라믹연구소 2013 Journal of Ceramic Processing Research Vol.14 No.3
Nanometre-sized Gd-doped ceria (GDC) particles were prepared by alternating and direct current electrolysis of mixed aqueous solutions containing Ce3+ ions (0.08 mol/l) and Gd3+ ions (0.02 mol/l) at 25 o -80 o C for 24 h under an electric field strength of 3.3 V/cm. The GDC particles of the median sizes of 2.4-5.6 nm were produced under an AC field at 1 Hz of 3.3 V/ cm, and the particle size and yield increased at a higher solution temperature. The increase of solution pH was also effective in increasing the particle yield. The addition of glycine to the Gd(NO3)3-Ce(NO3)3 solution increased the particle yield at a low electrolysis temperature under a DC field of 3.3 V/cm. The Gd2O3 content of the GDC particles produced in the glycinecontaining solution was close to the metal composition of the starting solution.
Purification of glutamic acid decarboxylase from Flammulina velutipes
Norifumi Shirasaka,Takahiro Yoshida,Takao Terashita 한국버섯학회 2010 한국버섯학회지 Vol.8 No.4
Gamma-Amino Butyric Acid (GABA), a four-carbon non protein amino acid, is widely distributed in nature and acts as the major suppressive neurotransmitter in the mammalian central nervous system. Recently, GABA has been reported to have several physiological functions such as antihypertensive, diuretic, relaxing and antidiabetic effects. Due to these unique biological functions, GABA has been used as functional ingredients for functional foods. Glutamic Acid Decarboxylase (GAD), which catalyzes decarboxylation of L-glutamic acid to GABA, has been purified from mammals, higher plants, and some microorganisms and their properties have already been reported. On the other hand, mushrooms are commonly appreciated as healthy food due to their nutritional properties, such as low calorie, rich in fiber, vitamin and mineral. L-Glutamic acid and GABA are also commonly distributed in edible mushrooms. The fact that mushrooms accumulate GABA suggests the existence of GAD. However, the enzyme property of mushroom GAD has not been reported. In the present study, we tried to purify and characterize the property of Flammulina veltipes. [Methods and Results] Mushroom (fruit-body of Flammulina veltipes) used in this study was purchased in local market. GAD activity was determined by formation of GABA from L-glutamic acid in the presence of pyridoxal-5’š- phosphate (PLP). The GAD activity was determined by the formation of GABA from L-glutamic acid. Fruit- body was crushed and then centrifuged to separate supernatant and cell debris. To investigate the localization of GAD, both supernatant and precipitate were subjected to enzyme reaction after dialysis. The cell debris showed stronger GAD activity than that of supernatant. The formation of GABA was observed between pH 4 and 6 and the maximum GAD activity was observed at pH 6. However, GAD activity was lost after dialysis for overnight against buffer of pH 6-11. These results suggest that GAD from Flammulina veltipes is stable at pH 4-5 in spite of its optimum pH for GABA production is around 6.
Tomonori Shirasaka,Shingo Kunioka,Masahiko Narita,Ryohei Ushioda,Keisuke Shibagaki,Yuta Kikuchi,Naohiro Wakabayashi,Natsuya Ishikawa,Hiroyuki Kamiya 대한흉부외과학회 2021 Journal of Chest Surgery (J Chest Surg) Vol.54 No.5
Background: Achieving external access to and manual occlusion of the left atrial ap- pendage (LAA) during minimally invasive mitral valve surgery (MIMVS) through a small right thoracotomy is difficult. Occlusion of the LAA using an epicardial closure device seems quite useful compared to other surgical techniques. Methods: Fourteen patients with atrial fibrillation underwent MIMVS with concomitant surgical occlusion of the LAA using double-layered endocardial closure stitches (n=6, endocardial suture group) or the AtriClip Pro closure device (n=8, AtriClip group) at our institution. The primary safety endpoint was any device-related adverse event, and the primary efficacy endpoint was successful complete occlusion of blood flow into the LAA as assessed by transthoracic echocardiography at hospital discharge. The primary efficacy endpoint for stroke reduction was the occurrence of ischemic or hemorrhagic neurologic events. Results: All patients underwent LAA occlusion as scheduled. The cardiopulmonary by- pass and aortic cross-clamp times in the endocardial suture group and the AtriClip group were 202±39 and 128±41 minutes, and 213±53 and 136±44 minutes, respectively (p=0.68, p=0.73). No patients in either group experienced any device-related serious adverse events, incomplete LAA occlusion, early postoperative stroke, or neurologic complication. Conclusion: Epicardial LAA occlusion using the AtriClip Pro during MIMVS in patients with mitral valve disease and atrial fibrillation is a simple, safe, and effective adjunctive procedure.
Yoshioka, Nasa,Shirasaka, Seiko The Korean Society of Systems Engineering 2015 시스템엔지니어링학술지 Vol.11 No.2
Various methods have been used for safety and reliability as it becomes more difficult to ensure safety owing to the increasing complexity and scale of systems. This study aims at making it easier and more efficient to discuss risks and countermeasures for completeness, review, and knowledge transfer by improving methods to create fault tree analyses which focus on the GSN [1], which are among the methods used to describe assurance cases. More specifically, the purpose of this study is to incorporate strategy and context, GSN concepts, along with reason, which is a new concept, into FTA; the study focuses on three points. One point is support for the safety designer to draw a mutually exclusive and collectively exhaustive (MECE) FTA. The second is to make it easier to understand diagrams and meanings of FTA compared with the usual methods. The third is to make creating an FTA more efficient and to pass on existing know-how. Eventually, FTA can achieve completeness, review, and knowledge transfer. An introduction is provided in the first section. Next, the methodology covered in this paper is explained in the second section. The third section describes the proposed notation method based on two proposals made in this paper. In the fourth and fifth sections, results and discussion are provided, respectively. Finally, in the sixth section, conclusions are described.
A Proposal of Quality Assessment for System Model
Onozuka, Yuki,Ioki, Makoto,Shirasaka, Seiko The Korean Society of Systems Engineering 2016 시스템엔지니어링학술지 Vol.12 No.2
Recently, the increased complexity of systems has made systems engineering necessary. It is very useful for system designers to understand the whole context of the concerned system based on systems engineering. A system model can be used to describe the outcome of a system design. A system model describes the system from the viewpoint of the stakeholder's needs using the mutually exclusive and collectively exhaustive principle. A system model can be used to smoothly design a large and complicated system based on the systems engineering development process. Many companies and countries are attempting to apply model-based systems engineering, and the significance of the system model quality is increasing as system models are referenced during system development. In this paper, we propose a quality assessment method for ontology which is one of system models by focusing on the system development process. First, in this process, a system developer should explicitly show the relationship between viewpoints. Then, the system developer should select dependent rather than independent viewpoints. With dependent viewpoints, each viewpoint used to describe the system has some logical relationship. The set of viewpoints makes it possible to show, not only tangible and physical system parts, but also conceptual system parts. In this paper, we develop an ontological system model of a Japanese weather observation system. By comparing some ontological system models, we verify the effectiveness of explicitly describing the relationships between viewpoints and select dependent viewpoints.