Screening of Recurrence Related MicroRNA in Ductal Carcinoma In Situ and Functional Study of MicroRNA-654-5p

Shi Li,Tianjie Pu,Lin Xiao,Hongwei Gao,Li Li,Feng Ye,Yueping Liu,Hong Bu 한국유방암학회 2019 Journal of breast cancer Vol.22 No.1

Purpose: Ductal carcinoma in situ (DCIS) contributes to 20%–30% of newly diagnosed cases of breast cancer in China. Although the breast cancer-specific mortality of DCIS is extremely low, a small proportion of DCIS patients still show relapse or metastasis, leading to poor prognosis. Little is known about the molecular mechanism for DCIS metastasis, partly due to the limited number of poor prognosis patients. This study analyzed the clinicopathological features and screened key microRNAs (miRNAs) contributing to local or distant recurrence. Methods: The clinicopathological features of DCIS were evaluated and survival analysis were performed to clarify risk factors associated with poor prognosis. Using miRNA arrays and real-time quantitative polymerase chain reaction (RT-qPCR) on DCIS formalin-fixed and paraffin-embedded samples with or without microinvasion with different clinical outcomes, potential DCIS metastasis-related miRNAs were screened out and further validated. The influence of one identified miRNA, miRNA-654-5p, on DCIS progression was analyzed. Results: Poor prognosis was significantly associated with larger tumor size and higher lymph node metastasis rate (both p < 0.05). Both were independent prognostic factors for DCIS. According to RT-qPCR results, distinct miRNA expression profiles were identified between DCIS and DCIS with microinvasion (DCIS-Mi) patients. In the DCIS panel, miRNA-654-5p was significantly upregulated in the patients with poor prognosis. In vitro, miRNA-654-5p promoted MDA-MB-231 cell mobility in healing tests and metastasis in the Transwell study. Conclusion: The panel of high-risk miRNAs in DCIS and DCIS-Mi differs markedly. miRNA-654-5p is significantly upregulated DCIS patients having poor prognosis and may be essential for local and distant recurrence in DCIS.

Grey Relative Evaluation of Airport Apron Safety Risk based on THEIL Index

Shi Li,Luo Fan 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.7

Aiming at the airport apron safety risk evaluation, using a comprehensive integrated view, combining the quantitative method with qualitative method, a grey relative comprehensive evaluation model of apron safety risk based on THEIL index is proposed. First, objective weight is calculated by THEIL index, combined with experience and knowledge of the subjective weight to determine the final comprehensive weight. Then, based on comprehensive weight, the fuzzy evaluation and grey correlation are used to obtain the results of degree of association, and specific risk evaluation order of aprons is achieved. Finally, the validity of the model is verified by an example, and it provides an effective method for the evaluation of airport apron safety risk.

Privacy Enhancement and Secure Data Transmission Mechanism for Smart Grid System

( Shi Li ),( Kyung Choi ),( Inshil Doh ),( Kijoon Chae ) 한국정보처리학회 2011 한국정보처리학회 학술대회논문집 Vol.18 No.1

With the growth of Smart Grid technologies, security and privacy will become the most important issues and more attention should be paid. There are some existing solutions about anonymization of smart meters, however, they still have some potential threats. In this paper, we describe an enhanced method to protect the privacy of consumer data. When metering data are required by a utility or the electrical energy distribution center for operational reasons, data are delivered not with the real IDs but with temporary IDs. In addition, these temporary IDs are changed randomly to prevent the attackers from analyzing the energy usage patterns. We also describe secure data transmission method for securing data delivered. In this way, we can enhance the privacy of Smart Grid System with low overhead.

Heat dissipation in high-power semiconductor lasers with heat pipe cooling system

Shili Shu,Guanyu Hou,Lijie Wang,Sicong Tian,Leonid L. Vassiliev,Cunzhu Tong 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.6

This study focuses on the application of heat pipes in thermal management for high-power semiconductor lasers. The heat pipe cooling systems are used for heat dissipation in high-power semiconductor lasers. These systems are used instead of water cooling machines to realize a compact and lightweight laser module. The n-shaped heat pipe cooling system, which consists of eight 6 mm copper heat pipes with sintered powder wicks, can easily handle a heat load of up to 73 W from a single-laser unit. The fabricated U-shaped heat pipe cooling system, which consists of ten 12 mm copper heat pipes with sintered powder wicks, can easily handle a heat load of up to 300 W from five laser units. The optical power of the multi-laser module cooled by the U-shaped heat pipe cooling system reaches 210 W. These results indicate that high-power semiconductor lasers can be cooled using heat pipe cooling systems instead of water cooling machines.

In situ polymerization of poly(styrene-alt-maleic anhydride)/organic montmorillonite nanocomposites and their ionomers as crystallization nucleating agents for poly(ethylene terephthalate)

Shili Xing,Rui Li,Jingjing Si,Ping Tang 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.38 No.-

The poly(styrene-alt-maleic anhydride)/organic montmorillonite (SMA/OMMT) nanocomposites areobtained through in situ polymerization of styrene and maleic anhydride. The OMMT is exfoliated intosmall platelets and dispersed well in SMA copolymers, which is thus easily made into ionomers/OMMT(IM) nanocomposites. The IMs are employed as nucleating agents for poly(ethylene terephthalate) (PET)and the crystallization behavior is investigated by DSC isothermally and non-isothermally, respectively. The crystallization rate of PET is significantly accelerated and melt-crystallization temperature isincreased with the addition of IMs which acted as heterogeneous nucleating agent due to goodmiscibility between anhydride and PET, and large interfaces provided by exfoliated OMMT.

LIGHTWEIGHT MIXTURE FAULTS DETECTION METHOD FOR GASOLINE ENGINE USING ON-LINE TREND ANALYSIS

Shili Wu,Zhenmin Tang,Zhaosong Guo 한국자동차공학회 2017 International journal of automotive technology Vol.18 No.3

Mixture faults detection is meaningful for gasoline engines because proper mixture is the basic prerequisite for healthy running of a combustion engine. Among existing methods for faults detection, the data-driven trend analysis technique is widely used due to the simplicity and efficiency in time-domain. The CUSUM (Cumulative Sum Of Errors) algorithm is good at real-time trend extraction, but it’s easy to be costly on the fuel trim signal during the engine in normal working conditions, which will increase battery energy consumption because engine failure is rarely occurs. Hence, the conventional treatment methods of artifacts in the CUSUM algorithm are modified by means of decay function and detection time analysis. The thresholds are tuned according to the characteristics of artifacts instead of residual variability, which leads to better results of trend extraction and less computation. Then, the revised CUSUM algorithm is used for monitoring the mixture abnormal behaviors, and the mixture faults can be detected in real time through analyzing the variation features of fuel trim signal. The lightweight faults detector using the advanced CUSUM algorithm (FD-A-CUSUM) is evaluated on the experimental data collected from a Ford engine. The validation results show that while engine works under normal conditions, the computation of FD-A-CUSUM has decreased by 72.79 % in comparison with the detection method using the original CUSUM algorithm (FD-O-CUSUM), and the false alarm ratio of FD-A-CUSUM is 3.37 %. Futhermore, the detection results of FD-A-CUSUM for two leakage faults have achieved 91.18 % test accuracy.

Nonlinear 3D finite element analysis of suction caisson-tower-soil system subjected to horizontal earthquake excitation

Ma Shili,Xie Liquan,Ji Yifan,Su Tsung-chow 대한조선학회 2022 International Journal of Naval Architecture and Oc Vol.14 No.1

Suction caissons are widely used as a promising alternative foundation for offshore structures under variable offshore environments. In this paper, a three-dimensional finite-element model which takes into account soil inelasticity was used to study the seismic behavior of a suction caisson in clay taken from an offshore wind farm in the Hebei province of China. The results showed that the maximum acceleration of the soil increases with increasing depth. There is a distinct amplification for relatively low frequencies when seismic waves propagate to the mudline. It was assumed that the rotation center of suction caisson under seismic conditions was virtually existent. The rotation center was obtained by the proposed formula to explore the movement positions of the suction caisson. The time of the peak of lateral displacement of the lid did not synchronize with that of the changing direction of displacement of the rotation center, indicating that the displacement of the lid can not be a comprehensive assessment of the position state of suction caissons. The point mass at the top of the wind turbine tower was responsible for the increase of vibration amplitude of displacement.

맥루한(McLuhan)의 핫(Hot)·쿨(Cool)미디어 이론에 기초한 현대 한자 미디어 디자인 기초연구

왕사립 ( Wang Shili ),김용구 ( Kim Yonggu ),홍찬석 ( Hong Chan-seok ) 한국기초조형학회 2020 한국기초조형학회 학술발표논문집 Vol.2020 No.2

에드워드 사이드의 ‘오리엔탈리즘’ 이론을 바탕으로 게임 캐릭터 디자인의 문화적 정체성에 관한 연구

왕사립(Wang Shili),김용구(KIM Yonggu),조동민(Cho Dong-Min),홍찬석(Hong chanseok) 한국디자인학회 2021 한국디자인학회 학술발표대회 논문집 Vol.2021 No.5

중국 대학 한국어교육의 흐름, 현황 및 발전방안에 대하여

허세립(XU, Shili),이인순(Li, Renshun) 고려대학교 한국학연구소 2018 한국학연구 Vol.65 No.-

중국 대학에서의 한국어교육은 70여 년의 역사를 갖고 있으며 현시점에서 바라볼 때 괄목할 만한 성과를 이루었다고 할 수 있다. 그동안 학계의 일각에서는 한국어 관련 학과의 ‘과열 성장’에 대한 우려의 목소리가 끊이지 않았다. 본고에서는 각 대학 한국어 관련 학과의 설립연도와 규모 및 발전수준 등에 입각하여 중국 대학에서의 한국어교육 발전 흐름에 대하여 준비기, 발전기, 도약기 등 세 단계로 나누어 논의하였다. 또한 문제점을 인식하여 거시적인 관점에서 전문대 응용한국어학과의 현황, 4년제 대학의 한국어학과의 현황, 대학원 교육의 현황, 한국학 연구의 현황 등에 대해 논의를 하였고 재학생 규모, 정원 충원율, 취업률 등 한국어교육에 있어서의 핵심부분을 바탕으로 중국 대학 한국어교육의 ‘건강 상태’에 대한 진단을 시도하였으며, 앞으로 한국어교육의 지속적인 발전을 위한 ‘지역특성화’, ‘포괄적인 우리 의식 강화’, ‘학과운영능력 강화’ 등의 대안을 제시하였다. 본 연구는 중국 대학에서의 한국어교육 발전 흐름 및 발전 현황, 발전 대안에 대한 거시적인 파악과 더불어 한국어 관련 학과의 기획․운영에 있어서 일정한 참고가치가 있을 것이다. Korean education in Chinese universities has a history of over 70 years and has gained remarkable achievements. Some experts and scholars used to show their concerns or even question about the “extraordinary development” of Korean education. According to the data of the founding time of majors relating to Korean and the development scale and level of Korean education in Chinese universities, this paper elaborates the three stages of the development history of Korean education, including the preparation period, development period and soar period. Based on some existing problems in Korean education and from a macroscopic perspective, this paper discusses the development of applied Korean education in technical institutes and the development of Korean majors in four-year universities and in postgraduate education, and that of Korean studies. Using the data of scale of students majoring in Korean and their admission and employment rate, this paper measures and judges the “health status” of majors relating to Korean education. This paper also brings about the development directions of enhancing the regional features, strengthening the sense of professional community and reinforcing the managing and operating capability of Korean major as the future development strategy of Korean education in Chinese universities. The research outcomes of this paper will macroscopically have positive influence on the development history, status and strategy of Korean education in Chinese universities and Korean studies. At the same time, it provides reference for planning and promoting the development of Korean education and related majors.