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( Shih-wen Hsu ),( Chien-yio Lin ),( Chuang-wei Wang ),( Wen-hung Chung ),( Chih-hsun Yang ),( Yao-yu Chang ) 대한피부과학회 2018 Annals of Dermatology Vol.30 No.5
We studied a family with Gorlin-Goltz syndrome. The novel mutations of our cases were located on the 21st exon of the PTCH1 gene (c.3450C>G). The father, who received a strategic 56-day vismodegib treatment for disease control, was the first patient with Gorlin syndrome treated with the hedgehog inhibitor in Taiwan. The lesions regressed gradually, with scar formation, and were subsequently removed via a wide excision. Further details are provided below. (Ann Dermatol 30(5) 597∼601, 2018)
Mapping Signals That Are Important for Nuclear and Nucleolar Localization in MCRS2
Chung-Wen Kuo,Shih-Tung Liu,Wen-Hung Wang 한국분자세포생물학회 2011 Molecules and cells Vol.31 No.6
MCRS2 is an oncoprotein that is sequestered in the nu-cleolus. When in the nucleolus, it promotes the transcrip-tion of the rRNA gene. MCRS2 also brings proteins into the nucleolus to change their function. This study analyzes the sequence of MCRS2 and determines that the nuclear localization signal, which has the sequence KRKK, is situ-ated between amino acids 66 and 69. Meanwhile, MCRS2 contains a bipartite nucleolar localization signal, which comprises a KKSK motif, located between amino acids 133 and 136, and a downstream 152-amino acid region, from amino acid 314 to 465. The results of this study are impor-tant to understand the function of MCRS2.
Ho, Wen-Fu,Tsou, Hsi-Kai,Wu, Shih-Ching,Hsu, Shih-Kuang,Chuang, Shao-Hsuan,Hsu, Hsueh-Chuan Techno-Press 2014 Biomaterials and biomedical engineering Vol.1 No.1
The purpose of this experiment was to evaluate the apatite-formation abilities of low-modulus Ti-7.5Mo substrates treated with NaOH aqueous solutions and subsequent ethyl alcohol aging before soaking them in simulated body fluid. Specimens of Ti-7.5Mo were initially treated with 5 M NaOH at $60^{\circ}C$ for 24 h, resulting in the formation of a porous network structure composed of sodium hydrogen titanate. Afterwards, the specimens were aged in ethyl alcohol at $60^{\circ}C$ for 5 or 10 min, and subsequently immersed in simulated body fluid at $37^{\circ}C$ for 3, 7 and 14 days. Ethyl alcohol aging significantly increased the apatite-forming abilities of Ti-7.5Mo. The amount of apatite deposited on the Ti-7.5Mo after NaOH treatment and subsequent ethyl alcohol aging was much greater, especially after the Ti-7.5Mo specimens were aged for 5 min. Due to its excellent combination of bioactivity, low elastic modulus and low processing costs, the Ti-7.5Mo treated with NaOH aqueous solutions and subsequently aged in ethyl alcohol has promising heavy load-bearing applications.
Hydroxyapatite prepared from eggshell and mulberry leaf extract by precipitation method
Wu, Shih-Ching,Hsu, Hsueh-Chuan,Hsu, Shih-Kuang,Liu, Mei-Yi,Ho, Wen-Fu Techno-Press 2019 Biomaterials and Biomechanics in Bioengineering Vol.4 No.1
Eggshell is a waste material after the usage of egg. In this work, biowaste chicken eggshells were used for preparing carbonated hydroxyapatite (HA) nanoparticles of high purity through aqueous precipitation method at room temperature. The eggshell-derived HA will be a cost-effective bioceramics for biomedical applications and an effective material-recycling technology. Additionally, mulberry leaf extract was used as a template to regulate the morphology, size and crystallinity of HA, and the effects of pH value were also examined. Characterization of the samples was performed by X-ray diffraction (XRD) and Fourier transform infrared (FT-IR) spectroscopy. Scanning electron microscopy (SEM) was used to determine the size, shape and morphology of HA. The results indicate that only one phase of HA were synthesized in the both absence and presence of mulberry leaf extract at pH of 7 and above, while DCPD or DCPA/DCPD phase was observed at pH 4 condition. The crystallite sizes of the HA samples obviously decreased when adding mulberry leaf extract as a template, while they decreased gradually as the solution pH levels increased. With increasing pH level from 7 to 14, the rod-like HA nanoparticles gradually changed to spherical shape at pH 14. Note that, the obtained product is Mg and Sr containing A- and B-type carbonate HA at alkaline pH and it can be a potential material for biomedical applications.
Ho, Wen-Fu,Tsou, Hsi-Kai,Wu, Shih-Ching,Hsu, Shih-Kuang,Chuang, Shao-Hsuan,Hsu, Hsueh-Chuan Techno-Press 2014 Biomaterials and Biomechanics in Bioengineering Vol.1 No.1
The purpose of this experiment was to evaluate the apatite-formation abilities of low-modulus Ti-7.5Mo substrates treated with NaOH aqueous solutions and subsequent ethyl alcohol aging before soaking them in simulated body fluid. Specimens of Ti-7.5Mo were initially treated with 5 M NaOH at $60^{\circ}C$ for 24 h, resulting in the formation of a porous network structure composed of sodium hydrogen titanate. Afterwards, the specimens were aged in ethyl alcohol at $60^{\circ}C$ for 5 or 10 min, and subsequently immersed in simulated body fluid at $37^{\circ}C$ for 3, 7 and 14 days. Ethyl alcohol aging significantly increased the apatite-forming abilities of Ti-7.5Mo. The amount of apatite deposited on the Ti-7.5Mo after NaOH treatment and subsequent ethyl alcohol aging was much greater, especially after the Ti-7.5Mo specimens were aged for 5 min. Due to its excellent combination of bioactivity, low elastic modulus and low processing costs, the Ti-7.5Mo treated with NaOH aqueous solutions and subsequently aged in ethyl alcohol has promising heavy load-bearing applications.
Contour-Model-Guided Volumetric Deformation Method for Medical Image Registration
Vincent Shih, Wen Shiang,Lin, Wei Chung,Rhee, Sang Yong 慶南大學校 附設 工業技術硏究所 1998 硏究論文集 Vol.16 No.-
부위들 사이에 혹은 그룹별 가능하도록 하기 위하여 해부학의 표준화를 위한 한 부위의 MR 영상을 표준인 참조 MR 영상으로 바꾸는 자동화된 방법이 제시한다. 이 방법에서는 먼저 입력된 영상과 참조영상의 전체적으로 나란히 놓기 위하여 선형변환을 하고, 능동 윤곽선 추출 기법을 이용하여 입력영상의 윤곽선과 곡면을 다듬는다. 그리고, 이 과정을 통하여 얻어진 윤곽선과 곡면의 대응관계를 기초로, 제안된 가중 지역 참조 좌표계를 이용하여 입력영상을 변형하는 비선형 변환을 한다. 우리는 이방법을 MR 영상의 등록을 위하여 실제 영상에 적용해 보았다. An automated method is proposed for anatomic standardization that elastically map one subject's MR image to a standard reference MR image to enable inter-subject and cross-group studies. In this method, linear transformations are first applied to grossly align the input image to the reference image. Then, the candidate corresponding regions in the input image are identified based on the contour information from the pre-segmented reference image. Next, and active contour model is employed to refine the contour and surface description of the input image. Based on the contour and surface correspondence established in these previous steps, a non-linear transformation is determined using the proposed weighted local reference coordinates systems to warp the input image. We tested this algorithm on various real images for registration of MR images.
Shih-Ku Lin,Shu-Yu Yang,Seon-Cheol Park,Ok-Jin Jang,Xiaomin Zhu,Yu-Tao Xiang,Wen-Chen Ouyang,Afzal Javed,M. Nasar Sayeed Khan,Sandeep Grover,Ajit Avasthi,Roy Abraham Kallivayalil,Kok Yoon Chee,Norliza 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.1
Objective: Pharmacotherapy including mood stabilizers and antipsychotics are frequently used in bipolar disorder (BD); however, the lack of consensus regarding the definition of polypharmacy hinders conducting comparative studies across different settings and countries. Research on Asian Prescription Pattern (REAP) is the largest and the longest lasting international collaborative research in psychiatry in Asia. The objective of REAP BD was to investigate the prescription patterns of psychotropic medications across Asian countries. The rates of polypharmacy and psychotropic drug load were also analyzed. Methods: The data collection was web-based. Prescription patterns were categorized as (1) mood stabilizer monotherapy: one mood stabilizer; (2) antipsychotic monotherapy: one antipsychotic; (3) simple polypharmacy: one mood stabilizer and one antipsychotic; and (4) complex polypharmacy: ≥ 2 mood stabilizers or/and antipsychotics. The psychotropic drug load in each patient was calculated using the defined daily dose method. Results: Among 2003 patients with BD (52.1% female, 42.4 years) from 12 countries, 1,619 (80.8%) patients received mood stabilizers, 1,644 (82.14%) received antipsychotics, and 424 (21.2%) received antidepressants, with 14.7% mood stabilizer monotherapy, 13.4% antipsychotic monotherapy, 48.9% simple polypharmacy, 20.3% complex polypharmacy, and 2.6% other therapy. The average psychotropic drug load was 2.05 ± 1.40. Results varied widely between countries. Conclusion: Over 70% of psychotropic regimens involved polypharmacy, which accords with the high prevalence of polypharmacy in BD under a permissive criterion (2 or more core psychotropic drugs) worldwide. Notably, ≥ 80% of our sample received antipsychotics, which may indicate an increasing trend in antipsychotic use for BD treatment.