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Shigeaki Kato 대한골대사학회 2023 대한골대사학회지 Vol.30 No.3
Vitamin D (VD) exerts a wide variety of biological actions in addition to its well-known roles in calcium homeostasis. Nutritional VD deficiency induces rachitic abnormalities in growing children and osteomalacia in adults, and it has been proposed to underlie the onset and development of multiple non-communicable chronic diseases. Therefore, the administration of VD or synthetic VD analogues represents a promising therapeutic strategy; indeed, VD and a VD agonist have shown clinical promise in mitigating osteoporosis and symptoms of insufficient calcium intake. However, even though high doses of VD analogues have shown pre-clinical efficacy against several diseases, including cancers, they have not yet had wide-spread clinical success. This difference may be due to limitation of clinical doses in light of the inherent calcemic action of VD. An approach to overcome this problem involves the development of VD analogues with lower calcemic activity, which could be administered in high doses to attenuate the onset and progress of disease. In a similar strategy, selective estrogen receptor modulators have had success as anti-osteoporosis drugs, and they have shown benefit for other estrogen target organs by serving as partial antagonists or agonists of estrogen receptor α. It is thus conceivable to generate synthetic partial antagonists or agonists for the VD receptor (VDR) that would exert beneficial effects on bone and other VD target organs. In this review, we discuss the molecular basis of the development of such synthetic VDR ligands from the viewpoint of roles of VDR in gene regulation.
Feedback System Using the PWM (Pulse Width Modulation) Power Amplifier with Huge Bandwidth
Shigeaki Wachi,Hirofumi Matsuo 대한전자공학회 2007 ITC-CSCC :International Technical Conference on Ci Vol.2007 No.7
A feedback system using a PWM power amplifier has time delay and nonlinearity problems. In this paper, we discuss the time delay problem that causes narrowing bandwidth of the feedback system, and the nonlinearity problem that causes the instability of the feedback system. And, we propose the solutions for both of them for the purpose of expanding the bandwidth. For the time delay problem, we propose an improved PWM method where we lade its information both on the rising edge and the falling edge. For the nonlinearity problem, we propose the PWM gain controller to cancel the nonlinearity.
Judicial Reform and Traditional Legal Culture in Contemporary Japan
Tanaka, Shigeaki 성균관대학교 동아시아학술원 2001 Sungkyun Journal of East Asian Studies Vol.1 No.1
Judicial Reform and Traditional Legal Culture in Contemporary Japan
Recent Trends in Ferrous PM Materials in Japan
Takajo Shigeaki 한국분말야금학회 1993 한국분말야금학회 학술대회논문집 Vol.1993 No.1
Ferrous powder metallurgy in Japan has developed in the last four decades, where every decade is featured by certain breakthroughs in materials. The progress in PM materials is closely related to newly developed powders. Low alloy steel powders for high strength PM components are grouped into three types: Ni and/or Mo containing completely alloyed powders, Ni containing partially alloyed powders, and Cr containing completely alloyed powders. Every type has its special characteristics. The tensile strength of PM materials is improved up to 2 GPa. The hardness is also increased to exceed 500 HV with normal hardening methods, and 700 HV with novel surface treatment techniques. The present maximum of fatigue strength is 550 MPa, and that of impact energy is 100 J. Novel PM materials with improved properties are applied to a variety of automobile and other components: power steering pumps, rocker anns, valve guides and inserts, bearings, torque sensors, etc. The future outlook for the ferrous PM is Quite positive, and the industry is expected to show renewed growth by applying many types of alloy steel powders and new ferrous PM materials.