Criticisms on the Objectives

Shick-mo Hwang 한국영어교육학회 1981 ENGLISH TEACHING(영어교육) Vol.- No.21

誤謬分析에 對한 再考

?寔模(Shick-Mo Hwang) 영남대학교 인문과학연구소 1985 人文硏究 Vol.7 No.3

Monolingual Dictionary 의 편찬과 (編纂) 활용 (活用)

황식모 ( Shick Mo Hwang ) 한국영어영문학회 1970 영어 영문학 Vol.36 No.-

Expression and Characterization of a Novel Deoxyribose 5-Phosphate Aldolase from Paenibacillus sp. EA001

( Yong Mo Kim ),( Nack Shick Choi ),( Yong Ook Kim ),( Dong Ho Son ),( Young Hyo Chang ),( Jae Jun Song ),( Joong Su Kim ) 한국미생물 · 생명공학회 2010 Journal of microbiology and biotechnology Vol.20 No.6

아데노바이러스를 이용한 IGF-1, TGF-β1 유전자 전달에 대한 인간 추간판 세포의 기질 생성 반응

이환모,박문수,김향,김학선,강응식,김남현,문성환 대한척추외과학회 2001 대한척추외과학회지 Vol.8 No.3

연구배경 : 유전자 전달에 의한 세포의 유전자 조작방법은 최근 근골격계의 질환의 치료에서 섬세한 약물전달 방법으로 각광받고 있다. IGF-1, BMP-2, TGF- 1은 추간판 고직의 기질 재생에 효과적인 성장 인자로 알려져 있다. BMP-2, OP-1, TGF- 1은 TGF계통으로 같은 세포내 신호전달 기전을 가지고 있다. 이에 반해 IGF-1은 상이한 신호전달 기전을 이용한다. 연구목적 : 세포내 신호전달 기전이 다른 IGF-1과 TGF- 1 단백 및 유전자를 사용하여 인간 추간판 세포의 기질 생성 반응을 보았다 대상 및 방법 : 15명의 환자에게 추간판 술식을 시행하고 요추 및 경추 추간판 조직을 채취하였다. 효소 분해로 추간판 세포를 분리하여 평면 배양하고 여기에 단일 유전자 전달군으로 아데노바이러스TGF 1(Ad/IGF- 1), Ad/IGF-1를 각각 감염시켰다. 이중 유전자 전달군에서는 세포배양에 Ad/TGF- 1+Ad/IGF-1조합을 감염시켰다. Ad/Iuciferase와 생리식염수 처리군은 대조군으로 정하였다. TGF- 1(2ng/ml)과 IGF-1(100ng/ml)도 세포 배양에 투여하여 성장인자 단백의 효과도 조사하였다. 새로 생성된 당단백은 S35 방사선 동위원소를 이용한 PD-10 column chromatography로 정량하였다. 결과 : 새로 생성된 당단백은 대조군에 비해 Ad/TGF- 1감염군에서 2.9배 Ad/IGF-1 감염군에서 1.8배(p<0.05) Ad/TGF- 1+Ad/IGF-1 혼합 갑염군에서는 대조군에 비해 3.9배의 당단백 생산 증가가 있었다(p<0.05), TGF- 1는 3.9배, IGF-1은 2.9배, TGF- 1+IGF-1 동시 투여시는 4.2배의 당단백 생성증가가 있었다.(p<0.05) 결론 : TGF-1, IGF-1 유전자 전달법은 인간의 추간판 세포의 기질 재생에 효과적인 기전을 제공한다. Background : Genetic modification of cells through gene transfer gains popularity as a sophisticated delivery system in the management of musculoskeletal disease. Anabolic growth factors like IGF-1 BMP-2 OP-1. and TGF-βl were candidate for therapeutic purposus for regenerating matrix of intervertebral disc. TGF-β1. OP-1 and BMP-2 share same pathway i.e. Smad while IGF-1 utilize P13K pathway. Accordingly it is logical to use two cytokine encoding genes which using different signal transduction pathway to upregulate matrix synthesis. Purpose : To elucidate the anabolic effect of the combination gene transfer(IGF-1 and TGF-β1 encoding gene) to human disc cells, cultured in alginate beads. Materials and Methods : Lumbar and cervical intervertebral disc tissue was obtained from surgical disc procedure from fifteen patients. After isolation and culture of the cells, cultures were transduced with first, Adenovirus-TGFβl construct(Ad/TGF-β1) and Ad/IGF-1 respectively, second, with combination of two viral constructs(Ad/TGF-β1+Ad/IGF-l). Cultures treated with saline and Adlluciferase served as control. Then cultures were incorporated into alginate beads. Exogenous TGF-β1(2 ng/ml) and IGF-l(l00 ng/ml) were administered also. Newly synthesized proteoglycan was assessed using 535 incorporation using chromatography on Sephadex G-2S in PD-10 column Results : In cultures transduced with single therapeutic gene construct, there were statistically significant 2.9 fold(Ad/TGF-β1) and 1.8 fold(Ad/IGF-1) increase in newly synthesized proteoglycan comparing contro[(p<O.oS). In culture transduced with double combination of therapeutic gene construct, there were 3.9 fold(Ad/TGF-βl+Ad/IGF-1) increase in newly synthesized proteoglycan comparing control(p<O.05). Culture treated with TGF-β1(2ng/ml) showed 3.9 fold increase and IGF-l(l00 ng/ml) 2.9 fold increase, TGF-β1+IGF-14.2 fold increase in proteoglycan synthesis compared to controL Conclusion : Combination gene therapy provided efficient mechanism of upregulating matrix regeneration of the human intervertebral disc cells.

대학배드민턴 선수의 행복증진 프로그램 개발과적용이 심리 및 생리적 변인에 미치는 영향

김정모 ( Jeong Mo Kim ),신정택 ( Jung Taek Shin ),박윤식 ( Yoon Shick Park ) 한국스포츠정책과학원(구 한국스포츠개발원) 2014 체육과학연구 Vol.25 No.3

본 연구의 목적은 행복증진 프로그램이 대학 배드민턴 선수의 심리 및 생리적 변인에 미치는 영향을 분석하는 것이다. 대학 배드민턴 선수 10명을 대상으로 선수 심층 면담 내용, 개방형 질문지, 기존의 행복증진 프로그램 선행연구, 전문가 회의를 통해 행복 증진 프로그램을 개발하였다. 행복증진 프로그램은 한 회기당 90-120분씩 총 12회기이며, 세부 내용은 오리엔테이션, 신뢰형성 및 행복에 대한 자기이해, 자아존중감 향상시키기, 내적통제성 기르기, 대인관계 개선, 스트레스 대처하기, 경기력 향상시키기, 행복증진 프로그램 실천및 종결로 구성되었다. 행복증진 프로그램의 효과를 검증하는 측정도구로 행복검사지Ⅰ, 행복검사지Ⅱ, 자아존중감, 내적통제성, 대인관계, 스트레스, 스트레스 대처, 인지된 경기력 검사지가 사용되었으며, 생리적 변인으로는 코티졸과 세로토닌을 활용되었다. 본 연구에서 얻은 결과는 다음과 같다. 첫째, 행복증진 프로그램은 대학배드민턴 선수의 행복감, 자아존중감, 내적통제성, 스트레스, 스트레스 대처는 통계적으로 긍정적인 효과가 있는 것으로 나타났다. 둘째, 본 행복증진 프로그램이 대학배드민턴 선수의 대인관계, 인지된 경기력, 코티졸, 세로토닌은 통계적으로 유의한 차이가 나타나지 않았다. 셋째, 개방형질문지와 심층면담 자료를 통해 연구대상자들이 행복증진 프로그램이 자신의 심리 및 생리적 변인에 효과가 있다고 인식하는 것으로 나타났다. The purpose of this study was to examine the effects of happiness improvement program on psychological variables which were happiness feeling, self-esteem, interpersonal relationship, internal-external locus of control, stress, coping, perceived performance and physiological variables such as cortisol and serotonin of collegiate badminton players. The participants consisted of 10 collegiate badminton players. Happiness improvement program for collegiate badminton players was developed by previous literatures, in-depth-interview, psychological test data, and consultation of happiness improvement experts. The happiness improvement program consisted of 12 intervention program: orientation, rapport development and the understanding happiness, self-esteem enhancement techniques, interpersonal relationship strategies, stress and coping management, peak performance methods, and action plan of happiness improvement program. Each program was applied to participants in about 90-120 minute a session(2-3 times session a week). The instruments of this study were made up of three broad categories: (a) psychological data, b) physiological data, and (c) qualitative data. Firstly, happiness improvement program significantly increased happiness feeling, self-esteem, internal-external locus of control, interpersonal relationship capability, coping skills of collegiate badminton players. Secondly, happiness improvement program significantly decreased stress of collegiate badminton players. Thirdly, participants positively perceived the effects of happiness improvement program on psycho-physiological variables. The limitations of this study and future implications were discussed.

Targeted cellular process profiling approach for cervical cancer

안웅식 ( Woong Shick Ahn ),( Hyun Jung Kim ),( Il Young Kuk ),( Ho Chul Lee ),( Chung Mok Park ),( Hae Nam Kim ),( Duck Young Ro ),( Tae Chul Park ),( Jun Mo Lee ),( Sung Eun Namkoong ),( Chong Kook Kim 대한산부인과학회 2004 대한산부인과학회 학술대회 Vol.90 No.-

cDNA Microarray Analysis of Gene Expression Profiles Associated with Cervical Cancer

Joo Hee Yoon,Joon Mo Lee,Sung Eun Namkoong,Su Mi Bae,Yong-Wan Kim,Sei-Jun Han,Young Lae Cho,Gye Hyun Nam,Chong Kook Kim,Jeong-Sun Seo,Woong Shick Ahn 대한암학회 2003 Cancer Research and Treatment Vol.35 No.5

Maternal, Fetal and Amniotic Fluid Prolactin Levels in Pregnancy-Induced Hypertension

Lim, Yong Taik,Lee, Joon Mo,Kim, Jong Bok,Ahn, Woong Shick,Rha, Jong Gu,Song, Seung Kyu CATHOLIC MEDICAL CENTER 1985 Bulletin of the Clinical Research Institute Vol.13 No.1

This study was undertaken in order (o elucidate the relative prolactin (PRL) concentrations in maternal, fetal and amniolic fluid and to deduct the possible role of prolactin in the pathogenesis of PIH. 1. Maternal serum prolactin concentrations There were no statistically significant differences between mild or severe pre-eclamptic and normotensive pregnant women, these values were 161.25+70.35, 155.8+68.28 and 182.26±78.25ng/ml, respectively (P>0.05). 2. Fetal cord serum prolactin concentrations There were no statistically significant differences between mild or severe pre-eclamptic and normotensive pregnant women, these values were 263.71+52.26, 239.5±25.34 and 284.46±45.47 ng/ml, respectively (P < 0.05). 3. Amniotic fluid prolactin concentrations Amniotic fluid prolactin concentrations were 238.70+49.38, 233.13+55.26 and 253.0+47.63 ng/ml in mild or severe pre-eclamptic and normotensive pregnant women, respectively. These differences dlid not show any statistically significant meaning (P>0.05). Considering above results, prolactin may have a minor role in the pathogenesis of PIH.

대학 품새 선수를 위한 심상훈련 프로그램 개발 및 적용에 과한 단일 사례 연구

조슬기(Jo, Seul-Gi),김정모(Kim, Jung-Mo),박윤식(Park, Yoon-Shick) 한국체육과학회 2014 한국체육과학회지 Vol.23 No.4

The purpose of this study was to examine the effect of image training program on competition anxiety, self-efficacy and sports image of collegiate Taekwondo form player. The participants was composed of a collegiate Taekwondo form player. The measures in this study were Sports Competition Anxiety Test, Competitive State Anxiety Inventory-2, Self-Efficacy Inventory, and Spore Image Ability Questionnaire. Image training program for collegiate Taekwondo form player was developed by data based on previous literatures, player interview, psychological test data, and sports psychologists consultation. The image training program consisted of goal setting, relaxation training, internal and external image perception training. Taekwondo skills imagery, competition image training and imagery control training. Each program was applied to participant in about 60 minute with 12 session. The results were as follows. Firstly, image training program decreased cognitive state anxiety intensity and increased self-confidence intensity. Secondly, image training program positively changed the direction of cognitive state anxiety, somatic state anxiety and self-confidence. Thirdly, image training program decreased competitive trait anxiety. Fourthly, image training program increased self-efficacy. Lastly, image training program positively changed intensity and direction of sports imagery of collegiate Taekwondo form player.