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A High-Current RFQ Accelerator for the ADS System in China
Shi-Nian Fu,Shou-Xian Fang,Xia-Ling Guan 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.4
An intense-beam Radio Frequency Quadrupole (RFQ) accelerator is under construction at Institute of High Energy Physics (IHEP), Beijing. It accelerates a proton beam with an average current of 3mA at a 6 % duty factor to 3.5 MeV from 75 keV. This four-vane type 352-MHz RFQ has a length of 4.7m and is separated into two resonantly coupled segments. This paper will present the physics design and the technology development of the RFQ, including the beam dynamics design study, the measurement of cold models, quadrupole and dipole field tuning of the long cavity, and the RF power source system. Now, the RFQ is being installed, and the beam tuning will start in 2006.
Wei-Hai Shi,Hao-Qiang Chao,Nian-Yuan Ye,Hong-Jian Shi 소화기인터벤션의학회 2019 Gastrointestinal Intervention Vol.8 No.1
Post-surgery small bowel obstruction (SBO) has substantial morbidity and mortality. Even with refinement of surgical technique, SBO still remains challenging with the most common causes of acute hospital admission. Most SBOs can be managed with conservative treatment. However, the pal-liative methods may fail to relieve the symptoms in some clinical settings. Currently, laparotomy is the standard of care for difficult SBO. And lapa-roscopy offers an alternative approach for operative intervention in SBO and was first described by Bastug et al in 1991. Emerging literature dem-onstrated that laparoscopic surgery for SBO is less invasive, resulting in a shorter hospital stay than open surgery. And most recurrent adhesive SBO can be managed with ileus tube placement. This case series is to evaluate the efficacy of transnasal ileus tube placement combined with laparoscopic surgery in the treatment of consecutive 5 cases of refractory SBO post oncologic gastrointestinal surgery.
Wei-Hai Shi,Hao-Qiang Chao,Nian-Yuan Ye,Hong-Jian Shi 소화기인터벤션의학회 2019 International journal of gastrointestinal interven Vol.8 No.1
Post-surgery small bowel obstruction (SBO) has substantial morbidity and mortality. Even with refinement of surgical technique, SBO still remains challenging with the most common causes of acute hospital admission. Most SBOs can be managed with conservative treatment. However, the pal-liative methods may fail to relieve the symptoms in some clinical settings. Currently, laparotomy is the standard of care for difficult SBO. And lapa-roscopy offers an alternative approach for operative intervention in SBO and was first described by Bastug et al in 1991. Emerging literature dem-onstrated that laparoscopic surgery for SBO is less invasive, resulting in a shorter hospital stay than open surgery. And most recurrent adhesive SBO can be managed with ileus tube placement. This case series is to evaluate the efficacy of transnasal ileus tube placement combined with laparoscopic surgery in the treatment of consecutive 5 cases of refractory SBO post oncologic gastrointestinal surgery.
Shi-run Yan,Xin-kui Wang,Zhen-hua Li,Kang-nian Fan,Mao-qing Kang,Shao-yi Peng 한국화학공학회 2004 Korean Journal of Chemical Engineering Vol.21 No.2
A novel non-phosgene process for the synthesis of methyl N-phenyl carbamate (MPC) by a reaction of phenylurea with methanol was studied. The reaction between phenylurea and methanol was found to be a spontaneous reaction that took place in the absence of catalyst and gave MPC as the main product. Addition of a catalyst markedly influenced the reaction behavior. A basic catalyst greatly enhanced the yield of MPC, whereas an acidic catalyst promoted the formation of aniline and methyl carbamate. Moderate strength of basicity showed the best catalytic performance in the cases studied. The mechanism of reaction and catalyst functioning was discussed.
Luo, Nian,Zhao, Lv-Cui,Shi, Qing-Qiang,Feng, Zi-Qiang,Chen, Di-Long,Li, Jing Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8
Background: Diallyl disulfide (DADS) may exert potent anticancer action both in vitro and in vivo. Although its effects on cancer are significant, the underlying mechanisms remain unknown. In this study, we sought to elucidate possible links between DADS and pyruvate kinase (PKM2). Materials and Methods: $KG1{\alpha}$, a leukemia cell line highly expressing PKM2 was used with a cell counting kit (CCK)-8 and flow cytometry (FCM) to investigate the effects of DADS. Relationships between PKM2 and DADS associated with phosphorylation of EGFR, ERK1/2 and MEK, were assessed by western blot analysis. Results: In $KG1{\alpha}$ cells highly expressing PKM2, we found that DADS could affect proliferation, apoptosis and EGFR/ERK/PKM2 signaling pathways, abrogating EGF-induced nuclear accumulation of PKM2. Conclusions: These results suggested that DADS suppressed the proliferation of $KG1{\alpha}$ cells, providing evidence that its proapoptotic effects are mediated through the inhibition of EGFR/ERK/PKM2 signaling pathways.
Hao Tang,Nian-Guang Li,Zhi-Hao Shi,Yu-Ping Tang,Qian-Ping Shi,Ze-Xi Dong,Peng-Xuan Zhang,Jin-ao Duan 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.10
The binding abilities of scutellarin (Scu) andscutellarein (Scue) with bovine serum albumin (BSA) wereinvestigated using equilibrium dialysis, high performanceliquid chromatography, fluorescence spectroscopy, competitivesite marker and molecular docking. The resultsshowed that the average protein binding ratios of Scu andScue with BSA were (79.85 ± 1.83) and (85.49 ± 1.21) %respectively. Under simulated physiological conditions, thefluorescence data indicated that Scu and Scue bound withBSA through a static mechanism. The thermodynamicparameters indicated that the interactions of Scu-BSA andScue-BSA mainly occurred by van der Waals forces andhydrogen bonds and it was easier for Scue to bind withBSA than Scu, indicating that the glucuronic acid moleculein Scu decreased the binding affinity. Site competitivemarker experiments showed that the binding sites of Scuand Scue mainly located within the sub-domain IIA ofBSA. Furthermore, molecular docking studies indicatedthat one BSA could bind three Scue, while one BSA couldcarry only two Scu. All these results clearly indicated theinteractions of Scu and Scue with BSA, which will lay thefoundation for further research to determine the pharmacologyand pharmacodynamics of Scu and Scue for treatingischemic cerebrovascular disease.
Jia-An Zhang,Nian-Fa Yang,Li-Wen Yang,Shi Wu,Ye-Hui Chen,Jin Zhang 한국고분자학회 2013 Macromolecular Research Vol.21 No.6
Three new chiral bisacylphosphine oxides, (-)-bis(menthylformyl)phenylphosphine oxide (1a), (+)-bis(2,4,6-trimethylbenzoyl)menthylphosphine oxide (2a), and (-)-bis(menthylformyl)menthylphosphine oxide (3a),were synthesized using menthol as a chiral source. The synthesized new chiral bisacylphosphine oxides were used as photoinitiators for the polymerization of 1-phenyldibenzosuberyl methacrylate (PDBSMA). The polymerization initiated by chiral bisacylphosphine oxides under UV light irradiation is helix-sense-selective. Among the three prepared chiral bisacylphosphine oxides, the helix-sense-selectivity of bis(menthylformyl)menthylphosphine oxide is highest. The highest specific rotation of poly(1-phenyldibenzosuberyl methacrylate) at 365 nm is +416. The feed molar ratio of monomer to chiral bisacylphosphine oxide and the polymerization temperature have an influence on the helix-sense-selectivity. The lower the feed molar ratio of monomer to chiral bisacylphosphine oxide, the better the helix-sense-selectivity is. The increase of polymerization temperature is propitious to increase the helix-senseselectivity of the photopolymerization.
Zhong Yong Chen,Bao Nian Wan,Yuejiang Shi 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.2
The trapping of runaway electrons into local magnetic mirrors in a toroidal magnetic field has been observed in slide away discharges in the HT-7 tokamak. When the discharges went into the slide-away region with Parail-Pogutse instabilities, strong oscillations in the hard X-ray flux and in the electron cyclotron emission are observed. The runaway electrons are trapped into the local magnetic mirrors when they are pitch angle scattered by the anomalous Doppler resonance effect.
Roles of Signaling Pathways in the Epithelial-Mesenchymal Transition in Cancer
Liu, Xia,Yun, Fen,Shi, Lin,Li, Zhe-Hai,Luo, Nian-Rong,Jia, Yong-Feng Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15
The epithelial-mesenchymal transition (EMT) is a cellular process though which an epithelial phenotype can be converted into a phenotype of mesenchymal cells. Under physiological conditions EMT is important for embryogenesis, organ development, wound repair and tissue remodeling. However, EMT may also be activated under pathologic conditions, especially in carcinogenesis and metastatic progression. Major signaling pathways involved in EMT include transforming growth factor ${\beta}(TGF-{\beta})$, Wnt, Notch, Hedgehog and other signaling pathways. These pathways are related to several transcription factors, including Twist, Smads and zinc finger proteins snail and slug. These interact with each other to provide crosstalk between the relevant signaling pathways. This review lays emphasis on studying the relationship between EMT and signaling pathways in carcinogenesis and metastatic progression.