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        Fabrication of porous polymer microparticles with tunable pore size and density through the combination of phase separation and emulsion-solvent evaporation approach

        Liu, Shanqin,Cai, Mingle,Deng, Renhua,Wang, Jianying,Liang, Ruijing,Zhu, Jintao 한국유변학회 2014 Korea-Australia rheology journal Vol.26 No.1

        A facile and versatile route to prepare porous polymer microparticles with tunable pore size and density through the combination of phase separation and emulsion-solvent evaporation method is demonstrated. When volatile organic solvent (e.g., chloroform) diffuses through the aqueous phase containing poly(vinyl alcohol) (PVA) and evaporates, n-hexadecane (HD) and polystyrene (PS) in oil-in-water emulsion droplets occur to phase separate due to the incompatibility between PS and HD, ultimately yielding microparticles with porous structures. Interestingly, density of the pores (pore number) on the shell of microparticles can be tailored from one to hundreds by simply varying the HD concentration and/or the rate of solvent evaporation. Moreover, this versatile approach for preparing porous microparticles with tunable pore size and density can be applied to other types of hydrophobic polymers, organic solvents, and alkanes, which will find potential applications in the fields of pharmaceutical, catalyst carrier, separation, and diagnostics.

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        Effects of Acupuncture and Qigong Meditation on Non-motor Symptoms of Parkinson’s Disease

        Jaejong Kim,Ki Heang Cho,So jung An,Shanqin Cui,Sun Wook Kim,Joseph Suh,Young Lee 대한침구의학회 2020 대한침구의학회지 Vol.37 No.4

        Background: Parkinson's disease(PD) affects not only motor symptoms, but also non motor symptoms. This study is a clinical trial to determine whether Qigong and acupuncture affect non-motor symptoms of PD. Methods: A 2-arm parallel and randomized trial was performed with 21 participants who had received either Qigong meditation only [control group (CG)] or acupuncture and Qigong meditation [experimental group (EG)]. The participants' levels of the discomfort in nonmotor symptoms from Parkinson's disease were evaluated by using the Unified Parkinson's Disease Rating Scales (UPDRS 1) and Test of Smell Identification (TSI) before and after 12 treatments at baseline and 1 month after 12 treatments. Results: The both CG and EG showed improvements in the UPDRS1 score after treatment by 5.6 ± 5.15 (p=0.003; 74%) and 4.8 ± 3.80 (p = 0.004; 79%), respectively. The both CG and the EG both did improvements in the TSI after treatment by 10.3 ± 4.37 (p < 0.001; 84%) and 12.6 ± 1.77 (p = 0.022; 100%), respectively. However, statistical differences were not observed between the CG and the EG using the UPDRS 1 and the TSI scores. Conclusion: The combination of Qigong and acupuncture and qigong alone was shown to improve nonmotor symptoms and olfactory function of PD. In the future, large-scale clinical studies on alternative treatment for PD and studies on mechanisms affecting non-motor symptoms of acupuncture and qigong are needed.

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