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4 Cases of circumscribed acral hypokeratosis
( Sewon Jung ),( Wooseok Jeong ),( Seunghyun Moon ),( Taekgeun Lee ),( Hyun Hwangbo ),( Sookkyung Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Circumscribed acral hypokeratosis (CAH) is a rare disorder characterized by a well-circumscribed and erythematous depressed patch on the palm or sole. Clinically, patches of depressed skin are seen most commonly on the thenar or hypothenar areas in middle-aged or elderly. Although the pathogenesis of CAH is not well established, trauma is uncommonly cited as a precipitating factor. Recent reports suggest that CAH may be caused by human papilloma virus (HPV). Histologically, it has a characteristic stair-like configuration between normal and involved skin with an abrupt thinning of the horny layer and a decreased granular layer, giving the clinical appearance of a punched-out lesion. The lack of epidermal atypia or cornoid lamellae clearly differentiates CAH from its clinical mimics, Bowen disease and porokeratosis. All lesions reported to date show benign biological behavior. We report four cases of circumscribed acral hypokeratosis occurring in old female with results from microscpic analysis, HPV testing and treatment.