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        혈우병(Hemophilia A)환자의 마취관리

        이상률,김경헌,승익상 대한마취과학회 1991 Korean Journal of Anesthesiology Vol.24 No.3

        Numerous advances have been applied for the management of hemophiliac patients and the life expectancy of them was markedly improved. But they have many problems yet such as transmission of infections, adverse reactions to plasma products, development of factor VIII inhibitor and inadequate coagulation in the medical and/or surgical treatment. Anesthetic care should be managed with gentle, atraumatic intubation and careful positioning of patient pointing to the prevention of bleeding from hemorrhagic diathesis. We present a case of hemophilia A who had in operation for olecranon fracture of left ulna. It is important that anesthesiologist should realize that certain pathophysiological changes, especially coagulation disorders, might be occurred during surgical procedures and that perioperative preparation and management for them should be kept well.

      • KCI등재

        동해 극전선역의 영양염류 순환과정 4 . Clorophyll a 분포 , 신생산 및 질산염의 수직확산

        문창호(Chang Ho Moon),양성렬(Sung Ryull Yang),조현진(Hyun Jin Cho),이승용(Seung Yong Lee),김석윤(Seok Yun Kim) 한국수산과학회 1998 한국수산과학회지 Vol.31 No.2

        A study on the biological and chemical characteristics in the middle last Sea of Korea was carried out at 31 stations in October 11∼18, 1995 on board the R/V Tam-yang. The chlorophyll a concentration, new and regenerated production, and the vertical diffusion of nitrate from the thermocline structure were investigated. From the vertical distribution of chlorophyll a, subsurface maxima were observed near the thermocline at most stations including the frontal zone, except at the southern stations where the maximum chlorophyll a concentration occurred at the surface. The nanophytoplankton was the most dominant fraction comprising 83.5% of total phytoplankton cell numbers, but netphytoplankton were common at the southern stations where the dominant species were Rhizosolenia sp. Nitrogenous new production and regenerated productions were measured using the stable isotope (15)^N nitrate and ammonia uptake method. The vertically integrated nitrogen production varied between 8.410 and 72.945 ㎎ N m^(-2) d^(-1), The f-ratio, which is the fraction of new production from primary production, waried between 0.03 and 0.72, indicating that 3% to 72% of primary production was Supported by the input of nutrients from below the euphotic zone and the rest are supported by ammonia recycled within the euphotic layer. This range of f-ratio encompasses from extremely oligotrophic to eutrophic area characteristics, The differences in productivity and f-ratio among stations were related to frontal structure and the bottom topography. The values were high near the frontal ions and low outside of it, and the station near Ulleng Island showed the highest f-ratio. Vertical diffusion coefficients were calculated from both the water column stability (Kz-1) of King and Devol`s equation (1979) and new nitrogen requirement (Kz-2), The values of Kz-2 (0.11∼0.55 ㎠/s) were relatively low compared to the valutas reported prewiously.

      • SCISCIESCOPUS

        Highly sensitive and selective isoprene sensing performance of ZnO quantum dots for a breath analyzer

        Park, Yunji,Yoo, Ran,Park, Seung ryull,Lee, Jun Ho,Jung, Hwaebong,Lee, Hyun-Sook,Lee, Wooyoung Elsevier 2019 Sensors and actuators. B Chemical Vol.290 No.-

        <P><B>Abstract</B></P> <P>We report the quantum-size effect on the sensing properties of ZnO nanoparticles for the detection of isoprene. For this purpose, two types of ZnO particles with different sizes, including nanoparticles (NPs, ˜25 nm) and quantum dots (QDs, ˜5 nm), were prepared by a wet chemical method. The ZnO QDs exhibited excellent sensing performance to 1 ppm isoprene compared to NPs. The maximum sensing response and response time were ˜42 and 8 s at 350 °C for the QDs, while ˜5.6 and 40 s at 500 °C for the NPs, respectively. The higher sensing response, rapid response, and lower optimal working temperature of the ZnO QDs can be attributed to an increase in oxygen vacancies, band gap, and specific surface area owing to the small size effect. Both ZnO NPs and QDs showed the lower limit of 0.01 ppm for detecting isoprene. It is noted that the sensing properties of ZnO QDs to 1 ppm isoprene are superior to previously reported isoprene sensors that are based on semiconducting metal oxides. Furthermore, we demonstrated that the low concentration (0.4–6.2 ppm) of isoprene can be selectively detected within ˜83 s using a recently developed miniaturized gas chromatography integrated with the ZnO QD sensor.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We report the size effect on the sensing properties of ZnO for isoprene detection. </LI> <LI> The ZnO nanoparticles and quantum dots were prepared by a wet-chemical method. </LI> <LI> The ZnO quantum dots exhibited enhanced sensing performance to 1 ppm isoprene. </LI> <LI> The higher sensing performance was explained by the quantum size effect. </LI> <LI> Isoprene could be selectively detected using a miniaturized gas chromatography. </LI> </UL> </P>

      • KCI등재

        사양중심의 터널 설계 사례 연구를 통한 성능기반 터널 설계 방안에 관한 고찰

        허진석,김승렬,황제돈,서영욱,정명근,Hur, Jin-Suk,Kim, Seung-Ryull,Hwang, Je-Don,Seo, Young-Wook,Jung, Myung-Keun 한국터널지하공간학회 2013 한국터널지하공간학회논문집 Vol.15 No.4

        성능설계는 건축과 토목분야의 구조물 설계에 대한 키워드로 떠오르고 있는 실정이다. 본 논문에서는 기존의 사양설계로 설계되어 시공 중이던 개착식 터널 구조물의 변형 사례에 대한 사례 연구를 통하여 터널에 대한 성능설계의 필요성을 고찰하고 있다. 이와 더불어 터널의 성능을 세분화하는 방법론을 소개함으로써 성능 기반 설계법 도입에 따른 현장 실무자의 이해를 돕고자 하였다. 해당 사례 연구는 전형적인 지반공학적 역해석 문제로, 상세한 지반조사, 시공 이력 분석 및 수치해석적 방법 등 다각적인 접근으로 변형의 원인을 규명하였으며 시공성 및 경제성을 만족하면서 소정의 성능 확보가 가능한 대책을 제안하였다. Performance-based design is becoming a key word for structure design in architectural and civil engineering spheres. In this paper, the need of the performance-based design, especially for tunnels, was enhanced by case study on the largely deformed cut-and-cover arch tunnel built by the prescribed design. In addition, this paper introduces effective method of subdivision on tunnel performance to help field engineer's comprehension. Case study dealing with the issue of typical backwards problem in geotechnical engineering was examined. First of all, the outline of the damaged culvert as well as the surrounding embankment is in detail described. The background, together with the cause of damage, is discussed based on the results of site investigation. Secondly, it was attempted to elucidate the deformation mechanism of the embankment by means of numerical analysis, and the countermeasures are proposed. Finally, the stability of the embankment with the countermeasures was evaluated.

      • Primary chemotherapy for newly diagnosed nonsmall cell lung cancer patients with synchronous brain metastases compared with whole-brain radiotherapy administered first : Result of a randomized pilot study

        Lee, Dae Ho,Han, Ji-Youn,Kim, Heung Tae,Yoon, Sung Jin,Pyo, Hong Ryull,Cho, Kwan Ho,Shin, Sang-Hoon,Yoo, Heon,Lee, Seung-Hoon,Lee, Jin Soo Wiley Subscription Services, Inc., A Wiley Company 2008 Cancer Vol.113 No.1

        <B>BACKGROUND.</B><P>This randomized pilot trial investigated whether primary chemotherapy was feasible in terms of efficacy, survival, toxicity profile, and quality of life compared with whole-brain radiotherapy (WBRT) given first in chemotherapy-naive patients nonsmall cell lung cancer (NSCLC) with synchronous brain metastasis when neurologic symptoms or signs are absent or controlled by supportive care.</P><B>METHODS.</B><P>After stratification by Eastern Cooperative Oncology Group performance status (ECOG PS) (0–1 vs 2), the number of intracranial metastases (<3 vs 3≤), and the presence of extrathoracic extracranial metastasis, eligible patients were randomized to the primary chemotherapy arm or the WBRT-first arm. World Health Organization (WHO) response criteria, National Cancer Institute Common Toxicity Criteria (NCI-CTC; version 2.0), and the European Organization for Research and Treatment of Cancer (EORTC) C-30/LC-13 questionnaire were used.</P><B>RESULTS.</B><P>A total of 48 patients were enrolled between August 2002 and November 2005. The response rate of chemotherapy and survival outcomes in the primary chemotherapy arm were not statistically different from those in the WBRT-first arm (overall response rate, 28.0% vs 39.1%; progression-free survival, 3.6 months vs 4.4 months; overall survival, 9.1 months vs 9.9 months). There was close correlation noted between intracranial and extracranial tumor responses (k = 0.82). However, in the WBRT-first arm, grade 3 of 4 neutropenia was more frequent (79% vs 40%) during chemotherapy and 4 patients (17.4%) did not receive further chemotherapy because of early death or poor performance after WBRT. Cognitive function appeared to deteriorate during primary chemotherapy, but was also found to deteriorate after WBRT.</P><B>CONCLUSIONS.</B><P>Primary chemotherapy is more feasible and can be an appropriate option for patients with synchronous brain metastasis when neurologic symptoms or signs are absent or controlled. The role and timing of WBRT should be defined in further studies in this clinical setting. Cancer 2008. © 2008 American Cancer Society.</P>

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