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Sergey Nikolaevich Novikov(Sergey Nikolaevich Novikov ),Irina Aleksandrovna Baldueva(Irina Aleksandrovna Baldueva ),Anton Yurievich Zozulya(Anton Yurievich Zozulya ),Natalya Viktorovna Emelyanova(Nata 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.1
Purpose: To perform the analysis of the peripheral blood lymphocyte changes after stereotactic ablative radiotherapy (SABR) in patients with oligometastatic cancers. Materials and Methods: The dynamics of the immune status in peripheral blood was prospectively evaluated in 46 patients with lung (17 cases) or liver (29 cases) metastases treated by SABR. Flow cytometry of peripheral blood lymphocyte subpopulations was performed before SABR, 3–4 weeks and 6–8 weeks after the end of SABR: 3 fractions of 15–20 Gy or 4 fractions of 13.5 Gy. The number of treated lesions varied from 1 (32 patients) to 2–3 (14 patients). Results: SABR induced a significant increase of T-lymphocytes (CD3+CD19–) (p = 0.001), T-helper (CD3+CD4+) (p = 0.004), activated cytotoxic T-lymphocytes (CD3+CD8+HLA-DR+) (p = 0.001), activated T-helpers (CD3+CD4+HLA-DR+) (p < 0.001). A significant decrease of T-regulated immune suppressive lymphocytes (CD4+CD25brightCD127low) (p = 0.002) and NKT-cells (CD3+CD16+CD56+) (p = 0.007) was recorded after the SABR. The comparative analysis demonstrated that lower doses of SABR (EQD2Gy(α/β=10) = 93.7–105.7 Gy) induced significant increase of T-lymphocytes, activated cytotoxic T-lymphocytes, and activated CD4+CD25+ T-helpers, while SABR with higher doses (EQD2Gy(α/β=10) = 150 Gy) was not associated with these effects. A more efficient activations of T-lymphocytes (p = 0.010), activated T-helpers (p < 0.001), and cytotoxic T-lymphocytes (p = 0.003) were associated with SABR to a single lesion. A significant increase of T-lymphocytes (p = 0.002), T-helpers (p = 0.003), and activated cytotoxic T-lymphocytes (p = 0.001) was observed after SABR for hepatic metastases in contrast to SABR for lung lesions. Conclusion: Changes in peripheral blood lymphocytes after SABR could be influenced by the location or the number of irradiated metastasis, and the dose of SABR.
Sergey Nikolaevich Novikov,Pavel Ivanovich Krzhivitskii,Yulia Sergeevna Melnik,Alina Albertovna Valitova,Zhanna Viktorovna Bryantseva,Irina Alexandrovna Akulova,Sergey Vasilevich Kanaev 대한방사선종양학회 2021 Radiation Oncology Journal Vol.39 No.1
Purpose: To determine the localization of sentinel lymph nodes (SLNs) in a large cohort of patients with breast cancer and validate the European Society for Therapeutic Radiology and Oncology (ESTRO), Radiation Therapy Oncology Group (RTOG), and Radiotherapy Comparative Effectiveness (RADCOMP) guidelines on regional lymph node clinical target volume (CTV-LN) delineation. Materials and Methods: A total of 254 women with cT1-3N0-1M0 breast cancer underwent single-photon emission computed tomography (SPECT-CT) visualization of SLNs after intra- and peritumoral injection of 99mTc-radiocolloids. All SPECT-CT images were fused with reference simulation computed tomography. A 3D atlas of SLNs was created and used for evaluation of CTV-LN defined by contouring guidelines. Results: SPECT-CT visualized 532 SLNs that were localized in axillary level I in 67.5%, level II in 15.4%, level III in 7.3%, internal mammary in 8.5%, and supraclavicular in 1.3% cases. The majority of level II–IV and internal mammary SLNs were inside the recommended CTV-LN. Axillary level I SLNs were covered by ESTRO and RTOG contours in 85% and 85% cases, respectively. “Out of contours” SLNs were mostly detected in lateral subgroup of level I LN (18.5%), while 98%–99% of anterior pectoral and central axillary SLNs were covered by CTV-LN. Internal mammary SLNs were visualized in 33 cases and were outside ESTRO and RTOG contours in 3 and 6 observations, respectively. Conclusion: SPECT-CT atlas of SLNs demonstrated that in most cases ESTRO and RTOG guidelines correctly represented CTV-LNs with the exception of lateral subgroup of SLNs.
Sergey Nikolaevich Novikov,Pavel Ivanovich Krzhivitskii,Zamira Achmedovna Radgabova,Maxim Andreevitch Kotov,Mikhail Markovich Girshovich,Anna Sergeevna Artemyeva,Yulia Sergeevna Melnik,Sergey Vasilevi 대한방사선종양학회 2021 Radiation Oncology Journal Vol.39 No.3
Purpose: To evaluate correlation of single photon emission computed tomography-computed tomography (SPECT-CT) data on lymph flow (LF) from oral tongue cancer (OC) and the topography of lymph nodes (LN) metastases; to determine the clinical value of lymph flow guided radiotherapy (LFGRT). Materials and Methods: SPECT-CT visualization of LF from the OC lesions was performed after peritumoral injection of 99mTc-phytate in 26 primary patients with clinical stage cT1-2N0M0 disease. We determined the individual drainage (unilateral/bilateral) from the tumor, and localization of sentinel LNs according to the neck levels. Metastases in LNs were verified with histology and a 2-year follow-up. Results: SPECT-CT detected bilateral LF in 10 (38.5%) of 26 patients; in 16 (61.5%) cases the drainage was unilateral. Histology revealed LNs metastases in three cases; regional recurrences were diagnosed in other four patients. In all seven observations metastases were located at the same site and level as the sentinel LNs. In eight (30.8%) of 26 patients sentinel LNs were visualized unilaterally at levels Ib-IIa; in five cases, unilaterally at levels I-IIa-III. In these patients, LFGRT demonstrated 59%-70% reduction of irradiated volume, and 26%-42% and 51%-70% decrease of the mean dose to the spinal cord and the contralateral parotid gland. In patients with a bilateral drainage the reduction of doses absorbed by the spinal cord and contralateral parotid gland was 19% and 6%, respectively. Conclusion: Localization of sentinel LNs determined by SPECT-CT corresponds to the localization of metastatic LNs in terms of side and levels.
Effect of Water Adsorbed by Nano-relief of Si (100) Surface
Sergey Novikov,Sergey Timoshenkov,Natalia Korobova 한국정보통신학회 2014 2016 INTERNATIONAL CONFERENCE Vol.6 No.1
Effect of water adsorbed by nano-relief solid surfaces on their emission properties has been investigated by the methods of tunneling microscopy and electron work function measurements. Using samples of oxidized aluminum-foil and doped single-crystal silicon Si (100) was shown that coherent metastable clusters of water adsorbed by nano-relief samples at the transition to the stable state of molecular water emitted energy in the form of dipole-dipole radiation (Dicke super radiation). Observed phenomena of photoluminescence (electron emission), bioluminescence (Biophotons radiation) are the bright manifestation of Dicke super radiation in various conditions.
Sergey V. Gnedenkov,Denis P. Opra,Sergey L. Sinebryukhov,Alexander K. Tsvetnikov,Alexander Y. Ustinov,Valentin I. Sergienko 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.3
Electrochemical energy production has been extensively used in large scale applications. At present,organic compounds are considered as efficient and environmentally friendly electrode materials. Thepaper describes the study of the possibility of using hydrolysis lignin as the lithium battery cathodematerial. Hydrolysis lignin features have been investigated by the impedance spectroscopy, scanningelectron microscopy, and energy-dispersive X-ray spectroscopy. The discharge performance ofhydrolysis lignin-based lithium battery was investigated at room temperature using 1 M LiBF4 in gbutyrolactonelectrolyte system. It was found that the specific capacity of hydrolysis lignin was equal to450 mAh g1 at a discharge current density of 25 mA/cm2. Two main voltage plateaus located at ~1.8 and~1.1 V were observed. The chemical composition of cathode materials upon battery discharge down to0.9 V was studied by the X-ray photoelectron spectroscopy and infrared spectroscopy. The suggestionson possible electrochemical reactions occurring in the lithium/hydrolysis lignin system were made onthe basis of the products composition analysis. The results demonstrate the potential of hydrolysis ligninbased batteries to be used as low-rate power sources.
Natural vibrations and hydroelastic stability of laminated composite circular cylindrical shells
Sergey A. Bochkareva,Sergey V. Lekomtsev 국제구조공학회 2022 Structural Engineering and Mechanics, An Int'l Jou Vol.81 No.6
This paper studies the dynamic behavior of laminated composite circular cylindrical shells interacting with a fluid. The mathematical formulation of the dynamic problem for an elastic body is developed based on the variational principle of virtual displacements and the relations of linear elasticity theory. The behavior of an ideal compressible fluid is described by the potential theory, the equations of which together with boundary conditions are transformed to a weak form. The hydrodynamic pressure exerted by the fluid on the internal surface of the shell is calculated according to the linearized Bernoulli equation. The numerical implementation of the mathematical formulation has been done using the semi-analytical finite element method. The influence of the ply angle and lay-up configurations of laminated composites on the natural vibration frequencies and the hydroelastic stability boundary have been analyzed for shells with different geometrical dimensions and under different kinematic boundary conditions set at their edges. It has been found that the optimal value of the ply angle depends on the level of filling of the shell with a fluid. The obtained results support the view that by choosing the optimal configuration of the layered composite material it is possible to change upwards or downwards the frequency and mode shape, as well as the critical velocity for stability loss over a wide range.
Influence of a soft FGM interlayer on contact stresses under a beam on an elastic foundation
Sergey M. Aizikovich,Boris I. Mitrin,Nikolai M. Seleznev,Yun-Che Wang,Sergey S. Volkov 국제구조공학회 2016 Structural Engineering and Mechanics, An Int'l Jou Vol.58 No.4
Contact interaction of a beam (flexible element) with an elastic half-plane is considered, when a soft inhomogeneous (functionally graded) interlayer is present between them. The beam is bent under the action of a distributed load applied to the surface and a reaction of the elastic interlayer and the half-space. Solution of the contact problem is obtained for different values of thickness and parameters of inhomogeneity of the layer. The interlayer is assumed to be significantly softer than the underlying halfplane; case of 100 times difference in Young’s moduli is considered as an example. The influence of the interlayer thickness and gradient of elastic properties on the distribution of the contact stresses under the beam is studied.
Sergey Mikhailovich Slepchenko,Sergey Vladimirovich Bugmyrin,Andrew Igorevich Kozlov,Galina Grigorievna Vershubskay,Dong Hoon Shin 대한기생충학열대의학회 2019 The Korean Journal of Parasitology Vol.57 No.6
The aim of this parasitological study is examining contemporary (the late 20th century) specimens of the arctic or subarctic areas in Western Siberia and comparing them with the information acquired from archaeological samples from the same area. In the contemporary specimens, we observed the parasite eggs of 3 different species: Opisthochis felineus, Ascaris lumbricoides, and Enterobius vermicularis. Meanwhile, in archaeoparasitological results of Vesakoyakha, Kikki-Akki, and Nyamboyto I burial grounds, the eggs of Diphyllobothrium and Taenia spp. were found while no nematode (soil-transmitted) eggs were observed in the same samples. In this study, we concluded helminth infection pattern among the arctic and subarctic peoples of Western Siberia throughout history as follows: the raw fish-eating tradition did not un-dergo radical change in the area at least since the 18th century; and A. lumbricoides or E. vermicularis did not infect the inhabitants of this area before 20th century. With respect to the Western Siberia, we caught glimpse of the parasite infection pattern prevalent therein via investigations on contemporary and archaeoparasitological specimens.