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Myrthala Juárez-Treviño,Antonio Costilla Esquivel,Lilia Marytza Leal Isida,Dionicio Ángel Galarza Delgado,Manuel E. de la O Cavazos,Lourdes Garza Ocañas,Rosalinda Sepúlveda Sepúlveda 대한정신약물학회 2019 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.17 No.1
Objective: This study was conducted to compare the efficacy of clozapine vs. risperidone in the treatment of aggression in conduct disorder in children and adolescents. Methods: Twenty-four children with conduct disorder aged 6 to 16 years were randomized in a prospective, double- blind trial into two groups to receive clozapine or risperidone for 16 weeks. The Modified Overt Aggression Scale score was used as the primary outcome of the study. Secondary outcomes were Child Behavior Checklist (CBCL) externalization (CBCL-E) and internalization factors; Aggression, Hyperactivity and Delinquency subscales of CBCL-E, Child Global Assessment Scale (CGAS), Barnes Akathisia Rating Scale, and Simpson-Angus Scale. Results: Both antipsychotics were similarly effective in the primary outcome and in most of the secondary ones. Clozapine was more effective in CBCL-E, the delinquency subscale and the CGAS scores than risperidone (p =0.039, 0.010, and 0.021). Two subjects from the clozapine group were excluded due to a low neutrophil count at week four. Conclusion: Clozapine and risperidone are effective for short-term treatment of aggression in children and adolescents with conduct disorder. Clozapine was more effective than risperidone in conduct externalization factors, delinquency trait and global functioning in children and adolescents. Stronger efficacy of clozapine should be investigated in larger sample sizes using pharmacogenomic studies. White blood cell counts need to be monitored when prescribing clozapine.
Corona R.M.,Castillo-Sepúlveda S.,Altbir D,Escrig J. 한국물리학회 2021 Current Applied Physics Vol.21 No.-
Vortex domain walls (DWs) are characterized by their chirality, an important property that needs to be controlled for the use of such walls in potential technological applications. In this work we explore a wire-ring structure in which we have alternate hard and soft magnetic materials. Our results evidence that, depending on the materials, it is possible to control the DW chirality when it goes through the ring section. Therefore, this system can be used as a device that controls domain wall chirality.
Asynchronies during invasive mechanical ventilation: narrative review and update
Saavedra Santiago Nicolás,Barisich Patrick Valentino Sepúlveda,Maldonado José Benito Parra,Lumini Romina Belén,Gómez-González Alberto,Gallardo Adrián 대한중환자의학회 2022 Acute and Critical Care Vol.37 No.4
Invasive mechanical ventilation is a frequent therapy in critically ill patients in critical care units. To achieve favorable outcomes, patient and ventilator interaction must be adequate. However, many clinical situations could attempt against this principle and generate a mismatch between these two actors. These asynchronies can lead the patient to worst outcomes; because of that is vital to recognize and treat these entities as soon as possible. Early detection and recognition of the different asynchronies could favor the reduction of the days of mechanical ventilation, the days of hospital stay, and in intensive care and improve clinical results.
Multicriteria-Based Computer-Aided Pronunciation Quality Evaluation of Sentences
Néstor Becerra Yoma,Leopoldo Benavides Berrios,Jorge Wuth Sepúlveda,Hiram Vivanco Torres 한국전자통신연구원 2013 ETRI Journal Vol.35 No.1
The problem of the sentence-based pronunciation evaluation task is defined in the context of subjective criteria. Three subjective criteria (that is, the minimum subjective word score, the mean subjective word score, and first impression) are proposed and modeled with the combination of word-based assessment. Then, the subjective criteria are approximated with objective sentence pronunciation scores obtained with the combination of word-based metrics. No a priori studies of common mistakes are required, and class-based language models are used to incorporate incorrect and correct pronunciations. Incorrect pronunciations are automatically incorporated by making use of a competitive lexicon and the phonetic rules of students’ mother and target languages. This procedure is applicable to any second language learning context, and subjective-objective sentence score correlations greater than or equal to 0.5 can be achieved when the proposed sentence-based pronunciation criteria are approximated with combinations of word-based scores. Finally, the subjective-objective sentence score correlations reported here are very comparable with those published elsewhere resulting from methods that require a priori studies of pronunciation errors.
( Yo-sep Hwang ),( Seok Jin Bang ),( Tae Yun Kang ),( Jae Hyeok Choi ),( Sang Mok Jung ),( In Sung Kang ),( Se Young Jeon ),( Kwan Ha Park ),( Sanghoon Choi ) 한국어병학회 2019 한국어병학회지 Vol.32 No.1
The study investigated the dietary effects of medicinal herbs extract and multiple probiotics mixture on the growth performance, innate immune response and antibacterial activity of nile tilapia Oreochromis niloticus. Tilapia were divided in four groups. The first is a fish group fed a basal diet added with 40% medicinal herbs extract (MHE). The second is a fish group fed a basal diet supplied with 2×10<sup>8</sup> CFU/g of 2 Bacillus sp, 2 Lactobacillus sp and 2 Yeast sp, respectively (PB). The third group was fed with a mixture of probiotics (2 Bacillus sp, 2 Lactobacillus sp and 2 Yeast sp) with the medicinal herbs extract added in basal diet (MHE+PB). The fourth group was fed only a basal diet (C). In a non-specific immune parameters analysis, respiratory burst activity, lysozyme activity, phagocytic activity (PA), alternative complement pathway activity (ACH<sub>50</sub>) and superoxide dismutase (SOD) activity were significantly (p<0.05) increased in the group MHE+PB compared to other groups. Both PB and MHE groups showed a significant (p<0.05) increase in respiratory burst activity, lysozyme activity compared to the control C group, whereas no significant differences were observed in PA, ACH<sub>50</sub> and SOD activity compared to the control group. In challenging test, fish were administered with Edwardsiella tarda (E. tarda) on 30 days after feeding with each experimental diet and viable E. tarda cell reduction was checked over 21 days post injection. MHE+PB group showed a significantly (p< 0.05) reduced E. tarda cells compared to other groups. No significant antibacterial difference (p >0.05) was observed between PB and MHE only treated group. Compared to the control, a significant antibacterial difference (p< 0.05) appeared in PB but not in MHE (p >0.05). The results suggest that the probiotics and MHE mixture could be utilized as an alternative to antibiotics in the control of fish diseases caused by E. tarda.
Growth and Quality of Soybean Sprouts Affected by Chitosan Treatment and Watering Time
( Yo Sep Kim ),( Na Young Park ),( Hong Kyoon No ) 한국키틴키토산학회 2014 한국키틴키토산학회지 Vol.19 No.3
The effects of chitosan concentrations (0.05 and 0.1%) and watering times (1 and 5 min/every 20 min) on growth and selected quality of soybean sprouts were evaluated. In chitosan concentration studies, soaking of soybeans in 0.05% chitosan solution was more effective in increasing total weight of soybean sprouts than soaking in 0.1% chitosan solution. In chitosan treatment and watering time studies, soybeans were soaked in water (W) or 0.05% chitosan solution (CH) for 8 h and then cultivated by spraying water for 1 min (W-1 and CH-1) or 5 min (W-5 and CH-5) for 3 days at 20±2oC. Increase in watering time from 1 min to 5 min increased total weight of soybean sprouts (W-1 vs. W-5 and CH-1 vs. CH-5). At the same watering time, chitosan treatment was more effective in increasing total weight than water treatment (W-1 vs. CH-1 and W-5 vs. CH-5). No significant differences in hardness, mineral content, and DPPH radical scavenging activity were observed among four treatment groups. However, the moisture content increased with increasing watering time. Total free amino acid contents of W-5, CH-1, and CH-5soybean sprouts were all comparable, but higher than that of W-1 soybean sprouts. Increased shelf life of CH-5 soybean sprouts, compared with W-5, was not observed during storage at 10°C for 21 days.