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화학방사선 요법이 치아발육에 미치는 영향에 관한 증례보고
백병주,양정숙,김영신,김재곤,이성영 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.2
하악 좌측부위의 횡문근육종으로 2년동안의 화학요법과 6주간의 방사선요법으로 치료를 받았고, 이에 따른 후유증으로 치아의 발육장애를 동반한 8세 환아에 대해, 임상적, 방사선학적으로 관찰을 시행하고, 치료한 결과 다음을 보고하는 바이다. 1. 구강내 소견으로서 맹출한 영구치의 경미한 법랑질 형성부전과 치아우식이 관찰되었으며, 하악 좌측부위의 미맹출된 제 1 대구치로 인해 수직고경이 상실되어 과개교합이 형성되었다. 2. 방사선학적으로 맹출한 영구치의 치근은 짧은 치근에서부터 무형성증에 이르기까지 다양한 치근으 발육장애를 보였으며, 미맹출 상태인 제 2 소구치와 제 2 대구치는 왜소치나 형성부전의 소견을 보였다. 3. 치료는 보존치료 및 저석회화 소견을 보이는 영구치를 위해 불소도포를 시행하였고, 향후 적절한 수직고경의 회복과 심미적 개선을 위한 포괄적인 보철치료가 수행되어야 할 것으로 사료된다. Chemoradiation therapy used on pediatric oncology patients often causes dental developmental anomalies that affect future dental care. Defects noted include tooth and root agenesis, root thining and shortening, and localized enamel defects. The effect of radiotherapy usually are confined to the radiation site, but the effects of chemotherapy may be more wide spread because of its systemic distribution and structures and organs unrelated to the primary tumor may be affected. Many pediatric cancers are treated with a combination of radiation and multiagent chemotherapy to create synergic and additive effects. Dental treatment affected by chemoradiation damage to developing teeth includes orthodontic tooth movement, prosthetic abutment considerations, periodontal health, space maintenance, requirements for home fluoride regimens to protect hypomineralized areas, restoration options for hypoplastic/hypomineralized teeth, and endodonitc procedures. The following case demonstrate chemoradiation therapy effects on the dental development.
양식장 배출물 발효물의 어류 사료 첨가에 따른 넙치, Paralichthys olivaceus의 혈액학적 변동에 미치는 영향
강주찬,지정훈,송승엽,문상욱,강지웅,이영돈,김세재 한국어병학회 2004 한국어병학회지 Vol.17 No.1
본 연구는 우리나라 주요 양식어류인 넙치, Paralichthys olivaceus를 대상으로 육상수조식양식장 배출물 발효물의 어류 사료 첨가에 따른 혈액학적 변동에 미치는 영향을 검토하였다. 젖산균 및 효모를 사용하여 발효한 양식장 배출물의 이화학적 분석을 실시하였고, 발효물을 0.1, 0.5, 1.0 및 5.0% 농도로 8주간 투여하였다. 투여 4주째 및 8주째에 각 투여 구간별로 혈액학적 항목을 중심으로 그 차이를 확인하였다. 배출물 발효농도별 유의한 차이는 나타나지 않았지만, 분석시기에 따른 적혈구수, 혈색소 농도 및 혈색소 지수가 증가하는 경향을 나타내었으나, 주요 혈청 무기 및 유기성분은 배출 발효물 농도별로 유의한 차이는 나타나지 않았다. 또한 혈청 효소학적 조사에서는 조사시기별로 변동은 나타났지만, 동일 조시시기에서 각 구간별 유의한 차이는 나타나지 않았다. 따라서 이러한 육상 약식장 유래의 배출물 발효산물에 대한 다양한 방면의 연구가 진행되어야겠다. Effects of oral administration with fermented product from sewage in land-based seawater fish farm on haematological disturbance in the olive flounder, Paralichthys olivaceus was investigated. After 4 weeks of conditioning with a basal diet, fish were divided into 4 groups and provided experimental diet (0.1,0.5, 1.0 and 2.0%) supplement of fermented sewage for 80 days. Proximal analysis was performed for the product of sewage which was fermented by lactic acid and yeast. RBC count, hemoglobin concentration and hematocrit value were increased according to the treated periods, however, no statistical difference was observed between control and treatment groups. There were no significant difference in serum organic, inorganic compounds and enzyme activities between control and treatment groups. This study hypothesized that the supplement of fermented product from sewage in land-based seawater fish farm might be an additive sup plement for source of fish diet in view of haematological examination. Recycling of the sewage may be an economic artificial sources of diet for fish aquaculture practices.
이성희,차재순,이주연 충북대학교 한국과학재단 지정 첨단원예기술개발 연구센터 1997 연구보고서 Vol.2 No.-
고추에 있어서 전신획득저항성 및 PR 단백질 축적과의 관계를 알아보기 위하여 TMV pepper strain을 고추잎에 접종하고 4일후 고추역병균 P. capsici를 고추줄기에 접종후 역병발생량을 비교하였다. TMV를 전접종한 고추에서는 TMV를 전접종하지 않은 고추에서보다 역병발생량이 크게 감소하였는데, TMV를 전접종한 고추의 역병 발병도와 병반길이는 역병접종 10일째에 TMV를 전접종하지 않은 고추의 약 50% 수준이었다. 담배의 PR1b와 PR5a 항혈청을 이용한 immuno-blot으로 추적한 고추의 PR1 과 PR5 단백질은 TMV 접종엽과 접종상위엽에서 TMV 접종 24시간후부터 세포간극에서 동시에 검출되기 시작하였다. PR1 과 PR5 단백질은 TMV 접종엽에서는 TMV 접종 4-5일후 잎이 탈락할때까지 그 양이 크게 증가하였다. PR5는 TMV 접종상위엽에서 TMV 접종후 그 양이 크게 증가하지는 않았지만 실험종료일인 TMV 접종 20일후까지 검출되었다. 이러한 결과는 고추에서 TMV 검염에 의해 역병에 대한 전신획득저항성이 유도되며, 전신획득저항성이 유도되는 동안 매우 빠르게 고추전신에서 PR 단백질의 생산이 유도되고, 생성된 PR 단백질들이 오래동안 유지됨을 암시하고 있다. Induction of systemic acquired resistance (SAR) against phytophthora blight and PR protein accumulation by TMV in pepper plant (Capsicum annuum cv. Nockwang) were examined to understand the mechanism of systemic acquired resistance in pepper plant. The zoospore suspension of Phytophthora capsici was inoculated on stem of pepper plant on which TMV-pepper strain had been inoculated on fully expanded 3 leaves, and the amount of phytophthora blight incidence was determined with time course. Both disease severity and lesion length of phytophthora blight were much smaller in TMV pre-inoculated pepper plant than in uninoculated control plant. The amount of phytophthora blight in TMV pre-inoculated pepper was about 50% of uninoculated control plant's at 10 days after P. capsici inoculation. PR1 and PR5 protein were monitored in intercellular fluid of TMV inoculated and uninoculated upper leaves by immuno-blot with tobacco PR1b and PR5a antibody to find accumulation of PR proteins locally and systemically during induction of SAR. PR1 and PR5 were detected from 24 hours after TMV inoculation both TMV inoculated and uninoculated upper leaves, and increased rapidly in TMV inoculated leaves until th leaves were defoliated on 4-5 days after TMV inoculation. PR5 was not increased in uninoculated upper leaves as much as in TMV inoculated leaves, but it can be detected until 20 days after TMV inoculation. These results suggest that TMV infection induces SAR against phytophthora blight in pepper plant, and PR proteins is accumulated very rapidly after TMV infection systematically during induction of SAR and maintained for quite long time in pepper plant.
김영건,육은주,김성걸,임의혁,성자원,김병호,허승식,이기천,정현용,이헌영 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2
A clinical analysis was performed of 3055 pateints with peptic ulcer who were diagnosed with gastroduodenoscopy, in Hospital of Chungnam National University College of Medicine from July 1988 to May 1993. 1) During the period 1988-1993, The proportion of gastric ulcer among peptic ulcer decreased from 47.8% to 42.8%, but that of duodenal ulcer increased from 36.8% to 39.6%. 2) Of the 3055 cases, the number of patients with esophageal ulcer was 98(3.2%), with gastric ulcer 1407(41.6%), with. duodenal ulcer 1104(36.1%), with channel ulcer 149(4.9%), and with combind ulcer 297(9.7%). 3) We observed a peak incidence of peptic ulcer in the 50-69age group, gastric ulcer in the 5069age, duodenal ulcer in the 40-59age group. The ratio of male to female was 3.6 : 1 in peptic ulcer, 4.4 : 1 in gastric ulcer, 3.0 : 1 in duodenal ulcer. 4) The common site was angle in gastric ulcer, and bulb in duodenal ulcer. 5) The active stage was 39.4% of gastric ulcer, and 37.4% of duodenal ulcer, the healing stage was 34.2% of gastric ulcer, and 17.9% of duodenal ulcer, and the scar stage of gastric ulcer was 26.4%, and duodenal ulcer was 44.7%. 6) The size of ulcer was less than 1Cm in 66.7% of gastric ulcer, and in 75.5% of duodenal ulcer, the size of ulcer was greater than 2Cm in 13.2% of gastric ulcer, and in 6.5% of duodenal ulcer. 7) The frequency of multiple ulcer was 29.9% in gastric ulcer, and 16.5% in duodenal ulcer.
중력가속도의 변화에 따른 자동운반차량용 서스펜션의 진동모드에 관한 연구
주만식,김민주,이승수,최영철,추정근,김중완,전언찬 동아대학교 해양자원연구소 2000 硏究論文集 Vol.13 No.1
This study is to choose the most proper model for AGV Throughout simulation of behavior of suspension to reduce trial and error because there is no AGV treating heavy weight at harbor loading and unloading at home. Therefore, we estimate the vibration modes of the various suspensions applied to AGV, which is over 75 ton included the weight of two containers using the Matlab in the case of G and 5G, one of the simulation programs.
리네졸리드로 치료한 반코마이신 내성 Enterococcus faecium 뇌수막염 : 증례보고 및 문헌고찰
이창섭,박성주,이용철,이양근,이흥범 대한감염학회 2010 감염과 화학요법 Vol.42 No.3
Vancomycin-resistant enterococci (VRE) infection is a serious problem because optimal therapy has not been established. Different agents in various combinations, including teicoplanin, chloramphenicol, and quinupristin/dalfopristin, have been used to treat patients with VRE meningitis, but the efficacy of these agents is not satisfactory because of their limited ability to penetrate into the cerebrospinal fluid. We report a case of nosocomial vancomycin-resistant Enterococcus faecium meningitis in a patient with ventriculoperitoneal shunt that was successfully treated with linezolid. We will also review previously reported cases of vancomycinresistant E. faecium meningitis treated by linezolid.
상부소환관협착에 대한 Savary-Gilliard Dilatation의 치료효과와 안전성에 관한 관찰
정현용,육은주,임의혁,김병호,성자원,이기천,허승식,이헌영,김영건 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2
For the patient with stenosis of upper digestive tract caused by either benign or malignant process, esophageal dilatation is an important therapeutic modality. We reviewed retrospectively 39 cases treated by Savary-Gilliard dilatation for upper digestive tract stenosis, and results were follows : (1) Dysphagia was improved in 95% of the patients. (2) Eight patients(20%) sufferd perforation, five of them were managed with conservative medical measures, others were managed operatively. (3) In the cases with benign stenosis dysphagia was not noticed for 8.8 months, but with malignant stenosis dysphagia was reappeared after 2.8 months despite concomitant chemoradiotherapy. In conclusion, Savary-Gilliard dilatation was an effective measure for symptome due to upper digestive tract stenosis, but more careful attention for perforation should be necessitated. Also another therapeutic modality for treatment of malignant stenosis was inevitable.
중학교 과학 교과서 분별 증류 실험의 비교 분석 및 개선
柳五鉉,崔文永,宋周眩,권정근,白盛惠,朴國泰 한국교원대학교 과학교육연구소 2001 청람과학교육연구논총 Vol.11 No.1
이 연구의 목적은 제 6차 교육과정에 의한 중학교 1학년 과학 교과서 분별 증류 실험의 문제점을 파악하고, 중학생들이 분별 증류 실험을 능률적으로 수행할 수 있는 실험 방법을 제시하고자 하는 것이다. 이를 위한 첫 번째 단계로서 현재 사용되고 있는 8종의 과학 교과서를 분별 증류 실험 장치와 액체 혼합물의 종류에 따라 6가지로 분류하였다. 두 번째 단계로서 액체 혼합물을 가열 방법에 따라 직접가열과 물 중탕 가열로 나누어 교과서 실험과정에 따라 같은 실험을 세 번 실시하였다. 세 번째 단계로서 실험 결과의 문제점을 해결하기 위한 대안 실험을 실시하였다. 대안 실험에서는 알코을 램프로 직접가열 하는 방법과 기름 중탕으로 가열하는 방법, 그리고 가열 맨틀을 사용하여 가열하는 방법을 사용하였다. 연구결과, 가지 달린 둥근 플라스크를 직접 가열하는 실험 결과가 가지 달린 시험관을 물 중탕으로 가열하는 실험 결과보다 이론적인 결과에 근접하였다. 그리고 가지 달린 둥근 플라스크를 직접 가열하는 실험에서 플라스크 윗 부분을 보온해 주는 실험이 보온하지 않은 실험보다 실험 결과가 더 나았다. 대안 실험에서는 액체 혼합물의 증류 온도 증가를 보면서 가열 맨틀의 가열 온도를 을려 준 실험의 결과가 이론적인 결과에 가장 가까웠다. 이러한 연구 결과로부터 가지 달린 시험관을 물 중탕으로 가열하는 분별 증류 실험 장치는 탐구실험 수업에 부적절한 것이므로 개선이 요구되며, 중학교 과학실 여건을 고려할 때, 액체 혼합물의 증류 온도 증가를 보면서 가열 맨틀의 가열 온도를 변화시키는 분별 증류 실험이 가장 능률적인 방법임을 알 수 있었다. The purpose of this study was to find out the problems on the fractional distillation experiments in the middle school science textbooks based on the 6th curriculum and to suggest an efficient experiment method for the middle school students. The first step was the classification of the experiments in 8 science textbooks according to heating apparatus and liquid mixtures. The second step was doing each experiment 3 times followed by the experimental process in the textbooks. The third step was developing the alternative experiments for solving the problems found in the second step. The heating method used in the alternative experiments were direct heating, oil bath, and heating mantle. The results of the second step showed that the direct heating experiment of branched round flask was more close to the theoretical prediction than the experiment of water bath heating of branched test tube. Also the direct heating experiment of thermally insulated branched round flask was better than the result of the experiment which was not insulated. The results of the third step showed that the experiment using heating mantle regulated heating power by observing the temperature of distillate gave the closest result to the theoretical prediction. From the above results, it is concluded that the experiment using branched test-tube with water bath heating is not adequate for the fractional distillation and an alternative experiment using insulated branched round flask with heating mantle regulated heating power during experiment is recommended.
농업인 평생학습체계 구축을 위한 농업인교육 발전방안 연구
정철영,송병국,김진모,문택석,허영준,주대진,최수정,한승완 한국농업교육학회 2008 농업교육과 인적자원개발 Vol.40 No.2
이 연구의 목적은 우리나라 농업인의 평생학습체계 구축을 위한 농촌진흥기관의 역할을 정립하고, 한국농업대학의 농업인대학 운영 본부화 방안을 수립하는데 있다. 이를 위해 관련 문헌고찰, 농업인 및 농촌진흥기관의 농업인 교육 담당자들의 인식 및 요구분석, 전문가 자문 및 협의회 등의 방법을 활용하였으며, 이를 토대로 도출된 연구의 결과를 제시하면 다음과 같다. 첫째, 농촌진흥기관의 농업인교육관련 연계를 위해서는 한국농업대학이 농업인평생교육기관으로 평가인정을 받고, 전국의 농업인대학을 총체적으로 지원하는 역할을 수행하는 것이 바람직하다. 이때 지역의 농업기술센터는 한국농업대학과 협력적 관계를 구축하여 학점은행제 운영에 소요되는 교육 및 이력관리를 지원하는 역할을 수행하는 것이 필요하다. 둘째, 한국농업대학의 농업인대학 운영본부화를 위하여 평생학습원의 조직이 추가되는 것이 바람직하다. 이에 따라 평생학습원의 비전, 미션 및 전략이 제시되었으며, 조직의 기능 및 세부과제가 제시되었다. 셋째, 농업인교육의 학점은행제를 도입을 위한 체계를 설정한 후, 농업관련 기존 표준교육과정 분석, 농업인 요구분석, 전국 농업인대학 교육과정 분석, 기존 농업관련 전공 교육과정 분석, 전문가 검토 등의 과정을 거쳐서 '영농 전문학사'와 '농업 경영 학사'의 표준교육과정을 개발하였다. 넷째, 고졸미만 농업인을 위한 사전학습제도화를 위하여 농업인교육의 평가인정을 통한 방안과 One-Stop 평생학습모델을 통한 방안을 제시하였다. The purposes of this research were to assign the role of rural development organizations, and to establish the strategy for the making headquarter of farmer's university. The study was performed as follows: (1) analyzing the related literatures, documents, records review, (2) need analysis of farmers and members ig rural development organizations in terms of farmer's lifelong learning, (3) consulting experts. The following four findings are the results of this study: (1) Korean national agricultural college should be headquarter of farmer's universities and be approve for lifelong learning credit. Also, agricultural technology & extension centers should run educational program for the lifelong learning credit. (2) For the doing role of headquarter of farmer's university, division of lifelong learning should be add to department of technology training in Korea agricultural college. In relation with this, vision, mission and strategy of division of lifelong learning were suggested. (3) Steps for introduction of credit bank system of farmer education were suggested. Also standard curriculums of 'farming associate degree' and 'agricultural management bachelor's degree' were developed through analyzing existing standard curriculum related with agriculture, analyzing need of farmer, analyzing curriculum of farmer's university, analyzing curriculum of agriculture major. (4) For farmer who do not have high school graduate, two solutions were suggested which are approving farmer's education and one-stop lifelong learning model.
장향동,백광균,구경림,옥선미,최진석,고은주,류성렬 한국공업화학회 2004 응용화학 Vol.8 No.2
Aflatoxin B₁ was known to have the strongest poisonous character among Aflatoxin compounds. To search the production of Aflatoxin B1 according to the change of temperature, relative humidity and incubation days, orange incubated with Aspergillus parasiticus KCCM 35078 was incubated at 20℃, 25℃, 30℃ at relative humidity 60%, 70%, 80% and for incubation time 3, 4, 5, 6, 7 days.. Production of Aflatoxin B₁ shows that the highest production appeared at 25℃ and its relative humidity 70%. The result that was quantitatively analyzed by using HPLC was 77.41ppm, and by using Fluoroscence detector was 87.87ppm. - Production of Aflatoxin B₁ shows that the lowest production appreared at 20℃ and its relative humidity 80%(HPLC), 60%(Fluoroscence detector). The result that was quantitatively analyzed by using HPLC was 4.47ppm, and by using Fluoroscence detector was 4.17ppm. The structure of Aflatoxin B₁ was identify with authentic sample by using instrumental analysis methods of GC/MS, ¹H-NMR, FT-IR respectively.