퇴행성 슬관절염 환자 평가 설문도구의 내적 신뢰도, 상관성에 관한 연구

류성룡,안경애,서병관,강중원,이상훈,이재동,최도영,김건식,이두익,이윤호 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objective : The aim of this study is to evaluate internal reliability and correlation among assessment instruments of knee OA. Methods : Data were obtained from 85 patients with knee OA. They were asked to answer VAS pain scale, two disease-specific questionnaires (WOMAC and LFI) and one instrument about health-related quality(KHAQ). Reliability was assessed using cronbach's alpha. Correlation was assessed by examining the pearson's correlation coefficients. Results : Cronbach's alpha of all Index except WOMAC stiffness subscale(.6679) exceeded the value of 0.70. A good correlation was obtained between WOMAC Subscale (especially Pain Subscale) and LFI (.726<cronbach's alpha<.791). Also, Correlation between KHAQ and two disease-specific questionnaires (WOMAC and LFI) was good(.612<cronbach's alpha<.662). Conclusions : All used instruments have good internal reliability. also, There are good correlation among them. The treatment of knee OA must be focused on health related quality. For this, we should use proper assessment instruments.

주사용 발프로산 나트륨(DEPAKINE^(�)) 투여에 의한 항전간 효과의 유효성 및 안전성에 관한 임상적 연구

김성호,서성일,송시헌,김관태,김윤 최신의학사 1994 最新醫學 Vol.37 No.8

退行性關節炎 韓方治療에 對한 最近 硏究 動向 : 臨床硏究 方法論을 中心으로 Herbal Medicines in the Treatment of Osteoarthritis in Pubmed and Chinese Medical Journals

서병관,류성룡,이송실,허정은,백용현,이재동,최도영,조윤제,김남재,박동석 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Objective : The aim of this study was to review systemically clinical trials on the effectiveness and safety of herbal medicines in the treatment of osteoarthritis. Methods : Computerized literature searches were carried out on seven electronic databases, and hand-searching on some chinese medical journals in library of Kyung Hee Medical Center. Trial data were extracted in a standardized, predefined manner and assessed independently. Results : 1. Thirty reports of clinical trials and two reports of meta-analyses concerning herbal medicine were collected and reviewed Among these reports three medical herbs were applied as topical medicine and others as internal medicine. 2. The western studies established NSAIDs or placebo as their control group. Five chinese reports established formulated herb pill(Ruanshnagshenjin pill) as their control group and Six did not establish a control group at all. 3. ACR was the most highly used diagnostic criteria in the western studies while the Chinese used their official criteria established by their government or the criteria of their text books. 4. 20 reports chose the Lequesne functional index, SHAQ, WOMAC OA index, AIMS, and their own unique scoring system as the criteria of analysing the effect. Others chose clinical symptoms, articular functions, and lab finding as their criteria. 5. 7 single herbs and 19 formulated herbs were studied. Among the formulated herbs, Achyranthes japonica was studied in 10 of the studies and Angelica gigantis Radix in 8, making them the most often studied herbs among the studies.

한국형 액체금속로에 대한 신뢰도 분석 방법에 관한 연구

정관성,이낙영 충남대학교 기초과학연구소 2002 忠南科學硏究誌 Vol.29 No.1

The reliability analysis methods for Korea Advanced Liquid Metal Reactors(KALIMA) are considered in this paper. KALIMA is a new type of reactors and different from the existing reactors. The methods of selecting and analysing the initiating failure events for a power inherently safety module in KALIMA are suggested. And the reliability physical methods for the passive system which is a chief safety system of KALIMA are also investigated.

효모 세포벽 분해효소 생산균의 탐색 및 효소생산 최적조건의 조사

차성관,최혜숙,김왕준,윤석후,김영배 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.2

담자효모 세포벽을 분해하는 효소 생산균의 탐색을 위하여 50여 토양시료와 방선균 1000여개의 미생물을 가지고 3차에 걸친 탐색작업을 실시한 결과 1차적으로 autolysed washed yeast 배지 위에서 투명한 생성크기로 493개 균주를 선발하였으며, 이 균주들을 2차적으로 생효모 한천배지 위에서의 투명한 생성 크기로 117개 균주를 선발 하였다. 선발된 균주들을 가지고 용해활성도의 측정방법을 이용하여 최종적으로 St-1702 균주가 선발되었고, St-1702 균주는 동정 실험결과 잠정적으로 Streptomyces eurythermus 또는 그 유연균으로 동정되어졌다. St-1702 균주를 이용하여 효소생산 최적조건을 조사한 결과 최적배지 및 배양조건은 다음과 같았다 : freeze dried yeast 2% glucose 1%, K_2HPO_4 1%, MgSO_4·7H_2O, 1% peptone 0.5% (NH_4)_2CO_3 0.2% 초기 pH 값 7.0의 배지 및 30℃에서 3일간 배양. 최적배지에서 선발균주를 배양한 배양액을 이용하여 담자효모들의 원형질체 형성 실험을 한 결과 시중에서 구입된 효모 세포벽 분해 효소들보다 더 높은 원형질체 형성률을 보여 주었다. Thousand actinomycetes and 50 soil samples were used for the isolation of microorganisms producing yeast cell wall lytic enzymes. Among 493 strains producing large clear zones on autolysed washed yeast (AWY), 117 strains were selected on living yeast cell agar plates. With the method of lytic activity, one strain (St-1702) was selected, which was temporarily identified as Streptomyces eurythermus. The optimal condition for enzyme production of this strain was partially determined as follows: incubation of the strain for 3 days at 30℃ in the medium containing 2% freeze dried yeast cell, 1% glucose, 1% K_2HPO_4, 0.01% MgSO_4·^7H_2O, 0.5% peptone, and 0.2% (NH_4)_2CO_3 with pH 7.0. The protoplast formation of yeast by using the enzyme produced by this strain was compared with commercial enzymes.

지역혁신체제 구축과 지방과학기술행정의 역할

李盛根,李官律 嶺南大學校社會科學硏究所 2003 社會科學硏究 Vol.23 No.1

본 연구는 지역혁신체제 구축을 위한 지방과학기술행정의 역할을 모색하는데 그 목적이 있다. 이를 위해 본 연구에서는 지역혁신체제의 의의, 지역혁신체제와 지역발전, 지역혁신체제와 지방과학기술행정에 대해서 이론적으로 고찰하였다. 따라서 본 연구에서는 지역혁신체제 구축을 위한 지방과학기술행정의 역할제고 방안을 제도적 측면, 조직과 인력측면, 과학기술 예산측면, 평가시스템 측면, 그리고 사업내용적 측면에서 제시하였다. 그 주요내용은 다음과 같다. 첫째, 제도적 측면에서 볼 때, 지방과학기술행정을 위한 법적 기반의 확립과 지역혁신정보시스템이 구축되어야 한다. 둘째, 조직과 인력측면에서 볼 때, 지방과학기술행정을 전담할 수 있는 전문조직과 전문인력이 확충되어야 한다. 셋째, 과학기술 예산측면에서 볼 때, 지역혁신사업을 안정적으로 추진 할 수 있는 예산확보와 혁신기금의 조성이 이루어져야 한다. 넷째, 평가시스템 측면에서 볼 때, 지역단위에서 자율성을 확보하는 “지역혁신평가단”을 설립해야 하고, 지역혁신사업의 평가기준을 확립해야 한다. 다섯째, 사업내용적 측면에서 볼 때, 지역혁신사업의 사업범위가 물리적 하부구조 중심에서 탈피하여 제도적 기반확충과 혁신네트워크 구축을 강조해야 한다.

佛敎人의 目標와 倫理 : 修行階位와修行法을 중심으로

김성관 圓光大學校 社會思想硏究所 1993 社會思想硏究 Vol.3 No.-

접합면의 차이에 따른 두개골 외판의 생존

박성근,송중원,한기환,강진성,박관규 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.3

Onlay graft of the calvarial bone has been popularized in craniofacial surgery because absorption of the calvarial bone is less than that of the endochondral bone. But the problems with using the calvarial bone are its rigidity and difficulty in setting a precise apposition. When the outer tables of the calvarial bone are used for augmentation and reconstruction of the convex zygoma, forehead, or chin, it is better to place the cancellous surface over the convex recipient bone to get a precise apposition. Whereas, it is better to place the cortical surface over the concave nose or orbital cavity to achieve a good apposition. Therfore, our study was designed to determine the differences of bone absorption and regeneration between cancellous and cortial bone contact to facial bone, and between preserved periosteum and detached periosteum in autograft of calvarial bone in dog models. Outer tables of the calvarial bone were placed in subperiosteal pockets of the upper and lower maxilla in four different ways : Group I ; The cancellous surface was placed in contact with the bare recipient bone, and the cortical surface attached with periosteum was accordingly contacted with the elevated periosteum of the recipient bone. Group Ⅱ ; The corical surface attached with periosteum was placed in contact with the bare recipient bone and the cancellous surface was contacted with the elevated periosteum of the recipient bone, Group Ⅲ ; The arrangenent was similar to Group Ⅰ except that the periosteum of the graft was deprived. Group Ⅳ ; The arrangement was similar to Group Ⅱ except that the periosteum of the graft was deprived. Volume measurements using a caliper technique and histological study were made 20 weeks postoperatively. The volume of maintenance is as follows ; Group Ⅰ, 84.2% ; Group Ⅱ, 77.6% ; Group Ⅲ, 77.0%, and Group Ⅳ, 69.5%. The histolgical contribution of living bone was assessed by a modified point counting technique : Group Ⅰ, 86.6%, Group Ⅱ, 83.8% ; Group Ⅲ, 79.6% and Group Ⅳ, 77.6%. Greater volume maintenance and histological contribution of living bone were found when cancelllous surface rather that the cortical were placed in contact with the recipient bone and the grafts from their periosteum were preserved. We concluded that in order to expect better survival of a grafted bone, the cancellous surface of the graft should contact with the recipient bone and that the periosteum of the graft should be preserved.

중추신경계 화농성 감염의 수술적치험

김성호,송시헌,김관태,김윤 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2

Authors experienced 36 surgical cases of pyogenic central nervous system infections including brain abscess, subdural empyema, skull osteomylitis with epidural abscess, intraspinal abscess and other rare infections. The incidence was hightest in the 5th and 6th decade, and male patients were predominant. About 56% of the CNS infections were occured after opdraions. The most common causative organisms were staphylococcus aureus. WBC count, ESR and body temperature were not diagnostic in CNS infections. No patient died among the brain abscess cases and the overall mortality rate of CNS infections was 8%.

인슐린의존형 당뇨병환자에서 임신중 병발한 당뇨병성 케톤산증 1예

이성근,신영구,이성규,정윤석,이관우,김현만,김행수 아주대학교 1997 아주의학 Vol.2 No.2

저자등은 인슐린의존형 당뇨병환자에서 임신중에 병발한 당뇨병성 케톤산증을 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. IDDM is an autoimmune disease resulted from beta cell destruction and insulin deficiency, and developed mostly in children and puberty. Ketoaddosis remains one of the most senous complications that can occur in the pregnant diabetic. A 26-year-old woman, gravida 1, para 0, was admitted at 32 weeks gestation because of fever lasted for 6 days. She had been treated with insulin pump during the pregnancy. Blood sugar was well controlled before admission, and the etiology of her ketoacidosis was urinary tract infection and no insulin-intake. DKA was treated with fluids and intravenous insulin. Urinary tract infection was treated with antibiotics, based on culture test. Healthy newbom was later delivered by cesarean section due to fetal distress. We experienced a case of DKA in pregnant woman and report it with a review on literature.