철결핍성 빈혈과 동반된 심부뇌정맥 혈전증

정필욱,홍석찬,이광호,정진상 대한신경과학회 1999 대한신경과학회지 Vol.17 No.5

Zigbee를 이용한 무선 실시간 전광판

金範錫,金星坤,韓必熙,朴樹榮,李宜宣,崔祐榮 明知大學校 産業技術硏究所 2009 産業技術硏究所論文集 Vol.28 No.-

In general, LED display system displays the fixed text in ROM. In this paper, we propose the wireless real-time LED display system in which the text can be easily displayed in any text color and display mode by users And the system can be set up in any place by using Zigbee communication.

폴리카보네이트 브라켓 부착 시 결합강도 증진을 위한 표면처리 효과

김석필,김년경,이현정,황현식 대한치과교정학회 2006 대한치과교정학회지 Vol.36 No.5

본 연구는 폴리카보네이트 브라켓 부착 시 표면처리가 결합강도를 증진시키는지 알아보고자 시행되었다. 소의 하악 중절치를 포매하여 만든 100개의 시편에 광중합형 레진 접착제를 이용하여 폴리카보네이트 브라켓(Alice, 광명 데이콤, 대한민국)을 부착하였다. 대조군의 경우, 표면처리 없이 부착한 반면, 실험군의 경우 샌드블라스팅 처리한 경우, plastic conditioner 처리하여 부착한 경우, 그리고 샌드블라스팅과 함께 plastic conditioner 처리한 경우로 구분하여 접착하였다. 만능시험기를 이용하여 전단결합강도를 측정하고 파절양상을 비교 분석한 결과, plastic conditioner나 샌드블라스팅으로 표면처리를 시행한 경우 표면처리를 시행하지 않은 경우에 비해 높은 결합강도를 보였다 (p<0.001). 샌드블라스팅과 Plastic conditioner를 모두 처리한 경우는 샌드블라스팅만이나 plastic conditioner만 처리한 경우보다 높은 결합강도를 보였으며, 특히 샌드블라스팅만 처리한 경우에 비해서는 통계적 유의차를 보였다 (p<0.05). 이상의 연구결과는 폴리카보네이트 브라켓 부착 시 결합강도 증진을 위해서 베이스의 표면처리가 필요하며 샌드블라스팅 후 plastic conditioner 도포가 가장 효과적임을 보여주었다. Objective: The purpose of this study was to evaluate whether the bond strength of polycarbonate brackets can be increased through surface treatment. Methods: One hundred polycarbonate brackets (Alice) were bonded to bovine incisors with light-cured adhesive. The bracket bases were treated with one of three methods; sandblasting, plastic conditioner application, and combined treatment with sandblasting and plastic conditioner. The brackets without any surface treatment served as the control. The shear bond strength was tested with a universal testing machine, and failure pattern was assessed with the adhesive remnant index. Results: The shear bond strength in all experimental groups was higher than that of the control group (p<0.001). The group treated with plastic conditioner after sandblasting showed statistically higher shear bond strength than the sandblasting only group (p<0.05). The group treated with plastic conditioner after sandblasting showed higher shear bond strength than plastic conditioner only group, but the difference was not statistically significant. Conclusion: The above results suggest that the surface treatments of polycarbonate bracket is mandatory to improve bond strength, and the most effective method is an application of plastic conditioner after sandblasting.

요로결석 환자에서 Pethidine, Nalbuphine, Ketorolac의 진통효과 비교

장석준,박인철,정성필,최성욱,이한식 대한응급의학회 1996 대한응급의학회지 Vol.7 No.2

Ureter stone cause severe flank and abdominal pain. In emergency room, these patients require rapid pain relief and diagnosis. Therefore, authors have conducted a study on the efficacy of three types of commonly used analgesics including non opioid analgesics; intramuscular ketorolac 30mg and nalbuphine 10mg was compared with pethidine 50mg in 74 patients who visited SEVERANCE hospital emergency care center with complaint of flank colicky pain from Jan1. 1996 to Mar 31. 1996. Pain was assessed before the drug administration, and then at 10min, 20min, 30min time interval after the first dose. Visual analogue scale was used to assess the pain intensity and scale was self drawn by each patient during the time of pain assessment. Additional need of rescue analgesia and adverse effecfs of first-line analgesia was also recorded. Statistical significant was confirmed using ANOVA and Chi square test. The difference in the decrease of pain intensity was not significant among the three analgesics(P=0.65). Rescue anagesia was required in 37.1% of pethidine, 42.8% of nalbuphine, 16.6% of ketorolac and totally 33.8%. The incidence of all types of adverse event of pethidine, nalbuphine and ketorolac were 14.2%, 14.2% and 5.5% in respectively. The results of this study have shown that non opioid analgesics are as effective as opioid analgesia. Therefore, non opioid analgesics can be tried first line of pain relief drug of renal coliky pain with minimal adverse effects.

교정치료 시 브라켓 부착 및 제거에 따른 치아색 변화

김석필,황인남,조진형,황현식 대한치과교정학회 2006 대한치과교정학회지 Vol.36 No.2

본 연구는 교정용 브라켓 부착을 위한 레진 접착부위 및 그 인접부위 즉, primer만 도포된 부위의 색변화를 알아보기 위하여 시행되었다. 교정치료를 위해 발치된 60개의 건전한 소구치를 재료로 사용하여 분광측정기로 색을 측정한 후 CIE L*a*b* 색표계로 기록하였다. 20개의 소구치에 광중합형 접착레진으로 브라켓을 부착한 후 부착 전과 제거 후의 색을 측정하였으며 다른 20개의 소구치에는 primer만 도포하고 도포 전과 도포 후의 색을 측정한 후, L* 값을 이용하여 명암 변화를 살펴본 결과 브라켓 부착 및 primer 도포 모두의 경우 명도가 감소하는 경향을 보였으며, a* 값과 b* 값을 이용하여 색상 변화를 살펴본 결과 황색이 증가하는 양상을 나타내었다. 또한 측정된 L*a*b* 값을 이용하여 색변화를 산출하고 임상적으로 인지할 수 있는 색변화 값 3.7을 기준치로 하여 비교 및 분석을 시행한 결과 브라켓 부착 전과 제거 후의 색변화는 기준치보다 큰 것으로 나타났으며 primer 도포에 따른 색변화는 기준치보다 크지 않은 것으로 나타났다. 한편 primer만 도포한 경우 칫솔질에 따른 색변화를 알아보고자 나머지 20개의 소구치를 대조로 하여 칫솔질을 시행한 결과 칫솔질 시행 후 색변화는 기준치보다 큰 것으로 나타났다. 브라켓 제거 후 자연광 노출의 영향을 알아보기 위하여 모든 경우에 추가적으로 photoaging을 시행한 결과 부기적인 색변화는 기준치보다 작은 것으로 나타났다. 이상의 결과는 교정치료를 위한 브라켓 부착으로 인해 브라켓 부착 및 인접부위의 치아색 변화가 있음을 의미하며 임상과정에서 이에 대한 고려가 필요함을 시사하였다. The purpose of this study was to evaluate the tooth color changes of resin bonding sites and their adjacent sites on orthodontic bracket bonding. Sixty extracted sound premolars were used and the tooth color was recorded according to the CIE L*a*b* color system using a spectrophotometer. The tooth colors of the twenty premolars were measured and compared before bracket bonding and after removal. On a further twenty premolars, the tooth color was measured before and after only primer application. In the change of L* values, according to the bracket bonding and primer application, the lightness was decreased, and in the change of a* and b* values, the color was changed into a more yellowish color. The color differences (ΔE*) were calculated from the L*a*b* values and compared with the standard value of clinical detection (ΔE*=3.7). The color differences between before the bracket bonding and after removal noted exceeded the standard value and those of between before and after the primer application were not larger than the standard value. Tooth brushing was performed after application of the primer to evaluate the color changes according to the primer abrasion. As a control, toothbrushing was performed on the last twenty premolars. The color differences noted were larger than the standard value after toothbrushing. Also, to evaluate the color changes of the tooth which is exposed to sun irradiation after bracket removal, additional photoaging was performed and the color was measured for all teeth. The additional color differences after photoaging were smaller than the standard value. The above results suggest that the tooth color changes after fixed orthodontic treatment.

답손(Dapsone)중독환자의 예후와 특성 분석

장석준,정성필,김승환,구홍두,심호식 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

We reviewed 26 dapsone intoxication patients who had visited Severance Hospital Emergency Care Center from January 1991 to January 1995 : 13 of them ingested intentionally, but the other ingested accidentally. Among the admitted patients the highest and lowtheest initial value of methemoglobin level is 59.6% & 10.1%. The frequency of symptoms at presentation was following 16 patients complained cyanosis of lip area, 10 patients complained dyspnea, 4 patients complained mental change, 4 patients complained vomiting, 2 patients complained nausea. The inital level of methemoglobin was less than 50% except in one patient. In the view points of total doses of methylene blue used, less than 100mg was used in 9 patients(34.6%) but in one case, amount of 6400mg was loaded. There were 5 patients(19.2%) in September & 4 patients (15.4%) in January. In respect of result, there were 13 discharged cases (50%) for symptom improvement, and 5 mortality cases(19.2%). The transferred cases from Gangwondo account 19 patients(73.1%). All of them is not directly emergency care center visiting patients but transferred patients from remotely located hospitals. Dapsone intoxication results in severe tissue hypoxic symptoms from malfunction of normal hemoglobin thus only with appropriate available doses of methylene blue & activated charcoal, good outcomes will be expected. If aggressive therapy such as hemodialysis is introduced in treatment of severe dapsone intoxication, the outcomes may be slightly improved better than in other supportive care cases.

학교체육의 문제점과 개선방향

강필중,김석일 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.3

Divided into the internal, external of Physical Education and social political problems, the problems of Physical Education have been investigated and the plans of solution have been looked over in this research. Recently, the opinions for reconsideration and improvement about Physical Education have gathered the power from the social point of view. Now it's the time that Physical Education should be more emphasized and more recognized of being an absolutely necessary thing for the health of the students and people and for the life on a high level than be considered by mean of chasing after the private opinions and the personal profits. And the continuous administrative effort is needed so that Physical Education Policy which the government suggested may solve the conflicts of Physical Education organization and be driven forward in a right direction continuously.

체육수업의 문제와 정상화 방안에 대한 고찰

한이석,윤필규 龍仁大學校 體育科學硏究所 2003 體育科學硏究論叢 Vol.13 No.2

The physical training study is which who easily does not negate a fact will not be able in breakdown difficulty condition. With the humbleness one attitude which recognizes the fact which is rather now school physical training prejudice of the society against a breakdown being born one physical training or negation time by the physical training humanity and justice end and the conduct which two of ten extend to become accomplished together newly it jumps when the psychiatry practice needs, is. It believes that nomalizes a school physical training the cold start for must be started from the teacher. Because from the present point of view value of physical training it will be able to deliver most the fact that properly is because is a game master in the school or the society. Also it develops the aim of the physical training program which is clear. It practices and the student and the parents, the possibility the education administration changing the recognition of the field in order to be, also the person must take charge of a spontaneous role rightly is the game master. Consequently currently, the hazard which nomalizes a breakdown difficulty physical training education the fact that it is most urgent the game master where becomes the subject of study means that does to be exchanged first. The teacher is exchanged and when and the students will naturally be exchanged and these people has and to be formed a fresh eye and. Like this change from hazard the reeducation which is appropriate for the effort and a transformation of the teacher, annual income, it is system in the same time when it introduces the incentive system back and the objectivity evaluation must be accomplished. Namely, it encourages the chance of academic society activity, annual income and reeducation of research announcement or the seminar back and it obtains new education information the indication magnetic pole to the same time when, it gives the magnification back of economic support and promotion chance it leads and and must give the effort and a toil of the teacher and and and human nature it does as a favor as to raise a self-conceit and a phase. The teacher who is excellent awards and, with upgrade and the mountain range increase back same compensation to lead the chance it will be able to grow more preparation it does as a favor and the teacher who is disablement in opposition presses hard a duty characteristic and must do to withdraw from teaching profession. When like as this specialist the natural features which demands the duty characteristic of the game master is created, the teaching profession to be opened always and the teacher who endeavors eagerly being received and special treatment and also the teacher who is excellent it will be able to demand more good Daewoo and. From the game master who is excellent accomplishes the role and a responsibility as the teacher sincerely the value of study and the students who receive a proper physical training education to respect the game master and properly to be recognized a huge contribution and and the place where it changes the time of the society against a physical training in foreseeable future to be done. The society which changes the fresh eye will induce the investment which is appropriate against a school physical training and the good physical training environment in the same time when it raises a physical training humanity and justice self-conceit and the phase which begin the game master will do to contribute in education for the whole man practice.

백일주 양조중 맛성분의 변화

박석규,박필숙,손봉수,문주석 순천대학교 기초과학연구소 1993 基礎科學硏究誌 Vol.4 No.-

Changes in taste components of Backilju, an old Korean cleraed rice wine, were investigated. During brewing, pH and titratable acidity of mash were decreased or increased in the range of 3.41→3.81 and 8.62→6.74, respectively. The final product of Backilju filtrate, fermented for 100 days, contained 0.36% reducing sugar, 2.68% total sugar, 606.6 ㎎% total acid, 2.5 ㎎% volatile acid and 22.9㎎ solid/ml extract. Major volatile components analized by GC/MS methods were 3-methyl-1-butanol acetate, 4-decanol and dimethyl disulfide. Calcium(20.26ppm) was the most abundant, followed by magnesium(3.19ppm) and zinc(1.87ppm). Nucleotides and their related compounds were inosine(0.12→0.44 mM/ml), ADP(0.16→0.33 mM/ml) and hypoxanthine(0.33→0.04 mM/ml). Compared with other Korean traditional Yakju, Backilju contained more total acid and mineral but less sugar and volatile acid.

TNF-α 유전자형과 방광암과의 관계

정필두,김은정,엄민식,서정원,윤석중,김종석,이상철,김원재 충북대학교 의학연구소 2001 忠北醫大學術誌 Vol.11 No.2

연구목적: TNF-α는 일부 종양의 종양화 과정과 관련이 있는 것으로 알려져 있다. 본 연구는 TNF-α 발현에 영향을 미치는 TNF-α 촉진자 -308 부위의 유전적 다형성이 방광암과 관련이 있는지 유무를 알고자 시행하였다. 대상 및 방법: 유전자 분석을 위하여 환자 113명 및 대조군 109명으로부터 혈액을 채취하여 genomic DNA를 분리한 후 PCR-RFLP 및 direct DNA sequencing을 통하여 TNF-α유전자의 다형성을 조사하여 방광암의 발생, 병기 및 분화도와 비교 검토하였다. 결과: TNF-α 촉진자 -308 부위의 유전형은 대조군에서는 GG형이 83.5%(90례 및 GA형이 16.5%(19례)로 관찰되었으며 AA형은 없었다. 환자군에서는 GG 형이 85.4%(97례), GA형 및 AA형은 각각 13.1%(15례)및 0.8%(1례)에서 관찰되었다. 두 군 모두에서 GG형이 가장 많이 나타났으며 다음으로 GA형을 보이고 AA형은 1례의 방광암 환자에서만 관찰되었다. -308부위의 경우도 두 군 사이에 유전자형의 차이는 없었다(p=0.259) 분화도별 분포를 보면 grade I이 20례, grade II가 49례, grade Ⅲ은 34례였고 병기별로 표재성인 경우가 90례였으며 침윤성은 14례였다. 분화도가 나빠질수록 GA형이 증가하였다(p=0.04). 그러나 병기와 TNF-α promoter -308부위의 유전자형 사이에는 유의한 상관 관계가 없었다(p=0.123). 결론: 방광암 환자의 혈액에서 GA genotype이 관찰되는 경우, 분화도가 나쁠 가능성이 매우 높기 때문에 좀 더 적극적인 치료와 세밀한 추적관찰을 함으로써 방광암으로 인한 사망과 암의 진행을 예방할 수 있을 것으로 기대한다. Purpose : Tumor necrosis factor-alpha (TNF-α) is involved in tumorigenesis of several cancers as an endogenous tumor promoter. The purpose of this study was to investigate whether genetic polymorphism of TNF-α promoter region (-308) was associated with human bladder tumor. Materials and Methods: The DNA from 113 and 109 respective blood samples of bladder tumor Patients and control group was analyzed by PCR-based restriction fragment length polymorphism (RFLP) and direct DNA sequencing methods to characterize the genetic polymorphism of -308 promoter region of the TNF-α gene in bladder tumor patients. We compared the association of bladder tumor with genetic Polymorphism of TNF-α promoter region(-308) in relation to the stage, grade, recurrence and progressio. Results : Eighty-six percents(97/113) of bladder tumor patients and 83.5% (90/109) of control group showed genotype GG at -308 region of TNF-α. Difference in genetic variations of TNF-α promoter (-308) did not exist between bladder tumor patients and control group(p=0.259). Tumor grade was significantly related to the GA genotype (p=0.04). The higher is the grade in bladder tumor, the more frequent was the GA genotype. Tumor stage, recurrence and progression were not significantly associated with genetic polymorphism of TNF-α promoter region (-308). Conclusion: The GA genotype of TNF-a promoter region (-308) had a significant impact on TNF-α production and was related to higher grade tumor compared to GG genotype. TNF-α serum levels in bladder tumor patients were significantly higher than controls. These data suggested that TNF-α might involve the tumorigenesis of the bladder rather than treatment or prevention of bladder tumor.