Single cell gap polymer-stabilized blue-phase transflective LCDs using internal nanowire grid polarizer

Hong-Qing Cui,Zhi-Cheng Ye,Wei Hu,XiaoWen Lin,T.C. Chung,Tean-Sen Jen,Yan-Qing Lu 한국정보디스플레이학회 2011 Journal of information display Vol.12 No.3

Optically isotropic liquid crystal (LC) mixture such as blue-phase LC and nanostructured LC composites exhibit the advantages of fast response time, high contrast ratio and wide-viewing angle due to the induced birefringence along the horizontal electric field. Utilizing this mixture, a novel single cell gap in-plane switching-type polymer-stabilized blue-phase transflective liquid crystal display by embedding the nanowire grid polarizer as a polarization-dependent reflective polarizer in the R region is proposed. This device can be used as a normal black mode without any quarter-wave plate or patterned in-cell phase retarder. Moreover, the transmittance is identical to the reflectance so that it will be suitable for single gamma driving. Detailed electro-optic performances, such as voltage-dependent light efficiency and viewing angle of the proposed device configuration, are investigated.

Analysis of Small Fragment Deletions of the APC gene in Chinese Patients with Familial Adenomatous Polyposis, a Precancerous Condition

Chen, Qing-Wei,Zhang, Xiao-Mei,Zhou, Jian-Nong,Zhou, Xin,Ma, Guo-Jian,Zhu, Ming,Zhang, Yuan-Ying,Yu, Jun,Feng, Ji-Feng,Chen, Sen-Qing Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.12

Background: : Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disease mainly caused by mutations of the adenomatous polyposis coli (APC) gene with almost complete penetrance. These colorectal polyps are precancerous lesions that will inevitable develop into colorectal cancer at the median age of 40-year old if total proctocolectomy is not performed. So identification of APC germline mutations has great implications for genetic counseling and management of FAP patients. In this study, we screened APC germline mutations in Chinese FAP patients, in order to find novel mutations and the APC gene germline mutation characteristics of Chinese FAP patients. Materials and Methods: The FAP patients were diagnosed by clinical manifestations, family histories, endoscope and biopsy. Then patients peripheral blood samples were collected, afterwards, genomic DNA was extracted. The mutation analysis of the APC gene was conducted by direct polymerase chain reaction (PCR) sequencing for micromutations and multiplex ligation-dependent probe amplification (MLPA) for large duplications and/or deletions. Results: We found 6 micromutations out of 14 FAP pedigrees, while there were no large duplications and/or deletions found. These germline mutations are c.5432C>T(p. Ser1811Leu), two c.3926_3930delAAAAG (p.Glu1309AspfsX4), c.3921_3924delAAAA (p.Ile1307MetfsX13), c3184_3187delCAAA(p.Gln1061AspfsX59) and c4127_4126delAT (p.Tyr1376LysfsX9), respectively, and all deletion mutations resulted in a premature stop codon. At the same time, we found c.3921_3924delAAAA and two c.3926_3930delAAAAG are located in AAAAG short tandem repeats, c3184_3187delCAAA is located in the CAAA interrupted direct repeats, and c4127_4128 del AT is located in the 5'-CCTGAACA-3', 3'-ACAAGTCC-5 palindromes (inverted repeats) of the APC gene. Furthermore, deletion mutations are mostly located at condon 1309. Conclusions: Though there were no novel mutations found as the pathogenic gene of FAP in this study, we found nucleotide sequence containing short tandem repeats and palindromes (inverted repeats), especially the 5 bp base deletion at codon 1309, are mutations in high incidence area in APC gene,.

Single cell gap polymer-stabilized blue-phase transflective LCDs using internal nanowire grid polarizer

Cui, Hong-Qing,Ye, Zhi-Cheng,Hu, Wei,Lin, Xiao Wen,Chung, T.C.,Jen, Tean-Sen,Lu, Yan-Qing The Korean Infomation Display Society 2011 Journal of information display Vol.12 No.3

Optically isotropic liquid crystal (LC) mixture such as blue-phase LC and nanostructured LC composites exhibit the advantages of fast response time, high contrast ratio and wide-viewing angle due to the induced birefringence along the horizontal electric field. Utilizing this mixture, a novel single cell gap in-plane switching-type polymer-stabilized blue-phase transflective liquid crystal display by embedding the nanowire grid polarizer as a polarization-dependent reflective polarizer in the R region is proposed. This device can be used as a normal black mode without any quarter-wave plate or patterned in-cell phase retarder. Moreover, the transmittance is identical to the reflectance so that it will be suitable for single gamma driving. Detailed electro-optic performances, such as voltage-dependent light efficiency and viewing angle of the proposed device configuration, are investigated.

Interleukin-17 Indirectly Promotes M2 Macrophage Differentiation through Stimulation of COX-2/PGE2 Pathway in the Cancer Cells

Qingli Li,Lunxu Liu,Qiuyang Zhang,Sen Liu,Dongxia Ge,Zongbing You 대한암학회 2014 Cancer Research and Treatment Vol.46 No.3

PurposeInterleukin-17 (IL-17) is a proinflammatory cytokine that plays important roles ininflammation, autoimmunity, and cancer. The purpose of this study was to determineif IL-17 indirectly regulates macrophage differentiation through up-regulation ofcyclooxygenase-2 (COX-2) expression in the cancer cell lines. Materials and MethodsHuman cervical cancer HeLa, human lung cancer A549, and mouse prostate cancerMyc-CaP/CR cell lines were treated with recombinant IL-17; Western blot analysis,enzyme-linked immunosorbent assay, and quantitative real-time polymerase chainreaction analysis were utilized to examine the cellular responses. ResultsIL-17 up-regulated expression of COX-2 mRNA and protein in HeLa, A549, and Myc-CaP/CR cell lines. IL-17’s effects were mediated through nuclear factor-κB andERK1/2 signaling pathways as the inhibitors of these pathways could inhibit IL-17-induced COX-2 expression. The conditional medium obtained from the cancer cellscontained prostaglandin E2, the levels of which were increased by IL-17 treatment. When treated with the conditional medium, particularly with the IL-17-induced conditionalmedium, mouse RAW264.7 macrophages and human THP-1 monocytes expressedhigher levels of IL-10 (a marker of M2 macrophages) than inducible nitricoxide synthase or tumor necrosis factor α (markers of M1 macrophages). In contrast,when RAW264.7 and THP-1 cells were treated directly with IL-17, expression of thesemarker genes was not markedly changed. ConclusionThe results of this study suggest that IL-17 indirectly promotes M2 macrophagedifferentiation through stimulation of the COX-2/PGE2 pathway in the cancer cells,thus IL-17 plays an indirect role in regulating the tumor immune microenvironment.

Prevalence and Multilocus Genotyping of Giardia lamblia in Cattle in Jiangxi Province, China: Novel Assemblage E Subtypes Identified

Sen Li,Yang Zou,Xue-Liang Zhang,Ping Wang,Xiao-Qing Chen,Xing-Quan Zhu 대한기생충학열대의학회 2020 The Korean Journal of Parasitology Vol.58 No.6

Giardia lamblia is a common enteric pathogen associated with diarrheal diseases. There are some reports of G. lamblia infection among different breeds of cattle in recent years worldwide. However, it is yet to know whether cattle in Jiangxi province, southeastern China is infected with G. lamblia. The objectives of the present study were to investigate the prevalence and examine the multilocus genotypes of G. lamblia in cattle in Jiangxi province. A total of 556 fecal samples were collected from 3 cattle breeds (dairy cattle, beef cattle, and buffalo) in Jiangxi province, and the prevalence and genotypes of G. lamblia were determined by the nested PCR amplification of the beta-giardin (bg) gene. A total of 52 samples (9.2%) were positive for G. lamblia. The highest prevalence of G. lamblia was detected in dairy cattle (20.0%), followed by that in beef cattle (6.4%), and meat buffalo (0.9%). Multilocus sequence typing of G. lamblia was performed based on sequences of the bg, triose phosphate isomerase and glutamate dehydrogenase loci, and 22, 42, and 52 samples were amplifiable, respectively, forming 15 MLGs. Moreover, one mixed G. lamblia infection (assemblages A and E) was found in the present study. Altogether, 6 novel assemblage E subtypes (E41*-E46*) were identified for the first time. These results not only provided baseline data for the control of G. lamblia infection in cattle in this southeastern province of China, but also enriched the molecular epidemiological data and genetic diversity of G. lamblia in cattle.

A Fast Kernel Regression Framework for Video Super-Resolution

( Wen-sen Yu ),( Ming-hui Wang ),( Hua-wen Chang ),( Shu-qing Chen ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.1

A series of kernel regression (KR) algorithms, such as the classic kernel regression (CKR), the 2- and 3-D steering kernel regression (SKR), have been proposed for image and video super-resolution. In existing KR frameworks, a single algorithm is usually adopted and applied for a whole image/video, regardless of region characteristics. However, their performances and computational efficiencies can differ in regions of different characteristics. To take full advantage of the KR algorithms and avoid their disadvantage, this paper proposes a kernel regression framework for video super-resolution. In this framework, each video frame is first analyzed and divided into three types of regions: flat, non-flat-stationary, and non-flat-moving regions. Then different KR algorithm is selected according to the region type. The CKR and 2-D SKR algorithms are applied to flat and non-flat-stationary regions, respectively. For non-flat-moving regions, this paper proposes a similarity-assisted steering kernel regression (SASKR) algorithm, which can give better performance and higher computational efficiency than the 3-D SKR algorithm. Experimental results demonstrate that the computational efficiency of the proposed framework is greatly improved without apparent degradation in performance.

IP电影:符号消费、异化符号消费及意义构建

杨森(Sen Yang),刘庆(Qing Liu) YIXIN 출판사 2023 Journal of Humanities and Social Sciences Vol.1 No.1

Model Based on Alkaline Phosphatase and Gamma-Glutamyltransferase for Gallbladder Cancer Prognosis

Xu, Xin-Sen,Miao, Run-Chen,Zhang, Ling-Qiang,Wang, Rui-Tao,Qu, Kai,Pang, Qing,Liu, Chang Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15

Purpose: To evaluate the prognostic value of alkaline phosphatase (ALP) and gamma-glutamyltransferase (GGT) in gallbladder cancer (GBC). Materials and Methods: Serum ALP and GGT levels and clinicopathological parameters were retrospectively evaluated in 199 GBC patients. Receiver operating characteristic (ROC) curve analysis was performed to determine the cut-off values of ALP and GGT. Then, associations with overall survival were assessed by multivariate analysis. Based on the significant factors, a prognostic score model was established. Results: By ROC curve analysis, $ALP{\geq}210U/L$ and $GGT{\geq}43U/L$ were considered elevated. Overall survival for patients with elevated ALP and GGT was significantly worse than for patients within the normal range. Multivariate analysis showed that the elevated ALP, GGT and tumor stage were independent prognostic factors. Giving each positive factor a score of 1, we established a preoperative prognostic score model. Varied outcomes would be significantly distinguished by the different score groups. By further ROC curve analysis, the simple score showed great superiority compared with the widely used TNM staging, each of the ALP or GGT alone, or traditional tumor markers such as CEA, AFP, CA125 and CA199. Conclusions: Elevated ALP and GGT levels were risk predictors in GBC patients. Our prognostic model provides infomration on varied outcomes of patients from different score groups.

Assessment of wind-induced fragility of transmission towers under quasi-static wind load

Dahai Wang,Sen Li,Chao Sun,Guoqing Huang,Qing-shan Yang 한국풍공학회 2021 Wind and Structures, An International Journal (WAS Vol.33 No.4

Overhead power transmission line systems consisting of long-span conductors and high-rise towers are windsensitive structures featured with significant structural nonlinearity and fragility under wind hazards. To assess wind-induced structural fragility of a transmission tower, a novel efficient quasi-static approach, which is based on the analytical probability distribution of extreme wind effect in frequency domain and the probabilistic wind-resistant capacity, is developed in the present study. The 90-degree wind direction (perpendicular to conductors), which is always the worst scenario, is considered in this paper. The structural nonlinearity and failure modes are captured using a nonlinear static push-over analysis method, which simulates the failure process of the tower structure with random initial geometric defects. Wind-resistance performance of the tower is quantified based on the principle of energy equivalence. Damage of the tower is classified into three levels including slight damage, severe damage, and collapse. The tower fragility curve, which predicts damage of the tower as a function of wind speed, is presented and discussed.

Interaction of Coping Styles and Psychological Stress on Anxious and Depressive Symptoms in Chinese Breast Cancer Patients

Wang, Xi,Wang, Shu-Sen,Peng, Rou-Jun,Qin, Tao,Shi, Yan-Xia,Teng, Xiao-Yu,Liu, Dong-Gen,Chen, Wei-Qing,Yuan, Zhong-Yu Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

Purpose: This study aimed to assess possible interactive effects of coping styles and psychological stress on depression and anxiety symptoms in Chinese women shortly after diagnosis of breast cancer. Methods: Four hundred and one patients with breast cancer were face-to-face interviewed by trained research staff according to a standardized questionnaire including information on socio-demographic characteristics, psychological stress, coping styles, and anxiety and depressive symptoms. Interactive effects were assessed by hierarchical multiple regression analyses. Results: There were significant associations of the four domains of psychological stress with anxiety and depressive symptoms except for the relationship between "worrying about health being harmed" and depressive symptoms. "Abreaction coping behavior" and "escaping coping behavior" significantly increased the level of both anxiety and depressive symptoms; whereas an "active coping style" reswulted in significant decrease. The interaction of "active coping behavior" with "worrying about health being harmed" significantly increased the risk of the anxiety symptoms, while adopting "self-relaxing coping behavior" was associated with significant decrease. The interaction of "worry about daily life and social relationship being restricted" with "escaping coping behavior" significantly increased the risk of the depressive symptoms. Conclusions: The results of this study suggest that certain coping styles might moderate the association of psychological stress with anxiety and depressive symptoms in Chinese women with breast cancer.