Effects of colchicine on renal fibrosis and apoptosis in obstructed kidneys

( Sejoong Kim ),( Eun Sook Jung ),( Jeonghwan Lee ),( Nam Ju Heo ),( Ki Young Na ),( Jin Suk Han ) 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.3

Background/Aims: Colchicine is an established drug for microtubule stabilization that may reduce tissue injury. No data were available that its effects may depend on the dosage of colchicine. We investigated the anti-fibrotic and apoptotic effects of various dose of colchicine in a unilateral ureteral obstruction (UUO) model. Methods: Thirty-six Sprague-Dawley rats were randomly assigned into six groups. Two sham groups were divided into a vehicle-treated or colchicine-treated group (100 μg/kg/day). Four UUO groups were treated with either vehicle or three different doses of colchicine for 7 days (30, 60, and 100 μg/kg/day, intraperitoneally). All of the animals were sacrificed on day 7. Results: Colchicine treatment diminished acetylated α-tubulin and tumor growth factor-β immunoreactivities in the cortical area of the 7-day obstructed kidneys, which was in dose dependent manner. Colchicine attenuated tubulointerstitial damage and apoptosis in both cortical and medullary area, and beneficial effects of colchicine therapy were dramatically shown at the higher dosage of colchicine. The expression levels of cleaved caspase-3, ED-1, and fibronectin were decreased in UUO animals. Conclusions: We found that the proper dosage of colchicine may have anti-fibrotic and anti-apoptotic effects in obstructed kidneys. For clinical applications, an optimal dose of colchicine should be evaluated to maximize the prevention of renal disease progression.

Time-varying effects of body mass index on mortality among hemodialysis patients: Results from a nationwide Korean registry

( Sejoong Kim ),( Jong Cheol Jeong ),( Shin Young Ahn ),( Kibbeum Doh ),( Dong-chan Jin ),( Ki Young Na ) 대한신장학회 2019 Kidney Research and Clinical Practice Vol.38 No.1

Background: Unlike patterns observed in the general population, obesity is associated with better survival among hemodialysis patients, which could be explained by reverse causation or illness-related weight loss. However, the time-varying effect of body mass index (BMI) on hemodialysis survival has not been investigated. Therefore, this study investigated the time-varying effect of BMI on mortality after starting hemodialysis. Methods: In the present study, we examined Korean Society of Nephrology data from 16,069 adult patients who started hemodialysis during or after the year 2000. Complete survival data were obtained from Statistics Korea. Survival analysis was performed using Cox regression and a non-proportional hazard fractional polynomial model. Results: During the median follow-up of 8.6 years, 9,272 patients (57.7%) died. Compared to individuals with normal BMI (18.5-24.9 kg/m2), the underweight group (< 18.5 kg/m2) had a higer mortality hazard ratio (HR, 1.292; 95% confidence interval [CI], 1.203-1.387; P < 0.001) and the overweight group (25.0-29.9 kg/m2) had a lower mortality HR (0.904; 95% CI, 0.829-0.985; P = 0.022). The underweight group had increasing HRs during the first 3 to 7 years after starting hemodialysis, which varied according to age group. The young obese group (< 40 years old) had a U-shaped temporal trend in their mortality HRs, which reflected increased mortality after 7 years. Conclusion: The obese hemodialysis group had better survival during the early post-dialysis period, although the beneficial effect of obesity disappeared 7 years after starting hemodialysis. The young obese group also had an increased mortality HR after 7 years.

Kidney and Organ on a Chip

Sejoong KIM 한국생물공학회 2020 한국생물공학회 학술대회 Vol.2020 No.10

Effects of Sodium Citrate on Salt Sensitivity and Kidney Injury in Chronic Renal Failure

Kim, Sejoong,Yang, Jin Young,Jung, Eun Sook,Lee, Jeonghwan,Heo, Nam Ju,Lee, Jae Wook,Na, Ki Young,Han, Jin Suk The Korean Academy of Medical Sciences 2014 Journal of Korean medical science Vol.29 No.12

First-principles quantum transport with electron-vibration interactions: A maximally localized Wannier functions approach

Kim, Sejoong,Marzari, Nicola American Physical Society 2013 Physical review. B, Condensed matter and materials Vol.87 No.24

Pharmacokinetic profile that reduces nephrotoxicity of gentamicin in a perfused kidney-on-a-chip

Kim, Sejoong,LesherPerez, Sasha Cai,Kim, Byoung choul C,Yamanishi, Cameron,Labuz, Joseph M,Leung, Brendan,Takayama, Shuichi IOP Publishing 2016 Biofabrication Vol.8 No.1

Biocompatible Peritoneal Dialysis Solution Preserves Residual Renal Function

Kim, Sejoong,Oh, Kook-Hwan,Oh, Jieun,Kim, Soo Jin,Chung, Wookyung,Song, Young Rim,Na, Ki Young,Oh, Yun Kyu,Ahn, Curie,Kim, Sung Gyun,Tan, Kathryn C.B. S. Karger AG 2012 American journal of nephrology Vol.36 No.4

<P>Abstract</P><P><B><I>Background/Aims:</I></B> The long-term effects of biocompatible peritoneal dialysis (PD) solution on residual renal function (RRF), inflammation, adipokines and metabolic acidosis are controversial. We evaluated the effects of biocompatible PD solution in continuous ambulatory PD (CAPD) patients for an additional 12-month period. <B><I>Method:</I></B> Among 91 incident patients who started CAPD with either biocompatible PD solution (Balance®, Fresenius; LS, n = 48) or conventional PD solution (CAPD/DPCA®, Fresenius; CS, n = 43), 63 patients, who were followed for 12 months, were enrolled and followed for an additional 12 months. <B><I>Results:</I></B> After 24 months of treatment, the glomerular filtration rate (GFR) of the LS group was twofold higher compared to the CS group (33.5 ± 30.7 vs. 16.3 ± 17.9 l/week/1.73 m<SUP>2</SUP>, respectively, p <I>= </I>0.021). In a subgroup of patients with an initial GFR >2 ml/min/1.73 m<SUP>2</SUP>, the GFR of the LS group was significantly higher than the rate of the CS group after 24 months (43.7 ± 30.5 vs. 18.6 ± 19.0 l/week/1.73 m<SUP>2</SUP>, respectively, p = 0.042). Over a 24-month period, effluent cancer antigen-125 levels were significantly increased in the LS group compared to the CS group, while effluent interleukin-6 levels did not differ between the two groups. The serum tCO<SUB>2</SUB> levels were consistently higher in the LS group compared to the CS group. <B><I>Conclusions:</I></B> We found that the effect of LS on preserving RRF may be maintained over a 24-month treatment period in CAPD patients, and LS use may have other benefits, such as the correction of metabolic acidosis.</P><P>Copyright © 2012 S. Karger AG, Basel</P>

외부 충격이 제주도 관광관련 산업에 미치는 경제적 영향과 파급효과

이세중 ( Sejoong Lee ),강태헌 ( Taeheon Kang ) 전남대학교 지역개발연구소 2021 지역개발연구 Vol.53 No.1

이 연구에서는 제주도의 관광관련 산업이 다른 지역에 비해 외부 충격에 더욱 취약한 속성을 갖고 있는지 여부를 검토하였다. 아울러 이와 같은 취약성으로 인해 외부 충격시 제주경제가 추가적으로 경험한 피해의 규모를 추정하였다. 최근 발생한 세월호 사건, 사드 사태 및 COVID-19 사태를 외부 충격으로 정의하고 분석한 결과, 제주도의 관광관련 산업은 이와 같은 외부 충격 발생시, 타 지역에 비해 추가적인 충격을 경험하는 것으로 나타났다. 이 분석결과는 제주도의 관광관련 산업이 여타 시도에 비해 전반적으로 외부 충격에 취약한 성격을 가지고 있음을 시사한다. 또한 이러한 관광산업의 취약성에서 기인하는 제주경제에의 추가적인 부담 규모를 지역산업연관표의 각종 유발계수를 이용하여 분석하였다. 그 결과 제주도 관광산업의 외부 충격에 대한 취약성으로 인해 실질 총산출, 부가가치 및 고용은 전국 평균에 비해 큰 폭으로 하락하는 것으로 나타났다. 대표적으로 제주도의 추가적인 실질 부가가치의 감소 규모는 충격의 종류에 따라 -0.48%에서 -2.91% 사이로 추정된다. 이 연구 결과는 제주도 관광산업의 충격에의 취약성을 실증적으로 검증하였다는 데 의의가 있다. 또한 이러한 제주도 관광관련 산업의 특성상 충격 발생시, 충격을 완화하고 관광관련 산업이 복원력을 가질 수 있도록 관광정책의 방향을 정립할 필요가 있음을 시사한다. This study examines whether the tourism-related industries in Jeju island are more vulnerable to external shocks than the other regions. In addition, we estimate the additional impacts that Jeju economy experiences during the shocks. Adopting three external shocks such as Sewol ferry accident, THAAD incident, and COVID-19 diffusion, we find that Jeju's tourism-related industries are generally more fragile to external shocks than the other regions. We also measure the additional declines in output, value added, and employment of Jeju island due to the shocks, using the regional input-output tables. The results of this study imply that the tourism-related industries in Jeju island are more vulnerable to external crisis shocks. Thus, policy makers in Jeju island need to prepare tourism-related policies that help mitigate the external impacts and recover from the shocks.

Cost Stickiness and Stock Price Crash Risk

Lee, Sejoong,Jung, Chan Shik,Lee, Dongheun 한국국제경영관리학회 2021 국제경영리뷰 Vol.25 No.2

본 연구는 미국의 주식시장에 상장된 모든 기업을 대상으로 기업 원가의 하방경직성이 주가급락위험에 어떠한 영향을 미치는지 고 찰한다. 이 때 다음과 같은 두 가지 큰 연구 흐름을 기초로, 원가의 하방경직성이 미래의 주가급락의 선행요인 기능을 행하는지 분석한 다. 즉, 경영진의 낙관적인 기대가 원가의 하방경직성을 초래한다는 것과, 기업에 불리한 정보를 감추는 동기가 바로 이러한 낙관적 기 대에서 비롯된다는 것이다. 실증분석 결과, 원가의 하방경직성이 심할수록 주가급락위험이 유의하게 증가함을 발견하였다. 본 연구는 이어서 상품시장에서의 경쟁이 심할수록 경영진이 불리한 정보를 감추려고 하는 동기가 감소함으로써 주가급락위험도 감소하는지 분 석한 결과, 실제로 상품시장의 경쟁이 치열할수록 주가급락위험이 유효하게 감소함을 발견하였다. 또한 본고의 주요 실증결과의 원인 이 2007년~2009년 동안 발생하고 유지되었던 미국발 글로벌 금융위기에 국한된다는 반론 또한 가능하기에, 금융위기 이전(1981 년~2006년)과 금융위기 이후(2010년~2019년)로 표본을 구분하여 각각 회귀분석 한 결과, 본고의 주요 결론은 여전히 강건함을 발견하였다. This study investigates the relationship between a firm’s cost stickiness and future stock price crash risk. We explore whether cost stickiness acts as a leading indicator of future stock price crash. The result of the empirical research supports our hypotheses. We also examine the effect of product market competition on the relationship between cost stickiness and stock price crash and find that the relationship becomes weak under high product market competition. In addition, we also test our empirical model excluding the period from 2007 to 2009 to explore whether our main results originate from the financial crisis periods when most firms experience stock price crash. We re-examine our empirical model by dividing our sample periods into two periods, from 1981 to 2006 and from 2010 to 2019. We find our empirical results are robust. This study implies that cost stickiness may capture managerial optimism that may lead bad new hoarding and stock price crash.

Ne-naissance - Rethinking the a'ak reforms by King Sejong and Pak Yon

Kim Sejoong 서울대학교 동양음악연구소 1999 동양음악 Vol.21 No.-