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RISS 인기검색어
- 검색키워드
- 저자 : Sedmak, (검색결과 3 건)
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Human Cytomegalovirus Inhibition of Interferon Signal Transduction
Miller, Daniel M.,Cebulla, Colleen M.,Sedmak, Daniel D. The Microbiological Society of Korea 2000 The journal of microbiology Vol.38 No.4
Cytomegalovirus (CMV), a beta-herpesvirus with worldwide distribution, exhibits host persistence, a distinguishing characteristic of all herpesviruses. This persistence is dependent upon restricted gene expression in infected cells as well as the ability of productively infected cells to escape from normal cell-mediated anti-viral immunosurveillance. Type I (IFN-$\alpha$/$\beta$) and type II (IFN-γ) interferons are major components of the innate defense system against viral infection. They are potent inducers of MHC class I and II antigens and of antigen processing proteins. Additionally, IFNS mediate direct antiviral effects through induction effector molecules that block viral infection and replications such as 2', 5-oligoadenylate synthetase (2, 5-OAS). IFNS function through activation of well-defined signal transduction pathways that involve phosphorylation of constituent proteins and ultimate formation of active transcription factors. Recent studies have shown that a number of diverse viruses, including CMV, EBV, HPV mumps and Ebola, are capable of inhibiting IFN-mediated signal transduction through a variety of mechanisms. As an example, CMV infection inhibits the ability of infected cells Is transcribe HLA class I and II antigens as well as the antiviral effector molecules 2, 5-OAS and MxA I. EMSA studies have shown that IFN-$\alpha$ and IFN-γ are unable to induce complete signal transduction in the presence of CMV infection, phenomena that are associated with specific decreases in JAKl and p48. Viral inhibition of IFN signal transduction represents a new mechanistic paradigm for increased viral survival, a paradigm predicting widespread consequences in the case of signal transduction factors common to multiple cytokine pathways.
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Printing orientation influence on tensile strength of PA12 specimens obtained by SLS
Ivana Jevtić,Zorana Golubović,Goran Mladenović,Filippo Berto,Aleksandar Sedmak,Aleksa Milovanović,Miloš Milošević 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.11
Selective laser sintering (SLS) is one of the additive manufacturing technologies dedicated to the production of high-quality parts with complex geometries. Here, polyamide 12 (PA12) is a commonly used material, for manufacturing parts with sufficient mechanical and thermal properties. In SLS, many manufacturing parameters have an effect on the mechanical properties of final parts. Even the decision regarding the orientation of a part in a powder bed may have a significant effect on the mechanical properties. In this research, the influence of horizontal (H) and vertical (V) printing orientations on the ultimate tensile strength (UTS) of fabricated PA12 specimens are examined. Our research findings show that H specimens exhibit larger deformations and smaller UTS value scatter in comparison with V specimens. Also, worth pointing out is the fact that V-oriented specimens have a higher elastic modulus. One can assume that the sintering process is more effective in V specimens, due to a more uniform laser beam trajectory than in the H specimens’ case.
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Manufacturing parameter influence on FDM polypropylene tensile properties
Aleksa Milovanović,Zorana Golubović,Snežana Kirin,Tomáš Babinský,Ivo Šulák,Miloš Milošević,Aleksandar Sedmak 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.11
Polypropylene (PP) is a relatively new material in fused deposition modeling (FDM) technology. The main feature of this material is its ability to significantly elongate under applied load, unlike any other thermoplastic material used in FDM technology. Not much research has been conducted on this FDM material so far, hence, the subject of this paper is the investigation of printing parameters’ influence on PP tensile properties. Targeted parameters are layer height, infill density, and the orientation of raster lines, resulting in four different manufacturing regimes. To have a better insight into the experimental results, the data are analysed using ANOVA statistical method with Tukey HSD post hoc test. Obtained statistical results have proven the printing parameter’s influence on tensile results, emphasizing the influence on elastic modulus. Here, Tukey test results show the maximal number of homogeneous subsets evidencing that all printing parameters have an influence on elastic modulus values.
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