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Short-term feeding of baicalin inhibits age-associated NF-kB activation
Kim, Dae Hyun,Kim, Hyung Keun,Park, Secongjoon,Kim, Ji Young,Zou, Yani,Cho, Ki Ho,Kim, Young Suk,Kim, Dong Hyun,Yu, Byung Pal,Choi, Jae Sue,Chung, Hae Young 경희대학교 동서의학연구소 2006 東西醫學硏究所 論文集 Vol.2006 No.-
Baicalin is a flavonoid isolated from Scutellaria baicalensis and is known to affect multiple biological functions, including the inhibition of aldose reductase, HIV infection, and nitric oxide producing activity. Oxidative stress is considered a major cause of aging and various age-related diseases, and among the key cellular components exquisitely sensitive to oxidative stress is the transcription factor, nuclear factor-KB (NF-KB). In the present study, we attempted to elucidate the mechanisms underlying the suppression of age-related NF-KB activation by baicalin in kidney tissue from old rats. Results showed NF-KB activation and the upregulation of NF-KB targeting genes, hemoxygenase-1, inducible nitric oxide synthase (iNOS), and COX-2 with age. In contrast, the increased expression of these NF-KB targeting genes was effectively inhibited by baicalin. Baicalin was shown to inhibit the NF-KB cascade via three signal transduction pathways, NIK/IKK, extracellular signal-regulated kinase (ERK), and p38 mitogenactivated protein kinase (MAPK). Our results clearly indicated the anti-oxidative effects of baicalin on age-related redox imbalance. Thus, the significance of the current study is the new information revealing the anti-oxidative properties of baicalin and the role it plays in the regulation of age-related alterations.
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