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김동섭,신정철,고명규,최준규,장세진 한양대학교 의과대학 1998 한양의대 학술지 Vol.18 No.1
The congential fibrosis syndorme is rare congenital disorder which is characterized by blepharoptosis, varying degrees of limitation of eye movement, especially in vertical gaze, and abnormal head position. These clinical findings result from the fibrous replacement of normal contractile extraocular muscle tissue. The authors report one sporadic case of congential fibrosis syndrome. The 14 year-old-girl showed bilateral ptosis, fixed ocular misalignment in downward gaze, limited ductions and versions, and characteristic chin up position. The surgical management attempted to achieve functional readjustment of the ocular alignment and lid position and to correct cosmetically unacceptable abnormal head position. Result of histopathologic examination obtained at surgery shows replacement of the extraocular muscles, conjuctiva and Tenon's capsule by collagen and dense fibrous tissue. The surgical outcome is considered satisfactory when compared with preoperative status although the limitation of vertical eye movement remains unchanged after surgery.
Effects of Some Coumarin Derivatives on the Bovine Lens Aldose Reductase Activity
Moon, Chang-Kiu,Lee, Se-Chang,Yun, Yeo-Pyo,Ha, Bae-Jin,Yook, Chang-Soo The Pharmaceutical Society of Korea 1988 Archives of Pharmacal Research Vol.11 No.4
Nine coumarin dervatives were examined for thier inhibitory effects on bovine lens aldose reductase activity (bovine-LAR). More than 50% inhibition of BLAR activities was observed in the cases of treatments with decursin, decursinol, esculin, isoimperatorin, oxypeucedanine and isobergapten at the concentration of $10^{-4}$M. Especially, BLAR activity was completely inhibited by the treatment of decursin and decursinol at this concentration. At $10^{-5}$ M, only three coumarins-decursin, decursinol and isoimperatorin, were found to have still relatively higher inhibitory effect.
한국 공황장애 환자에서 COMT 및 5-HTTLPR 다형성의 연관 분석 : 재현 연구
김세웅,최태규,이상혁,Kim, Se-Woong,Choi, Tai Kiu,Lee, Sang-Hyuk 대한생물정신의학회 2016 생물정신의학 Vol.23 No.4
Objectives We investigated whether the catechol-O-methyltransferase (COMT) and serotonin related gene polymorphisms may be associated with agoraphobia in patients with panic disorder in Korea. Methods The COMT gene (rs4680), 5-hydroxytryptamine (serotonin) transporter linked polymorphic region (5-HTTLPR) gene (rs25531), serotonin receptor 1A (HTR1A) gene (rs6295) genotypes were analyzed in 406 patients with panic disorder and age-sex matched 206 healthy controls. Patients with panic disorder were dichotomized by the presence of agoraphobia. The following instruments were applied : the Beck Depression Inventory, the Beck Anxiety Inventory, the Panic Disorder Severity Scale. Results There was a significant difference in the distribution of 5-HTTLPR genotype between panic patients with agoraphobia and without agoraphobia (p = 0.024). That is, the panic patients with agoraphobia had a significant excess of the less active 5-HTTLPR allele (S allele). (p = 0.039) Also, we replicated previous western reports which indicated a significant difference in the distribution of COMT genotype between the patients with panic disorder and the healthy controls (p = 0.040). However, no significant associations of agora-phobia or panic disorder with HTR1A gene polymorphisms were found. Conclusions This result supports that the COMT polymorphisms may be associated with panic disorder and suggests that the 5-HTTLPR polymorphisms may play a role in the pathogenesis of agoraphobia in the Korean patients with panic disorder.
Recent Development of National Competency Standards in Korean Rubber Product Manufacturing
( Soon-jung Yang ),( Se-kiu Lee ),( Sung-yong ),( Sun Pyo Jeong ),( Jeong Seok Oh ) 한국고무학회 2017 엘라스토머 및 콤포지트 Vol.52 No.4
The national competency standards (NCS) is the national standard for standardizing the skills needed to suc-cessfully carry out the duties of industrial sites. It consists of competency units and their sub units. Two standards were developed for the manufacturing of Korean rubber products: rubber compounding and rubber product manufacturing. Each standard consists of ten competency units and their elements. Learning modules will be developed in the near future. It is expected that researchers and workers in the Korean rubber industry will utilize these standards.