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Savas Sencan,Gunay Yolcu,Serhad Bilim,Ozge Kenis-Coskun,Osman Hakan Gunduz 대한통증학회 2022 The Korean Journal of Pain Vol.35 No.1
Background: Coccygodynia is one of the chronic, refractory painful musculoskeletal disorders. Interventional procedures are applied to patients unresponsive to initial treatment in coccygodynia. This study aims to compare the treatment outcomes of ganglion impar block (GIB) and caudal epidural steroid injection (CESI) in patients with chronic coccygodynia. Methods: This study was a prospective randomized comparison study conducted between June 2019 and January 2021. Patients diagnosed with chronic coccygodynia were randomly divided into two groups: the GIB group and the CESI group. The severity of pain, presence of neuropathic pain, and quality of life were evaluated using the Numeric Rating Scale, Leeds Assessment of the Neuropathic Symptoms and Signs Scale, and Short Form-12 Health Survey (SF-12), respectively. Results: A total of 34 patients in each group were included in the final analyses. While there was a significant decrease in pain intensity in both groups in the 3-month follow-up, this decrease was more significant in the GIB group at the 3rd week. There was a significant improvement in the SF-12 physical score and the number of patients with neuropathic pain in both groups in the 3rd week, but this improvement was not observed in the 3rd month. Conclusions: Although GIB may provide more pain relief in short term, both GIB and CESI are useful treatment methods in coccygodynia unresponsive to more conservative treatments.
Savas Guzel,Ozden Serin,Eda Celik Guzel,Banu Buyuk,Güzin Yılmaz,Guvenc Güvenen 대한내과학회 2013 The Korean Journal of Internal Medicine Vol.28 No.2
Background/Aims: Acute coronary syndrome (ACS) is characterized by increased inflammatory processes and endothelial activation. We investigated the association between ACS and inflammatory mediators and matrix-degrading enzymes. Methods: We prospectively enrolled 55 consecutive patients with ACS: 25 with unstable angina (UA) and 30 with non-ST elevated myocardial infarction (NSTEMI). For comparison, 25 age- and sex-matched subjects with no significant coronary artery stenosis were included as the control group. Peripheral serum levels of interleukin (IL)-33, matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP-1, and C-reactive protein (CRP) were measured on admission, and at 12, 24, 48, and 72 hours after the initial evaluation. Results: Compared to serum levels in the control group, serum levels of IL-33 decreased in the NSTEMI group (p < 0.05), and levels of MMP-9 and tissue inhibitor of matrix metalloproteinase (TIMP)-1 increased in the UA group (p < 0.01, p < 0.05, respectively) and NSTEMI group (p < 0.05, p < 0.05, respectively). IL-33 levels were significantly lower on admission than at 12 hours after the initial evaluation (p < 0.05). IL-33 levels were negatively correlated with MMP-9 levels (r = -0.461, p < 0.05) and CRP levels (r = -0.441, p < 0.05). Conclusions: Elevated levels of MMP-9, TIMP-1, and decreased levels of IL-33 play a role in the development and progression of ACS.
CASE REPORT : Acute Generalized Exanthematous Pustulosis Associatedwith Tigecycline
( Savas Ozturk ),( Cemal Ustun ),( Sultan Pehlivan ),( Haydar Ucak ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.2
Acute generalized exanthematous pustulosis (AGEP) is a severe and rare eruption that develops mostly from factors related to drugs. It is characterized by a fever and a pustular eruption on the erythematous skin with an acute onset and without follicular localization. Etiopathogenesis has not yet been fully explained. Although it is similar to pustular psoriasis, its clinical, historical and histopathological characteristics are different. In this article, we present a case of AGEP associated with tigecycline that developed in a patient followed up in the intensive care unit for three months with an intra-abdominal injury after a trauma and Acinetobacter baumannii infection.
Savas Sencan,Ipek Saadet Edipoglu,Fatma Gul Ulku Demir,Gunay Yolcu,Osman Hakan Gunduz 대한통증학회 2019 The Korean Journal of Pain Vol.32 No.4
Background: Ganglion impar blockade is a reliable and effective treatment option used in patients with coccydynia. Our primary objective was to specify the role of corticosteroids in impar blockade. We compared applications of local anesthetic with the local anesthetic + corticosteroid combination in terms of treatment efficiency in patients with chronic coccydynia. Methods: Our study was a prospective randomize double-blind study. The patients were divided into 2 groups after randomization. The first group (group SL) was made up of patients where a corticosteroid + local anesthetic were used during ganglion impar blockade. In the second group (group L) we used only local anesthetic. We evaluated numeric rating scale (NRS) and Beck depression scale, which were employed before the procedure and in 1st and 3rd months after the procedure. Results: Seventy-three patients were included in the final analysis. We detected a significantly greater decrease in NRS values in the 1st month in group SL than in group L (P = 0.001). In the same way, NRS values in the 3rd month were significantly lower in the group with steroids (P = 0.0001). During the evaluation of the Beck test, we detected significantly greater decreases in the 1st month (P = 0.017) and 3rd month (P = 0.021) in the SL group than in the L group. Conclusions: Ganglion impar blockade decreases pain in the treatment of chronic coccydynia and improve depression. Addition of steroids in a ganglion impar blockade is required for treatment response that should accumulate over a long period of time.
( Savas Sencan ),( Emel Guler ),( Isa Cuce ),( Kemal Erol ) 대한통증학회 2017 The Korean Journal of Pain Vol.30 No.1
We report a case of fluoroscopy-guided intraarticular steroid injection for sternoclavicular joint (SCJ) arthritis caused by limited cutaneous systemic sclerosis (SSc). A 50-year-old woman diagnosed with limited cutaneous SSc presented with swelling and pain in the right SCJ. MRI revealed signs of inflammation consistent with right-sided sternoclavicular joint arthritis. After the failure of oral medications, we performed fluoroscopy-guided injection in this region. She reported complete resolution of her symptoms at 4 and 12-week follow-ups. This outcome suggests that a fluoroscopy-guided SCJ injection might be a safe and successful treatment option for sternoclavicular joint arthritis. (Korean J Pain 2017; 30: 59-61)
Additively Manufactured Custom Soft Gripper with Embedded Soft Force Sensors for an Industrial Robot
Savas Dilibal,Haydar Sahin,Josiah Owusu Danquah,Md. Omar Faruk Emon,Jae-Won Choi 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.22 No.4
Soft robotic grippers are required for power grasping of objects without inducing damage. Additive manufacturing can be used to produce custom-made grippers for industrial robots, in which soft joints and links are additively manufactured. In this study, a monoblock soft robotic gripper having three geometrically gradient fingers with soft sensors was designed and additively manufactured for the power grasping of spherical objects. The monoblock structure design reduces the number of components to be assembled for the soft gripper, and the gripper is designed with a single cavity to enable bending by the application of pneumatic pressure, which is required for the desired actuation. Finite element analysis (FEA) using a hyperelastic material model was performed to simulate the actuation. A material extrusion process using a thermoplastic polyurethane (TPU) was used to manufacture the designed gripper. Soft sensors were produced by a screen printing process that uses a flexible material and ionic liquids. The grasping capability of the manufactured gripper was experimentally evaluated by changing the pneumatic pressure (0–0.7 MPa) of the cavity. Experimental results show that the proposed monoblock gripper with integrated soft sensors successfully performed real-time grasp detection for power grasping.
Savas Kanbur,Gulcin Ozcan Ates,Sinem Altinisik,Ulas Cinar,Fatma Baycan 한국고분자학회 2021 폴리머 Vol.45 No.6
A new thiophene benzimidazole based polymer (TBIP) was synthesized and then the TBIP-Br, TBIP-BF₄ and TBIP-ClO₄ polymer salts were obtained in water. All polymer salts can be dissolved in environmentally friendly solvents such as water or ethanol. Electrochemical and optical properties of the polymers were elucidated with cyclic voltammetry (CV) and ultraviolet-visible absorption (UV-Vis) spectroscopy. By using CV, the highest occupied molecular orbital (HOMO) values were found as approximately 1.70 eV. According to the atomic force microscopy (AFM) images of the thin film of TBIP, there are homogeneously distributed and smaller particles on the film surface, while the surface of TBIP-Br and TBIP-ClO₄ thin films is rougher due to -Br and -ClO₄ counter ions being bigger than -BF₄. Additionally, the antimicrobial activity of TBIP polymers was also investigated. All TBIP and its salts were showed antimicrobial activity against S. aureus ATCC 6538 and no antimicrobial activity against E. coli ATCC 1301 and ATCC 25922.
Duration Prediction Models for Construction Projects: In Terms of Cost or Physical Characteristics?
Savas Bayram 대한토목학회 2017 KSCE Journal of Civil Engineering Vol.21 No.6
The purpose of this study is to investigate and to validate the ‘Bromilow’s Time-cost (BTC) model’ and the ‘Love et al.’s Time- Floor (LTF) model’ for Turkish public building projects, to check their appropriateness and to compare their prediction performances on project duration. The LTF model formulates the project duration in terms of gross floor area & floor numbers while the BTC model formulated it in terms of cost. Despite the consideration of the different characteristics, both models were inspired from Australian building projects. The study also presents ‘best-fit models’ as a benchmark for the BTC and the LTF models in order to fill the gap in construction duration predictions. The research data were collected from a total of 530 Turkish public building projects which were completed in seven geographic regions by performing an archive search work. 80% of the total data (i.e. from 424 projects) were used to establish the models while the remaining 20% (106 projects) were used for validation. Eight project characteristics of; total construction area, building height, gross floor area, floor numbers, contract sum, actual cost, contract duration and the actual duration were collected. Since there was no central archiving conduction to obtain these characteristics, more than a thousand tender documents were examined, and for 530 documents these characteristics were available. Consequently, it was found that the BTC model is superior to the LTF model, which confirms that ‘cost’ is a more significant predictor of the ‘duration’ than ‘gross floor area’ & ‘floor numbers’. However, the proposed ‘best-fit model’ indicated that the ‘area’ and the ‘height’ are the main predictors of the ‘duration’ as well as the ‘cost’.