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Clinical Characteristics of Esophageal Motility Disorders in Patients With Heartburn
( Satsuki Takahashi ),( Tomoaki Matsumura ),( Tatsuya Kaneko ),( Mamoru Tokunaga ),( Hirotaka Oura ),( Tsubasa Ishikawa ),( Ariki Nagashima ),( Wataru Shiratori ),( Naoki Akizue ),( Yuki Ohta ),( Atsu 대한소화기기능성질환·운동학회 2021 Journal of Neurogastroenterology and Motility (JNM Vol.27 No.4
Background/Aims Esophageal motility disorders (EMDs) contribute to the pathophysiology of gastroesophageal reflux disease. However, the causes of EMDs and their impact on gastroesophageal reflux disease-associated symptoms remain unknown. This study aims to elucidate clinical features associated with various types of EMDs in patients with heartburn symptoms. Methods Of the 511 patients who underwent high-resolution manometry, 394 who were evaluated for heartburn symptoms were examined. Patients subjected to high-resolution manometry were classified into 4 groups: outflow obstruction group, hypermotility group, hypomotility group, and normal motility group. Symptoms were evaluated using 3 questionnaires. Patient characteristics and symptoms for each EMD type were compared with those of the normal motility group. Results Of the 394 patients, 193 (48.9%) were diagnosed with EMDs, including 71 with outflow obstruction, 15 with hypermotility, and 107 with hypomotility. The mean dysphagia score was significantly higher in each of the 3 EMD groups compared with those with normal motility. The mean acid reflux and dyspepsia scores were significantly lower in the outflow obstruction group (P < 0.05). The mean body mass index and median Brinkman index were significantly higher in the hypermotility group (P = 0.001 and P = 0.018, respectively), whereas the mean diarrhea and constipation scores were significantly lower in the hypomotility group (P < 0.05). Conclusions The results of our study indicate that different EMDs have distinct characteristics. Cigarette smoking and high body mass index were associated with esophageal hypermotility. Assessment of the dysphagia symptom scores may help identify patients with EMDs. (J Neurogastroenterol Motil 2021;27:545-554)
Yui Nanba,Yuhei Matsuda,Satsuki Watanabe,Mayu Takeda,Takafumi Abe,Kazumichi Tominaga,Minoru Isomura,Takahiro Kanno 대한구강악안면외과학회 2023 대한구강악안면외과학회지 Vol.49 No.5
Objectives: Although a few studies have investigated the relationship between kidney and oral function (number of remaining teeth), their results remain inconclusive. Therefore, this study aimed to investigate the relationship between kidney function and oral health in community-dwelling healthy elderlies and examine the factors associated with kidney function. Materials and Methods: We used cross-sectional data from the Shimane prefecture cohort recruited by the Center for Community-Based Health Research and Education in 2019. We collected clinical data on dental status, background factors and kidney function (estimated glomerular filtration rate [eGFR], mL/min/1.73 m2 and creatinine levels, mg/dL). Results: The study enrolled 481 participants, whose mean age was 66.7±7.4 years, and 223 (46.4%) participants were men. Multivariate analysis revealed significant correlations between eGFR (B=0.17, P=0.04), creatinine (B=–0.54, P<0.01), and the number of remaining teeth. The number of remaining teeth was associated with creatinine and eGFR, which are indicators of kidney function. Conclusion: This study suggests that preserving the teeth may prevent decline in kidney function. Dental professionals should provide instructions and professional care to reduce the risk of systemic diseases such as kidney dysfunction.
Okumura, Toshiaki,Saito, Kaoru,Nade, Toshihiro,Misumi, Satsuki,Masuda, Yasuhisa,Sakuma, Hironori,Nakayama, Sachio,Fujita, Kazuhisa,Kawamura, Tadashi Asian Australasian Association of Animal Productio 2007 Animal Bioscience Vol.20 No.4
The effects of intramuscular fat on the sensory characteristics of M. longissimus dorsi in Japanese Black steers were investigated by a trained analytical panel (average 13.4 panelists). Five sets (10 head) of artificial identical twins were divided into 2 groups, high level of intramuscular fat group (HG) which utilized the fattening method of increasing intramuscular fat and low level of intramuscular fat group (LG) which did not use the above method. Regarding M. longissmus dorsi which was produced for use in the sensory evaluation, crude fat contents of HG and LG was 25.8% and 23.2% respectively (p<0.05). Warner-Bratzler shear force, water holding capacity, cooking loss and fatty acid composition of HG and LG were similar between the two groups. M. Longissimus dorsi taken from HG and LG were tested for their sensory characteristics by a trained panel. HG was given higher points for juiciness than LG (p<0.05). There were no significant differences for tenderness and flavor between the two groups. Overall acceptability which synthesized each of the sensory characteristics of HG and LG were 5.04 and 4.69 points respectively (p = 0.05). These results suggested that juiciness increased with the increase of intramuscular fat, and this raised the overall acceptability of M. longissimus dorsi.
Makoto Kinoshita,Masahito Nakataki,Ryoma Morigaki,Satsuki Sumitani,Satoshi Goto,Ryuji Kaji,Tetsuro Ohmori 대한정신약물학회 2018 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.16 No.4
No previous reports have described a case in which deep brain stimulation elicited an acute mood swing from a depressive to manic state simply by switching one side of the bilateral deep brain stimulation electrode on and off. The patient was a 68-year-old woman with a 10-year history of Parkinson’s disease. She underwent bilateral subthalamic deep brain stimulation surgery. After undergoing surgery, the patient exhibited hyperthymia. She was scheduled for admission. On the first day of admission, it was clear that resting tremors in the right limbs had relapsed and her hyperthymia had reverted to depression. It was discovered that the left-side electrode of the deep brain stimulation device was found to be accidentally turned off. As soon as the electrode was turned on, motor impairment improved and her mood switched from depression to mania. The authors speculate that the lateral balance of stimulation plays an important role in mood regulation. The current report provides an intriguing insight into possible mechanisms of mood swing in mood disorders.
Park, Seung‐,Yeol,Lee, Sung‐,Hyeon,Kawasaki, Nana,Itoh, Satsuki,Kang, Keunsoo,Hee Ryu, Soo,Hashii, Noritaka,Kim, Jin‐,Man,Kim, Ji‐,Yeon,Hoe Kim, Jung Wiley Subscription Services, Inc., A Wiley Company 2012 International journal of cancer: Journal internati Vol.130 No.10
<P><B>Abstract</B></P><P>Aberrant glycosylation has been observed in many types of cancer, but the mechanism of glycosylation change is still poorly understood. To elucidate relationships between glycosylation and colon cancer progression, we analyzed glycosylation status of β‐haptoglobin (β‐Hp) obtained from 46 cancer patients, 14 inflammatory bowel disease patients and 38 normal subjects. <I>Aleuria aurantia</I> lectin reactivity with cancer β‐Hp was much higher than in the other two study groups. These results were confirmed by lectin blotting and microarray assay using other lectins directed to fucosyl residues. Levels of such glycans were correlated with stage of colon cancer progression. Reactivity with fucosylated glycans was eliminated by treatment with α1‐3/4 fucosidase but not α1‐6 fucosidase, indicating that enhanced lectin reactivity with the fucose moiety of colon cancer β‐Hp is due to Fucα1‐3/4GlcNAc. Moreover, site‐specific glycan occupancy was determined by sequential LC/MS analysis. Mass spectrometric analysis showed that fucosylation of β‐Hp was higher in colon cancer patients than in other subjects. In particular, fucosylation at Asn 241 of β‐Hp in sera of colon cancer patients was clearly higher than in the other groups, and the ratio of fucosylated glycopeptides containing Asn 241 decreased greatly after treatment with α1‐3/4 fucosidase. In conclusion, the level of α1‐3/4 fucosyl epitope at Asn 241 of β‐Hp is potentially useful as a novel marker for colon cancer.</P>
Literature Review on Recent Magnetocardiography and Impedance-Magnetocardiography Technologies
Kandori, A.,Miyashita, T.,Ogata, K.,Seki, Y.,Suzuki, D.,Tsukamoto, A.,Saito, K.,Yokosawa, K.,Tsukada, K.,Yamada, Satsuki,Watanabe, Shigeyuki,Horigome, Hitoshi,Yamaguchi, Iwao The Korean Superconductivity Society 2006 Progress in superconductivity Vol.8 No.1
We have developed magnetocardiography(MCG) and impedance magnetocardiography(I-MCG) for detecting heart disease by using dc-SQUID technology. The MCG system, using low-Tc SQUID, is being applied commercially for diagnosing heart disease. Using the low-Tc MCG system, many clinical studies on detection of abnormality have been performed. Furthermore, we have developed a portable MCG system using high-Tc SQUID. For detecting changes in kinetic impedance in the heart, an I-MCG system has been demonstrated. The I-MCG system could detect the mechanical movement of the heart. In this report, we review current clinical applications of magnetocardiography and impedance magnetocardiography.
Literature Review on Recent Magnetocardiography and Impedance-MagnetocardiographyTechnologies
Y. Seki,A. Tsukamoto,K. Tsukada,Hitoshi Horigome,Miki Yokokawa,Yoshihide Chiba,Kimio Tanaka,A. Kandori,T. Miyashita,K. Ogata,D. Suzuki,K. Saito,K. Yokosawa,Satsuki Yamada,Shigeyuki Watanabe,Iwao Yamag 한국초전도학회 2006 Progress in superconductivity Vol.8 No.1